Dr Helene Gautier

Interests

I showed that communication between axons and oligodendrocyte progenitor cells during remyelination is essential for efficient myelin repair.

I'm now interested on how neurons sense their mechanical environment and if it influences their electrical properties.

Oligodendrocyte progenitor cell filled with lucifer yellow, identified by NG2 labelling. White trace: electrophysiological recording
Oligodendrocyte progenitor cell filled with lucifer yellow, identified by NG2 labelling. White trace: electrophysiological recording
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Research Focus

Keywords

Neuromechanics

electrophysiology

neurons

oligodendrocyte progenitor cells

ion channels

Clinical conditions

Multiple sclerosis

Spinal cord injury

Equipment

Calcium imaging

Cell culture

Confocal microscopy

Electrophysiological recording techniques

Field potential recording

Fluorescence microscopy

Immunohistochemistry

Whole cell patch clamp

Collaborators

Cambridge

Robin Franklin

Ragnhildur Karadottir

Associated News Items


Publications

2013

Lundgaard I, Luzhynskaya A, Stockley JH, Wang Z, Evans KA, Swire M, Volbracht K, Gautier HO, Franklin RJ, Charles Ffrench-Constant, Attwell D, Káradóttir RT (2013), “Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.” PLoS Biol 11(12):e1001743 Details

2010

Christ AF, Franze K, Gautier H, Moshayedi P, Fawcett J, Franklin RJ, Karadottir RT, Guck J (2010), “Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy.” J Biomech Details

2009

Meme S, Calas AG, Montécot C, Richard O, Gautier H, Gefflaut T, Doan BT, Même W, Pichon J, Beloeil JC (2009), “MRI characterization of structural mouse brain changes in response to chronic exposure to the glufosinate ammonium herbicide.” Toxicol Sci 111(2):321-30 Details

2008

Gautier H, Auger J, Legros C, Lapied B (2008), “Calcium-activated potassium channels in insect pacemaker neurons as unexpected target site for the novel fumigant dimethyl disulfide.” J Pharmacol Exp Ther 324(1):149-59 Details

2007

Wicher D, Derst C, Gautier H, Lapied B, Heinemann SH, Agricola HJ (2007), “The satiety signaling neuropeptide perisulfakinin inhibits the activity of central neurons promoting general activity.” Front Cell Neurosci 1:3 Details

2006

Lavialle-Defaix C, Gautier H, Defaix A, Lapied B, Grolleau F (2006), “Differential regulation of two distinct voltage-dependent sodium currents by group III metabotropic glutamate receptor activation in insect pacemaker neurons.” J Neurophysiol 96(5):2437-50 Details