Dr Sadaf Farooqi
Senior Research Associate
Dr Sadaf Farooqi is pleased to consider applications from prospective PhD students.
Using a candidate gene approach in patients with severe, early onset obesity recruited to the Genetics Of Obesity Study (GOOS), we have identified patients with mutations in genes encoding leptin, the leptin receptor and targets of leptin action (including the melanocortin 4 receptor, MC4R). We have demonstrated that the central leptin-melanocortin axis plays a critical role in the regulation of human food intake. We are currently using neuroimaging particularly functional MRI to study the brain response to hunger and satiety in defined subsets of patients with molecularly defined causes for their obesity.
Magnetic resonance imaging (MRI)
Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, Lank E, Bottomley B, Lopez-Fernandez J, Ferraz-Amaro I, Dattani MT, Ercan O, Myhre AG, Retterstol L, Stanhope R, Edge JA, McKenzie S, Lessan N, Ghodsi M, De Rosa V, Perna F, Fontana S, Barroso I, Undlien DE, O’Rahilly S (2007), “Clinical and Molecular Genetic Spectrum of Congenital Leptin Receptor Deficiency” New Eng J 356(3):237-47 Details
Gray J, Yeo GSH, Cox JJ, Morton J, Adlam AL, Keogh JM, Yanovski JA, El Gharbawy A, Han JC, Tung YCL, Hodges JR, Raymond FL, O'Rahilly S, Farooqi IS (2006), “Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene” Diabetes 55(12):3366-3371
Yeo G, Connie Hung C, Rochford J, Keogh J, Gray J, Sivaramakrishnan S, O'Rahilly S, Farooqi IS (2004), “A de novo mutation affecting human TrkB associated with severe obesity and developmental delay” Nat Neurosci 7(11):1187-9 Details