Miss Jessica Santivanez

Jessica Santivanez

University position

PhD student
Supervised by Professor Maria Grazia Spillantini

Departments

Department of Clinical Neurosciences

Institutes

Clifford Allbutt Building

Email

jas265@cam.ac.uk

Home page

http://www.linkedin.com/profile... (personal home page)

Research Themes

Clinical and Veterinary Neuroscience

Cellular and Molecular Neuroscience

Interests

I am investigating the role of alpha-synuclein in the pathogenesis of alpha-synucleinopathies such as Parkinson's disease (PD). Current work involves the differentiation of neurons from human induced pluripotent stem (iPS) cells derived from healthy individuals and PD patients. I am examining the synaptic protein distribution and electrophysiological properties of neurons belonging to distinct brain regions affected in PD: the cortex and the midbrain.

Forebrain neural precursor cells derived from a Parkinson's disease patient iPSC line
iPSC colony expressing pluripotency markers Oct4 (green) and SSEA-4 (green)
View image full-size (1024x1024 pixels)

Research Focus

Keywords

alpha-synuclein

aggregation

neurodegeneration

Parkinson's disease

dopaminergic

Clinical conditions

Dementia with Lewy Bodies

Multiple system atrophy

Parkinson's disease

Equipment

Cell culture

Confocal microscopy

Cryosectioning

ELISA

Flow cytometry

Fluorescence microscopy

Whole cell patch clamp

Collaborators

No collaborators listed

Associated News Items


Publications

2016

Calo L, Wegrzynowicz M, Santivañez-Perez J, Grazia Spillantini M. (2016), “Synaptic failure and α-synuclein.” Mov Disord 31(2):169-77

2014

Zhao H, Santiváñez Perez J, Lu K, George AJ, Ma D (2014), “Role of Toll-like receptor 4 in renal graft ischemia-reperfusion injury.” Am J Physiol Renal Physiol Details