Dr ILIAS KAZANIS
Senior Research Associate
My research focuses on the regulation of adult brain cytogenesis, especilly on the biology of the subependymal zone neurogenic/gliogenic niche. I am interested in the role of components of the extracellular matrix (ECM/ such as integrins, laminins and tenascin-C), as well as of structural elements of the niche (such as ependymal cells and blood vessels) in the regulation of adult stem cell behaviour. When and how the neural stem cell transforms from a very active progenitor into a relatively quiescent cell? What is the contribution of ECM molecules in this process? How is the niche microenvironment altered when stem cells become activated in order to regenerate the neural tissue? Recently I have started exploring more intensively the oligodendrogenic properties of the subependymal zone, especially in the context of the ageing brain, as well as the potential to develop new methods to isolate neural progenitors from the niche.
neural stem cell
Charles ffrench_Constant Web: http://www.crm.ed.ac.uk/researc...
Joanne Conover Web: http://crb.uconn.edu/faculty...
Mary Dickinson Web: http://www.bcm.edu/physio/...
Andreas Faissner Web: http://www.ruhr-uni-bochum.de/igsn/re...
Mike Modo Web: http://www.mirm.pitt.edu/people/...
Kazanis I, Lathia JD, Vadakkan TJ, Raborn E, Wan R, Mughal MR, Eckley DM, Sasaki T, Patton B, Mattson MP, Hirschi KK, Dickinson ME, ffrench-Constant C (2010), “Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals.” J Neurosci 30(29):9771-81 Details
Kazanis I, Belhadi A, Faissner A, Ffrench-Constant C (2007), “The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C.” J Neurosci 27(51):13991-6 Details
Ekonomou A, Kazanis I, Malas S, Wood H, Alifragis P, Denaxa M, Karagogeos D, Constanti A, Lovell-Badge R, Episkopou V (2005), “Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.” PLoS Biol 3(6):e186 Details
Kazanis I (2012), “Reforming the Greek health system: A role for non-medical, clinical bioscientists.” Health Policy Details
Kazanis I (2012), “Can adult neural stem cells create new brains? Plasticity in the adult mammalian neurogenic niches: realities and expectations in the era of regenerative biology.” Neuroscientist 18(1):15-27 Details
Kazanis I, Ffrench-Constant C (2012), “The number of stem cells in the subependymal zone of the adult rodent brain is correlated with the number of ependymal cells and not with the volume of the niche.” Stem Cells Dev 21(7):1090-6 Details
Kazanis I, Ffrench-Constant C (2011), “Extracellular matrix and the neural stem cell niche.” Dev Neurobiol 71(11):1006-17 Details
Marthiens V, Kazanis I, Moss L, Long K, Ffrench-Constant C (2010), “Adhesion molecules in the stem cell niche--more than just staying in shape?” J Cell Sci 123(Pt 10):1613-22 Details
Kazanis I (2009), “The subependymal zone neurogenic niche: a beating heart in the centre of the brain: how plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed.” Brain 132(Pt 11):2909-21 Details
Kazanis I, Lathia J, Moss L, ffrench-Constant C (2008), “The neural stem cell microenvironment” StemBook doi/10.3824/stembook.1.15.1
Kan L, Jalali A, Zhao LR, Zhou X, McGuire T, Kazanis I, Episkopou V, Bassuk AG, Kessler JA (2007), “Dual function of Sox1 in telencephalic progenitor cells.” Dev Biol 310(1):85-98 Details
Kazanis I (2005), “CNS injury research; reviewing the last decade: methodological errors and a proposal for a new strategy.” Brain Res Brain Res Rev 50(2):377-86 Details
Kazanis I, Giannakopoulou M, Philippidis H, Stylianopoulou F (2004), “Alterations in IGF-I, BDNF and NT-3 levels following experimental brain trauma and the effect of IGF-I administration.” Exp Neurol 186(2):221-34 Details
Kazanis I, Bozas E, Philippidis H, Stylianopoulou F (2003), “Neuroprotective effects of insulin-like growth factor-I (IGF-I) following a penetrating brain injury in rats.” Brain Res 991(1-2):34-45 Details
Mantelas A, Stamatakis A, Kazanis I, Philippidis H, Stylianopoulou F (2003), “Control of neuronal nitric oxide synthase and brain-derived neurotrophic factor levels by GABA-A receptors in the developing rat cortex.” Brain Res Dev Brain Res 145(2):185-95 Details
Benekou A, Bolaris S, Kazanis E, Bozas E, Philippidis H, Stylianopoulou F (2001), “In utero radiation-induced changes in growth factor levels in the developing rat brain.” Int J Radiat Biol 77(1):83-93 Details
Giannakopoulou M, Mansour M, Kazanis E, Bozas E, Philpipidis H, Stylianopoulou F (2000), “NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide.” Neuropathol Appl Neurobiol 26(6):513-21 Details