Professor Hugh Markus

University position

Professor

Professor Hugh Markus is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Email

hsm32@medschl.cam.ac.uk

Research Theme

Clinical and Veterinary Neuroscience

Interests

I use molecular genetic and neuroimaging (MRI and Transcranial Doppler) techniques to investigate the pathogenesis of, and develop treatments for, cerebrovascular disease. A particular interest is in cerebral small vessel disease, a major cause of stroke and the major cause of vascular cognitive impairment; here we are studying genetic determinants (for both monogenic and polygenic disease), the mechanisms of cognitive decline using advanced multimodal MRI, and evaluating new therapeutic approaches. I am involved in a number of international studies of stroke genetics including the WTCCC2 ischaemic stroke study and the International Stroke Genetics Consortium. I run a National clinical referral service for patients with the monogenic from of stroke CADASIL.

My research is currently funded by the Wellcome Trust, NIHR, British Heart Foundation, Stroke Association, Alzheimers Research UK and the EU FP7.

Research Focus

Keywords

stroke

genetics

cerebral small vessel disease

vascular cognitive impairment

neuroimaging

Clinical conditions

Stroke

Equipment

genetics

Haemodynamic monitoring

Magnetic resonance imaging (MRI)

Neuropsychological testing

Randomised control trials

Collaborators

Cambridge

John O'Brien

United Kingdom

Tom Barrick Web: http://www.sgul.ac.uk/researc...

Gary Ford Web: http://www.ncl.ac.uk/biomedi...

Robin Morris Web: http://www.iop.kcl.ac.uk/staff/p...

Peter Rothwell Web: http://www.clneuro.ox.ac.uk/team/pr...

Cathie Sudlow Web: http://www.ccbs.ed.ac.uk/members...

Associated News Items


Publications

2014

Benjamin P, Lawrence AJ, Lambert C, Patel B, Chung AW, MacKinnon AD, Morris RG, Barrick TR, Markus HS (2014), “Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease.” Neuroimage Clin 4:828-37 Details

Bonati LH, Ederle J, Dobson J, Engelter S, Featherstone RL, Gaines PA, Beard JD, Venables GS, Markus HS, Clifton A, Sandercock P, Brown MM, CAVATAS Investigators (2014), “Length of carotid stenosis predicts peri-procedural stroke or death and restenosis in patients randomized to endovascular treatment or endarterectomy.” Int J Stroke 9(3):297-305 Details

Brookes RL, Herbert V, Paul S, Hannesdottir K, Markus HS, Morris RG (2014), “Executive dysfunction, awareness deficits and quality of life in patients with cerebral small vessel disease: a structural equation model.” Neuropsychology 28(2):247-53 Details

Cotlarciuc I, Malik R, Holliday EG, Ahmadi KR, Paré G, Psaty BM, Fornage M, Hasan N, Rinne PE, Ikram MA, Markus HS, Rosand J, Mitchell BD, Kittner SJ, Meschia JF, van Meurs JB, Uitterlinden AG, Worrall BB, Dichgans M, Sharma P, METASTROKE and the International Stroke Genetics Consortium (2014), “Effect of genetic variants associated with plasma homocysteine levels on stroke risk.” Stroke 45(7):1920-4 Details

Damotte V, Guillot-Noel L, Patsopoulos NA, Madireddy L, El Behi M, International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, De Jager PL, Baranzini SE, Cournu-Rebeix I, Fontaine B (2014), “A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.” Genes Immun 15(2):126-32 Details

Davis OS, Band G, Pirinen M, Haworth CM, Meaburn EL, Kovas Y, Harlaar N, Docherty SJ, Hanscombe KB, Trzaskowski M, Curtis CJ, Strange A, Freeman C, Bellenguez C, Su Z, Pearson R, Vukcevic D, Langford C, Deloukas P, Hunt S, Gray E, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Edkins S, Bumpstead SJ, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski JA, Markus HS, Mathew CG, Palmer CN, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Barroso I, Peltonen L, Dale PS, Petrill SA, Schalkwyk LS, Craig IW, Lewis CM, Price TS, Wellcome Trust Case Control Consortium, Donnelly P, Plomin R, Spencer CC (2014), “The correlation between reading and mathematics ability at age twelve has a substantial genetic component.” Nat Commun 5:4204 Details

Dichgans M, Malik R, König IR, Rosand J, Clarke R, Gretarsdottir S, Thorleifsson G, Mitchell BD, Assimes TL, Levi C, O'Donnell CJ, Fornage M, Thorsteinsdottir U, Psaty BM, Hengstenberg C, Seshadri S, Erdmann J, Bis JC, Peters A, Boncoraglio GB, März W, Meschia JF, Kathiresan S, Ikram MA, McPherson R, Stefansson K, Sudlow C, Reilly MP, Thompson JR, Sharma P, Hopewell JC, Chambers JC, Watkins H, Rothwell PM, Roberts R, Markus HS, Samani NJ, Farrall M, Schunkert H, METASTROKE Consortium, CARDIoGRAM Consortium, C4D Consortium, International Stroke Genetics Consortium (2014), “Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.” Stroke 45(1):24-36 Details

Dregan A, Charlton J, Wolfe CD, Gulliford MC, Markus HS (2014), “Is Sodium Valproate, an HDAC inhibitor, associated with reduced risk of stroke and myocardial infarction? A nested case-control study.” Pharmacoepidemiol Drug Saf 23(7):759-67 Details

Harlaar N, Meaburn EL, Hayiou-Thomas ME, Wellcome Trust Case Control Consortium, Davis OS, Docherty S, Hanscombe KB, Haworth CM, Price TS, Trzaskowski M, Dale PS, Plomin R (2014), “Genome-wide association study of receptive language ability of 12-year-olds.” J Speech Lang Hear Res 57(1):96-105 Details

Hayes DF, Markus HS, Leslie RD, Topol EJ (2014), “Personalized medicine: risk prediction, targeted therapies and mobile health technology.” BMC Med 12:37 Details

Herbert V, Brookes RL, Markus HS, Morris RG (2014), “Verbal fluency in cerebral small vessel disease and Alzheimer's disease.” J Int Neuropsychol Soc 20(4):413-21 Details

Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, Sharma P, Slowik A, Thijs V, Walters M, Worrall BB, Sale MM, Algra A, Kappelle LJ, Wijmenga C, Norrving B, Sandling JK, Rönnblom L, Goris A, Franke A, Sudlow C, Rothwell PM, Levi C, Holliday EG, Fornage M, Psaty B, Gretarsdottir S, Thorsteinsdottir U, Seshadri S, Mitchell BD, Kittner S, Clarke R, Hopewell JC, Bis JC, Boncoraglio GB, Meschia J, Ikram MA, Hansen BM, Montaner J, Thorleifsson G, Stefanson K, Rosand J, de Bakker PI, Farrall M, Dichgans M, Markus HS, Bevan S, On behalf of the GARNET Collaborative Research Group, Wellcome Trust Case Control Consortium 2, Australian Stroke Genetic Collaborative, the METASTROKE Consortium, and the International Stroke Genetics Consortium (2014), “Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12.” Neurology Details

Lawrence AJ, Chung AW, Morris RG, Markus HS, Barrick TR (2014), “Structural network efficiency is associated with cognitive impairment in small-vessel disease.” Neurology 83(4):304-11 Details

Mäkelä KM, Traylor M, Oksala N, Kleber ME, Seppälä I, Lyytikäinen LP, Hernesniemi JA, Kähönen M, Bevan S, Rothwell PM, Sudlow C, Dichgans M, Wellcome Trust Case Control Consortium 2 (WTCCC2), Delgado G, Grammer TB, Scharnagl H, Markus HS, März W, Lehtimäki T (2014), “Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events.” Atherosclerosis 234(1):214-7 Details

Malik R, Bevan S, Nalls MA, Holliday EG, Devan WJ, Cheng YC, Ibrahim-Verbaas CA, Verhaaren BF, Bis JC, Joon AY, de Stefano AL, Fornage M, Psaty BM, Ikram MA, Launer LJ, van Duijn CM, Sharma P, Mitchell BD, Rosand J, Meschia JF, Levi C, Rothwell PM, Sudlow C, Markus HS, Seshadri S, Dichgans M, Wellcome Trust Case Control Consortium 2 (2014), “Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies.” Stroke 45(2):394-402 Details

Nalls MA, Saad M, Noyce AJ, Keller MF, Schrag A, Bestwick JP, Traynor BJ, Gibbs JR, Hernandez DG, Cookson MR, Morris HR, Williams N, Gasser T, Heutink P, Wood N, Hardy J, Martinez M, Singleton AB, International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC) (2014), “Genetic comorbidities in Parkinson's disease.” Hum Mol Genet 23(3):831-41 Details

Opherk C, Gonik M, Duering M, Malik R, Jouvent E, Hervé D, Adib-Samii P, Bevan S, Pianese L, Silvestri S, Dotti MT, De Stefano N, Liem M, Boon EM, Pescini F, Pachai C, Bracoud L, Müller-Myhsok B, Meitinger T, Rost N, Pantoni L, Lesnik Oberstein S, Federico A, Ragno M, Markus HS, Tournier-Lasserve E, Rosand J, Chabriat H, Dichgans M (2014), “Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL.” Stroke 45(4):968-72 Details

Power RA, Nagoshi C, DeFries JC, Plomin R, Wellcome Trust Case Control Consortium 2 (2014), “Genome-wide estimates of inbreeding in unrelated individuals and their association with cognitive ability.” Eur J Hum Genet 22(3):386-90 Details

Psychosis Endophenotypes International Consortium, Wellcome Trust Case-Control Consortium 2, Bramon E, Pirinen M, Strange A, Lin K, Freeman C, Bellenguez C, Su Z, Band G, Pearson R, Vukcevic D, Langford C, Deloukas P, Hunt S, Gray E, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Edkins S, Bumpstead SJ, Arranz MJ, Bakker S, Bender S, Bruggeman R, Cahn W, Chandler D, Collier DA, Crespo-Facorro B, Dazzan P, de Haan L, Di Forti M, Dragović M, Giegling I, Hall J, Iyegbe C, Jablensky A, Kahn RS, Kalaydjieva L, Kravariti E, Lawrie S, Linszen DH, Mata I, McDonald C, McIntosh A, Myin-Germeys I, Ophoff RA, Pariante CM, Paunio T, Picchioni M, Psychiatric Genomics Consortium, Ripke S, Rujescu D, Sauer H, Shaikh M, Sussmann J, Suvisaari J, Tosato S, Toulopoulou T, Van Os J, Walshe M, Weisbrod M, Whalley H, Wiersma D, Blackwell JM, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski JA, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Wood NW, Barroso I, Peltonen L, Lewis CM, Murray RM, Donne (2014), “A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation.” Biol Psychiatry 75(5):386-97 Details

Rees E, Walters JT, Chambert KD, O'Dushlaine C, Szatkiewicz J, Richards AL, Georgieva L, Mahoney-Davies G, Legge SE, Moran JL, Genovese G, Levinson D, Morris DW, Cormican P, Kendler KS, O'Neill FA, Riley B, Gill M, Corvin A, Wellcome Trust Case Control Consortium, Sklar P, Hultman C, Pato C, Pato M, Sullivan PF, Gejman PV, McCarroll SA, O'Donovan MC, Owen MJ, Kirov G (2014), “CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1.” Hum Mol Genet 23(6):1669-76 Details

Rothwell PM, Markus HS (2014), “Improved medical treatment in secondary prevention of stroke.” Lancet 383(9914):290-1 Details

