Elena Vecino

Elena Vecino

University position

Visiting Professor

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Email

elena.vecino@ehu.es

Home page

http://www.ehu.es/GOBE (personal home page)

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

Retinal ganglion cell (RGC) regeneration: Our interest is to understand the different factors that affect the RGCs to regenerate their axons in vitro. How integrins and extracellular matrix affect the transport and axonal regeneration.

The implications of the research will help us to understand what happens in glaucoma, the first cause of blindness worldwide where a subpopulation of retinal ganglion cells die after the elevation of the intraocular pressure.

I am a visiting Professor (from University of the Basque Country) at the Centre for Brain Repair until July 2012.

Pig Retinal Ganglion Cell retrogradly labelled with DiI.
Pig Retinal Ganglion Cell retrogradly labelled with DiI.
Click image to view full-size

Research Focus

Keywords

Regeneration

Retinal Ganglion Cells

Transport

Integrins

Neuroprotection

Clinical conditions

Glaucoma

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Collaborators

Cambridge

Michael Coleman

James Fawcett

Keith Martin

International

Gustavo Aguirre Web: http://Philadelphya Veterinary Medic...

Sansar Sharma Web: http://NY Medical College

Key publications

Elena Vecino and Sansar C.Sharma (2012), “Glaucoma Animal Models” Glaucoma ISBN: 978-953-307-591-4 Pags. 319-334 PDF

Hernandez M, Rodriguez FD, Sharma SC, Vecino E (2009), “Immunohistochemical changes in rat retinas at various time periods of elevated intraocular pressure.” Mol Vis 15:2696-709 PDF Details

Elena Vecino (2008), “Neurotrophins: Responsible for death and survival ” Brain Melecules: From Vitamins to Molecules for Axonal Guidance, Transworld Research Network, Kerala, India 181-193 PDF

M. García, V. Forster, D. Hicks and E. Vecino (2003), “ In vivo expression of neurotrophins and neurotrophin receptors is conserved in adult porcine retina in vitro.” Invest. Ophthal. Vis. Sci. 44:4532-4541. PDF

M. García, V. Forster, D. Hicks and E. Vecino, (2002), “Effects of Müller glia on cell survival and neuritogenesis in adult porcine retina in vitro.” Invest. Ophthal. Vis. Sci. 43:3735-3743. PDF

Publications

2012

Galdos M, Bayón A, Rodriguez FD, Micó C, Sharma SC, Vecino E (2012), “Morphology of retinal vessels in the optic disk in a Göttingen minipig experimental glaucoma model.” Vet Ophthalmol 15 Suppl 1:36-46 Details

2011

Acera A, Suárez T, Rodríguez-Agirretxe I, Vecino E, Durán JA (2011), “Changes in tear protein profile in patients with conjunctivochalasis.” Cornea 30(1):42-9 Details

Acera A, Vecino E, Rodríguez-Agirretxe I, Aloria K, Arizmendi JM, Morales C, Durán JA (2011), “Changes in tear protein profile in keratoconus disease.” Eye (Lond) 25(9):1225-33 Details

Del Río P, Irmler M, Arango-González B, Favor J, Bobe C, Bartsch U, Vecino E, Beckers J, Hauck SM, Ueffing M (2011), “GDNF-induced osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration.” Glia 59(5):821-32 Details

Galdos M, Vecino E (2011), “[Ultrastructural changes in the trabecular meshwork and increased IOP. Which came first, the chicken or the egg?].” Arch Soc Esp Oftalmol 86(8):241-2 Details

Pinar-Sueiro S, Rodríguez-Puertas R, Vecino E (2011), “[Cannabinoid applications in glaucoma].” Arch Soc Esp Oftalmol 86(1):16-23 Details

Pinar-Sueiro S, Urcola H, Rivas MA, Vecino E (2011), “Prevention of retinal ganglion cell swelling by systemic brimonidine in a rat experimental glaucoma model.” Clin Experiment Ophthalmol 39(8):799-807 Details

Rodríguez FD, Vecino E (2011), “Stem cell plasticity, neuroprotection and regeneration in human eye diseases.” Curr Stem Cell Res Ther 6(1):73-81 Details

2010

Hernández M, Pearce-Kelling SE, Rodriguez FD, Aguirre GD, Vecino E (2010), “Altered expression of retinal molecular markers in the canine RPE65 model of Leber congenital amaurosis.” Invest Ophthalmol Vis Sci 51(12):6793-802 Details

Pinar-Sueiro S, Martínez-Fernández R, Lage-Medina S, Aldamiz-Echevarria L, Vecino E (2010), “Optic neuropathy in methylmalonic acidemia: the role of neuroprotection.” J Inherit Metab Dis

