Dr Howard Baylis

Howard Baylis

University position

Reader and Deputy Head of Department

Dr Howard Baylis is pleased to consider applications from prospective PhD students.

Departments

Department of Zoology

Email

hab28@cam.ac.uk

Home page

http://www.zoo.cam.ac.uk/directo... (personal home page)

Research Theme

Cellular and Molecular Neuroscience

Interests

We are investigating the functions of genes involved in Alzheimer’s disease using C. elegans. We have focussed on presenilin genes as presenilin mutations in human cause familial Alzheimer’s disease. We aim to address the mechanism by which presenilin mutations alter neuronal function by dissecting their role at the synapse and investigating their interactions with inositol 1,4,5-trisphosphate (IP3) signalling.

We also study other aspects of IP3 signalling in the nervous system including studies on the role of IP3 signalling in polymodal sensory neurones.

Research Focus

Keywords

signalling

presenilin

inositol 1,4,5-trisphosphate

Caenorhabditis elegans

calcium

Clinical conditions

Alzheimer's disease

Equipment

Behavioural analysis

Calcium imaging

Confocal microscopy

Fluorescence microscopy

Microscopy

Collaborators

Cambridge

Maria Giannakou

United Kingdom

David Sattelle Web: http://www.ucl.ac.uk/WIBR/re...

Associated News Items


    Key publications

    Baylis HA (2010), “Linking presenilins to synaptic function and calcium signaling in C. elegans” Alzheimer's & Dementia 6: S61

    Walker DS, Vázquez-Manrique RP, Gower NJ, Gregory E, Schafer WR, Baylis HA (2009), “Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans.” PLoS Genet 5(9):e1000636 Details

    Publications

    2015

    Kowalski MP, Baylis HA, Krude T (2015), “Non-coding stem-bulge RNAs are required for cell proliferation and embryonic development in C. elegans” J Cell Sci. 128: 2118-2129

    Nagy AI, Vázquez-Manrique RP, Lopez M, Christov C, Sequedo MD, Herzog M, Herlihy AE, Bodak M, Gatsi R, Baylis HA (2015), “IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans” EMBO Rep. 16: 341-350

    2013

    Favrin G, Bean DM, Bilsland E, Boyer H, Fischer BE, Russell S, Crowther DC, Baylis HA, Oliver SG, Giannakou ME (2013), “Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly.” Sci Rep 3:3512 Details

    2012

    Baylis HA, Vázquez-Manrique RP (2012), “Genetic analysis of IP3 and calcium signalling pathways in C. elegans.” Biochim Biophys Acta 1820(8):1253-68 Details

    2011

    Baylis HA, Vázquez-Manrique RP (2011), “Reverse genetic strategies in Caenorhabditis elegans: towards controlled manipulation of the genome.” ScientificWorldJournal 11:1394-410 Details

    in press

    Gonzalez-Cabo P, Bolinches-Amorós A, Cabello J, Ros S, Moreno S, Baylis H A, Palau F and Vazquez-Manrique R P (in press), “Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans. ” J Biol Chem

    2011

    González-Cabo P, Bolinches-Amorós A, Cabello J, Ros S, Moreno S, Baylis HA, Palau F, Vázquez-Manrique RP (2011), “Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans.” J Biol Chem 286(24):21304-14 Details

    2010

    Vázquez-Manrique RP, Legg JC, Olofsson B, Ly S, Baylis HA (2010), “Improved gene targeting in C. elegans using counter-selection and Flp-mediated marker excision.” Genomics 95(1):37-46 Details

    2009

    Parker S, Baylis HA (2009), “Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity.” Commun Integr Biol 2(5):382-4 Details

    Parker S, Walker DS, Ly S, Baylis HA (2009), “Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans.” Mol Biol Cell 20(6):1763-71 Details

    2008

    Kwan CS, Vázquez-Manrique RP, Ly S, Goyal K, Baylis HA (2008), “TRPM channels are required for rhythmicity in the ultradian defecation rhythm of C. elegans.” BMC Physiol 8:11 Details

    Vázquez-Manrique RP, Nagy AI, Legg JC, Bales OA, Ly S, Baylis HA (2008), “Phospholipase C-epsilon regulates epidermal morphogenesis in Caenorhabditis elegans.” PLoS Genet 4(3):e1000043 Details

    2007

    Baylis HA, Goyal K (2007), “TRPM channel function in Caenorhabditis elegans.” Biochem Soc Trans 35(Pt 1):129-32 Details

    Parker S, Peterkin HS, Baylis HA (2007), “Muscular dystrophy associated mutations in caveolin-1 induce neurotransmission and locomotion defects in Caenorhabditis elegans.” Invert Neurosci 7(3):157-64 Details

    Vázquez-Manrique RP, González-Cabo P, Ortiz-Martín I, Ros S, Baylis HA, Palau F (2007), “The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation.” Genomics 89(3):392-401 Details

