Dr Michael Hastings FRS, FMedSci

Michael Hastings FMedSci

University position

Joint Head, Division of Neurobiology

Dr Michael Hastings FRS, FMedSci is pleased to consider applications from prospective PhD students.

Institutes

Medical Research Council Laboratory of Molecular Biology

Email

mha@mrc-lmb.cam.ac.uk

Home page

http://www2.mrc-lmb.cam.ac.uk/NB/Hast...

Research Themes

Cellular and Molecular Neuroscience

Systems and Computational Neuroscience

Interests

Cellular and molecular basis to circadian rhythms in mammals and its relevance to metabolic and neurological disease.

The brain's circadian clock- the suprachiasmatic nuclei. Yours are keeping you awake as you read this page!
The brain's circadian clock- the suprachiasmatic nuclei. Yours are keeping you awake as you read this page!
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Research Focus

Keywords

circadian

sleep

suprachiasmatic

hypothalamus

neural circuit

Clinical conditions

Alzheimer's disease

Depressive disorders

Digestion and nutrition disorders

Hormonal disorders

Huntington's disease

Seasonal affective disorder

Sleep disorders

Equipment

Behavioural analysis

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Recombinant protein expression

Collaborators

Cambridge

Jenny Morton

United Kingdom

Andrew loudon Web: http://www.ls.manchester.ac.uk/people/...

Pat Nolan Web: http://www.mgu.har.mrc.ac.uk/researc...

Bill Wisden Web: http://www.imperial.ac.uk/AP/face...

International

Joe Takahashi Web: http://www.hhmi.org/researc...

Key publications

Brancaccio M, Maywood ES, Chesham JE, Loudon AS, Hastings MH (2013), “A Gq-Ca2+ axis controls circuit-level encoding of circadian time in the suprachiasmatic nucleus.” Neuron 78(4):714-28 Details

Maywood ES, Drynan L, Chesham JE, Edwards MD, Dardente H, Fustin JM, Hazlerigg DG, O'Neill JS, Codner GF, Smyllie NJ, Brancaccio M, Hastings MH (2013), “Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse.” Proc Natl Acad Sci U S A 110(23):9547-52 Details

Maywood ES, Chesham JE, O'Brien JA, Hastings MH (2011), “A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits.” Proc Natl Acad Sci U S A 108(34):14306-11 Details

O'Neill JS, Maywood ES, Chesham JE, Takahashi JS, Hastings MH (2008), “cAMP-dependent signaling as a core component of the mammalian circadian pacemaker.” Science 320(5878):949-53 Details

Maywood ES, O'Neill JS, Reddy AB, Chesham JE, Prosser HM, Kyriacou CP, Godinho SI, Nolan PM, Hastings MH (2007), “Genetic and molecular analysis of the central and peripheral circadian clockwork of mice.” Cold Spring Harb Symp Quant Biol 72:85-94 Details

Publications

2014

Hastings MH, Brancaccio M, Maywood ES (2014), “Circadian pacemaking in cells and circuits of the suprachiasmatic nucleus.” J Neuroendocrinol 26(1):2-10 Details

Maywood ES, Chesham JE, Smyllie NJ, Hastings MH (2014), “The Tau mutation of casein kinase 1ε sets the period of the mammalian pacemaker via regulation of Period1 or Period2 clock proteins.” J Biol Rhythms 29(2):110-8 Details

Pauls S, Foley NC, Foley DK, LeSauter J, Hastings MH, Maywood ES, Silver R (2014), “Differential contributions of intra-cellular and inter-cellular mechanisms to the spatial and temporal architecture of the suprachiasmatic nucleus circadian circuitry in wild-type, cryptochrome-null and vasoactive intestinal peptide receptor 2-null mutant mice.” Eur J Neurosci Details

Xiao L, Zhang C, Li X, Gong S, Hu R, Balasubramanian R, Crowley W WF Jr, Hastings MH, Zhou QY (2014), “Signaling role of prokineticin 2 on the estrous cycle of female mice.” PLoS One 9(3):e90860 Details

2013

Anand SN, Maywood ES, Chesham JE, Joynson G, Banks GT, Hastings MH, Nolan PM (2013), “Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.” J Neurosci 33(17):7145-53 Details

Hastings MH (2013), “m(6)A mRNA methylation: a new circadian pacesetter.” Cell 155(4):740-1 Details

