Dr Michael Hastings FRS, FMedSci

Collaborators

Key publications

Maywood ES, Chesham JE, O'Brien JA, Hastings MH (2011), “A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits.” Proc Natl Acad Sci U S A 108(34):14306-11 Details

O'Neill JS, Maywood ES, Chesham JE, Takahashi JS, Hastings MH (2008), “cAMP-dependent signaling as a core component of the mammalian circadian pacemaker.” Science 320(5878):949-53 Details

Maywood ES, O'Neill JS, Reddy AB, Chesham JE, Prosser HM, Kyriacou CP, Godinho SI, Nolan PM, Hastings MH (2007), “Genetic and molecular analysis of the central and peripheral circadian clockwork of mice.” Cold Spring Harb Symp Quant Biol 72:85-94 Details

Publications

2011

Atkinson SE, Maywood ES, Chesham JE, Wozny C, Colwell CS, Hastings MH, Williams SR (2011), “Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus.” J Biol Rhythms 26(3):210-20 Details

Ferrari E, Maywood ES, Restani L, Caleo M, Pirazzini M, Rossetto O, Hastings MH, Niranjan D, Schiavo G, Davletov B (2011), “Re-Assembled Botulinum Neurotoxin Inhibits CNS Functions without Systemic Toxicity.” Toxins (Basel) 3(4):345-55 Details

Maywood ES, Chesham JE, Meng QJ, Nolan PM, Loudon AS, Hastings MH (2011), “Tuning the period of the mammalian circadian clock: additive and independent effects of CK1εTau and Fbxl3Afh mutations on mouse circadian behavior and molecular pacemaking.” J Neurosci 31(4):1539-44 Details

2010

Maywood ES, Fraenkel E, McAllister CJ, Wood N, Reddy AB, Hastings MH, Morton AJ (2010), “Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding.” J Neurosci 30(30):10199-204 Details

Meng QJ, Maywood ES, Bechtold DA, Lu WQ, Li J, Gibbs JE, Dupré SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS (2010), “Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.” Proc Natl Acad Sci U S A 107(34):15240-5 Details

2009

Deery MJ, Maywood ES, Chesham JE, Sládek M, Karp NA, Green EW, Charles PD, Reddy AB, Kyriacou CP, Lilley KS, Hastings MH (2009), “Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock.” Curr Biol 19(23):2031-6 Details

Fustin JM, O'Neill JS, Hastings MH, Hazlerigg DG, Dardente H (2009), “Cry1 circadian phase in vitro: wrapped up with an E-box.” J Biol Rhythms 24(1):16-24 Details

2008

Jethwa PH, I'Anson H, Warner A, Prosser HM, Hastings MH, Maywood ES, Ebling FJ (2008), “Loss of prokineticin receptor 2 signaling predisposes mice to torpor.” Am J Physiol Regul Integr Comp Physiol 294(6):R1968-79 Details

Meng QJ, Logunova L, Maywood ES, Gallego M, Lebiecki J, Brown TM, Sládek M, Semikhodskii AS, Glossop NR, Piggins HD, Chesham JE, Bechtold DA, Yoo SH, Takahashi JS, Virshup DM, Boot-Handford RP, Hastings MH, Loudon AS (2008), “Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.” Neuron 58(1):78-88 Details

O'Neill JS, Hastings MH (2008), “Increased coherence of circadian rhythms in mature fibroblast cultures.” J Biol Rhythms 23(6):483-8 Details

2007

Loudon AS, Meng QJ, Maywood ES, Bechtold DA, Boot-Handford RP, Hastings MH (2007), “The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species.” Cold Spring Harb Symp Quant Biol 72:261-71 Details

Prosser HM, Bradley A, Chesham JE, Ebling FJ, Hastings MH, Maywood ES (2007), “Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei.” Proc Natl Acad Sci U S A 104(2):648-53 Details

2006

Maywood ES, Reddy AB, Wong GK, O'Neill JS, O'Brien JA, McMahon DG, Harmar AJ, Okamura H, Hastings MH (2006), “Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling.” Curr Biol 16(6):599-605 Details

2005

Morton AJ, Wood NI, Hastings MH, Hurelbrink C, Barker RA, Maywood ES (2005), “Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease.” J Neurosci 25(1):157-63 Details