    2006

    Vázquez-Manrique RP, González-Cabo P, Ros S, Aziz H, Baylis HA, Palau F (2006), “Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant.” FASEB J 20(1):172-4 Details

    2005

    Baylis HA (2005), “VAV's got rhythm.” Cell 123(1):5-7 Details

    Gower NJ, Walker DS, Baylis HA (2005), “Inositol 1,4,5-trisphosphate signaling regulates mating behavior in Caenorhabditis elegans males.” Mol Biol Cell 16(9):3978-86 Details

    2004

    Culetto E, Baylis HA, Richmond JE, Jones AK, Fleming JT, Squire MD, Lewis JA, Sattelle DB (2004), “The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit.” J Biol Chem 279(41):42476-83 Details

    Culletto E, Baylis HA, Richmond JE, Jones AK, Fleming JT, Squire MD, Lewis JA, Sattelle DB (2004), “The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit” J Biol Chem 279:42476-42483

    Walker DS, Ly S, Gower NJ, Baylis HA (2004), “IRI-1, a LIN-15B homologue, interacts with inositol-1,4,5-triphosphate receptors and regulates gonadogenesis, defecation, and pharyngeal pumping in Caenorhabditis elegans.” Mol Biol Cell 15(7):3073-82 Details

    Yin X, Gower NJ, Baylis HA, Strange K (2004), “Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans.” Mol Biol Cell 15(8):3938-49 Details

    2002

    Walker DS, Gower NJ, Ly S, Bradley GL, Baylis HA (2002), “Regulated disruption of inositol 1,4,5-trisphosphate signaling in Caenorhabditis elegans reveals new functions in feeding and embryogenesis.” Mol Biol Cell 13(4):1329-37 Details

    Walker DS, Gower NJD, Ly S, Bradley GL, Baylis HA (2002), “Regulated disruption of inositol 1,4,5-trisphosphate (IP3) signaling in C, elegans reveals new functions in feeding and embryogenesis” Mol Biol Cell 13:1329-1337

    Walker DS, Ly S, Lockwood KC, Baylis HA (2002), “A direct interaction between IP(3) receptors and myosin II regulates IP(3) signaling in C. elegans.” Curr Biol 12(11):951-6 Details

    2001

    Gower NJ, Temple GR, Schein JE, Marra M, Walker DS, Baylis HA (2001), “Dissection of the promoter region of the inositol 1,4,5-trisphosphate receptor gene, itr-1, in C. elegans: a molecular basis for cell-specific expression of IP3R isoforms.” J Mol Biol 306(2):145-57 Details

    1999

    Baylis HA, Furuichi T, Yoshikawa F, Mikoshiba K, Sattelle DB (1999), “Inositol 1,4,5-trisphosphate receptors are strongly expressed in the nervous system, pharynx, intestine, gonad and excretory cell of Caenorhabditis elegans and are encoded by a single gene (itr-1).” J Mol Biol 294(2):467-76 Details

    Miguel-Aliaga I, Culetto E, Walker DS, Baylis HA, Sattelle DB, Davies KE (1999), “The Caenorhabditis elegans orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability.” Hum Mol Genet 8(12):2133-43 Details

    1998

    Buckingham SD, Adcock C, Sansom MS, Sattelle DB, Baylis HA (1998), “Functional characterization of a mutated chicken alpha7 nicotinic acetylcholine receptor subunit with a leucine residue inserted in transmembrane domain 2.” Br J Pharmacol 124(4):747-55 Details

    Matsuda K, Buckingham SD, Freeman JC, Squire MD, Baylis HA, Sattelle DB (1998), “Effects of the alpha subunit on imidacloprid sensitivity of recombinant nicotinic acetylcholine receptors.” Br J Pharmacol 123(3):518-24 Details

    Mongan NP, Baylis HA, Adcock C, Smith GR, Sansom MS, Sattelle DB (1998), “An extensive and diverse gene family of nicotinic acetylcholine receptor alpha subunits in Caenorhabditis elegans.” Receptors Channels 6(3):213-28 Details

    1997

    Baylis HA, Matsuda K, Squire MD, Fleming JT, Harvey RJ, Darlison MG, Barnard EA, Sattelle DB (1997), “ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit. Molecular cloning and functional expression.” Receptors Channels 5(3-4):149-58 Details

    Rauh JJ, Holyoke CW, Kleier DA, Presnail JK, Benner EA, Cordova D, Howard MH, Hosie AM, Buckingham SD, Baylis HA, Sattelle DB (1997), “Polycyclic dinitriles: a novel class of potent GABAergic insecticides provides a new radioligand, [3H]BIDN.” Invert Neurosci 3(2-3):261-8 Details

    1996

    Baylis HA, Sattelle DB, Lane NJ (1996), “Genetic analysis of cholinergic nerve terminal function in invertebrates.” J Neurocytol 25(12):747-62 Details