Steinberg S, de Jong S, Mattheisen M, Costas J, Demontis D, Jamain S, Pietiläinen OP, Lin K, Papiol S, Huttenlocher J, Sigurdsson E, Vassos E, Giegling I, Breuer R, Fraser G, Walker N, Melle I, Djurovic S, Agartz I, Tuulio-Henriksson A, Suvisaari J, Lönnqvist J, Paunio T, Olsen L, Hansen T, Ingason A, Pirinen M, Strengman E, GROUP, Hougaard DM, Orntoft T, Didriksen M, Hollegaard MV, Nordentoft M, Abramova L, Kaleda V, Arrojo M, Sanjuán J, Arango C, Etain B, Bellivier F, Méary A, Schürhoff F, Szoke A, Ribolsi M, Magni V, Siracusano A, Sperling S, Rossner M, Christiansen C, Kiemeney LA, Franke B, van den Berg LH, Veldink J, Curran S, Bolton P, Poot M, Staal W, Rehnstrom K, Kilpinen H, Freitag CM, Meyer J, Magnusson P, Saemundsen E, Martsenkovsky I, Bikshaieva I, Martsenkovska I, Vashchenko O, Raleva M, Paketchieva K, Stefanovski B, Durmishi N, Pejovic Milovancevic M, Lecic Tosevski D, Silagadze T, Naneishvili N, Mikeladze N, Surguladze S, Vincent JB, Farmer A, Mitchell PB, Wright A, Schofield PR, Fullerton JM, (2014), “Common variant at 16p11.2 conferring risk of psychosis.” Mol Psychiatry 19(1):108-14 Details

2013

Adib-Samii P, Rost N, Traylor M, Devan W, Biffi A, Lanfranconi S, Fitzpatrick K, Bevan S, Kanakis A, Valant V, Gschwendtner A, Malik R, Richie A, Gamble D, Segal H, Parati EA, Ciusani E, Holliday EG, Maguire J, Wardlaw J, Worrall B, Bis J, Wiggins KL, Longstreth W, Kittner SJ, Cheng YC, Mosley T, Falcone GJ, Furie KL, Leiva-Salinas C, Lau BC, Saleem Khan M, Australian Stroke Genetics Collaborative, Wellcome Trust Case-Control Consortium-2 (WTCCC2), METASTROKE, Sharma P, Fornage M, Mitchell BD, Psaty BM, Sudlow C, Levi C, Boncoraglio GB, Rothwell PM, Meschia J, Dichgans M, Rosand J, Markus HS, International Stroke Genetics Consortium (2013), “17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status.” Stroke 44(6):1609-15 Details

Bevan S, Markus HS (2013), “Genetic profiles in ischaemic stroke.” Curr Atheroscler Rep 15(8):342 Details

Blue Mountains Eye Study (BMES), Wellcome Trust Case Control Consortium 2 (WTCCC2) (2013), “Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus.” Hum Mol Genet 22(22):4653-60 Details

Brookes RL, Hannesdottir K, Markus HS, Morris RG (2013), “Lack of awareness of neuropsychological deficit in cerebral small vessel disease: the relationship with executive and episodic memory functions.” J Neuropsychol 7(1):19-28 Details

Brookes RL, Willis TA, Patel B, Morris RG, Markus HS (2013), “Depressive symptoms as a predictor of quality of life in cerebral small vessel disease, acting independently of disability; a study in both sporadic small vessel disease and CADASIL.” Int J Stroke 8(7):510-7 Details

Charlton RA, Barrick TR, Markus HS, Morris RG (2013), “Verbal working and long-term episodic memory associations with white matter microstructure in normal aging investigated using tract-based spatial statistics.” Psychol Aging 28(3):768-77 Details

Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Mishra A, Wang YX, Wang JJ, Rochtchina E, Polasek O, Wright AF, Amin N, van Leeuwen EM, Wilson JF, Pennell CE, van Duijn CM, de Jong PT, Vingerling JR, Zhou X, Chen P, Li R, Tay WT, Zheng Y, Chew M, Consortium for Refractive Error and Myopia, Burdon KP, Craig JE, Iyengar SK, Igo RP Jr, Lass JH Jr, Fuchs' Genetics Multi-Center Study Group, Chew EY, Haller T, Mihailov E, Metspalu A, Wedenoja J, Simpson CL, Wojciechowski R, Höhn R, Mirshahi A, Zeller T, Pfeiffer N, Lackner KJ, Wellcome Trust Case Control Consortium 2, Bettecken T, Meitinger T, Oexle K, Pirastu M, Portas L, Nag A, Williams KM, Yonova-Doing E, Klein R, Klein BE, Hosseini SM, Paterson AD, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions, and Complications Research Group, Makela KM, Lehtimaki T, Kahonen M, Rai (2013), “Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.” Am J Hum Genet 93(2):264-77 Details

Gulli G, Marquardt L, Rothwell PM, Markus HS (2013), “Stroke risk after posterior circulation stroke/transient ischemic attack and its relationship to site of vertebrobasilar stenosis: pooled data analysis from prospective studies.” Stroke 44(3):598-604 Details

Holliday EG, Smith AV, Cornes BK, Buitendijk GH, Jensen RA, Sim X, Aspelund T, Aung T, Baird PN, Boerwinkle E, Cheng CY, van Duijn CM, Eiriksdottir G, Gudnason V, Harris T, Hewitt AW, Inouye M, Jonasson F, Klein BE, Launer L, Li X, Liew G, Lumley T, McElduff P, McKnight B, Mitchell P, Psaty BM, Rochtchina E, Rotter JI, Scott RJ, Tay W, Taylor K, Teo YY, Uitterlinden AG, Viswanathan A, Xie S, Wellcome Trust Case Control Consortium 2, Vingerling JR, Klaver CC, Tai ES, Siscovick D, Klein R, Cotch MF, Wong TY, Attia J, Wang JJ (2013), “Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.” PLoS One 8(1):e53830 Details

Kaudewitz D, Lee R, Willeit P, McGregor R, Markus HS, Kiechl S, Zampetaki A, Storey RF, Channon KM, Mayr M (2013), “Impact of intravenous heparin on quantification of circulating microRNAs in patients with coronary artery disease.” Thromb Haemost 110(3):609-15 Details

Kerry SM, Markus HS, Khong TK, Cloud GC, Tulloch J, Coster D, Ibison J, Oakeshott P (2013), “Home blood pressure monitoring with nurse-led telephone support among patients with hypertension and a history of stroke: a community-based randomized controlled trial.” CMAJ 185(1):23-31 Details

Lanfranconi S, Markus HS (2013), “Stroke subtyping for genetic association studies? A comparison of the CCS and TOAST classifications.” Int J Stroke 8(8):626-31 Details

Lau AY, Zhao Y, Chen C, Leung TW, Fu J, Huang Y, Suwanwela NC, Han Z, Tan KS, Ratanakorn D, Markus HS, Wong KS, for the CLAIR Study Investigators (2013), “Dual antiplatelets reduce microembolic signals in patients with transient ischemic attack and minor stroke: subgroup analysis of CLAIR study.” Int J Stroke Details

Lawrence AJ, Patel B, Morris RG, MacKinnon AD, Rich PM, Barrick TR, Markus HS (2013), “Mechanisms of cognitive impairment in cerebral small vessel disease: multimodal MRI results from the St George's cognition and neuroimaging in stroke (SCANS) study.” PLoS One 8(4):e61014 Details

LeishGEN Consortium, Wellcome Trust Case Control Consortium 2, Fakiola M, Strange A, Cordell HJ, Miller EN, Pirinen M, Su Z, Mishra A, Mehrotra S, Monteiro GR, Band G, Bellenguez C, Dronov S, Edkins S, Freeman C, Giannoulatou E, Gray E, Hunt SE, Lacerda HG, Langford C, Pearson R, Pontes NN, Rai M, Singh SP, Smith L, Sousa O, Vukcevic D, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Wilson ME, Deloukas P, Peltonen L, Christiansen F, Witt C, Jeronimo SM, Sundar S, Spencer CC, Blackwell JM, Donnelly P (2013), “Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.” Nat Genet 45(2):208-13 Details

Markus HS (2013), “WellcomeTrust genome-wide association study of ischemic stroke.” Stroke 44(6 Suppl 1):S20-2 Details

Markus HS (2013), “Author Response.” Neurology 80(10):971 Details

Markus HS, Mäkelä KM, Bevan S, Raitoharju E, Oksala N, Bis JC, O'Donnell C, Hainsworth A, Lehtimäki T (2013), “Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis.” Stroke 44(5):1220-5 Details

Markus HS, van der Worp HB, Rothwell PM (2013), “Posterior circulation ischaemic stroke and transient ischaemic attack: diagnosis, investigation, and secondary prevention.” Lancet Neurol 12(10):989-98 Details

Mechelli R, Umeton R, Policano C, Annibali V, Coarelli G, Ricigliano VA, Vittori D, Fornasiero A, Buscarinu MC, International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium,2, Romano S, Salvetti M, Ristori G (2013), “A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis.” PLoS One 8(5):e63300 Details

Meschia JF, Arnett DK, Ay H, Brown RD Jr, Benavente OR, Cole JW, de Bakker PI, Dichgans M, Doheny KF, Fornage M, Grewal RP, Gwinn K, Jern C, Conde JJ, Johnson JA, Jood K, Laurie CC, Lee JM, Lindgren A, Markus HS, McArdle PF, McClure LA, Mitchell BD, Schmidt R, Rexrode KM, Rich SS, Rosand J, Rothwell PM, Rundek T, Sacco RL, Sharma P, Shuldiner AR, Slowik A, Wassertheil-Smoller S, Sudlow C, Thijs VN, Woo D, Worrall BB, Wu O, Kittner SJ, NINDS SiGN Study (2013), “Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes.” Stroke 44(10):2694-702 Details

Moynihan B, Paul S, Markus HS (2013), “User experience of a centralized hyperacute stroke service: a prospective evaluation.” Stroke 44(10):2743-7 Details

Patel B, Lawrence AJ, Chung AW, Rich P, Mackinnon AD, Morris RG, Barrick TR, Markus HS (2013), “Cerebral microbleeds and cognition in patients with symptomatic small vessel disease.” Stroke 44(2):356-61 Details

Pichler I, Del Greco M F, Gögele M, Lill CM, Bertram L, Do CB, Eriksson N, Foroud T, Myers RH, PD GWAS Consortium, Nalls M, Keller MF, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Benyamin B, Whitfield JB, Genetics of Iron Status Consortium, Pramstaller PP, Hicks AA, Thompson JR, Minelli C (2013), “Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study.” PLoS Med 10(6):e1001462 Details

Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler AK, Akterin S, Bergen SE, Collins AL, Crowley JJ, Fromer M, Kim Y, Lee SH, Magnusson PK, Sanchez N, Stahl EA, Williams S, Wray NR, Xia K, Bettella F, Borglum AD, Bulik-Sullivan BK, Cormican P, Craddock N, de Leeuw C, Durmishi N, Gill M, Golimbet V, Hamshere ML, Holmans P, Hougaard DM, Kendler KS, Lin K, Morris DW, Mors O, Mortensen PB, Neale BM, O'Neill FA, Owen MJ, Milovancevic MP, Posthuma D, Powell J, Richards AL, Riley BP, Ruderfer D, Rujescu D, Sigurdsson E, Silagadze T, Smit AB, Stefansson H, Steinberg S, Suvisaari J, Tosato S, Verhage M, Walters JT, Multicenter Genetic Studies of Schizophrenia Consortium, Levinson DF, Gejman PV, Kendler KS, Laurent C, Mowry BJ, O'Donovan MC, Owen MJ, Pulver AE, Riley BP, Schwab SG, Wildenauer DB, Dudbridge F, Holmans P, Shi J, Albus M, Alexander M, Campion D, Cohen D, Dikeos D, Duan J, Eichhammer P, Godard S, Hansen M, Lerer FB, Liang KY, Maier W, Mallet J, Nertney DA, Nestadt G, Norton N, O'Neill FA, Papadimitriou (2013), “Genome-wide association analysis identifies 13 new risk loci for schizophrenia.” Nat Genet 45(10):1150-9 Details

Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Mälarstig A, Baumert J, Bis JC, Guo X, Hottenga JJ, Shin SY, Lopez LM, Lahti J, Tanaka T, Yanek LR, Oudot-Mellakh T, Wilson JF, Navarro P, Huffman JE, Zemunik T, Redline S, Mehra R, Pulanic D, Rudan I, Wright AF, Kolcic I, Polasek O, Wild SH, Campbell H, Curb JD, Wallace R, Liu S, Eaton CB, Becker DM, Becker LC, Bandinelli S, Räikkönen K, Widen E, Palotie A, Fornage M, Green D, Gross M, Davies G, Harris SE, Liewald DC, Starr JM, Williams FM, Grant PJ, Spector TD, Strawbridge RJ, Silveira A, Sennblad B, Rivadeneira F, Uitterlinden AG, Franco OH, Hofman A, van Dongen J, Willemsen G, Boomsma DI, Yao J, Swords Jenny N, Haritunians T, McKnight B, Lumley T, Taylor KD, Rotter JI, Psaty BM, Peters A, Gieger C, Illig T, Grotevendt A, Homuth G, Völzke H, Kocher T, Goel A, Franzosi MG, Seedorf U, Clarke R, Steri M, Tarasov KV, Sanna S, Schlessinger D, Stott DJ, Sattar N, Buckley BM, Ru (2013), “Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.” Circulation 128(12):1310-24 Details

Sim X, Jensen RA, Ikram MK, Cotch MF, Li X, MacGregor S, Xie J, Smith AV, Boerwinkle E, Mitchell P, Klein R, Klein BE, Glazer NL, Lumley T, McKnight B, Psaty BM, de Jong PT, Hofman A, Rivadeneira F, Uitterlinden AG, van Duijn CM, Aspelund T, Eiriksdottir G, Harris TB, Jonasson F, Launer LJ, Wellcome Trust Case Control Consortium 2, Attia J, Baird PN, Harrap S, Holliday EG, Inouye M, Rochtchina E, Scott RJ, Viswanathan A, Global BPGen Consortium, Li G, Smith NL, Wiggins KL, Kuo JZ, Taylor KD, Hewitt AW, Martin NG, Montgomery GW, Sun C, Young TL, Mackey DA, van Zuydam NR, Doney AS, Palmer CN, Morris AD, Rotter JI, Tai ES, Gudnason V, Vingerling JR, Siscovick DS, Wang JJ, Wong TY (2013), “Genetic loci for retinal arteriolar microcirculation.” PLoS One 8(6):e65804 Details

Traylor M, Bevan S, Rothwell PM, Sudlow C, Wellcome Trust Case Control Consortium 2 (WTCCC2), Dichgans M, Markus HS, Lewis CM (2013), “Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes.” Genet Epidemiol 37(5):495-503 Details

Verhoeven VJ, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Höhn R, MacGregor S, Hewitt AW, Nag A, Cheng CY, Yonova-Doing E, Zhou X, Ikram MK, Buitendijk GH, McMahon G, Kemp JP, Pourcain BS, Simpson CL, Mäkelä KM, Lehtimäki T, Kähönen M, Paterson AD, Hosseini SM, Wong HS, Xu L, Jonas JB, Pärssinen O, Wedenoja J, Yip SP, Ho DW, Pang CP, Chen LJ, Burdon KP, Craig JE, Klein BE, Klein R, Haller T, Metspalu A, Khor CC, Tai ES, Aung T, Vithana E, Tay WT, Barathi VA, Consortium for Refractive Error and Myopia (CREAM), Chen P, Li R, Liao J, Zheng Y, Ong RT, Döring A, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Evans DM, Timpson NJ, Verkerk AJ, Meitinger T, Raitakari O, Hawthorne F, Spector TD, Karssen LC, Pirastu M, Murgia F, Ang W, Wellcome Trust Case Control Consortium 2 (WTCCC2), Mishra A, Montgomery GW, Pennell CE, Cumberland PM, Cotlarciuc I, Mitchell P, Wang JJ, Schache M, Janmahasatian S, Igo RP Jr, Lass JH, Chew E, Iyengar SK (2013), “Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.” Nat Genet 45(3):314-8 Details

Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley SR, Sivaprasad S, Markus HS, Mitchell JA, Warner TD, Kiechl S, Mayr M (2013), “Circulating microRNAs as novel biomarkers for platelet activation.” Circ Res 112(4):595-600 Details

Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S, Dichgans M, Rothwell PM, Sudlow C, Farrall M, Silander K, Kaunisto M, Wagner P, Saarela O, Kuulasmaa K, Virtamo J, Salomaa V, Amouyel P, Arveiler D, Ferrieres J, Wiklund PG, Ikram MA, Hofman A, Boncoraglio GB, Parati EA, Helgadottir A, Gretarsdottir S, Thorsteinsdottir U, Thorleifsson G, Stefansson K, Seshadri S, DeStefano A, Gschwendtner A, Psaty B, Longstreth W, Mitchell BD, Cheng YC, Clarke R, Ferrario M, Bis JC, Levi C, Attia J, Holliday EG, Scott RJ, Fornage M, Sharma P, Furie KL, Rosand J, Nalls M, Meschia J, Mosely TH, Evans A, Palotie A, Markus HS, Grant PJ, Spector TD, EuroCLOT Investigators, Wellcome Trust Case Control Consortium 2, MOnica Risk, Genetics, Archiving and Monograph, MetaStroke, International Stroke Genetics Consortium (2013), “Ischemic stroke is associated with the ABO locus: the EuroCLOT study.” Ann Neurol 73(1):16-31 Details

Wong KS, Wang Y, Leng X, Mao C, Tang J, Bath PM, Markus HS, Gorelick PB, Liu L, Lin W, Wang Y (2013), “Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis.” Circulation 128(15):1656-66 Details

Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, Cheng YC, Chen WM, Malik R, McCarthy NS, Holliday EG, Speed D, Hasan N, Pucek M, Rinne PE, Sever P, Stanton A, Shields DC, Maguire JM, McEvoy M, Scott RJ, Ferrucci L, Macleod MJ, Attia J, Markus HS, Sale MM, Worrall BB, Mitchell BD, Dichgans M, Sudlow C, Meschia JF, Rothwell PM, Caulfield M, Sharma P, International Stroke Genetics Consortium (2013), “Genome-wide analysis of blood pressure variability and ischemic stroke.” Stroke 44(10):2703-9 Details

2012

Bellenguez C, Strange A, Freeman C, Wellcome Trust Case Control Consortium, Donnelly P, Spencer CC (2012), “A robust clustering algorithm for identifying problematic samples in genome-wide association studies.” Bioinformatics 28(1):134-5 Details

Bevan S, Traylor M, Adib-Samii P, Malik R, Paul NL, Jackson C, Farrall M, Rothwell PM, Sudlow C, Dichgans M, Markus HS (2012), “Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations.” Stroke 43(12):3161-7 Details

Brookes RL, Hannesdottir K, Lawrence R, Morris RG, Markus HS (2012), “Brief Memory and Executive Test: evaluation of a new screening test for cognitive impairment due to small vessel disease.” Age Ageing 41(2):212-8 Details

Geeganage CM, Diener HC, Algra A, Chen C, Topol EJ, Dengler R, Markus HS, Bath MW, Bath PM, Acute Antiplatelet Stroke Trialists Collaboration (2012), “Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and meta-analysis of randomized controlled trials.” Stroke 43(4):1058-66 Details

Giwa MO, Williams J, Elderfield K, Jiwa NS, Bridges LR, Kalaria RN, Markus HS, Esiri MM, Hainsworth AH (2012), “Neuropathologic evidence of endothelial changes in cerebral small vessel disease.” Neurology 78(3):167-74 Details

Gulli G, Markus HS (2012), “The use of FAST and ABCD2 scores in posterior circulation, compared with anterior circulation, stroke and transient ischemic attack.” J Neurol Neurosurg Psychiatry 83(2):228-9 Details

Helgadottir A, Gretarsdottir S, Thorleifsson G, Holm H, Patel RS, Gudnason T, Jones GT, van Rij AM, Eapen DJ, Baas AF, Tregouet DA, Morange PE, Emmerich J, Lindblad B, Gottsäter A, Kiemeny LA, Lindholt JS, Sakalihasan N, Ferrell RE, Carey DJ, Elmore JR, Tsao PS, Grarup N, Jørgensen T, Witte DR, Hansen T, Pedersen O, Pola R, Gaetani E, Magnadottir HB, Wijmenga C, Tromp G, Ronkainen A, Ruigrok YM, Blankensteijn JD, Mueller T, Wells PS, Corral J, Soria JM, Souto JC, Peden JF, Jalilzadeh S, Mayosi BM, Keavney B, Strawbridge RJ, Sabater-Lleal M, Gertow K, Baldassarre D, Nyyssönen K, Rauramaa R, Smit AJ, Mannarino E, Giral P, Tremoli E, de Faire U, Humphries SE, Hamsten A, Haraldsdottir V, Olafsson I, Magnusson MK, Samani NJ, Levey AI, Markus HS, Kostulas K, Dichgans M, Berger K, Kuhlenbäumer G, Ringelstein EB, Stoll M, Seedorf U, Rothwell PM, Powell JT, Kuivaniemi H, Onundarson PT, Valdimarsson E, Matthiasson SE, Gudbjartsson DF, Thorgeirsson G, Quyyumi AA, Watkins H, Farrall M, Thorsteinsdottir U, Stefansson K (2012), “Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.” J Am Coll Cardiol 60(8):722-9 Details

Holliday EG, Maguire JM, Evans TJ, Koblar SA, Jannes J, Sturm JW, Hankey GJ, Baker R, Golledge J, Parsons MW, Malik R, McEvoy M, Biros E, Lewis MD, Lincz LF, Peel R, Oldmeadow C, Smith W, Moscato P, Barlera S, Bevan S, Bis JC, Boerwinkle E, Boncoraglio GB, Brott TG, Brown RD Jr, Cheng YC, Cole JW, Cotlarciuc I, Devan WJ, Fornage M, Furie KL, Grétarsdóttir S, Gschwendtner A, Ikram MA, Longstreth WT Jr, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Parati EA, Psaty BM, Sharma P, Stefansson K, Thorleifsson G, Thorsteinsdottir U, Traylor M, Verhaaren BF, Wiggins KL, Worrall BB, Sudlow C, Rothwell PM, Farrall M, Dichgans M, Rosand J, Markus HS, Scott RJ, Levi C, Attia J, Australian Stroke Genetics Collaborative, International Stroke Genetics Consortium, Wellcome Trust Case Control Consortium 2 (2012), “Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.” Nat Genet 44(10):1147-51 Details

International Stroke Genetics Consortium (ISGC), Wellcome Trust Case Control Consortium 2 (WTCCC2), Bellenguez C, Bevan S, Gschwendtner A, Spencer CC, Burgess AI, Pirinen M, Jackson CA, Traylor M, Strange A, Su Z, Band G, Syme PD, Malik R, Pera J, Norrving B, Lemmens R, Freeman C, Schanz R, James T, Poole D, Murphy L, Segal H, Cortellini L, Cheng YC, Woo D, Nalls MA, Müller-Myhsok B, Meisinger C, Seedorf U, Ross-Adams H, Boonen S, Wloch-Kopec D, Valant V, Slark J, Furie K, Delavaran H, Langford C, Deloukas P, Edkins S, Hunt S, Gray E, Dronov S, Peltonen L, Gretarsdottir S, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Boncoraglio GB, Parati EA, Attia J, Holliday E, Levi C, Franzosi MG, Goel A, Helgadottir A, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Worrall BB, Kittner SJ, Mitchell BD, Kissela B, Meschia JF, Thijs V, Lindgren A, Macleod MJ, Slowik A, Walters M, Rosand J, Shar (2012), “Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.” Nat Genet 44(3):328-33 Details

Irish Schizophrenia Genomics Consortium and the Wellcome Trust Case Control Consortium 2 (2012), “Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.” Biol Psychiatry 72(8):620-8 Details

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Büning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zh (2012), “Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.” Nature 491(7422):119-24 Details

Keller MF, Saad M, Bras J, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Büchel F, Sharma M, Gibbs JR, Schulte C, Moskvina V, Durr A, Holmans P, Kilarski LL, Guerreiro R, Hernandez DG, Brice A, Ylikotila P, Stefánsson H, Majamaa K, Morris HR, Williams N, Gasser T, Heutink P, Wood NW, Hardy J, Martinez M, Singleton AB, Nalls MA, International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2) (2012), “Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.” Hum Mol Genet 21(22):4996-5009 Details

Kennedy F, Lanfranconi S, Hicks C, Reid J, Gompertz P, Price C, Kerry S, Norris J, Markus HS, CADISS Investigators (2012), “Antiplatelets vs anticoagulation for dissection: CADISS nonrandomized arm and meta-analysis.” Neurology 79(7):686-9 Details

Knight J, Spain SL, Capon F, Hayday A, Nestle FO, Clop A, Wellcome Trust Case Control Consortium, Genetic Analysis of Psoriasis Consortium, I-chip for Psoriasis Consortium, Barker JN, Weale ME, Trembath RC (2012), “Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis.” Hum Mol Genet 21(23):5185-92 Details

Markus HS (2012), “Stroke genetics: prospects for personalized medicine.” BMC Med 10:113 Details

Su Z, Gay LJ, Strange A, Palles C, Band G, Whiteman DC, Lescai F, Langford C, Nanji M, Edkins S, van der Winkel A, Levine D, Sasieni P, Bellenguez C, Howarth K, Freeman C, Trudgill N, Tucker AT, Pirinen M, Peppelenbosch MP, van der Laan LJ, Kuipers EJ, Drenth JP, Peters WH, Reynolds JV, Kelleher DP, McManus R, Grabsch H, Prenen H, Bisschops R, Krishnadath K, Siersema PD, van Baal JW, Middleton M, Petty R, Gillies R, Burch N, Bhandari P, Paterson S, Edwards C, Penman I, Vaidya K, Ang Y, Murray I, Patel P, Ye W, Mullins P, Wu AH, Bird NC, Dallal H, Shaheen NJ, Murray LJ, Koss K, Bernstein L, Romero Y, Hardie LJ, Zhang R, Winter H, Corley DA, Panter S, Risch HA, Reid BJ, Sargeant I, Gammon MD, Smart H, Dhar A, McMurtry H, Ali H, Liu G, Casson AG, Chow WH, Rutter M, Tawil A, Morris D, Nwokolo C, Isaacs P, Rodgers C, Ragunath K, MacDonald C, Haigh C, Monk D, Davies G, Wajed S, Johnston D, Gibbons M, Cullen S, Church N, Langley R, Griffin M, Alderson D, Deloukas P, Hunt SE, Gray E, Dronov S, Potter SC, Tashakkori- (2012), “Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.” Nat Genet 44(10):1131-6 Details

Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, Fornage M, Ikram MA, Malik R, Bevan S, Thorsteinsdottir U, Nalls MA, Longstreth W, Wiggins KL, Yadav S, Parati EA, Destefano AL, Worrall BB, Kittner SJ, Khan MS, Reiner AP, Helgadottir A, Achterberg S, Fernandez-Cadenas I, Abboud S, Schmidt R, Walters M, Chen WM, Ringelstein EB, O'Donnell M, Ho WK, Pera J, Lemmens R, Norrving B, Higgins P, Benn M, Sale M, Kuhlenbäumer G, Doney AS, Vicente AM, Delavaran H, Algra A, Davies G, Oliveira SA, Palmer CN, Deary I, Schmidt H, Pandolfo M, Montaner J, Carty C, de Bakker PI, Kostulas K, Ferro JM, van Zuydam NR, Valdimarsson E, Nordestgaard BG, Lindgren A, Thijs V, Slowik A, Saleheen D, Paré G, Berger K, Thorleifsson G, Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2), Hofman A, Mosley TH, Mitchell BD, Furie K, Clarke R, Levi C, Seshadri S, Gschwendtner A, Boncoraglio GB, Sharma P, Bis JC, Gretarsdottir S, Psaty BM, Rothwell PM, Rosand J, Meschia JF, Stefansson (2012), “Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.” Lancet Neurol 11(11):951-62 Details

Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J, Collaborative Association Study of Psoriasis (CASP), Genetic Analysis of Psoriasis Consortium, Psoriasis Association Genetics Extension, Wellcome Trust Case Control Consortium 2, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC (2012), “Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.” Nat Genet 44(12):1341-8 Details

van Koolwijk LM, Ramdas WD, Ikram MK, Jansonius NM, Pasutto F, Hysi PG, Macgregor S, Janssen SF, Hewitt AW, Viswanathan AC, ten Brink JB, Hosseini SM, Amin N, Despriet DD, Willemse-Assink JJ, Kramer R, Rivadeneira F, Struchalin M, Aulchenko YS, Weisschuh N, Zenkel M, Mardin CY, Gramer E, Welge-Lüssen U, Montgomery GW, Carbonaro F, Young TL, DCCT/EDIC Research Group, Bellenguez C, McGuffin P, Foster PJ, Topouzis F, Mitchell P, Wang JJ, Wong TY, Czudowska MA, Hofman A, Uitterlinden AG, Wolfs RC, de Jong PT, Oostra BA, Paterson AD, Wellcome Trust Case Control Consortium 2, Mackey DA, Bergen AA, Reis A, Hammond CJ, Vingerling JR, Lemij HG, Klaver CC, van Duijn CM (2012), “Common genetic determinants of intraocular pressure and primary open-angle glaucoma.” PLoS Genet 8(5):e1002611 Details

2011

Bevan S, Markus HS (2011), “Genetics of common polygenic ischaemic stroke: current understanding and future challenges.” Stroke Res Treat 2011:179061 Details

Bevan S, Meidtner K, Lorenz M, Sitzer M, Grant PJ, Markus HS (2011), “Adiponectin level as a consequence of genetic variation, but not leptin level or leptin: adiponectin ratio, is a risk factor for carotid intima-media thickness.” Stroke 42(6):1510-4 Details

Bis JC, Kavousi M, Franceschini N, Isaacs A, Abecasis GR, Schminke U, Post WS, Smith AV, Cupples LA, Markus HS, Schmidt R, Huffman JE, Lehtimäki T, Baumert J, Münzel T, Heckbert SR, Dehghan A, North K, Oostra B, Bevan S, Stoegerer EM, Hayward C, Raitakari O, Meisinger C, Schillert A, Sanna S, Völzke H, Cheng YC, Thorsson B, Fox CS, Rice K, Rivadeneira F, Nambi V, Halperin E, Petrovic KE, Peltonen L, Wichmann HE, Schnabel RB, Dörr M, Parsa A, Aspelund T, Demissie S, Kathiresan S, Reilly MP, Taylor K, Uitterlinden A, Couper DJ, Sitzer M, Kähönen M, Illig T, Wild PS, Orru M, Lüdemann J, Shuldiner AR, Eiriksdottir G, White CC, Rotter JI, Hofman A, Seissler J, Zeller T, Usala G, Ernst F, Launer LJ, D'Agostino RB Sr, O'Leary DH, Ballantyne C, Thiery J, Ziegler A, Lakatta EG, Chilukoti RK, Harris TB, Wolf PA, Psaty BM, Polak JF, Li X, Rathmann W, Uda M, Boerwinkle E, Klopp N, Schmidt H, Wilson JF, Viikari J, Koenig W, Blankenberg S, Newman AB, Witteman J, Heiss G, Duijn Cv, Scuteri A, Homuth G, Mitchell BD, Gudnaso (2011), “Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.” Nat Genet 43(10):940-7 Details

Conde L, Bevan S, Sitzer M, Klopp N, Illig T, Thiery J, Seissler J, Baumert J, Raitakari O, Kähönen M, Lyytikäinen LP, Laaksonen R, Viikari J, Lehtimäki T, Koernig W, Halperin E, Markus HS (2011), “Novel associations for coronary artery disease derived from genome wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodeling.” Atherosclerosis 219(2):684-9 Details

Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Dilthey A, Pirinen M, Stone MA, Appleton L, Moutsianas L, Leslie S, Wordsworth T, Kenna TJ, Karaderi T, Thomas GP, Ward MM, Weisman MH, Farrar C, Bradbury LA, Danoy P, Inman RD, Maksymowych W, Gladman D, Rahman P, Spondyloarthritis Research Consortium of Canada (SPARCC), Morgan A, Marzo-Ortega H, Bowness P, Gaffney K, Gaston JS, Smith M, Bruges-Armas J, Couto AR, Sorrentino R, Paladini F, Ferreira MA, Xu H, Liu Y, Jiang L, Lopez-Larrea C, Díaz-Peña R, López-Vázquez A, Zayats T, Band G, Bellenguez C, Blackburn H, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Freeman C, Gillman M, Gray E, Gwilliam R, Hammond N, Hunt SE, Jankowski J, Jayakumar A, Langford C, Liddle J, Markus HS, Mathew CG, McCann OT, McCarthy MI, Palmer CN, Peltonen L, Plomin R, Potter SC, Rautanen A, Ravindrarajah R, Ricketts M, Samani N, Sawcer SJ, Strange A, Trembath RC, Viswanathan AC, Waller M, Westo (2011), “Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.” Nat Genet 43(8):761-7 Details

GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group, Wellcome Trust Case Control Consortium 2, Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, Schofield C, Groves CJ, Burch L, Carr F, Strange A, Freeman C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Gray E, Hunt S, Jankowski J, Langford C, Markus HS, Mathew CG, Plomin R, Rautanen A, Sawcer SJ, Samani NJ, Trembath R, Viswanathan AC, Wood NW, MAGIC investigators, Harries LW, Hattersley AT, Doney AS, Colhoun H, Morris AD, Sutherland C, Hardie DG, Peltonen L, McCarthy MI, Holman RR, Palmer CN, Donnelly P, Pearson ER (2011), “Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.” Nat Genet 43(2):117-20 Details

International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B, Gwilliam R, Zipp F, Jayakumar A, Martin R, Leslie S, Hawkins S, Giannoulatou E, D'alfonso S, Blackburn H, Martinelli Boneschi F, Liddle J, Harbo HF, Perez ML, Spurkland A, Waller MJ, Mycko MP, Ricketts M, Comabella M, Hammond N, Kockum I, McCann OT, Ban M, Whittaker P, Kemppinen A, Weston P, Hawkins C, Widaa S, Zajicek J, Dronov S, Robertson N, Bumpstead SJ, Barcellos LF, Ravindrarajah R, Abraham R, Alfredsson L, Ardlie K, Aubin C, Baker A, Baker K, Baranzini SE, Bergamaschi L, Bergamaschi R, Bernstein A, Berthele A, Boggild M, Bradfield JP, Brassat D, Broadley SA, Buck D, Butzkueven H, Capra R, Carroll WM, Cavalla P, Celius EG, Cepok S, Chiavacci R, Clerget-Darpoux F, (2011), “Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.” Nature 476(7359):214-9 Details

King A, Bath PM, Markus HS (2011), “Clopidogrel versus dipyridamole in addition to aspirin in reducing embolization detected with ambulatory transcranial Doppler: a randomized trial.” Stroke 42(3):650-5 Details

King A, Serena J, Bornstein NM, Markus HS, ACES Investigators (2011), “Does impaired cerebrovascular reactivity predict stroke risk in asymptomatic carotid stenosis? A prospective substudy of the asymptomatic carotid emboli study.” Stroke 42(6):1550-5 Details

Markus HS (2011), “Stroke genetics.” Hum Mol Genet 20(R2):R124-31 Details

Markus HS, McCollum C, Imray C, Goulder MA, Gilbert J, King A (2011), “The von Willebrand inhibitor ARC1779 reduces cerebral embolization after carotid endarterectomy: a randomized trial.” Stroke 42(8):2149-53 Details

Nitkunan A, Lanfranconi S, Charlton RA, Barrick TR, Markus HS (2011), “Brain atrophy and cerebral small vessel disease: a prospective follow-up study.” Stroke 42(1):133-8 Details

Patel B, Markus HS (2011), “Magnetic resonance imaging in cerebral small vessel disease and its use as a surrogate disease marker.” Int J Stroke 6(1):47-59 Details

