Research in the Morton lab is focused on understanding the mechanisms underlying neurodegeneration and on developing strategies to delay or prevent the death of neurones in injured or degenerating brain, particularly in Huntington's disease (HD). My work focuses on investigating the progressive disruption of circadian rhythmicity in Huntington's disease using transgenic mouse models and finding ways to prevent this disruption.
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Associated News Items
Cuesta M, Aungier J, Morton AJ (2013), “Behavioral therapy reverses circadian deficits in a transgenic mouse model of Huntington's disease.” Neurobiol Dis 63C:85-91 Details
Wood NI, McAllister CJ, Cuesta M, Aungier J, Fraenkel E, Morton AJ (2013), “Adaptation to experimental jet-lag in R6/2 mice despite circadian dysrhythmia.” PLoS One 8(2):e55036 Details
Cuesta M, Aungier J, Morton AJ (2012), “The methamphetamine-sensitive circadian oscillator is dysfunctional in a transgenic mouse model of Huntington's disease.” Neurobiol Dis 45(1):145-55 Details