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Research Focus

Keywords

  • Neurochemistry
  • Cognition
  • Neurocognition
  • Behaviour
  • Animal Models
  • Clinical Conditions

  • Anxiety disorders
  • Depressive disorders
  • Schizophrenia
  • Other 
  • Equipment & Techniques

  • Behavioural analysis
  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)
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    Dr Hannah Clarke PhD

    University Position
    Associate Professor
    Dr Hannah Clarke is pleased to consider applications from prospective PhD students.

    Interests

    Understanding the neural and neurochemical basis of behaviours mediated by the prefrontal cortex and their relevance to psychiatric disorders.

    Key Publications

    Differential Effects of the Inactivation of Anterior and Posterior Orbitofrontal Cortex on Affective Responses to Proximal and Distal Threat, and Reward Anticipation in the Common Marmoset.

    DOI: http://doi.org/10.1093/cercor/bhab240
    Journal: Cereb Cortex
    E-pub date: 30 Mar 2022
    Authors: ZM Stawicka, R Massoudi, L Oikonomidis, L McIver, K Mulvihill, SKL Quah, GJ Cockcroft, HF Clarke, NK Horst, CM Wood, AC Roberts

    Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat.

    DOI: http://doi.org/10.1038/s41467-020-19167-0
    Journal: Nat Commun
    E-pub date: 26 Oct 2020
    Authors: L Alexander, CM Wood, PLR Gaskin, SJ Sawiak, TD Fryer, YT Hong, L McIver, HF Clarke, AC Roberts

    Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

    DOI: http://doi.org/10.1073/pnas.1902087116
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 16 Jul 2019
    Authors: AM Santangelo, SJ Sawiak, T Fryer, Y Hong, Y Shiba, HF Clarke, PJ Riss, V Ferrari, R Tait, J Suckling, FI Aigbirhio, AC Roberts

    Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.

    DOI: http://doi.org/10.1523/JNEUROSCI.2451-18.2018
    Journal: J Neurosci
    E-pub date: 17 Apr 2019
    Authors: JL Zeredo, SKL Quah, CU Wallis, L Alexander, GJ Cockcroft, AM Santangelo, J Xia, Y Shiba, JW Dalley, RN Cardinal, AC Roberts, HF Clarke

    Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex.

    DOI: http://doi.org/10.1016/j.neuron.2018.11.021
    Journal: Neuron
    E-pub date: 16 Jan 2019
    Authors: L Alexander, PLR Gaskin, SJ Sawiak, TD Fryer, YT Hong, GJ Cockcroft, HF Clarke, AC Roberts

    Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion.

    DOI: http://doi.org/10.1073/pnas.1620115114
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 16 May 2017
    Authors: CU Wallis, RN Cardinal, L Alexander, AC Roberts, HF Clarke

    Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.

    DOI: http://doi.org/10.1523/JNEUROSCI.0718-14.2014
    Journal: J Neurosci
    E-pub date: 28 May 2014
    Authors: HF Clarke, RN Cardinal, R Rygula, YT Hong, TD Fryer, SJ Sawiak, V Ferrari, G Cockcroft, FI Aigbirhio, TW Robbins, AC Roberts

    Cognitive inflexibility after prefrontal serotonin depletion.

    DOI: http://doi.org/10.1126/science.1094987
    Journal: Science
    E-pub date: 7 May 2004
    Authors: HF Clarke, JW Dalley, HS Crofts, TW Robbins, AC Roberts

    Publications

    Differential Contribution of Anterior and Posterior Midcingulate Subregions to Distal and Proximal Threat Reactivity in Marmosets.

    DOI: http://doi.org/10.1093/cercor/bhab121
    Journal: Cereb Cortex
    E-pub date: 26 Aug 2021
    Authors: SS Rahman, K Mulvihill, CM Wood, SKL Quah, NK Horst, HF Clarke, GJ Cockcroft, AM Santangelo, AC Roberts

    Hippocampal Interaction With Area 25, but not Area 32, Regulates Marmoset Approach-Avoidance Behavior.