Sobrin L, Green T, Sim X, Jensen RA, Tai ES, Tay WT, Wang JJ, Mitchell P, Sandholm N, Liu Y, Hietala K, Iyengar SK, Family Investigation of Nephropathy and Diabetes-Eye Research Group, Brooks M, Buraczynska M, Van Zuydam N, Smith AV, Gudnason V, Doney AS, Morris AD, Leese GP, Palmer CN, Wellcome Trust Case Control Consortium 2, Swaroop A, Taylor HA Jr, Wilson JG, Penman A, Chen CJ, Groop PH, Saw SM, Aung T, Klein BE, Rotter JI, Siscovick DS, Cotch MF, Klein R, Daly MJ, Wong TY (2011), “Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe).” Invest Ophthalmol Vis Sci 52(10):7593-602 Details

Topakian R, King A, Kwon SU, Schaafsma A, Shipley M, Markus HS, ACES Investigators (2011), “Ultrasonic plaque echolucency and emboli signals predict stroke in asymptomatic carotid stenosis.” Neurology 77(8):751-8 Details

UK Parkinson's Disease Consortium, Wellcome Trust Case Control Consortium 2, Spencer CC, Plagnol V, Strange A, Gardner M, Paisan-Ruiz C, Band G, Barker RA, Bellenguez C, Bhatia K, Blackburn H, Blackwell JM, Bramon E, Brown MA, Brown MA, Burn D, Casas JP, Chinnery PF, Clarke CE, Corvin A, Craddock N, Deloukas P, Edkins S, Evans J, Freeman C, Gray E, Hardy J, Hudson G, Hunt S, Jankowski J, Langford C, Lees AJ, Markus HS, Mathew CG, McCarthy MI, Morrison KE, Palmer CN, Pearson JP, Peltonen L, Pirinen M, Plomin R, Potter S, Rautanen A, Sawcer SJ, Su Z, Trembath RC, Viswanathan AC, Williams NW, Morris HR, Donnelly P, Wood NW (2011), “Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.” Hum Mol Genet 20(2):345-53 Details

2010

Adib-Samii P, Brice G, Martin RJ, Markus HS (2010), “Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: study in 200 consecutively recruited individuals.” Stroke 41(4):630-4 Details

Barrick TR, Charlton RA, Clark CA, Markus HS (2010), “White matter structural decline in normal ageing: a prospective longitudinal study using tract-based spatial statistics.” Neuroimage 51(2):565-77 Details

Charlton RA, Barrick TR, Lawes IN, Markus HS, Morris RG (2010), “White matter pathways associated with working memory in normal aging.” Cortex 46(4):474-89 Details

Charlton RA, Barrick TR, Markus HS, Morris RG (2010), “The relationship between episodic long-term memory and white matter integrity in normal aging.” Neuropsychologia 48(1):114-22 Details

Charlton RA, Schiavone F, Barrick TR, Morris RG, Markus HS (2010), “Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline.” J Neurol Neurosurg Psychiatry 81(1):13-9 Details

Debette S, Markus HS (2010), “The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis.” BMJ 341:c3666 Details

Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, Mössner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P, Trembath R (2010), “A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.” Nat Genet 42(11):985-90 Details

Groves RW, Liu L, Dopping-Hepenstal PJ, Markus HS, Lovell PA, Ozoemena L, Lai-Cheong JE, Gawler J, Owaribe K, Hashimoto T, Mellerio JE, Mee JB, McGrath JA (2010), “A homozygous nonsense mutation within the dystonin gene coding for the coiled-coil domain of the epithelial isoform of BPAG1 underlies a new subtype of autosomal recessive epidermolysis bullosa simplex.” J Invest Dermatol 130(6):1551-7 Details

International Stroke Genetics Consortium, Wellcome Trust Case-Control Consortium 2 (2010), “Failure to validate association between 12p13 variants and ischemic stroke.” N Engl J Med 362(16):1547-50 Details

Lamar M, Charlton RA, Morris RG, Markus HS (2010), “The impact of subcortical white matter disease on mood in euthymic older adults: a diffusion tensor imaging study.” Am J Geriatr Psychiatry 18(7):634-42 Details

Lanfranconi S, Markus HS (2010), “COL4A1 mutations as a monogenic cause of cerebral small vessel disease: a systematic review.” Stroke 41(8):e513-8 Details

Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, Albers GW, Kaste M, Marler JR, Hamilton SA, Tilley BC, Davis SM, Donnan GA, Hacke W, ECASS, ATLANTIS, NINDS and EPITHET rt-PA Study Group, Allen K, Mau J, Meier D, del Zoppo G, De Silva DA, Butcher KS, Parsons MW, Barber PA, Levi C, Bladin C, Byrnes G (2010), “Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials.” Lancet 375(9727):1695-703 Details

Mackinnon AD, Jerrard-Dunne P, Porteous L, Markus HS (2010), “Carotid intima-media thickness is greater but carotid plaque prevalence is lower in black compared with white subjects.” AJNR Am J Neuroradiol 31(10):1951-5 Details

Markus HS (2010), “Genetics studies in ischaemic stroke.” Transl Stroke Res 1(4):238-45 Details

Markus HS (2010), “Unravelling the genetics of ischaemic stroke.” PLoS Med 7(3):e1000225 Details

Markus HS, King A, Shipley M, Topakian R, Cullinane M, Reihill S, Bornstein NM, Schaafsma A (2010), “Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES): a prospective observational study.” Lancet Neurol 9(7):663-71 Details

Moynihan B, Davis D, Pereira A, Cloud G, Markus HS (2010), “Delivering regional thrombolysis via a hub-and-spoke model.” J R Soc Med 103(9):363-9 Details

Robinson TG, Potter JF, Ford GA, Bulpitt CJ, Chernova J, Jagger C, James MA, Knight J, Markus HS, Mistri AK, Poulter NR, COSSACS Investigators (2010), “Effects of antihypertensive treatment after acute stroke in the Continue or Stop Post-Stroke Antihypertensives Collaborative Study (COSSACS): a prospective, randomised, open, blinded-endpoint trial.” Lancet Neurol 9(8):767-75 Details

Topakian R, Barrick TR, Howe FA, Markus HS (2010), “Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis.” J Neurol Neurosurg Psychiatry 81(2):192-7 Details

Wong KS, Chen C, Fu J, Chang HM, Suwanwela NC, Huang YN, Han Z, Tan KS, Ratanakorn D, Chollate P, Zhao Y, Koh A, Hao Q, Markus HS, CLAIR study investigators (2010), “Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial.” Lancet Neurol 9(5):489-97 Details

2009

ACES Investigators (2009), “The Asymptomatic Carotid Emboli Study: study design and baseline results.” Int J Stroke 4(5):398-405 Details

Bevan S, Lorenz MW, Sitzer M, Markus HS (2009), “Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study.” Stroke 40(3):696-701 Details

Birns J, Jarosz J, Markus HS, Kalra L (2009), “Cerebrovascular reactivity and dynamic autoregulation in ischaemic subcortical white matter disease.” J Neurol Neurosurg Psychiatry 80(10):1093-8 Details

Birns J, Morris R, Jarosz J, Markus HS, Kalra L (2009), “Hypertension-related cognitive decline: is the time right for intervention studies?” Minerva Cardioangiol 57(6):813-30 Details

Bonati LH, Ederle J, McCabe DJ, Dobson J, Featherstone RL, Gaines PA, Beard JD, Venables GS, Markus HS, Clifton A, Sandercock P, Brown MM, CAVATAS Investigators (2009), “Long-term risk of carotid restenosis in patients randomly assigned to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial.” Lancet Neurol 8(10):908-17 Details

Charlton RA, Barrick TR, Markus HS, Morris RG (2009), “Theory of mind associations with other cognitive functions and brain imaging in normal aging.” Psychol Aging 24(2):338-48 Details

Debette S, Bevan S, Dartigues JF, Sitzer M, Lorenz M, Ducimetière P, Amouyel P, Markus HS (2009), “Fractalkine receptor/ligand genetic variants and carotid intima-media thickness.” Stroke 40(6):2212-4 Details

Debette S, Markus HS (2009), “The genetics of cervical artery dissection: a systematic review.” Stroke 40(6):e459-66 Details

Debette S, Metso TM, Pezzini A, Engelter ST, Leys D, Lyrer P, Metso AJ, Brandt T, Kloss M, Lichy C, Hausser I, Touzé E, Markus HS, Abboud S, Caso V, Bersano A, Grau A, Altintas A, Amouyel P, Tatlisumak T, Dallongeville J, Grond-Ginsbach C, CADISP-group (2009), “CADISP-genetics: an International project searching for genetic risk factors of cervical artery dissections.” Int J Stroke 4(3):224-30 Details

Ederle J, Bonati LH, Dobson J, Featherstone RL, Gaines PA, Beard JD, Venables GS, Markus HS, Clifton A, Sandercock P, Brown MM, CAVATAS Investigators (2009), “Endovascular treatment with angioplasty or stenting versus endarterectomy in patients with carotid artery stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial.” Lancet Neurol 8(10):898-907 Details

Ederle J, Featherstone RL, Brown MM, CAVATAS collaborators (2009), “Long-term outcome of endovascular treatment versus medical care for carotid artery stenosis in patients not suitable for surgery and randomised in the Carotid and Vertebral Artery Transluminal Angioplasty study (CAVATAS).” Cerebrovasc Dis 28(1):1-7 Details

Freilinger T, Bevan S, Ripke S, Gschwendtner A, Lichtner P, Müller-Myhsok B, Wichmann HE, Markus HS, Meitinger T, Dichgans M (2009), “Genetic variation in the lymphotoxin-alpha pathway and the risk of ischemic stroke in European populations.” Stroke 40(3):970-2 Details

Gschwendtner A, Bevan S, Cole JW, Plourde A, Matarin M, Ross-Adams H, Meitinger T, Wichmann E, Mitchell BD, Furie K, Slowik A, Rich SS, Syme PD, MacLeod MJ, Meschia JF, Rosand J, Kittner SJ, Markus HS, Müller-Myhsok B, Dichgans M, International Stroke Genetics Consortium (2009), “Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke.” Ann Neurol 65(5):531-9 Details

Gudbjartsson DF, Holm H, Gretarsdottir S, Thorleifsson G, Walters GB, Thorgeirsson G, Gulcher J, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Kucera G, Stubblefield T, Carter S, Roden D, Ng MC, Baum L, So WY, Wong KS, Chan JC, Gieger C, Wichmann HE, Gschwendtner A, Dichgans M, Kuhlenbäumer G, Berger K, Ringelstein EB, Bevan S, Markus HS, Kostulas K, Hillert J, Sveinbjörnsdóttir S, Valdimarsson EM, Løchen ML, Ma RC, Darbar D, Kong A, Arnar DO, Thorsteinsdottir U, Stefansson K (2009), “A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.” Nat Genet 41(8):876-8 Details

Gulli G, Khan S, Markus HS (2009), “Vertebrobasilar stenosis predicts high early recurrent stroke risk in posterior circulation stroke and TIA.” Stroke 40(8):2732-7 Details

Hannesdottir K, Nitkunan A, Charlton RA, Barrick TR, MacGregor GA, Markus HS (2009), “Cognitive impairment and white matter damage in hypertension: a pilot study.” Acta Neurol Scand 119(4):261-8 Details

Khan S, Rich P, Clifton A, Markus HS (2009), “Noninvasive detection of vertebral artery stenosis: a comparison of contrast-enhanced MR angiography, CT angiography, and ultrasound.” Stroke 40(11):3499-503 Details

King A, Markus HS (2009), “Doppler embolic signals in cerebrovascular disease and prediction of stroke risk: a systematic review and meta-analysis.” Stroke 40(12):3711-7 Details

Nitkunan A, Charlton RA, Barrick TR, McIntyre DJ, Howe FA, Markus HS (2009), “Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease.” NMR Biomed 22(3):285-91 Details

Schiavone F, Charlton RA, Barrick TR, Morris RG, Markus HS (2009), “Imaging age-related cognitive decline: A comparison of diffusion tensor and magnetization transfer MRI.” J Magn Reson Imaging 29(1):23-30 Details

