Dr Joseph Donnelly

Joseph Donnelly

University position

PhD student
Supervised by Professor Marek Czosnyka


Department of Clinical Neurosciences


Neurosurgery Unit



Home page


Research Theme

Clinical and Veterinary Neuroscience


Cerebral autoregulation describes the ability of the brain to keep its blood flow constant across a range of perfusion pressures. Traumatic brain injury is a condition where cerebral autoregulation plays a pivotal role; trauma directly impairs autoregulation, and the degree of autoregulation impairment is directly related to patient outcome.

My PhD research focusses on the clinical applications of cerebral autoregulation including methodological optimisation, interactions between cerebral autoregulation and other aspects of patient physiology, and using cerebral autoregulation to guide therapy.

Research Focus


Traumatic Brain Injury

Cerebral Autoregulation


Cerebral blood flow

Clinical conditions



Traumatic brain injury


Computational modelling

Haemodynamic monitoring



Marek Czosnyka

Peter Smielewski

United Kingdom

Samuel Lucas Web: http://www.birmingham.ac.uk/schools...


Philip Ainslie Web: http://chlvh.ok.ubc.ca/welcome...

Marcel Aries Web: http://www.umcg.nl/EN/Rese...

Keith Burgess Web: http://sydney.edu.au/medicin...

James Cotter Web: http://physed.otago.ac.nz/staff/j...

Associated News Items



    Donnelly J, Aries MJ, Czosnyka M (2015), “Further understanding of cerebral autoregulation at the bedside: possible implications for future therapy.” Expert Rev Neurother 15(2):169-85 Details

    Liu X, Czosnyka M, Donnelly J, Budohoski KP, Varsos GV, Nasr N, Brady KM, Reinhard M, Hutchinson PJ, Smielewski P (2015), “Comparison of frequency and time domain methods of assessment of cerebral autoregulation in traumatic brain injury.” J Cereb Blood Flow Metab 35(2):248-56 Details

    Tremblay JC, Lovering AT, Ainslie PN, Stembridge M, Burgess KR, Bakker A, Donnelly J, Lucas SJ, Lewis NC, Dominelli PB, Henderson WR, Dominelli GS, Sheel AW, Foster GE (2015), “Hypoxia, not pulmonary vascular pressure, induces blood flow through intrapulmonary arteriovenous anastomoses.” J Physiol 593(3):723-37 Details

    Varsos GV, Budohoski KP, Czosnyka M, Kolias AG, Nasr N, Donnelly J, Liu X, Kim DJ, Hutchinson PJ, Kirkpatrick PJ, Varsos VG, Smielewski P (2015), “Cerebral vasospasm affects arterial critical closing pressure.” J Cereb Blood Flow Metab 35(2):285-91 Details


    Burgess KR, Lucas SJ, Shepherd K, Dawson A, Swart M, Thomas KN, Lucas RA, Donnelly J, Peebles KC, Basnyat R, Ainslie PN (2014), “Influence of cerebral blood flow on central sleep apnea at high altitude.” Sleep 37(10):1679-87 Details

    Dias C, Gaio AR, Monteiro E, Barbosa S, Cerejo A, Donnelly J, Felgueiras O, Smielewski P, Paiva JA, Czosnyka M (2014), “Kidney-Brain Link in Traumatic Brain Injury Patients? A preliminary report.” Neurocrit Care Details

    Donnelly J, Czosnyka M (2014), “The thermodynamic brain.” Crit Care 18(6):693 Details

    Donnelly J, Czosnyka M, Sudhan N, Varsos GV, Nasr N, Jalloh I, Liu X, Dias C, Sekhon MS, Carpenter KL, Menon DK, Hutchinson PJ, Smielewski P (2014), “Increased Blood Glucose is Related to Disturbed Cerebrovascular Pressure Reactivity After Traumatic Brain Injury.” Neurocrit Care Details

    Griesdale DE, Sekhon MS, Menon DK, Lavinio A, Donnelly J, Robba C, Sekhon IS, Taylor A, Henderson WR, Turgeon AF, Gupta AK (2014), “Hemoglobin Area and Time Index Above 90 g/L are Associated with Improved 6-Month Functional Outcomes in Patients with Severe Traumatic Brain Injury.” Neurocrit Care Details

    Hoiland RL, Foster GE, Donnelly J, Stembridge M, Willie CK, Smith KJ, Lewis NC, Lucas SJ, Cotter JD, Yeoman DJ, Thomas KN, Day TA, Tymko MM, Burgess KR, Ainslie PN (2014), “Chemoreceptor responsiveness at sea level does not predict the pulmonary pressure response to high altitude.” Chest Details

    Lewis NC, Bailey DM, Dumanoir GR, Messinger L, Lucas SJ, Cotter JD, Donnelly J, McEneny J, Young IS, Stembridge M, Burgess KR, Basnet AS, Ainslie PN (2014), “Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation.” J Physiol 592(Pt 5):1009-24 Details

    Smith KJ, MacLeod D, Willie CK, Lewis NC, Hoiland RL, Ikeda K, Tymko MM, Donnelly J, Day TA, MacLeod N, Lucas SJ, Ainslie PN (2014), “Influence of high altitude on cerebral blood flow and fuel utilization during exercise and recovery.” J Physiol 592(Pt 24):5507-27 Details


    Burgess KR, Lucas SJ, Shepherd K, Dawson A, Swart M, Thomas KN, Lucas RA, Donnelly J, Peebles KC, Basnyat R, Ainslie PN (2013), “Worsening of central sleep apnea at high altitude--a role for cerebrovascular function.” J Appl Physiol (1985) 114(8):1021-8 Details

    Donnelly J, Green S (2013), “Effect of hypoxia on the dynamic response of hyperaemia in the contracting human calf muscle.” Exp Physiol 98(1):81-93 Details


    Donnelly J, Cowan DC, Yeoman DJ, Lucas SJ, Herbison GP, Thomas KN, Ainslie PN, Taylor DR (2011), “Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude.” Respir Physiol Neurobiol 177(3):213-7 Details

    Donnelly J, Lucas SJ, Thomas KN, Galvin SD, Ainslie PN (2011), “Profound hyperventilation and development of periodic breathing during exceptional orthostatic stress in a 21-year-old man.” Respir Physiol Neurobiol 177(1):66-70 Details

    Green S, Thorp R, Reeder EJ, Donnelly J, Fordy G (2011), “Venous occlusion plethysmography versus Doppler ultrasound in the assessment of leg blood flow during calf exercise.” Eur J Appl Physiol 111(8):1889-900 Details

    Lucas SJ, Burgess KR, Thomas KN, Donnelly J, Peebles KC, Lucas RA, Fan JL, Cotter JD, Basnyat R, Ainslie PN (2011), “Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m.” J Physiol 589(Pt 3):741-53 Details


    Fan JL, Burgess KR, Basnyat R, Thomas KN, Peebles KC, Lucas SJ, Lucas RA, Donnelly J, Cotter JD, Ainslie PN (2010), “Influence of high altitude on cerebrovascular and ventilatory responsiveness to CO2.” J Physiol 588(Pt 3):539-49 Details