Dr Ian Coyle-Gilchrist MBBS BSc MRCP


Frontotemporal dementia is one of the commonest forms of dementia before retirement age. It is very closely related to two other conditions, Progressive Supranuclear Palsy and Corticobasal Degeneration. Despite their importance there is a lack of up to date information about how many people in the UK are affected by these conditions.

People with these conditions are often reported as apathetic but at the same time make impulsive and rash decisions. Both apathy and impulsivity are a significant source of carer distress and patient morbidity.

I am working to produce up to date information on how common these conditions are. At the same time using a combination of different techniques I am examining the principle components of apathy and impulsivity with the eventual aim of supporting future trials of symptomatic treatments.

Research Focus







Clinical conditions

Corticobasal degeneration


Frontotemporal dementia

Progressive supranuclear palsy


Magnetic resonance imaging (MRI)

Neuropsychological testing


No collaborators listed

Associated News Items



Rohrer JD, Nicholas JM, Cash DM, van Swieten J, Dopper E, Jiskoot L, van Minkelen R, Rombouts SA, Cardoso MJ, Clegg S, Espak M, Mead S, Thomas DL, De Vita E, Masellis M, Black SE, Freedman M, Keren R, MacIntosh BJ, Rogaeva E, Tang-Wai D, Tartaglia MC, Laforce R Jr, Tagliavini F, Tiraboschi P, Redaelli V, Prioni S, Grisoli M, Borroni B, Padovani A, Galimberti D, Scarpini E, Arighi A, Fumagalli G, Rowe JB, Coyle-Gilchrist I, Graff C, Fallström M, Jelic V, StÃ¥hlbom AK, Andersson C, Thonberg H, Lilius L, Frisoni GB, Pievani M, Bocchetta M, Benussi L, Ghidoni R, Finger E, Sorbi S, Nacmias B, Lombardi G, Polito C, Warren JD, Ourselin S, Fox NC, Rossor MN (2015), “Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.” Lancet Neurol 14(3):253-62 Details


Coyle-Gilchrist I, Peck L (2014), “Not very NICE -letter to Editor” The Times 71157


Coyle-Gilchrist IT, Peck LF, Rowe JB (2012), “Research paper does not show causal link between benzodiazepine use and diagnosis of dementia.” BMJ 345:e7984; author reply e7993 Details


Mozid AM, Coyle-Gilchrist IT, Mazhar SS (2009), “Vasovagal ejaculation syncope.” Heart 95(23):1900 Details