UK IBD Genetics Consortium, Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, Wesley E, Parnell K, Zhang H, Drummond H, Nimmo ER, Massey D, Blaszczyk K, Elliott T, Cotterill L, Dallal H, Lobo AJ, Mowat C, Sanderson JD, Jewell DP, Newman WG, Edwards C, Ahmad T, Mansfield JC, Satsangi J, Parkes M, Mathew CG, Wellcome Trust Case Control Consortium 2, Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Duncanson A, Jankowski J, Markus HS, Mathew CG, McCarthy MI, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Samani N, Trembath RC, Viswanathan AC, Wood N, Spencer CC, Barrett JC, Bellenguez C, Davison D, Freeman C, Strange A, Donnelly P, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Deloukas P, Peltonen L, Mathew CG, Blackwell JM, Brown MA, Corvin A, McCarthy MI, S (2009), “Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.” Nat Genet 41(12):1330-4 Details

2008

Bevan S, Dichgans M, Gschwendtner A, Kuhlenbäumer G, Ringelstein EB, Markus HS (2008), “Variation in the PDE4D gene and ischemic stroke risk: a systematic review and meta-analysis on 5200 cases and 6600 controls.” Stroke 39(7):1966-71 Details

Bevan S, Dichgans M, Wiechmann HE, Gschwendtner A, Meitinger T, Markus HS (2008), “Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.” Stroke 39(4):1109-14 Details

Charlton RA, Landau S, Schiavone F, Barrick TR, Clark CA, Markus HS, Morris RG (2008), “A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage.” Neurobiol Aging 29(10):1547-55 Details

Dichgans M, Markus HS, Salloway S, Verkkoniemi A, Moline M, Wang Q, Posner H, Chabriat HS (2008), “Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL.” Lancet Neurol 7(4):310-8 Details

European Stroke Organisation (ESO) Executive Committee, ESO Writing Committee (2008), “Guidelines for management of ischaemic stroke and transient ischaemic attack 2008.” Cerebrovasc Dis 25(5):457-507 Details

Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D, ECASS Investigators (2008), “Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.” N Engl J Med 359(13):1317-29 Details

Hainsworth AH, Markus HS (2008), “Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review.” J Cereb Blood Flow Metab 28(12):1877-91 Details

Khan U, Crossley C, Kalra L, Rudd A, Wolfe CD, Collinson P, Markus HS (2008), “Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study.” Stroke 39(11):2943-9 Details

Markus HS (2008), “Genes, endothelial function and cerebral small vessel disease in man.” Exp Physiol 93(1):121-7 Details

Menon R, Kerry S, Norris JW, Markus HS (2008), “Treatment of cervical artery dissection: a systematic review and meta-analysis.” J Neurol Neurosurg Psychiatry 79(10):1122-7 Details

Menon RK, Markus HS, Norris JW (2008), “Results of a UK questionnaire of diagnosis and treatment in cervical artery dissection.” J Neurol Neurosurg Psychiatry 79(5):612 Details

Nitkunan A, Barrick TR, Charlton RA, Clark CA, Markus HS (2008), “Multimodal MRI in cerebral small vessel disease: its relationship with cognition and sensitivity to change over time.” Stroke 39(7):1999-2005 Details

Nitkunan A, Charlton RA, McIntyre DJ, Barrick TR, Howe FA, Markus HS (2008), “Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.” Magn Reson Med 59(3):528-34 Details

2007

Armstrong C, Abilleira S, Sitzer M, Markus HS, Bevan S (2007), “Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness.” Stroke 38(11):2895-9 Details

Cervical Artery Dissection in Stroke Study Trial Investigators (2007), “Antiplatelet therapy vs. anticoagulation in cervical artery dissection: rationale and design of the Cervical Artery Dissection in Stroke Study (CADISS).” Int J Stroke 2(4):292-6 Details

Charlton RA, McIntyre DJ, Howe FA, Morris RG, Markus HS (2007), “The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.” Brain Res 1164:108-16 Details

Gormley K, Bevan S, Markus HS (2007), “Polymorphisms in genes of the renin-angiotensin system and cerebral small vessel disease.” Cerebrovasc Dis 23(2-3):148-55 Details

Khan S, Cloud GC, Kerry S, Markus HS (2007), “Imaging of vertebral artery stenosis: a systematic review.” J Neurol Neurosurg Psychiatry 78(11):1218-25 Details

Khan U, Bevan S, Markus HS (2007), “NADPH oxidase polymorphisms in cerebral small vessel disease.” Cerebrovasc Dis 24(1):135-8 Details

Khan U, Hassan A, Vallance P, Markus HS (2007), “Asymmetric dimethylarginine in cerebral small vessel disease.” Stroke 38(2):411-3 Details

Khan U, Porteous L, Hassan A, Markus HS (2007), “Risk factor profile of cerebral small vessel disease and its subtypes.” J Neurol Neurosurg Psychiatry 78(7):702-6 Details

Labrum R, Bevan S, Sitzer M, Lorenz M, Markus HS (2007), “Toll receptor polymorphisms and carotid artery intima-media thickness.” Stroke 38(4):1179-84 Details

Lorenz MW, Karbstein P, Markus HS, Sitzer M (2007), “High-sensitivity C-reactive protein is not associated with carotid intima-media progression: the carotid atherosclerosis progression study.” Stroke 38(6):1774-9 Details

Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M (2007), “Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis.” Circulation 115(4):459-67 Details

Markus HS (2007), “Genetics: What is relevant for the stroke physician?” Int J Stroke 2(2):114-7 Details

Markus HS (2007), “Mild cognitive impairment after lacunar infarction: voxel-based morphometry and neuropsychological assessment.” Cerebrovasc Dis 23(5-6):323-4 Details

Markus HS, Khan U, Birns J, Evans A, Kalra L, Rudd AG, Wolfe CD, Jerrard-Dunne P (2007), “Differences in stroke subtypes between black and white patients with stroke: the South London Ethnicity and Stroke Study.” Circulation 116(19):2157-64 Details

McIntyre DJ, Charlton RA, Markus HS, Howe FA (2007), “Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.” J Magn Reson Imaging 26(6):1596-606 Details

Motallebzadeh R, Bland JM, Markus HS, Kaski JC, Jahangiri M (2007), “Neurocognitive function and cerebral emboli: randomized study of on-pump versus off-pump coronary artery bypass surgery.” Ann Thorac Surg 83(2):475-82 Details

Rangi PS, Markus HS, Punter MN, Clifton A (2007), “The use of intraoperative monitoring and treatment of symptomatic microemboli in carotid artery stenting: case report and discussion.” Neuroradiology 49(3):265-9 Details

2006

Abilleira S, Bevan S, Markus HS (2006), “The role of genetic variants of matrix metalloproteinases in coronary and carotid atherosclerosis.” J Med Genet 43(12):897-901 Details

Armstrong CA, Bevan SN, Gormley KT, Markus HS, Koblar SA (2006), “Tissue plasminogen activator -7351C/T polymorphism and lacunar stroke.” Stroke 37(2):329; author reply 329-30 Details

Charlton RA, Barrick TR, McIntyre DJ, Shen Y, O'Sullivan M, Howe FA, Clark CA, Morris RG, Markus HS (2006), “White matter damage on diffusion tensor imaging correlates with age-related cognitive decline.” Neurology 66(2):217-22 Details

Charlton RA, Morris RG, Nitkunan A, Markus HS (2006), “The cognitive profiles of CADASIL and sporadic small vessel disease.” Neurology 66(10):1523-6 Details

Dittrich R, Ritter MA, Kaps M, Siebler M, Lees K, Larrue V, Nabavi DG, Ringelstein EB, Markus HS, Droste DW (2006), “The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial.” Stroke 37(4):1065-9 Details

Lee JM, Markus HS (2006), “Does the white matter matter in Alzheimer disease and cerebral amyloid angiopathy?” Neurology 66(1):6-7 Details

Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M (2006), “Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS).” Stroke 37(1):87-92 Details

Markus HS, Alberts MJ (2006), “Update on genetics of stroke and cerebrovascular disease 2005.” Stroke 37(2):288-90 Details

Markus HS, Labrum R, Bevan S, Reindl M, Egger G, Wiedermann CJ, Xu Q, Kiechl S, Willeit J (2006), “Genetic and acquired inflammatory conditions are synergistically associated with early carotid atherosclerosis.” Stroke 37(9):2253-9 Details

Masdeu JC, Irimia P, Asenbaum S, Bogousslavsky J, Brainin M, Chabriat H, Herholz K, Markus HS, Martínez-Vila E, Niederkorn K, Schellinger PD, Seitz RJ, EFNS (2006), “EFNS guideline on neuroimaging in acute stroke. Report of an EFNS task force.” Eur J Neurol 13(12):1271-83 Details

Motallebzadeh R, Bland JM, Markus HS, Kaski JC, Jahangiri M (2006), “Health-related quality of life outcome after on-pump versus off-pump coronary artery bypass graft surgery: a prospective randomized study.” Ann Thorac Surg 82(2):615-9 Details

Nitkunan A, McIntyre DJ, Barrick TR, O'Sullivan M, Shen Y, Clark CA, Howe FA, Markus HS (2006), “Correlations between MRS and DTI in cerebral small vessel disease.” NMR Biomed 19(5):610-6 Details

2005

Bevan S, Porteous L, Sitzer M, Markus HS (2005), “Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis.” Stroke 36(5):949-53 Details

Dichgans M, Markus HS (2005), “Genetic association studies in stroke: methodological issues and proposed standard criteria.” Stroke 36(9):2027-31 Details

Gormley K, Bevan S, Hassan A, Markus HS (2005), “Polymorphisms in genes of the endothelin system and cerebral small-vessel disease.” Stroke 36(8):1656-60 Details

Hassan A, Markus HS (2005), “Practicalities of genetic studies in human stroke.” Methods Mol Med 104:223-40 Details

Mackinnon AD, Aaslid R, Markus HS (2005), “Ambulatory transcranial Doppler cerebral embolic signal detection in symptomatic and asymptomatic carotid stenosis.” Stroke 36(8):1726-30 Details

Markus HS (2005), “Current treatments in neurology: stroke.” J Neurol 252(3):260-7 Details

Markus HS, Droste DW, Kaps M, Larrue V, Lees KR, Siebler M, Ringelstein EB (2005), “Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.” Circulation 111(17):2233-40 Details

Markus HS, Hunt B, Palmer K, Enzinger C, Schmidt H, Schmidt R (2005), “Markers of endothelial and hemostatic activation and progression of cerebral white matter hyperintensities: longitudinal results of the Austrian Stroke Prevention Study.” Stroke 36(7):1410-4 Details

Markus HS, MacKinnon A (2005), “Asymptomatic embolization detected by Doppler ultrasound predicts stroke risk in symptomatic carotid artery stenosis.” Stroke 36(5):971-5 Details

Markus HS, Punter M (2005), “Can transcranial Doppler discriminate between solid and gaseous microemboli? Assessment of a dual-frequency transducer system.” Stroke 36(8):1731-4 Details

O'Sullivan M, Barrick TR, Morris RG, Clark CA, Markus HS (2005), “Damage within a network of white matter regions underlies executive dysfunction in CADASIL.” Neurology 65(10):1584-90 Details

O'Sullivan M, Morris RG, Markus HS (2005), “Brief cognitive assessment for patients with cerebral small vessel disease.” J Neurol Neurosurg Psychiatry 76(8):1140-5 Details

Pomeroy VM, Clark CA, Miller JS, Baron JC, Markus HS, Tallis RC (2005), “The potential for utilizing the "mirror neurone system" to enhance recovery of the severely affected upper limb early after stroke: a review and hypothesis.” Neurorehabil Neural Repair 19(1):4-13 Details

Singhal S, Markus HS (2005), “Cerebrovascular reactivity and dynamic autoregulation in nondemented patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).” J Neurol 252(2):163-7 Details

Singhal S, Rich P, Markus HS (2005), “The spatial distribution of MR imaging abnormalities in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and their relationship to age and clinical features.” AJNR Am J Neuroradiol 26(10):2481-7 Details