    DOI: http://doi.org/10.1093/cercor/bhz015
    Journal: Cereb Cortex
    E-pub date: 17 Dec 2019
    Authors: CU Wallis, GJ Cockcroft, RN Cardinal, AC Roberts, HF Clarke

    A Focus on the Functions of Area 25.

    DOI: http://doi.org/10.3390/brainsci9060129
    Journal: Brain Sci
    E-pub date: 3 Jun 2019
    Authors: L Alexander, HF Clarke, AC Roberts

    Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants.

    DOI: http://doi.org/10.1038/npp.2016.41
    Journal: Neuropsychopharmacology
    E-pub date: 31 Aug 2016
    Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EH Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

    Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants

    DOI: http://doi.org/10.1038/npp.2016.41;
    Journal: Neuropsychopharmacology
    E-pub date: 21 Mar 2016
    Authors: AM Santangelo, M Ito, Y Shiba, HF Clarke, EHS Schut, G Cockcroft, AC Ferguson-Smith, AC Roberts

    Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

    DOI: http://doi.org/10.1093/cercor/bhu102
    Journal: Cereb Cortex
    E-pub date: 1 Sep 2015
    Authors: R Rygula, HF Clarke, RN Cardinal, GJ Cockcroft, J Xia, JW Dalley, TW Robbins, AC Roberts

    Serotonergic, brain volume and attentional correlates of trait anxiety in primates.

    DOI: http://doi.org/10.1038/npp.2014.324
    Journal: Neuropsychopharmacology
    E-pub date: 1 May 2015
    Authors: Y Mikheenko, Y Shiba, S Sawiak, K Braesicke, G Cockcroft, H Clarke, AC Roberts

    Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.

    DOI: http://doi.org/10.1016/j.biopsych.2012.03.007
    Journal: Biological Psychiatry
    E-pub date: 15 Aug 2012
    Authors: C Agustín-Pavón, K Braesicke, Y Shiba, AM Santangelo, Y Mikheenko, G Cockroft, F Asma, H Clarke, M-S Man, AC Roberts

    Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus.

    DOI: http://doi.org/10.1523/JNEUROSCI.5066-10.2011
    Journal: J Neurosci
    E-pub date: 16 Mar 2011
    Authors: HF Clarke, GJ Hill, TW Robbins, AC Roberts

    Differential contributions of the primate ventrolateral prefrontal and orbitofrontal cortex to serial reversal learning.

    DOI: http://doi.org/10.1523/JNEUROSCI.2631-10.2010
    Journal: J Neurosci
    E-pub date: 27 Oct 2010
    Authors: R Rygula, SC Walker, HF Clarke, TW Robbins, AC Roberts

    Neurochemical modulation of orbitofrontal cortex function

    DOI: http://doi.org/10.1093/acprof:oso/9780198565741.003.0016
    Journal:
    E-pub date: 1 Feb 2010
    Authors: TW Robbins, L Clark, H Clarke, AC Roberts

    Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific.

    DOI: http://doi.org/10.1093/cercor/bhj120
    Journal: Cereb Cortex
    E-pub date: 1 Jan 2007
    Authors: HF Clarke, SC Walker, JW Dalley, TW Robbins, AC Roberts

    Prefrontal serotonin depletion affects reversal learning but not attentional set shifting.

    DOI: http://doi.org/10.1523/JNEUROSCI.3690-04.2005
    Journal: J Neurosci
    E-pub date: 12 Jan 2005
    Authors: HF Clarke, SC Walker, HS Crofts, JW Dalley, TW Robbins, AC Roberts

    The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze.

    DOI: http://doi.org/10.1016/s0014-2999(03)02182-4
    Journal: Eur J Pharmacol
    E-pub date: 29 Aug 2003
    Authors: MR Guscott, HF Clarke, F Murray, S Grimwood, LJ Bristow, PH Hutson