    Buckingham SD, Matsuda K, Hosie AM, Baylis HA, Squire MD, Lansdell SJ, Millar NS, Sattelle B (1996), “Wild-type and insecticide-resistant homo-oligomeric GABA receptors of Drosophila melanogaster stably expressed in a Drosophila cell line.” Neuropharmacology 35(9-10):1393-401 Details

    Fleming JT, Baylis HA, Sattelle DB, Lewis JA (1996), “Molecular cloning and in vitro expression of C. elegans and parasitic nematode ionotropic receptors.” Parasitology 113 Suppl:S175-90 Details

    Matsuda K, Hosie AM, Buckingham SD, Squire MD, Baylis HA, Sattelle DB (1996), “pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor.” Brain Res 739(1-2):335-8 Details

    1995

    Baylis HA, Megson A, Hall R (1995), “Infection with Theileria annulata induces expression of matrix metalloproteinase 9 and transcription factor AP-1 in bovine leucocytes.” Mol Biochem Parasitol 69(2):211-22 Details

    Hosie AM, Baylis HA, Buckingham SD, Sattelle DB (1995), “Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster.” Br J Pharmacol 115(6):909-12 Details

    Hosie AM, Shirai Y, Buckingham SD, Rauh JJ, Roush RT, Baylis HA, Sattelle DB (1995), “Blocking actions of BIDN, a bicyclic dinitrile convulsant compound, on wild-type and dieldrin-resistant GABA receptor homo-oligomers of Drosophila melanogaster expressed in Xenopus oocytes.” Brain Res 693(1-2):257-60 Details

    Millar NS, Baylis HA, Reaper C, Bunting R, Mason WT, Sattelle DB (1995), “Functional expression of a cloned Drosophila muscarinic acetylcholine receptor in a stable Drosophila cell line.” J Exp Biol 198(Pt 9):1843-50 Details

    Shirai Y, Hosie AM, Buckingham SD, Holyoke CW Jr, Baylis HA, Sattelle DB (1995), “Actions of picrotoxinin analogues on an expressed, homo-oligomeric GABA receptor of Drosophila melanogaster.” Neurosci Lett 189(1):1-4 Details

    Squire MD, Tornøe C, Baylis HA, Fleming JT, Barnard EA, Sattelle DB (1995), “Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2).” Receptors Channels 3(2):107-15 Details

    1994

    Boulter N, Knight PA, Hunt PD, Hennessey ES, Katzer F, Tait A, Williamson S, Brown D, Baylis HA, Hall R (1994), “Theileria annulata sporozoite surface antigen (SPAG-1) contains neutralizing determinants in the C terminus.” Parasite Immunol 16(2):97-104 Details

    1993

    Allsopp BA, Baylis HA, Allsopp MT, Cavalier-Smith T, Bishop RP, Carrington DM, Sohanpal B, Spooner P (1993), “Discrimination between six species of Theileria using oligonucleotide probes which detect small subunit ribosomal RNA sequences.” Parasitology 107 ( Pt 2):157-65 Details

    Baylis HA, Allsopp BA, Hall R, Carrington M (1993), “Characterisation of a glutamine- and proline-rich protein (QP protein) from Theileria parva.” Mol Biochem Parasitol 61(2):171-8 Details

    1992

    Baylis HA, Megson A, Brown CG, Wilkie GF, Hall R (1992), “Theileria annulata-infected cells produce abundant proteases whose activity is reduced by long-term cell culture.” Parasitology 105 ( Pt 3):417-23 Details

    Baylis HA, Megson A, Mottram JC, Hall R (1992), “Characterisation of a gene for a cysteine protease from Theileria annulata.” Mol Biochem Parasitol 54(1):105-7 Details

    1991

    Baylis HA, Sohal SK, Carrington M, Bishop RP, Allsopp BA (1991), “An unusual repetitive gene family in Theileria parva which is stage-specifically transcribed.” Mol Biochem Parasitol 49(1):133-42 Details

    Megson A, Inman GJ, Hunt PD, Baylis HA, Hall R (1991), “The gene for apocytochrome B of Theileria annulata resides on a small linear extrachromosomal element.” Mol Biochem Parasitol 48(1):113-5 Details

    Strauch E, Takano E, Baylis HA, Bibb MJ (1991), “The stringent response in Streptomyces coelicolor A3(2).” Mol Microbiol 5(2):289-98 Details

    1988

    Baylis HA, Bibb MJ (1988), “Transcriptional analysis of the 16S rRNA gene of the rrnD gene set of Streptomyces coelicolor A3(2).” Mol Microbiol 2(5):569-79 Details

    Baylis HA, Bibb MJ (1988), “Organisation of the ribosomal RNA genes in Streptomyces coelicolor A3(2).” Mol Gen Genet 211(2):191-6 Details

    1987

    Baylis HA, Bibb MJ (1987), “The nucleotide sequence of a 16S rRNA gene from Streptomyces coelicolor A3(2)” Nucleic Acids Res 15(17):7176 Details

    Lawlor EJ, Baylis HA, Chater KF (1987), “Pleiotropic morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2).” Genes Dev 1(10):1305-10 Details