Jason Stretton

Interests

My current research involves functional imaging of emotion disorders. Specifically, my interests lie in the processing of social rank information in depression and other affective disorders. Evolutionarily grounded theories of depression propose that the symptoms and behaviors associated with the disorder would have been adaptive to our ancestors in signalling powerlessness and in maintaining lesser social rank. I use novel social rank and social rejection fMRI paradigms to assess the neural basis of social hierarchy processing and whether this is maladaptive in depression.

My previous work (PhD) was interested in executive function and working memory in Temporal Lobe Epilepsy before and after anterior temporal lobe resection, using a combination of functional imaging and psychological measures.

Research Focus

Keywords

fMRI

depression

emotion

social rank

hippocampus

Clinical conditions

Amnesia

Anxiety disorders

Bipolar disorder

Depressive disorders

Epilepsy

Post-traumatic stress disorder

Equipment

Behavioural analysis

Magnetic resonance imaging (MRI)

Neuropsychological testing

Collaborators

Cambridge

Tim Dalgleish

United Kingdom

John Duncan Web: http://www.uclh.org/OurServ...

Associated News Items


    Publications

    2014

    Centeno M, Vollmar C, Stretton J, Symms MR, Thompson PJ, Richardson MP, O'Muircheartaigh J, Duncan JS, Koepp MJ (2014), “Structural changes in the temporal lobe and piriform cortex in frontal lobe epilepsy.” Epilepsy Res 108(5):978-81 Details

    Stretton J, Sidhu MK, Winston GP, Bartlett P, McEvoy AW, Symms MR, Koepp MJ, Thompson PJ, Duncan JS (2014), “Working memory network plasticity after anterior temporal lobe resection: a longitudinal functional magnetic resonance imaging study.” Brain 137(Pt 5):1439-53 Details

    2013

    Stretton J, Winston GP, Sidhu MK, Duncan JS et al (2013), “Disrupted segregation of working memory networks in temporal lobe epilepsy ” Neuroimage: Clinical 2(2): 273-281

    Sidhu MK, Stretton J, Winston GP, Bonelli S, Centeno M, Vollmar C, Symms M, Thompson PJ, Koepp MJ, Duncan JS (2013), “A functional magnetic resonance imaging study mapping the episodic memory encoding network in temporal lobe epilepsy.” Brain Details

    Wandschneider B, Centeno M, Vollmar C, Stretton J, O'Muircheartaigh J, Thompson PJ, Kumari V, Symms M, Barker GJ, Duncan JS, Richardson MP, Koepp MJ (2013), “Risk-taking behavior in juvenile myoclonic epilepsy.” Epilepsia 54(12):2158-65 Details

    Winston GP, Stretton J, Sidhu MK, Symms MR, Duncan JS (2013), “Progressive white matter changes following anterior temporal lobe resection for epilepsy.” Neuroimage Clin 4:190-200 Details

    Winston GP, Stretton J, Sidhu MK, Symms MR, Thompson PJ, Duncan JS (2013), “Structural correlates of impaired working memory in hippocampal sclerosis.” Epilepsia Details

    Yasuda CL, Centeno M, Vollmar C, Stretton J, Symms M, Cendes F, Mehta MA, Thompson P, Duncan JS, Koepp MJ (2013), “The effect of topiramate on cognitive fMRI.” Epilepsy Res 105(1-2):250-5 Details

    2012

    Centeno M, Vollmar C, O'Muircheartaigh J, Stretton J, Bonelli SB, Symms MR, Barker GJ, Kumari V, Thompson PJ, Duncan JS, Richardson MP, Koepp MJ (2012), “Memory in frontal lobe epilepsy: an fMRI study.” Epilepsia 53(10):1756-64 Details

    Chaudhary UJ, Centeno M, Carmichael DW, Vollmar C, Rodionov R, Bonelli S, Stretton J, Pressler R, Eriksson SH, Sisodiya S, Friston K, Duncan JS, Lemieux L, Koepp M (2012), “Imaging the interaction: Epileptic discharges, working memory, and behavior.” Hum Brain Mapp Details

    Daga P, Winston G, Modat M, White M, Mancini L, Cardoso MJ, Symms M, Stretton J, McEvoy AW, Thornton J, Micallef C, Yousry T, Hawkes DJ, Duncan JS, Ourselin S (2012), “Accurate localization of optic radiation during neurosurgery in an interventional MRI suite.” IEEE Trans Med Imaging 31(4):882-91 Details

    Stretton J, Thompson PJ (2012), “Frontal lobe function in temporal lobe epilepsy.” Epilepsy Res 98(1):1-13 Details

    Stretton J, Winston G, Sidhu M, Centeno M, Vollmar C, Bonelli S, Symms M, Koepp M, Duncan JS, Thompson PJ (2012), “Neural correlates of working memory in Temporal Lobe Epilepsy--an fMRI study.” Neuroimage 60(3):1696-703 Details

    Vollmar C, O'Muircheartaigh J, Symms MR, Barker GJ, Thompson P, Kumari V, Stretton J, Duncan JS, Richardson MP, Koepp MJ (2012), “Altered microstructural connectivity in juvenile myoclonic epilepsy: the missing link.” Neurology 78(20):1555-9 Details

    Williams EJ, Stretton J, Centeno M, Bartlett P, Burdett J, Symms M, Duncan JS, Micallef C (2012), “Clinical language fMRI with real-time monitoring in temporal lobe epilepsy: online processing methods.” Epilepsy Behav 25(1):120-4 Details

    Winston GP, Daga P, Stretton J, Modat M, Symms MR, McEvoy AW, Ourselin S, Duncan JS (2012), “Optic radiation tractography and vision in anterior temporal lobe resection.” Ann Neurol 71(3):334-41 Details

    2011

    Bonelli SB, Powell R, Thompson PJ, Yogarajah M, Focke NK, Stretton J, Vollmar C, Symms MR, Price CJ, Duncan JS, Koepp MJ (2011), “Hippocampal activation correlates with visual confrontation naming: fMRI findings in controls and patients with temporal lobe epilepsy.” Epilepsy Res 95(3):246-54 Details

    Vulliemoz S, Vollmar C, Koepp MJ, Yogarajah M, O'Muircheartaigh J, Carmichael DW, Stretton J, Richardson MP, Symms MR, Duncan JS (2011), “Connectivity of the supplementary motor area in juvenile myoclonic epilepsy and frontal lobe epilepsy.” Epilepsia 52(3):507-14 Details

    Winston GP, Mancini L, Stretton J, Ashmore J, Symms MR, Duncan JS, Yousry TA (2011), “Diffusion tensor imaging tractography of the optic radiation for epilepsy surgical planning: a comparison of two methods.” Epilepsy Res 97(1-2):124-32 Details