Hastings MH (2013), “Physiology. A looser clock to cure jet lag.” Science 342(6154):52-3 Details

Hastings MH, Goedert M (2013), “Circadian clocks and neurodegenerative diseases: time to aggregate?” Curr Opin Neurobiol 23(5):880-7 Details

O'Neill JS, Maywood ES, Hastings MH (2013), “Cellular mechanisms of circadian pacemaking: beyond transcriptional loops.” Handb Exp Pharmacol (217):67-103 Details

Zhang L, Hastings MH, Green EW, Tauber E, Sladek M, Webster SG, Kyriacou CP, Wilcockson DC (2013), “Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra.” Curr Biol 23(19):1863-73 Details

2012

McGlincy NJ, Valomon A, Chesham JE, Maywood ES, Hastings MH, Ule J (2012), “Regulation of alternative splicing by the circadian clock and food related cues.” Genome Biol 13(6):R54 Details

2011

Atkinson SE, Maywood ES, Chesham JE, Wozny C, Colwell CS, Hastings MH, Williams SR (2011), “Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus.” J Biol Rhythms 26(3):210-20 Details

Ferrari E, Maywood ES, Restani L, Caleo M, Pirazzini M, Rossetto O, Hastings MH, Niranjan D, Schiavo G, Davletov B (2011), “Re-Assembled Botulinum Neurotoxin Inhibits CNS Functions without Systemic Toxicity.” Toxins (Basel) 3(4):345-55 Details

Maywood ES, Chesham JE, Meng QJ, Nolan PM, Loudon AS, Hastings MH (2011), “Tuning the period of the mammalian circadian clock: additive and independent effects of CK1εTau and Fbxl3Afh mutations on mouse circadian behavior and molecular pacemaking.” J Neurosci 31(4):1539-44 Details

2010

Maywood ES, Fraenkel E, McAllister CJ, Wood N, Reddy AB, Hastings MH, Morton AJ (2010), “Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding.” J Neurosci 30(30):10199-204 Details

Meng QJ, Maywood ES, Bechtold DA, Lu WQ, Li J, Gibbs JE, Dupré SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS (2010), “Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.” Proc Natl Acad Sci U S A 107(34):15240-5 Details

2009

Deery MJ, Maywood ES, Chesham JE, Sládek M, Karp NA, Green EW, Charles PD, Reddy AB, Kyriacou CP, Lilley KS, Hastings MH (2009), “Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock.” Curr Biol 19(23):2031-6 Details

Fustin JM, O'Neill JS, Hastings MH, Hazlerigg DG, Dardente H (2009), “Cry1 circadian phase in vitro: wrapped up with an E-box.” J Biol Rhythms 24(1):16-24 Details

2008

Jethwa PH, I'Anson H, Warner A, Prosser HM, Hastings MH, Maywood ES, Ebling FJ (2008), “Loss of prokineticin receptor 2 signaling predisposes mice to torpor.” Am J Physiol Regul Integr Comp Physiol 294(6):R1968-79 Details

Meng QJ, Logunova L, Maywood ES, Gallego M, Lebiecki J, Brown TM, Sládek M, Semikhodskii AS, Glossop NR, Piggins HD, Chesham JE, Bechtold DA, Yoo SH, Takahashi JS, Virshup DM, Boot-Handford RP, Hastings MH, Loudon AS (2008), “Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.” Neuron 58(1):78-88 Details

O'Neill JS, Hastings MH (2008), “Increased coherence of circadian rhythms in mature fibroblast cultures.” J Biol Rhythms 23(6):483-8 Details

2007

Loudon AS, Meng QJ, Maywood ES, Bechtold DA, Boot-Handford RP, Hastings MH (2007), “The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species.” Cold Spring Harb Symp Quant Biol 72:261-71 Details

Prosser HM, Bradley A, Chesham JE, Ebling FJ, Hastings MH, Maywood ES (2007), “Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei.” Proc Natl Acad Sci U S A 104(2):648-53 Details

2006

Maywood ES, Reddy AB, Wong GK, O'Neill JS, O'Brien JA, McMahon DG, Harmar AJ, Okamura H, Hastings MH (2006), “Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling.” Curr Biol 16(6):599-605 Details

2005

Morton AJ, Wood NI, Hastings MH, Hurelbrink C, Barker RA, Maywood ES (2005), “Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease.” J Neurosci 25(1):157-63 Details