Joshua Bernstock

University position

MD/PhD student

Departments

Department of Clinical Neurosciences

Institutes

WT MRC Stem Cell Institute and Cambridge Centre for Brain Repair

Email

jdb82@cam.ac.uk

Home page

http://www-neurosciences.medschl.cam....

Research Theme

Cellular and Molecular Neuroscience

Interests

Ischemic stroke continues to be a leading cause of morbidity/mortality throughout the world. The paucity of therapeutic options stands in stark contrast to the intensity of research efforts/number of clinical trials that have been performed. While reductionist methods have done much to enhance our understanding of ischemic brain injury, accumulating evidence has come to suggest that beyond the restoration of perfusion it will likely not be possible to identify a single dominant therapeutic target. Therefore, a focus on i) plurifunctional molecular pathways and ii) plurifunctional therapeutic modalities capable of influencing brain ischemia are urgently warranted. Critically, upregulation of the post-translational modification of proteins by the Small Ubiquitin-like MOdifier (SUMO) protein(s) via a process dubbed SUMOylation has been shown capable of maintaining homeostasis in natural models (e.g. hibernation) and in preclinical models of brain ischemia.

Research Focus

Keywords

stroke

SUMOylation

hibernation

post-translational modifications

neural stem cells

Clinical conditions

Cancers

Cerebrovascular disorders

Multiple sclerosis

Stroke

Traumatic brain injury

Equipment

Behavioural analysis

Cell culture

Confocal microscopy

Enzyme assays

Fluorescence microscopy

Immunohistochemistry

Magnetic resonance imaging (MRI)

Microscopy

Protein purification

Recombinant protein expression

Collaborators

Cambridge

Robin Franklin

Stefano Pluchino

International

John Hallenbeck Web: https://neuroscience.nih.gov/ninds/F...

Associated News Items


    Key publications

    Bernstock JD, Lee YJ, Peruzzotti-Jametti L, Southall N, Johnson KR, Maric D, Volpe G, Kouznetsova J, Zheng W, Pluchino S, Hallenbeck JM. (2015), “A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation.” J Cereb Blood Flow Metab.