Professor Jean-Claude Baron

Jean-claude Baron-Cohen

University position

Professor

Professor Jean-Claude Baron is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Wolfson Brain Imaging Centre

Email

jcb54@cam.ac.uk

Home page

http://www.neurology.cam.ac.uk/stroke/... (personal home page)

Research Themes

Clinical and Veterinary Neuroscience

Cognitive and Behavioural Neuroscience

The Cambridge Neuroscience Community

Interests

My research focuses on the pathophysiology of ischaemic stroke and the mechanisms underlying subsequent deterioration or recovery, including neuronal damage, tissue inflammation and long-term plasticity processes. In terms of methodology, my approach is characterized by 1) combining brain imaging, both structural and functional (PET and fMRI) and assessment of performance measured using behavioural, cognitive or psychophysical tools; and 2) undertaking parallel studies in stroke patients and animal models, in the latter including microPET, in vitro autoradiographic and post mortem histopathologic techniques to inform the human studies.

Mapping the hypoxic brain tissue in the acute stage of stroke using PET and a selective hypoxia tracer
Mapping the hypoxic brain tissue in the acute stage of stroke using PET and a selective hypoxia tracer
Click image to view full-size

Research Focus

Keywords

stroke

functional recovery

plasticity

neuroimaging

PET

Clinical conditions

Aphasia

Cerebrovascular disorders

Dementia

Stroke

Equipment

Behavioural analysis

Computerised tomography

Cross-sectional and cohort studies

Haemodynamic monitoring

Magnetic resonance imaging (MRI)

Microscopy

Positron Emission Tomography (PET)

Collaborators

Cambridge

Elizabeth Warburton

Key publications

Calautti C, Naccarato M, Jones PS, Day DJ, Carpenter TA, Bullmore ET, Warburton EA, Baron JC (2007), “The relationship between motor deficit and hemisphere activation balance after stroke” NeuroImage 34:322-331

Takasawa M, Beech JS, Fryer TDF, Hughes JL Igase K, Jones PS, Smith R, Aigbirihio FI, Menon DK, Clark JC, Baron J-C (2007), “Imaging of Brain Hypoxia in Permanent and Temporary MCA Occlusion in the Rat Using 18F-Fluoromisonidazole and PET” J Cereb Blood Flow Metab 27:679-89

Guadagno JV, Jones PS, Fryer TD, Barret O, Aigbirhio FI, Carpenter TA, Price CJ, Gillard JH, Warburton EA, Baron JC (2006), “Local relationships between restricted water diffusion and oxygen consumption in the ischaemic human brain” Stroke 37:1741-48 Details

Publications

2008

Sharma N, Jones PS, Carpenter TA, Baron JC (2008), “Mapping the involvement of BA 4a and 4p during Motor Imagery.” Neuroimage 41(1):92-9 Details

Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, Gillard JH, Williams GB, Aigbirhio FI, Warburton EA, Østergaard L, Baron JC (2008), “How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET.” Stroke 39(3):870-7 Details

Takasawa M, Moustafa RR, Baron JC (2008), “Applications of nitroimidazole in vivo hypoxia imaging in ischemic stroke.” Stroke 39(5):1629-37 Details

2007

Calautti C, Naccarato M, Jones PS, Sharma N, Day DD, Carpenter AT, Bullmore ET, Warburton EA, Baron JC (2007), “The relationship between motor deficit and hemisphere activation balance after stroke: A 3T fMRI study.” Neuroimage 34(1):322-31 Details