Dr Jochen Guck
Dr Jochen Guck is pleased to consider applications from prospective PhD students.
Physics of Medicine
http://www.bss.phy.cam.ac.uk/~jg473/ (personal home page)
The paradigm that neurons in the CNS cannot regenerate is gone. While most research to date is biochemical, there are also physical aspects that need to be considered. We are developing tools to investigate axonal growth and to direct in a certain direction using physical stimuli. We are also investigating the importance of mechanical cues for normal differentiation and axonal pathfinding during development and after trauma. Specifically, we want to find out whether glial scars present after injury pose mechanical barriers to nerve regeneration. More generally, we are interested in the mechanical and optical properties of living cells and tissues using novel photonic tools to test their relevance and importance for biological function. Towards this end we could show that the deformability of cells can be used as a sensitive inherent marker for cancer diagnosis and sorting of stem cells and that glial cells in the retina act as living optical light guides (see image below).
Spinal cord injury
Traumatic brain injury
Atomic force microscopy
Andreas Reichenbach Web: http://www.uni-leipzig.de/~pfi/pf...
Lautenschläger F, Paschke S, Schinkinger S, Bruel A, Beil M, Guck J (2009), “The regulatory role of cell mechanics for migration of differentiating myeloid cells.” Proc Natl Acad Sci U S A 106(37):15696-701 Details
Solovei I, Kreysing M, Lanctôt C, Kösem S, Peichl L, Cremer T, Guck J, Joffe B (2009), “Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution.” Cell 137(2):356-68 Details
Franze K, Grosche J, Skatchkov SN, Schinkinger S, Schild D, Uckermann O, Travis K, Reichenbach A, Guck J (2007), “Müller Cells are Living Optical Fibers in the Vertebrate Retina” Proc Natl Acad Sci USA 104(20):8287-8292 Details
Lu Y, Franze K, Seifert G, Steinhäuser Ch, Kirchhoff F, Wolburg H, Guck J, Janmey P, Wei E, Käs J, Reichenbach A (2006), “Viscoelastic properties of individual glial cells and neurons in the CNS” Proc Natl Acad Sci 103(47):17759-177764