Dr James Rowe BA BM BCh PhD
University position
Senior Clinical Research Associate
Dr James Rowe BA BM BCh PhD is pleased to consider applications from prospective PhD students.
Departments
Department of Clinical Neurosciences
Institutes
Behavioural and Clinical Neuroscience Institute, MRC Cognition and Brain Sciences Unit and Neurology Unit
Research Themes
Interests
Characterisation and optimisation of prefrontal cortical functions in health and disease.
The functions of the prefrontal cortex remain controversial yet they are of great importance to our everyday life, thoughts, actions and self expression. I believe that the functions of the prefrontal cortex can best be understood in terms of its interactions with other brain regions. This calls for analyses of effective connectivity, usually based on neuroimaging like fMRI, MEG, PET or TMS.
These principles and methods are used to study the way we behave, and make decisions about behaviour, in response to the world around us. As a neurologist, I mainly study those with with neurodegenerative diseaes (dementia, Parkinson's disease) or other brain lesions (tumours/stroke). However, in collaboration with scientists at the MRC-CBU, we have been studying the response to emotions and foods, with implicatons for uderstanding the rise in violent behaviours and obseity.
Research Focus
Keywordsdementia Parkinson's disease MRI connectivity prefrontal |
Clinical conditionsCognitive impairment Dementia Movement disorders Parkinson's disease Progressive supranuclear palsy |
Equipment
Behavioural analysis
Computational modelling
Magnetic resonance imaging (MRI)
Magnetoencephalography (MEG)
Neuropsychological testing
Saccadometry
Collaborators
Cambridge | InternationalGitte Moos Knudsen Web: http://www.cimbi.dk Hartwig Siebner Web: http://www.cimbi.dk |
Key publications
Passamonti L, Rowe JB, Schwarzbauer C, Ewbank MP, von dem Hagen E, Calder AJ (2009), “Personality predicts the brain's response to viewing appetizing foods: the neural basis of a risk factor for overeating.” J Neurosci 29(1):43-51 Details
Rowe JB, Hughes L, Ghosh BC, Eckstein D, Williams-Gray CH, Fallon S, Barker RA, Owen AM (2008), “Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition.” Brain 131(Pt 8):2094-105 Details
Rowe JB, Sakai K, Lund TE, Ramsøy T, Christensen MS, Baare WF, Paulson OB, Passingham RE (2007), “Is the prefrontal cortex necessary for establishing cognitive sets?” J Neurosci 27(48):13303-10 Details
Rowe JB, Siebner H, Filipovic SR, Cordivari C, Gerschlager W, Rothwell J, Frackowiak R (2006), “Aging is associated with contrasting changes in local and distant cortical connectivity in the human motor system” Neuroimage 32(2):747-60 Details
Rowe JB, Toni I, Josephs O, Frackowiak RSJ, Passingham RE (2000), “The prefrontal cortex: maintenance or response selection in working memory” Science 288:1556-1560
Publications
2008
Christensen MS, Kristiansen L, Rowe JB, Nielsen JB (2008), “Action-blindsight in healthy subjects after transcranial magnetic stimulation.” Proc Natl Acad Sci U S A 105(4):1353-7 Details
Korsholm K, Madsen KH, Frederiksen JL, Rowe JB, Lund TE (2008), “Cortical neuroplasticity in patients recovering from acute optic neuritis.” Neuroimage 42(2):836-44 Details
Passamonti L, Rowe JB, Ewbank M, Hampshire A, Keane J, Calder AJ (2008), “Connectivity from the ventral anterior cingulate to the amygdala is modulated by appetitive motivation in response to facial signals of aggression.” Neuroimage 43(3):562-70 Details
Rowe JB, Hughes L, Williams-Gray CH, Bishop S, Fallon S, Barker RA, Owen AM (2008), “The val(158)met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease.” Neurobiol Aging Details
2006
Christensen MS, Ramsøy TZ, Lund TE, Madsen KH, Rowe JB (2006), “An fMRI study of the neural correlates of graded visual perception.” Neuroimage 31(4):1711-25 Details
2005
Lund TE, Nørgaard MD, Rostrup E, Rowe JB, Paulson OB (2005), “Motion or activity: their role in intra- and inter-subject variation in fMRI.” Neuroimage 26(3):960-4 Details
Rounis E, Lee L, Siebner HR, Rowe JB, Friston KJ, Rothwell JC, Frackowiak RS (2005), “Frequency specific changes in regional cerebral blood flow and motor system connectivity following rTMS to the primary motor cortex.” Neuroimage 26(1):164-76 Details
Rowe JB, Stephan KE, Friston K, Frackowiak RS, Passingham RE (2005), “The prefrontal cortex shows context-specific changes in effective connectivity to motor or visual cortex during the selection of action or colour.” Cereb Cortex 15(1):85-95 Details
Rowe JB, Stephan KE, Friston KJ, Frackowiak RSJ, Passingham RE (2005), “Context-dependent changes of prefrontal cortical connectivity to motor and visual areas during the selection of action and colour” Cerebral Cortex 15(1):85-95
Vitali P, Abutalebi J, Tettamanti M, Rowe J, Scifo P, Fazio F, Cappa SF, Perani D (2005), “Generating animal and tool names: an fMRI study of effective connectivity.” Brain Lang 93(1):32-45 Details
2003
Grèzes J, Armony JL, Rowe J, Passingham RE (2003), “Activations related to "mirror" and "canonical" neurones in the human brain: an fMRI study.” Neuroimage 18(4):928-37 Details
2002
Parker GJ, Stephan KE, Barker GJ, Rowe JB, MacManus DG, Wheeler-Kingshott CA, Ciccarelli O, Passingham RE, Spinks RL, Lemon RN, Turner R (2002), “Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractography.” Neuroimage 15(4):797-809 Details
Rowe J, Friston K, Frackowiak R, Passingham R (2002), “Attention to action: specific modulation of corticocortical interactions in humans.” Neuroimage 17(2):988-98 Details
Rowe J, Stephan KE, Friston K, Frackowiak R, Lees A, Passingham R (2002), “Attention to action in Parkinson's disease: impaired effective connectivity among frontal cortical regions.” Brain 125(Pt 2):276-89 Details
Sakai K, Rowe JB, Passingham RE (2002), “Parahippocampal reactivation signal at retrieval after interruption of rehearsal.” J Neurosci 22(15):6315-20 Details
Sakai K, Rowe JB, Passingham RE (2002), “Active maintenance in prefrontal area 46 creates distractor-resistant memory.” Nat Neurosci 5(5):479-84 Details
Toni I, Rowe J, Stephan KE, Passingham RE (2002), “Changes of cortico-striatal effective connectivity during visuomotor learning.” Cereb Cortex 12(10):1040-7 Details
2001
Rowe JB, Passingham RE (2001), “Working memory for location and time: activity in prefrontal area 46 relates to selection rather than maintenance in memory.” Neuroimage 14(1 Pt 1):77-86 Details