2004

Aydin N, Marvasti F, Markus HS (2004), “Embolic Doppler ultrasound signal detection using discrete wavelet transform.” IEEE Trans Inf Technol Biomed 8(2):182-90 Details

Cloud GC, Markus HS (2004), “Vertebral Artery Stenosis.” Curr Treat Options Cardiovasc Med 6(2):121-127 Details

Hassan A, Hunt BJ, O'Sullivan M, Bell R, D'Souza R, Jeffery S, Bamford JM, Markus HS (2004), “Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction.” Brain 127(Pt 1):212-9 Details

Hussain MB, Singhal S, Markus HS, Singer DR (2004), “Abnormal vasoconstrictor responses to angiotensin II and noradrenaline in isolated small arteries from patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).” Stroke 35(4):853-8 Details

Jerrard-Dunne P, Sitzer M, Risley P, Buehler A, von Kegler S, Markus HS (2004), “Inflammatory gene load is associated with enhanced inflammation and early carotid atherosclerosis in smokers.” Stroke 35(11):2438-43 Details

Mackinnon AD, Aaslid R, Markus HS (2004), “Long-term ambulatory monitoring for cerebral emboli using transcranial Doppler ultrasound.” Stroke 35(1):73-8 Details

Mackinnon AD, Jerrard-Dunne P, Sitzer M, Buehler A, von Kegler S, Markus HS (2004), “Rates and determinants of site-specific progression of carotid artery intima-media thickness: the carotid atherosclerosis progression study.” Stroke 35(9):2150-4 Details

Markus HS (2004), “Cerebral perfusion and stroke.” J Neurol Neurosurg Psychiatry 75(3):353-61 Details

Marvasti S, Gillies D, Marvasti F, Markus HS (2004), “Online automated detection of cerebral embolic signals using a wavelet-based system.” Ultrasound Med Biol 30(5):647-53 Details

O'Sullivan M, Morris RG, Huckstep B, Jones DK, Williams SC, Markus HS (2004), “Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis.” J Neurol Neurosurg Psychiatry 75(3):441-7 Details

O'Sullivan M, Singhal S, Charlton R, Markus HS (2004), “Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia.” Neurology 62(5):702-7 Details

Schmidt R, Scheltens P, Erkinjuntti T, Pantoni L, Markus HS, Wallin A, Barkhof F, Fazekas F (2004), “White matter lesion progression: a surrogate endpoint for trials in cerebral small-vessel disease.” Neurology 63(1):139-44 Details

Sidhu JS, Kaposzta Z, Markus HS, Kaski JC (2004), “Effect of rosiglitazone on common carotid intima-media thickness progression in coronary artery disease patients without diabetes mellitus.” Arterioscler Thromb Vasc Biol 24(5):930-4 Details

Singhal S, Bevan S, Barrick T, Rich P, Markus HS (2004), “The influence of genetic and cardiovascular risk factors on the CADASIL phenotype.” Brain 127(Pt 9):2031-8 Details

2003

Cloud GC, Crawley F, Clifton A, McCabe DJ, Brown MM, Markus HS (2003), “Vertebral artery origin angioplasty and primary stenting: safety and restenosis rates in a prospective series.” J Neurol Neurosurg Psychiatry 74(5):586-90 Details

Cloud GC, Markus HS (2003), “Diagnosis and management of vertebral artery stenosis.” QJM 96(1):27-54 Details

Cloud GC, Rich PM, Markus HS (2003), “Serial MRI of a mycotic aneurysm of the cavernous carotid artery.” Neuroradiology 45(8):546-9 Details

Dong Y, Hassan A, Zhang Z, Huber D, Dalageorgou C, Markus HS (2003), “Yield of screening for CADASIL mutations in lacunar stroke and leukoaraiosis.” Stroke 34(1):203-5 Details

Hassan A, Hunt BJ, O'Sullivan M, Parmar K, Bamford JM, Briley D, Brown MM, Thomas DJ, Markus HS (2003), “Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis.” Brain 126(Pt 2):424-32 Details

Jerrard-Dunne P, Cloud G, Hassan A, Markus HS (2003), “Evaluating the genetic component of ischemic stroke subtypes: a family history study.” Stroke 34(6):1364-9 Details

Jerrard-Dunne P, Evans A, McGovern R, Hajat C, Kalra L, Rudd AG, Wolfe CD, Markus HS (2003), “Ethnic differences in markers of thrombophilia: implications for the investigation of ischemic stroke in multiethnic populations: the South London Ethnicity and Stroke Study.” Stroke 34(8):1821-6 Details

Jerrard-Dunne P, Markus HS, Steckel DA, Buehler A, von Kegler S, Sitzer M (2003), “Early carotid atherosclerosis and family history of vascular disease: specific effects on arterial sites have implications for genetic studies.” Arterioscler Thromb Vasc Biol 23(2):302-6 Details

Jerrard-Dunne P, Sitzer M, Risley P, Steckel DA, Buehler A, von Kegler S, Markus HS, Carotid Atherosclerosis Progression Study (2003), “Interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: the Carotid Atherosclerosis Progression Study (CAPS).” Stroke 34(2):402-7 Details

O'Sullivan M, Rich PM, Barrick TR, Clark CA, Markus HS (2003), “Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.” AJNR Am J Neuroradiol 24(7):1348-54 Details

Risley P, Jerrard-Dunne P, Sitzer M, Buehler A, von Kegler S, Markus HS, Carotid Atherosclerosis Progression Study (2003), “Promoter polymorphism in the endotoxin receptor (CD14) is associated with increased carotid atherosclerosis only in smokers: the Carotid Atherosclerosis Progression Study (CAPS).” Stroke 34(3):600-4 Details

Schon F, Martin RJ, Prevett M, Clough C, Enevoldson TP, Markus HS (2003), “"CADASIL coma": an underdiagnosed acute encephalopathy.” J Neurol Neurosurg Psychiatry 74(2):249-52 Details

Sitzer M, Puac D, Buehler A, Steckel DA, von Kegler S, Markus HS, Steinmetz H (2003), “Internal carotid artery angle of origin: a novel risk factor for early carotid atherosclerosis.” Stroke 34(4):950-5 Details

2002

Cullinane M, Kaposzta Z, Reihill S, Markus HS (2002), “Online automated detection of cerebral embolic signals from a variety of embolic sources.” Ultrasound Med Biol 28(10):1271-7 Details

Hassan A, Sham PC, Markus HS (2002), “Planning genetic studies in human stroke: sample size estimates based on family history data.” Neurology 58(10):1483-8 Details

Kaposzta Z, Clifton A, Molloy J, Martin JF, Markus HS (2002), “S-nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty.” Circulation 106(24):3057-62 Details

Kaposzta Z, Martin JF, Markus HS (2002), “Switching off embolization from symptomatic carotid plaque using S-nitrosoglutathione.” Circulation 105(12):1480-4 Details

Markus HS, Martin RJ, Simpson MA, Dong YB, Ali N, Crosby AH, Powell JF (2002), “Diagnostic strategies in CADASIL.” Neurology 59(8):1134-8 Details

Markus HS, Risley P, Mendall MA, Steinmetz H, Sitzer M (2002), “Helicobacter pylori infection, the cytotoxin gene A strain, and carotid artery intima-media thickness.” J Cardiovasc Risk 9(1):1-6 Details

O'Sullivan M, Lythgoe DJ, Pereira AC, Summers PE, Jarosz JM, Williams SC, Markus HS (2002), “Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis.” Neurology 59(3):321-6 Details

Sitzer M, Markus HS, Mendall MA, Liehr R, Knorr U, Steinmetz H (2002), “C-reactive protein and carotid intimal medial thickness in a community population.” J Cardiovasc Risk 9(2):97-103 Details

Tinkler K, Cullinane M, Kaposzta Z, Markus HS (2002), “Asymptomatic embolisation in non-valvular atrial fibrillation and its relationship to anticoagulation therapy.” Eur J Ultrasound 15(1-2):21-7 Details

2001

Cullinane M, Markus HS (2001), “Evaluation of a 1 MHz transducer for transcranial Doppler ultrasound including embolic signal detection.” Ultrasound Med Biol 27(6):795-800 Details

Hassan A, Ali N, Dong Y, Carter ND, Markus HS (2001), “Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease.” Neurology 57(9):1726-8 Details

Kaposzta Z, Baskerville PA, Madge D, Fraser S, Martin JF, Markus HS (2001), “L-arginine and S-nitrosoglutathione reduce embolization in humans.” Circulation 103(19):2371-5 Details

Lythgoe D, Simmons A, Pereira A, Cullinane M, Williams S, Markus HS (2001), “Magnetic resonance markers of ischaemia: their correlation with vasodilatory reserve in patients with carotid artery stenosis and occlusion.” J Neurol Neurosurg Psychiatry 71(1):58-62 Details

O'Sullivan M, Jarosz JM, Martin RJ, Deasy N, Powell JF, Markus HS (2001), “MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL.” Neurology 56(5):628-34 Details

O'Sullivan M, Jones DK, Summers PE, Morris RG, Williams SC, Markus HS (2001), “Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline.” Neurology 57(4):632-8 Details

O'Sullivan M, Summers PE, Jones DK, Jarosz JM, Williams SC, Markus HS (2001), “Normal-appearing white matter in ischemic leukoaraiosis: a diffusion tensor MRI study.” Neurology 57(12):2307-10 Details

Rose SE, Chalk JB, Griffin MP, Janke AL, Chen F, McLachan GJ, Peel D, Zelaya FO, Markus HS, Jones DK, Simmons A, O'Sullivan M, Jarosz JM, Strugnell W, Doddrell DM, Semple J (2001), “MRI based diffusion and perfusion predictive model to estimate stroke evolution.” Magn Reson Imaging 19(8):1043-53 Details

Stone AF, Risley P, Markus HS, Butland BK, Strachan DP, Elwood PC, Mendall MA (2001), “Ischaemic heart disease and Cag A strains of Helicobacter pylori in the Caerphilly heart disease study.” Heart 86(5):506-9 Details

2000

Aydin N, Markus HS (2000), “Optimization of processing parameters for the analysis and detection of embolic signals.” Eur J Ultrasound 12(1):69-79 Details

Cullinane M, Reid G, Dittrich R, Kaposzta Z, Ackerstaff R, Babikian V, Droste DW, Grossett D, Siebler M, Valton L, Markus HS (2000), “Evaluation of new online automated embolic signal detection algorithm, including comparison with panel of international experts.” Stroke 31(6):1335-41 Details

Hassan A, Markus HS (2000), “Genetics and ischaemic stroke.” Brain 123 ( Pt 9):1784-812 Details

Lythgoe DJ, Ostergaard L, William SC, Cluckie A, Buxton-Thomas M, Simmons A, Markus HS (2000), “Quantitative perfusion imaging in carotid artery stenosis using dynamic susceptibility contrast-enhanced magnetic resonance imaging.” Magn Reson Imaging 18(1):1-11 Details

Markus HS (2000), “Transcranial Doppler ultrasound.” Br Med Bull 56(2):378-88 Details

Markus HS, Lythgoe DJ, Ostegaard L, O'Sullivan M, Williams SC (2000), “Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI.” J Neurol Neurosurg Psychiatry 69(1):48-53 Details

White RP, Deane C, Hindley C, Bloomfield PM, Cunningham VJ, Vallance P, Brooks DJ, Markus HS (2000), “The effect of the nitric oxide donor glyceryl trinitrate on global and regional cerebral blood flow in man.” J Neurol Sci 178(1):23-8 Details

White RP, Vallance P, Markus HS (2000), “Effect of inhibition of nitric oxide synthase on dynamic cerebral autoregulation in humans.” Clin Sci (Lond) 99(6):555-60 Details

1999

Al-Hamali S, Baskerville P, Fraser S, Walters H, Markus HS (1999), “Detection of distal emboli in patients with peripheral arterial stenosis before and after iliac angioplasty: a prospective study.” J Vasc Surg 29(2):345-51 Details

Aydin N, Padayachee S, Markus HS (1999), “The use of the wavelet transform to describe embolic signals.” Ultrasound Med Biol 25(6):953-8 Details