2009

Rivas MA, Vecino E (2009), “Animal models and different therapies for treatment of retinitis pigmentosa.” Histol Histopathol 24(10):1295-322 Details

Vecino E (2009), “[Methods in the biomedical research].” Arch Soc Esp Oftalmol 84(8):373-4 Details

2008

Acera A, Rocha G, Vecino E, Lema I, Durán JA (2008), “Inflammatory markers in the tears of patients with ocular surface disease.” Ophthalmic Res 40(6):315-21 Details

Hernández M, Urcola JH, Vecino E (2008), “Retinal ganglion cell neuroprotection in a rat model of glaucoma following brimonidine, latanoprost or combined treatments.” Exp Eye Res 86(5):798-806 Details

Vecino E (2008), “[Animal models in the study of the glaucoma: past, present and future].” Arch Soc Esp Oftalmol 83(9):517-9 Details

Vecino E (2008), “[Spin-offs and the centrifugal force of the university].” Arch Soc Esp Oftalmol 83(5):285-6 Details

Vecino E (2008), “[Gene therapy against retinosis pigmentary].” Arch Soc Esp Oftalmol 83(4):213-4 Details

2007

Hernández M, Guerrikagoitia I, Martínez-Millan L, Vecino E (2007), “NMDA-receptor blockade enhances cell apoptosis in the developing retina of the postnatal rat.” Int J Dev Biol 51(2):117-22 Details

2006

Suarez T, Vecino E (2006), “Expression of endothelial leukocyte adhesion molecule 1 in the aqueous outflow pathway of porcine eyes with induced glaucoma.” Mol Vis 12:1467-72 Details

Urcola JH, Hernández M, Vecino E (2006), “Three experimental glaucoma models in rats: comparison of the effects of intraocular pressure elevation on retinal ganglion cell size and death.” Exp Eye Res 83(2):429-37 Details

2005

Garcá M, Ruiz-Ederra J, Hernández-Barbáchano H, Vecino E (2005), “Topography of pig retinal ganglion cells.” J Comp Neurol 486(4):361-72 Details

Ruiz-Ederra J, García M, Hernández M, Urcola H, Hernández-Barbáchano E, Araiz J, Vecino E (2005), “The pig eye as a novel model of glaucoma.” Exp Eye Res 81(5):561-9 Details

Ruiz-Ederra J, García M, Martín F, Urcola H, Hernández M, Araiz J, Durán J, Vecino E (2005), “[Comparison of three methods of inducing chronic elevation of intraocular pressure in the pig (experimental glaucoma)].” Arch Soc Esp Oftalmol 80(10):571-9 Details

2004

Bonnet D, Garcia M, Vecino E, Lorentz JG, Sahel J, Hicks D (2004), “Brain-derived neurotrophic factor signalling in adult pig retinal ganglion cell neurite regeneration in vitro.” Brain Res 1007(1-2):142-51 Details

García-Crespo D, Vecino E (2004), “Differential expression of calretinin in the developing and regenerating zebrafish visual system.” Histol Histopathol 19(4):1193-9 Details

Ruiz-Ederra J, García M, Hicks D, Vecino E (2004), “Comparative study of the three neurofilament subunits within pig and human retinal ganglion cells.” Mol Vis 10:83-92 Details

Vecino E, Hernández M, García M (2004), “Cell death in the developing vertebrate retina.” Int J Dev Biol 48(8-9):965-74 Details

2003

García M, Forster V, Hicks D, Vecino E (2003), “In vivo expression of neurotrophins and neurotrophin receptors is conserved in adult porcine retina in vitro.” Invest Ophthalmol Vis Sci 44(10):4532-41 Details

García M, Vecino E (2003), “Role of Müller glia in neuroprotection and regeneration in the retina.” Histol Histopathol 18(4):1205-18 Details

García M, Vecino E (2003), “[Intracellular pathways leading to apoptosis of retinal cells].” Arch Soc Esp Oftalmol 78(7):351-64 Details

Kinkl N, Ruiz J, Vecino E, Frasson M, Sahel J, Hicks D (2003), “Possible involvement of a fibroblast growth factor 9 (FGF9)-FGF receptor-3-mediated pathway in adult pig retinal ganglion cell survival in vitro.” Mol Cell Neurosci 23(1):39-53 Details

Ruiz-Ederra J, Hitchcock PF, Vecino E (2003), “Two classes of astrocytes in the adult human and pig retina in terms of their expression of high affinity NGF receptor (TrkA).” Neurosci Lett 337(3):127-30 Details

2002

García M, Forster V, Hicks D, Vecino E (2002), “Effects of müller glia on cell survival and neuritogenesis in adult porcine retina in vitro.” