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EMAIL ik255@cam.ac.uk
Department
  • Haematology
    • Institute
  • Wellcome – MRC Cambridge Stem Cell Institute
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    Research Theme Lifelong Brain Development and Brain Ageing Beyond the Neuron
    Research Focus

    Keywords

  • Neural Stem Cells
  • Brain
  • Neural Regeneration
  • Remyelination
  • Oligodendrocyte Progenitor Cells
  • Niche

    • Clinical Conditions

  • Dementia
  • Stroke
  • Multiple sclerosis
  • Traumatic brain injury

    • Equipment & Techniques

  • Cell culture
  • Immunohistochemistry
  • Confocal microscopy

    • Science Culture

  • Equality, Diversity, Inclusion and Wellbeing
  • Public Outreach

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    Dr ILIAS KAZANIS

    (he/him/his)
    University Position
    Visiting Scientist
    Dr ILIAS KAZANIS is pleased to consider applications from prospective PhD students.

    Interests

    My research focuses on the regulation of adult brain cytogenesis, especilly on the biology of the subependymal zone neurogenic/gliogenic niche. I am interested in the role of components of the extracellular matrix (ECM/ such as integrins, laminins and tenascin-C), as well as of structural elements of the niche (such as ependymal cells and blood vessels) in the regulation of adult stem cell behaviour. When and how the neural stem cell transforms from a very active progenitor into a relatively quiescent cell? What is the contribution of ECM molecules in this process? How is the niche microenvironment altered when stem cells become activated in order to regenerate the neural tissue? Recently I have started exploring more intensively the oligodendrogenic properties of the subependymal zone, especially in the context of the ageing brain, as well as the potential to develop new methods to isolate neural progenitors from the niche.

    Investigating the role of Platelets in regulating Neural Stem Cells

    Collaborators

    Cambridge
  • Ragnhildur Thora Karadottir
  • Robin Franklin

    • Key Publications

    Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice.

    DOI: http://doi.org/10.1016/j.stemcr.2017.01.007
    Journal: Stem Cell Reports
    E-pub date: 14 Mar 2017
    Authors: I Kazanis, KA Evans, E Andreopoulou, C Dimitriou, C Koutsakis, RT Karadottir, RJM Franklin

    Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.

    DOI: http://doi.org/10.1016/j.expneurol.2015.03.018
    Journal: Exp Neurol
    E-pub date: 1 Jul 2015
    Authors: I Kazanis, M Feichtner, S Lange, P Rotheneichner, S Hainzl, M Öller, K Schallmoser, E Rohde, HA Reitsamer, S Couillard-Despres, H-C Bauer, RJM Franklin, L Aigner, FJ Rivera

    Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals.

    DOI: http://doi.org/10.1523/JNEUROSCI.0700-10.2010
    Journal: J Neurosci
    E-pub date: 21 Jul 2010
    Authors: I Kazanis, JD Lathia, TJ Vadakkan, E Raborn, R Wan, MR Mughal, DM Eckley, T Sasaki, B Patton, MP Mattson, KK Hirschi, ME Dickinson, C ffrench-Constant

    Publications

    Being a Neural Stem Cell: A Matter of Character But Defined by the Microenvironment.

    DOI: http://doi.org/10.1007/978-3-319-69194-7_6
    Journal: Adv Exp Med Biol
    E-pub date: 1 Aug 2017
    Authors: E Andreopoulou, A Arampatzis, M Patsoni, I Kazanis

    How Necessary is the Vasculature in the Life of Neural Stem and Progenitor Cells? Evidence from Evolution, Development and the Adult Nervous System.

    DOI: http://doi.org/10.3389/fncel.2016.00035
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2016
    Authors: C Koutsakis, I Kazanis

    Oligodendrocyte progenitor cells: the ever mitotic cells of the CNS.

    DOI: http://doi.org/10.2741/s444
    Journal: Front Biosci (Schol Ed)
    E-pub date: 1 Jan 2016
    Authors: B Neumann, I Kazanis

    Beyond Clotting: A Role of Platelets in CNS Repair?

    DOI: http://doi.org/10.3389/fncel.2015.00511
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2015
    Authors: FJ Rivera, I Kazanis, C Ghevaert, L Aigner

    Disc1 variation leads to specific alterations in adult neurogenesis.

    DOI: http://doi.org/10.1371/journal.pone.0108088
    Journal: PLoS One
    E-pub date: 1 Aug 2014
    Authors: JS Chandran, I Kazanis, SJ Clapcote, F Ogawa, JK Millar, DJ Porteous, C Ffrench-Constant

    The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche.

    DOI: http://doi.org/10.1016/j.expneurol.2013.06.025
    Journal: Exp Neurol
    E-pub date: 1 Oct 2013
    Authors: I Kazanis, N Gorenkova, J-W Zhao, RJM Franklin, M Modo, C Ffrench-Constant

    Neurogenesis in the adult mammalian brain: how much do we need, how much do we have?