Jones DK, Lythgoe D, Horsfield MA, Simmons A, Williams SC, Markus HS (1999), “Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI.” Stroke 30(2):393-7 Details

Kaposzta Z, Young E, Bath PM, Markus HS (1999), “Clinical application of asymptomatic embolic signal detection in acute stroke: a prospective study.” Stroke 30(9):1814-8 Details

Lythgoe DJ, Williams SC, Cullinane M, Markus HS (1999), “Mapping of cerebrovascular reactivity using BOLD magnetic resonance imaging.” Magn Reson Imaging 17(4):495-502 Details

Markus HS (1999), “Transcranial Doppler ultrasound.” J Neurol Neurosurg Psychiatry 67(2):135-7 Details

Markus HS, Reid G (1999), “Frequency filtering improves ultrasonic embolic signal detection.” Ultrasound Med Biol 25(5):857-60 Details

Markus HS, Sitzer M, Carrington D, Mendall MA, Steinmetz H (1999), “Chlamydia pneumoniae infection and early asymptomatic carotid atherosclerosis.” Circulation 100(8):832-7 Details

Molloy J, Markus HS (1999), “Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis.” Stroke 30(7):1440-3 Details

Ruigrok Y, Cox TC, Markus HS (1999), “Positional vertebrobasilar transient ischaemic attacks treated with vertebral angioplasty.” Cerebrovasc Dis 9(3):171-4 Details

White RP, Hindley C, Bloomfield PM, Cunningham VJ, Vallance P, Brooks DJ, Markus HS (1999), “The effect of the nitric oxide synthase inhibitor L-NMMA on basal CBF and vasoneuronal coupling in man: a PET study.” J Cereb Blood Flow Metab 19(6):673-8 Details

1998

Cullinane M, Wainwright R, Brown A, Monaghan M, Markus HS (1998), “Asymptomatic embolization in subjects with atrial fibrillation not taking anticoagulants: a prospective study.” Stroke 29(9):1810-5 Details

Markus HS, Hambley H (1998), “Neurology and the blood: haematological abnormalities in ischaemic stroke.” J Neurol Neurosurg Psychiatry 64(2):150-9 Details

Markus HS, Mendall MA (1998), “Helicobacter pylori infection: a risk factor for ischaemic cerebrovascular disease and carotid atheroma.” J Neurol Neurosurg Psychiatry 64(1):104-7 Details

Markus HS, Ruigrok Y, Ali N, Powell JF (1998), “Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma.” Stroke 29(9):1908-11 Details

Molloy J, Khan N, Markus HS (1998), “Temporal variability of asymptomatic embolization in carotid artery stenosis and optimal recording protocols.” Stroke 29(6):1129-32 Details

Molloy J, Martin JF, Baskerville PA, Fraser SC, Markus HS (1998), “S-nitrosoglutathione reduces the rate of embolization in humans.” Circulation 98(14):1372-5 Details

Panerai RB, White RP, Markus HS, Evans DH (1998), “Grading of cerebral dynamic autoregulation from spontaneous fluctuations in arterial blood pressure.” Stroke 29(11):2341-6 Details

Ringelstein EB, Droste DW, Babikian VL, Evans DH, Grosset DG, Kaps M, Markus HS, Russell D, Siebler M (1998), “Consensus on microembolus detection by TCD. International Consensus Group on Microembolus Detection.” Stroke 29(3):725-9 Details

White RP, Barnes P, Markus HS (1998), “Symptomatic haemodynamically significant carotid occlusion treated by posterior circulation revascularization.” Cerebrovasc Dis 8(3):148-51 Details

White RP, Deane C, Vallance P, Markus HS (1998), “Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia.” Stroke 29(2):467-72 Details

1997

Ali NS, Powell J, Swaminathan R, Markus HS (1997), “The relationship between MTHFR genotype, serum homocysteine and folate levels.” Biochem Soc Trans 25(3):386S Details

Deane CR, Markus HS (1997), “Colour velocity flow measurement: in vitro validation and application to human carotid arteries.” Ultrasound Med Biol 23(3):447-52 Details

Markus HS, Ackerstaff R, Babikian V, Bladin C, Droste D, Grosset D, Levi C, Russell D, Siebler M, Tegeler C (1997), “Intercenter agreement in reading Doppler embolic signals. A multicenter international study.” Stroke 28(7):1307-10 Details

Markus HS, Ali N, Swaminathan R, Sankaralingam A, Molloy J, Powell J (1997), “A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease.” Stroke 28(9):1739-43 Details

Markus HS, Kapadia R, Sherwood RA (1997), “Relationship between lipoprotein (a) and both stroke and carotid atheroma.” Ann Clin Biochem 34 ( Pt 4):360-5 Details

Markus HS, Molloy J (1997), “Use of a decibel threshold in detecting Doppler embolic signals.” Stroke 28(4):692-5 Details

White RP, Markus HS (1997), “Impaired dynamic cerebral autoregulation in carotid artery stenosis.” Stroke 28(7):1340-4 Details

1996

Markus HS, Clifton A, Buckenham T, Taylor R, Brown MM (1996), “Improvement in cerebral hemodynamics after carotid angioplasty.” Stroke 27(4):612-6 Details

Molloy J, Markus HS (1996), “Multigated Doppler ultrasound in the detection of emboli in a flow model and embolic signals in patients.” Stroke 27(9):1548-52 Details

1995

Markus HS, Barley J, Lunt R, Bland JM, Jeffery S, Carter ND, Brown MM (1995), “Angiotensin-converting enzyme gene deletion polymorphism. A new risk factor for lacunar stroke but not carotid atheroma.” Stroke 26(8):1329-33 Details

Markus HS, Harrison MJ (1995), “Microembolic signal detection using ultrasound.” Stroke 26(9):1517-9 Details

Markus HS, Lees AJ, Lennox G, Marsden CD, Costa DC (1995), “Patterns of regional cerebral blood flow in corticobasal degeneration studied using HMPAO SPECT; comparison with Parkinson's disease and normal controls.” Mov Disord 10(2):179-87 Details

Markus HS, Tegeler CH (1995), “Experimental aspects of high-intensity transient signals in the detection of emboli.” J Clin Ultrasound 23(2):81-7 Details

Markus HS, Thomson ND, Brown MM (1995), “Asymptomatic cerebral embolic signals in symptomatic and asymptomatic carotid artery disease.” Brain 118 ( Pt 4):1005-11 Details

1994

Brown MM, Markus HS (1994), “Transcranial Doppler detection of asymptomatic cerebral microemboli.” J Heart Valve Dis 3(2):126-7 Details

Droste DW, Markus HS, Nassiri D, Brown MM (1994), “The effect of velocity on the appearance of embolic signals studied in transcranial Doppler models.” Stroke 25(5):986-91 Details

Markus HS, Clifton A, Buckenham T, Brown MM (1994), “Carotid angioplasty. Detection of embolic signals during and after the procedure.” Stroke 25(12):2403-6 Details

Markus HS, Costa DC, Lees AJ (1994), “HMPAO SPECT in Parkinson's disease before and after levodopa: correlation with dopaminergic responsiveness.” J Neurol Neurosurg Psychiatry 57(2):180-5 Details

Markus HS, Droste DW, Brown MM (1994), “Detection of asymptomatic cerebral embolic signals with Doppler ultrasound.” Lancet 343(8904):1011-2 Details

Markus HS, Vallance P, Brown MM (1994), “Differential effect of three cyclooxygenase inhibitors on human cerebral blood flow velocity and carbon dioxide reactivity.” Stroke 25(9):1760-4 Details

1993

Markus HS, Brown MM (1993), “Differentiation between different pathological cerebral embolic materials using transcranial Doppler in an in vitro model.” Stroke 24(1):1-5 Details

Markus HS, Droste D, Brown MM (1993), “Ultrasonic detection of cerebral emboli in carotid stenosis.” Lancet 341(8860):1606 Details

Markus HS, Harrison MJ, Adiseshiah M (1993), “Carotid endarterectomy improves haemodynamics on the contralateral side: implications for operating contralateral to an occluded carotid artery.” Br J Surg 80(2):170-2 Details

Markus HS, Muller AF, Toghill PJ (1993), “Splenic function, assessed by quantification of erythrocyte membrane pits, is normal in chronic active hepatitis and primary biliary cirrhosis.” J Hepatol 18(1):106-11 Details

Markus HS, Ring H, Kouris K, Costa DC (1993), “Alterations in regional cerebral blood flow, with increased temporal interhemispheric asymmetries, in the normal elderly: an HMPAO SPECT study.” Nucl Med Commun 14(8):628-33 Details

Markus HS, Tomkins AM, Stern GM (1993), “Increased prevalence of undernutrition in Parkinson's disease and its relationship to clinical disease parameters.” J Neural Transm Park Dis Dement Sect 5(2):117-25 Details

1992

Markus HS, Boland M (1992), “"Cognitive activity" monitored by non-invasive measurement of cerebral blood flow velocity and its application to the investigation of cerebral dominance.” Cortex 28(4):575-81 Details

Markus HS, Bunker CB, Kouris K, Costa DC, Harrison MJ (1992), “rCBF abnormalities detected, and sequentially followed, by SPECT in neuro-Behçet's syndrome with normal CT and MRI imaging.” J Neurol 239(7):363-6 Details

Markus HS, Chong EM, Wilcox RG (1992), “Gallopamil slow release: a double blind study of twice daily versus once daily treatment in chronic stable angina.” Eur J Clin Pharmacol 42(3):271-3 Details

Markus HS, Cox M, Tomkins AM (1992), “Raised resting energy expenditure in Parkinson's disease and its relationship to muscle rigidity.” Clin Sci (Lond) 83(2):199-204 Details

Markus HS, Duchen LW, Parkin EM, Kurtz AB, Jacobs HS, Costa DC, Harrison MJ (1992), “Creutzfeldt-Jakob disease in recipients of human growth hormone in the United Kingdom: a clinical and radiographic study.” Q J Med 82(297):43-51 Details

Markus HS, Harrison MJ (1992), “Estimation of cerebrovascular reactivity using transcranial Doppler, including the use of breath-holding as the vasodilatory stimulus.” Stroke 23(5):668-73 Details

Markus HS, Hopkinson N (1992), “Migraine and headache in systemic lupus erythematosus and their relationship with antibodies against phospholipids.” J Neurol 239(1):39-42 Details

Markus HS, Kouris K, Costa DC, Ell PJ (1992), “SPECT in epilepsy.” Neurology 42(5):1127-8 Details

1991

Markus HS (1991), “A prospective follow up of thunderclap headache mimicking subarachnoid haemorrhage.” J Neurol Neurosurg Psychiatry 54(12):1117-8 Details

Markus HS, Harrison MJ, Costa DC (1991), “Single photon emission tomography in growth-hormone related Creutzfeldt-Jakob disease.” Lancet 338(8767):630-1 Details

Markus HS, Toghill PJ (1991), “Impaired splenic function in elderly people.” Age Ageing 20(4):287-90 Details

1990

Markus HS (1990), “Paralytic ileus associated with ipratropium.” Lancet 335(8699):1224 Details

1989

Markus HS (1989), “Diagnostic investigations in the elderly: the clinical usefulness of serum iron and transferrin measurements in the diagnosis of iron deficiency anaemia. An audit.” Br J Clin Pract 43(12):451-3 Details

Markus HS (1989), “Haematogenous osteomyelitis in the adult: a clinical and epidemiological study.” Q J Med 71(266):521-7 Details

Markus HS, Allison SP (1989), “Staphylococcus aureus meningitis from osteomyelitis of the spine.” Postgrad Med J 65(770):941-2 Details

Markus HS, Clark JV (1989), “Pulmonary haemorrhage in Henoch-Schönlein purpura.” Thorax 44(6):525-6 Details

Markus HS, O'Brien JT (1989), “Obstruction of the vena cava secondary to an enlarged bladder.” Br J Urol 64(1):102-3 Details

Markus HS, Wolverson A (1989), “Eyelid abscess in an egg nog drinker.” BMJ 299(6715):1570-1 Details