Dr Graham Murray
University position
Senior Clinical Research Associate
Dr Graham Murray is pleased to consider applications from prospective PhD students.
Departments
Institutes
Behavioural and Clinical Neuroscience Institute
Home page
http://www-bmu.psychiatry.cam.ac.uk/
Research Themes
Interests
My research investigates the brain basis of particular neuropsychiatric symptoms - namely delusions, hallucinations and anhedonia. It's already known that brain systems involving the neurotransmitter dopamine are disturbed in psychotic illnesses such as schizophrenia (and in Parkinson's Disease), but it isn't clear how these disturbances relate to the mental experience of patients. I believe that it is possible to explain delusions, hallucinations and anhedonia in terms of dopamine dysfunction via dopamine's known role in incentive salience (motivational importance), and I'm testing this theory with fMRI, computational neuroscience techniques, pharmacological and neuropsychological studies. This research is funded by an MRC Clinician Scientist award and NARSAD, and relates to my clinical work at CAMEO, the Cambridge early psychosis service.
I'm also interested in cognitive developmental epidemiology & the relationship between cognitive and motor functions across the lifespan.
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Research Focus
KeywordsPsychosis Dopamine Reward Motivation Incentive Salience |
Clinical conditionsBipolar disorder Depressive disorders Early psychosis Parkinson's disease Populations at high clinical risk for psychosis Schizophrenia |
Equipment
Behavioural analysis
Computational modelling
Magnetic resonance imaging (MRI)
Metabonomics
Neuropsychological testing
Randomised control trials
Collaborators
Cambridge | InternationalKent Berridge Web: http://www-personal.umich.edu/~berridge/ Nico Bunzeck Web: http://www.icn.ucl.ac.uk/Researc... Emrah Duzel Web: http://www.icn.ucl.ac.uk/Staff-L... Matti Isohanni Web: http://cc.oulu.fi/~maisoh... Mathias Pessiglione Web: http://www.ifrns.chups.jussieu.fr/institu... Marcus Richards Web: http://www.nshd.mrc.ac.uk/ Juha Veijola Web: http://kelo.oulu.fi/NFBC/ |
Key publications
Murray GK, Cheng F, Clark L, Barnett JH, Blackwell AD, Fletcher PC, Robbins TW, Bullmore ET, Jones PB (2008), “Reinforcement and reversal learning in first-episode psychosis.” Schizophr Bull 34(5):848-55 Details
Murray GK, Clark L, Corlett PR, Blackwell AD, Cools R, Jones PB, Robbins TW, Poustka L (2008), “Incentive motivation in first-episode psychosis: a behavioural study.” BMC Psychiatry 8:34 Details
Murray GK, Corlett PR, Clark L, Pessiglione M, Blackwell AD, Honey G, Jones PB, Bullmore ET, Robbins TW, Fletcher PC (2008), “Substantia nigra/ventral tegmental reward prediction error disruption in psychosis.” Mol Psychiatry 13(3):239, 267-76 Details
Publications
2009
Lebreton M, Barnes A, Miettunen J, Peltonen L, Ridler K, Veijola J, Tanskanen P, Suckling J, Jarvelin MR, Jones PB, Isohanni M, Bullmore ET, Murray GK (2009), “The brain structural disposition to social interaction.” Eur J Neurosci Details
Mäki P, Riekki T, Miettunen J, Isohanni M, Jones PB, Murray GK, Veijola J (2009), “Schizophrenia in the Offspring of Antenatally Depressed Mothers in the Northern Finland 1966 Birth Cohort: Relationship to Family History of Psychosis.” Am J Psychiatry Details
2008
Honey GD, Corlett PR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Bullmore ET, Menon DK, Fletcher PC (2008), “Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo.” J Neurosci 28(25):6295-303 Details
Jääskeläinen E, Miettunen J, Veijola J, McGrath JJ, Murray GK, Jones PB, Isohanni M (2008), “Associations between early development and outcome in schizophrenia--A 35-year follow-up of the Northern Finland 1966 Birth Cohort.” Schizophr Res 99(1-3):29-37 Details
Miettunen J, Törmänen S, Murray GK, Jones PB, Mäki P, Ebeling H, Moilanen I, Taanila A, Heinimaa M, Joukamaa M, Veijola J (2008), “Association of cannabis use with prodromal symptoms of psychosis in adolescence.” Br J Psychiatry 192:470-1 Details
Tanskanen P, Ridler K, Murray GK, Haapea M, Veijola JM, Jääskeläinen E, Miettunen J, Jones PB, Bullmore ET, Isohanni MK (2008), “Morphometric Brain Abnormalities in Schizophrenia in a Population-Based Sample: Relationship to Duration of Illness.” Schizophr Bull Details
2007
Barnett JH, Werners U, Secher SM, Hill KE, Brazil R, Masson K, Pernet DE, Kirkbride JB, Murray GK, Bullmore ET, Jones PB (2007), “Substance use in a population-based clinic sample of people with first-episode psychosis.” Br J Psychiatry 190:515-20 Details
