Mr Janosch Heller
I am interested in the molecular changes which occur on the Bruch's membrane in age-related macular degeneration. During the progression of the disease, anti-adhesive molecules such as tenascin-C become upregulated and cause the detachment of the retinal pigment epithelium from Bruch’s membrane. Subsequently, this leads to a degeneration of photoreceptors and to visual loss. Since the retinal pigment epithelium is crucial for the integrity of the retina, a transplantation of these cells into diseased eyes seems to be a promising treatment of age-related macular degeneration. However, transplantions have had limited success due to a lack of adhesion and degeneration of the grafted cells. Therefore, modulating the binding abilities of the retinal pigment epithelium to the pathological Bruch's membrane is key in developing a transplantational cure of the disease. This can be achieved via activation and over-expression of integrins that enhances adhesion and migration of the grafted cells.
Recombinant protein expression
No collaborators listed
Associated News Items
Calamai M, Specht CG, Heller J, Alcor D, Machado P, Vannier C, Triller A (2009), “Gephyrin oligomerization controls GlyR mobility and synaptic clustering.” J Neurosci 29(24):7639-48 Details