Dr Julio Acosta-Cabronero

University position

Alzheimer's Research UK Fellow

Departments

Department of Clinical Neurosciences

Institutes

Neurology Unit and Wolfson Brain Imaging Centre

Email

jac@cantab.net

Home page

http://www.neurology.cam.ac.uk/cogmeml...

Research Themes

Clinical and Veterinary Neuroscience

Cognitive and Behavioural Neuroscience

The Cambridge Neuroscience Community

Interests

In developing novel magnetic resonance imaging (MRI) methods of acquisition and analysis to elucidate the mechanisms underlying neurodegeneration in very early dementia.

White matter tract abnormalities in semantic dementia patients projected onto a skeletonised mean control tractography highlights (i) the involvement of the arcuate and uncinate bundles, and (ii) the sparing of tracts running caudally from the temporal lobe through the ILF. [AF = Arcuate fasciculus; UF = Uncinate fasciculus; ILF = Inferior longitudinal fasciculus].
View image full-size (1160x1366 pixels)

Research Focus

Keywords

MRI

DTI

SWI

Dementia

Neurodegeneration

Clinical conditions

Alzheimer's disease

Cognitive impairment

Semantic dementia

Equipment

Computational modelling

Cross-sectional and cohort studies

Magnetic resonance imaging (MRI)

Collaborators

Cambridge

Key publications

Acosta-Cabronero J, Alley S, Williams GB, Pengas G, Nestor PJ (2012), “Diffusion Tensor Metrics as Biomarkers in Alzheimer's Disease.” PLoS One 7(11):e49072 PDF Details

Acosta-Cabronero J, Patterson K, Fryer TD, Hodges JR, Pengas G, Williams GB, Nestor PJ (2011), “Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story.” Brain 134(Pt 7):2025-35 Details

Acosta-Cabronero J, Williams GB, Pengas G, Nestor PJ (2010), “Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease.” Brain 133(Pt 2):529-39 Details

Acosta-Cabronero J, Williams GB, Pereira JM, Pengas G, Nestor PJ (2008), “The impact of skull-stripping and radio-frequency bias correction on grey-matter segmentation for voxel-based morphometry” NeuroImage 39:1654-1665 Details

Publications

2012

Ghosh BC, Calder AJ, Peers PV, Lawrence AD, Acosta-Cabronero J, Pereira JM, Hodges JR, Rowe JB (2012), “Social cognitive deficits and their neural correlates in progressive supranuclear palsy.” Brain 135(Pt 7):2089-102 Details

Pengas G, Williams GB, Acosta-Cabronero J, Ash TW, Hong YT, Izquierdo-Garcia D, Fryer TD, Hodges JR, Nestor PJ (2012), “The relationship of topographical memory performance to regional neurodegeneration in Alzheimer's disease.” Front Aging Neurosci 4:17 Details

2011

de Rover M, Pironti VA, McCabe JA, Acosta-Cabronero J, Arana FS, Morein-Zamir S, Hodges JR, Robbins TW, Fletcher PC, Nestor PJ, Sahakian BJ (2011), “Hippocampal dysfunction in patients with mild cognitive impairment: A functional neuroimaging study of a visuospatial paired associates learning task.” Neuropsychologia 49(7):2060-70 Details

del Campo N, Tait RJ, Acosta-Cabronero J, Hong YT, Izquierdo-Garcia D, Smith R, Aigbirhio FI, Sahakian BJ, Müller U, Robbins TW, Fryer TD (2011), “Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.” Neuroimage 55(1):101-12 Details

Diaz-de-Grenu LZ, Acosta-Cabronero J, Pereira JM, Pengas G, Williams GB, Nestor PJ (2011), “MRI detection of tissue pathology beyond atrophy in Alzheimer's disease: Introducing T2-VBM.” Neuroimage 56(4):1946-53 Details

Teipel SJ, Reuter S, Stieltjes B, Acosta-Cabronero J, Ernemann U, Fellgiebel A, Filippi M, Frisoni G, Hentschel F, Jessen F, Klöppel S, Meindl T, Pouwels PJ, Hauenstein KH, Hampel H (2011), “Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study.” Psychiatry Res 194(3):363-71 Details

2010

Clatworthy PL, Williams GB, Acosta-Cabronero J, Jones SP, Harding SG, Johansen-Berg H, Baron JC (2010), “Probabilistic tractography of the optic radiations--an automated method and anatomical validation.” Neuroimage 49(3):2001-12 Details

Mion M, Patterson K, Acosta-Cabronero J, Pengas G, Izquierdo-Garcia D, Hong YT, Fryer TD, Williams GB, Hodges JR, Nestor PJ (2010), “What the left and right anterior fusiform gyri tell us about semantic memory.” Brain 133(11):3256-68 Details

Pereira JM, Xiong L, Acosta-Cabronero J, Pengas G, Williams GB, Nestor PJ (2010), “Registration accuracy for VBM studies varies according to region and degenerative disease grouping.” Neuroimage 49(3):2205-15 Details

2009

Acosta-Cabronero J, Hall LD (2009), “Measurements by MRI of the settling and packing of solid particles from aqueous suspensions” AIChE Journal 55(6):1426-33

Butler CR, Bhaduri A, Acosta-Cabronero J, Nestor PJ, Kapur N, Graham KS, Hodges JR, Zeman AZ (2009), “Transient epileptic amnesia: regional brain atrophy and its relationship to memory deficits.” Brain 132(Pt 2):357-68 Details

Kipps CM, Nestor PJ, Acosta-Cabronero J, Arnold R, Hodges JR (2009), “Understanding social dysfunction in the behavioural variant of frontotemporal dementia: the role of emotion and sarcasm processing.” Brain 132(Pt 3):592-603 Details

Pereira JM, Williams GB, Acosta-Cabronero J, Pengas G, Spillantini MG, Xuereb JH, Hodges JR, Nestor PJ (2009), “Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration.” Neurology 72(19):1653-60 Details

2006

Adlam AL, Patterson K, Rogers TT, Nestor PJ, Salmond CH, Acosta-Cabronero J, Hodges JR (2006), “Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?” Brain 129(Pt 11):3066-80 Details

2005

Heese F, Acosta-Cabronero J, Robson P, Hall LD (2005), “Measurement of particle separation by magnetic resonance imaging” IEEE Sensors Journal 5(2):268-72

Home