    DOI: http://doi.org/10.1007/7854_2012_227
    Journal: Curr Top Behav Neurosci
    E-pub date: 1 Aug 2013
    Authors: I Kazanis

    Niche derived oligodendrocyte progenitors: a source of rejuvenation or complementation for local oligodendrogenesis?

    DOI: http://doi.org/10.3389/fncel.2013.00188
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2013
    Authors: S Agathou, RT Káradóttir, I Kazanis

    Reforming the Greek health system: a role for non-medical, clinical bioscientists.

    DOI: http://doi.org/10.1016/j.healthpol.2012.03.020
    Journal: Health Policy
    E-pub date: 1 Jan 2013
    Authors: I Kazanis

    The number of stem cells in the subependymal zone of the adult rodent brain is correlated with the number of ependymal cells and not with the volume of the niche.

    DOI: http://doi.org/10.1089/scd.2011.0130
    Journal: Stem Cells Dev
    E-pub date: 1 May 2012
    Authors: I Kazanis, C Ffrench-Constant

    Can adult neural stem cells create new brains? Plasticity in the adult mammalian neurogenic niches: realities and expectations in the era of regenerative biology.

    DOI: http://doi.org/10.1177/1073858410390379
    Journal: Neuroscientist
    E-pub date: 1 Feb 2012
    Authors: I Kazanis

    Extracellular matrix and the neural stem cell niche.

    DOI: http://doi.org/10.1002/dneu.20970
    Journal: Dev Neurobiol
    E-pub date: 1 Nov 2011
    Authors: I Kazanis, C ffrench-Constant

    Adhesion molecules in the stem cell niche–more than just staying in shape?

    DOI: http://doi.org/10.1242/jcs.054312
    Journal: J Cell Sci
    E-pub date: 15 May 2010
    Authors: V Marthiens, I Kazanis, L Moss, K Long, C Ffrench-Constant

    The subependymal zone neurogenic niche: a beating heart in the centre of the brain: how plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed.

    DOI: http://doi.org/10.1093/brain/awp237
    Journal: Brain
    E-pub date: 1 Nov 2009
    Authors: I Kazanis

    The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C.

    DOI: http://doi.org/10.1523/JNEUROSCI.3279-07.2007
    Journal: J Neurosci
    E-pub date: 19 Dec 2007
    Authors: I Kazanis, A Belhadi, A Faissner, C Ffrench-Constant

    Dual function of Sox1 in telencephalic progenitor cells.

    DOI: http://doi.org/10.1016/j.ydbio.2007.07.026
    Journal: Dev Biol
    E-pub date: 1 Oct 2007
    Authors: L Kan, A Jalali, L-R Zhao, X Zhou, T McGuire, I Kazanis, V Episkopou, AG Bassuk, JA Kessler

    CNS injury research; reviewing the last decade: methodological errors and a proposal for a new strategy.

    DOI: http://doi.org/10.1016/j.brainresrev.2005.09.003
    Journal: Brain Res Brain Res Rev
    E-pub date: 15 Dec 2005
    Authors: I Kazanis

    Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.

    DOI: http://doi.org/10.1371/journal.pbio.0030186
    Journal: PLoS Biol
    E-pub date: 1 Jun 2005
    Authors: A Ekonomou, I Kazanis, S Malas, H Wood, P Alifragis, M Denaxa, D Karagogeos, A Constanti, R Lovell-Badge, V Episkopou

    Alterations in IGF-I, BDNF and NT-3 levels following experimental brain trauma and the effect of IGF-I administration.

    DOI: http://doi.org/10.1016/j.expneurol.2003.12.004
    Journal: Exp Neurol
    E-pub date: 1 Apr 2004
    Authors: I Kazanis, M Giannakopoulou, H Philippidis, F Stylianopoulou

    Neuroprotective effects of insulin-like growth factor-I (IGF-I) following a penetrating brain injury in rats.

    DOI: http://doi.org/10.1016/s0006-8993(03)03525-x
    Journal: Brain Res
    E-pub date: 21 Nov 2003
    Authors: I Kazanis, E Bozas, H Philippidis, F Stylianopoulou

    Control of neuronal nitric oxide synthase and brain-derived neurotrophic factor levels by GABA-A receptors in the developing rat cortex.

    DOI: http://doi.org/10.1016/j.devbrainres.2003.08.001
    Journal: Brain Res Dev Brain Res
    E-pub date: 12 Nov 2003
    Authors: A Mantelas, A Stamatakis, I Kazanis, H Philippidis, F Stylianopoulou

    In utero radiation-induced changes in growth factor levels in the developing rat brain.

    DOI: http://doi.org/10.1080/095530001453140
    Journal: Int J Radiat Biol
    E-pub date: 1 Jan 2001
    Authors: A Benekou, S Bolaris, E Kazanis, E Bozas, H Philippidis, F Stylianopoulou

    NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide.

    DOI: http://doi.org/10.1046/j.0305-1846.2000.00286.x
    Journal: Neuropathol Appl Neurobiol
    E-pub date: 1 Dec 2000
    Authors: M Giannakopoulou, M Mansour, E Kazanis, E Bozas, H Philpipidis, F Stylianopoulou