Dr Gregory Jefferis
MRC Programme Leader Track
Dr Gregory Jefferis is pleased to consider applications from prospective PhD students.
N / A
http://www2.mrc-lmb.cam.ac.uk/group-l... (personal home page)
Our broad goal is to understand how smell turns into behaviour in the fruit fly brain. We use a combination of genetic labelling and manipulation, targeted in vivo whole cell patch clamp recording and high resolution neuroanatomy to study olfactory circuits. Key interests include understanding how third order olfactory neurons of the lateral horn integrate information from specific olfactory channels. This process of selective integration is the fundamental unit of perception and is likely to underlie innate behavioural responses to general odours and sex pheromones. Please get in touch if you would like to find out more about the group.
No direct clinical relevance
Electrophysiological recording techniques
Genetic Labelling and Manipulation of Neurons
Image Registration (for 3D Brain Atlases)
Single Cell Labelling (MARCM)
Whole cell patch clamp
Richard Benton Web: http://www.unil.ch/cig/pag...
Barry Dickson Web: http://www.imp.ac.at/researc...
Torsten Rohlfing Web: http://www.stanford.edu/~rohlfing/
Glenn Turner Web: http://www.cshl.edu/public/...
Cachero S, Ostrovsky AD, Yu JY, Dickson BJ, Jefferis GS (2010), “Sexual dimorphism in the fly brain.” Curr Biol 20(18):1589-601 Details
Jefferis GSXE, Potter CJ, Chan AM, Marin EC, Rohlfing T, Maurer Jr CR, Luo L (2007), “Comprehensive Maps of Drosophila Higher Olfactory Centres - Spatial Segregation of Fruit and Pheromone Representation” Cell 128 (6):1187-1203
Jefferis GSXE, Marin EC, Stocker RF, Luo L (2001), “Target neuron prespecification in the olfactory map of Drosophila” Nature 414(6860):204-8
Masse NY, Turner GC, Jefferis GS (2009), “Olfactory information processing in Drosophila.” Curr Biol 19(16):R700-13 Details
Komiyama T, Johnson WA, Luo L, Jefferis GSXE (2003), “From lineage to wiring specificity - POU domain transcription factors control precise connections of Drosophila olfactory projection neurons” Cell 112 (2):157-67