Ms Alex van der Wateren MSc

Alex van der Wateren

University position

PhD student
Supervised by Chris Dobson

Departments

Department of Chemistry

Home page

http://www.cmd.ch.cam.ac.uk

Research Theme

Cellular and Molecular Neuroscience

Interests

I am interested in protein misfolding and aggregation, which are molecular processes underlying several neurodegenerative diseases. I study how post-translational modification of protein affects these processes in-vitro. For this, I use bulk kinetic essays as well as microscopic methods.

Research Focus

Keywords

alpha-synuclein

aggregation kinetics

ThT

nucleation

Clinical conditions

Alzheimer's disease

BSE

Parkinson's disease

vCJD

Equipment

Bulk-experiments using amyloid dyes

Microscopy

Protein purification

Recombinant protein expression

Collaborators

No collaborators listed

Associated News Items


    Publications

    2014

    Mariliis Tark-Dame, Hansjoerg Jerabek, Erik M. M. Manders, Ingrid M. van der Wateren, Dieter W. Heermann, Roel van Driel (2014), “Depletion of the Chromatin Looping Proteins CTCF and Cohesin Causes Chromatin Compaction: Insight into Chromatin Folding by Polymer Modelling” PLoS Comput Biol 10(10): e1003877