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC (2007), “Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions.” Brain 130(Pt 9):2387-400 Details
Murray GK, Jones PB, Kuh D, Richards M (2007), “Infant developmental milestones and subsequent cognitive function.” Ann Neurol 62(2):128-36 Details
2006
Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Robbins TW, Bullmore ET, Fletcher PC (2006), “Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis.” Arch Gen Psychiatry 63(6):611-21 Details
Isohanni M, Miettunen J, Mäki P, Murray GK, Ridler K, Lauronen E, Moilanen K, Alaräisänen A, Haapea M, Isohanni I, Ivleva E, Tamminga C, McGrath J, Koponen H (2006), “Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study.” World Psychiatry 5(3):168-71 Details
Murray GK, Jones PB, Moilanen K, Veijola J, Miettunen J, Cannon TD, Isohanni M (2006), “Infant motor development and adult cognitive functions in schizophrenia.” Schizophr Res 81(1):65-74 Details
Murray GK, Veijola J, Moilanen K, Miettunen J, Glahn DC, Cannon TD, Jones PB, Isohanni M (2006), “Infant motor development is associated with adult cognitive categorisation in a longitudinal birth cohort study.” J Child Psychol Psychiatry 47(1):25-9 Details
Pomarol-Clotet E, Honey GD, Murray GK, Corlett PR, Absalom AR, Lee M, McKenna PJ, Bullmore ET, Fletcher PC (2006), “Psychological effects of ketamine in healthy volunteers. Phenomenological study.” Br J Psychiatry 189:173-9 Details
Ridler K, Veijola JM, Tanskanen P, Miettunen J, Chitnis X, Suckling J, Murray GK, Haapea M, Jones PB, Isohanni MK, Bullmore ET (2006), “Fronto-cerebellar systems are associated with infant motor and adult executive functions in healthy adults but not in schizophrenia.” Proc Natl Acad Sci U S A 103(42):15651-6 Details
2005
Broome MR, Woolley JB, Tabraham P, Johns LC, Bramon E, Murray GK, Pariante C, McGuire PK, Murray RM (2005), “What causes the onset of psychosis?” Schizophr Res 79(1):23-34 Details
Isohanni M, Lauronen E, Moilanen K, Isohanni I, Kemppainen L, Koponen H, Miettunen J, Mäki P, Räsänen S, Veijola J, Tienari P, Wahlberg KE, Murray GK (2005), “Predictors of schizophrenia: evidence from the Northern Finland 1966 Birth Cohort and other sources.” Br J Psychiatry Suppl 48:s4-7 Details
Leeson VC, McKenna PJ, Murray G, Kondel TK, Laws KR (2005), “What happens to semantic memory when formal thought disorder remits? Revisiting a case study.” Cognit Neuropsychiatry 10(1):57-71 Details
Mäki P, Veijola J, Jones PB, Murray GK, Koponen H, Tienari P, Miettunen J, Tanskanen P, Wahlberg KE, Koskinen J, Lauronen E, Isohanni M (2005), “Predictors of schizophrenia--a review.” Br Med Bull 73-74:1-15 Details
Taanila A, Murray GK, Jokelainen J, Isohanni M, Rantakallio P (2005), “Infant developmental milestones: a 31-year follow-up.” Dev Med Child Neurol 47(9):581-6 Details
2004
Isohanni M, Isohanni I, Koponen H, Koskinen J, Laine P, Lauronen E, Miettunen J, Mäki P, Riala K, Räsänen S, Saari K, Tienari P, Veijola J, Murray G (2004), “Developmental precursors of psychosis.” Curr Psychiatry Rep 6(3):168-75 Details
Isohanni M, Murray GK, Jokelainen J, Croudace T, Jones PB (2004), “The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life. A 34-year follow-up of the Northern Finland 1966 birth cohort.” Schizophr Res 71(2-3):213-25 Details
Murray GK, Leeson V, McKenna PJ (2004), “Spontaneous improvement in severe, chronic schizophrenia and its neuropsychological correlates.” Br J Psychiatry 184:357-8 Details
2003
Murray GK, Nandhra H, Hymas N, Hunt N (2003), “Copying letters to patients. Psychiatrists omit information from letters when they know patients will be sent copies.” BMJ 326(7386):449 Details
1995
Takei N, Murray G, O'Callaghan E, Sham PC, Glover G, Murray RM (1995), “Prenatal exposure to influenza epidemics and risk of mental retardation.” Eur Arch Psychiatry Clin Neurosci 245(4-5):255-9 Details
1994
O'Callaghan E, Sham PC, Takei N, Murray G, Glover G, Hare EH, Murray RM (1994), “The relationship of schizophrenic births to 16 infectious diseases.” Br J Psychiatry 165(3):353-6 Details
Takei N, Sham P, O'Callaghan E, Murray GK, Glover G, Murray RM (1994), “Prenatal exposure to influenza and the development of schizophrenia: is the effect confined to females?” Am J Psychiatry 151(1):117-9 Details
1992
Sham PC, O'Callaghan E, Takei N, Murray GK, Hare EH, Murray RM (1992), “Schizophrenia following pre-natal exposure to influenza epidemics between 1939 and 1960.” Br J Psychiatry 160:461-6 Details