Dr Hannah Clarke

University position

Junior Research Fellow

Departments

Department of Physiology, Development and Neuroscience

Institutes

Behavioural and Clinical Neuroscience Institute

Home page

http://www.pdn.cam.ac.uk/

Research Themes

Cognitive and Behavioural Neuroscience

Cellular and Molecular Neuroscience

The Cambridge Neuroscience Community

Interests

Understanding the neural and neurochemical basis of behaviours mediated by the prefrontal cortex and their relevance to psychiatric disorders.

Dark-field photomicrograph of serotonergic fibres and teminals within the orbital sector of the PFC
Dark-field photomicrograph of serotonergic fibres and teminals within the orbital sector of the PFC
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Research Focus

Keywords

serotonin

prefrontal cortex

dopamine

obsessive compulsive disorder

reversal learning

Clinical conditions

Anxiety disorders

Cognitive impairment

Depressive disorders

Obsessive compulsive disorder

Post-traumatic stress disorder

Schizophrenia

Stress

Equipment

Behavioural analysis

FPLC/HPLC

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

Cambridge

Anne Ferguson-Smith

Trevor Robbins

Angela Roberts

Key publications

Clarke HF, Walker SC, Robbins TW, Roberts AC (2007), “Cognitive Inflexibility after Prefrontal Serotonin Depletion is Behaviorally and Neurochemically Specific” Cerebral Cortex 7(1):18-27 Details

Clarke HF, Walker SC, Crofts HS, Dalley JW, Robbins TW, Roberts AC (2005), “Prefrontal serotonin depletion affects reversal learning but not attentional set shifting” Journal of Neuroscience 12:532-538 Details

Clarke H.F.,Crofts HS, Dalley JW, Robbins TW, and Roberts AC (2004), “Cognitive inflexibility in the marmoset after prefrontal serotonin depletion” Science 304:878-880

Publications

2011

Clarke HF, Hill GJ, Robbins TW, Roberts AC (2011), “Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus.” J Neurosci 31(11):4290-7 Details

2010

Rygula R, Walker SC, Clarke HF, Robbins TW, Roberts AC (2010), “Differential contributions of the primate ventrolateral prefrontal and orbitofrontal cortex to serial reversal learning.” J Neurosci 30(43):14552-9 Details

2009

Man MS, Clarke HF, Roberts AC (2009), “The role of the orbitofrontal cortex and medial striatum in the regulation of prepotent responses to food rewards.” Cereb Cortex 19(4):899-906 Details

2008

Clarke HF, Robbins TW, Roberts AC (2008), “Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex.” J Neurosci 28(43):10972-82 Details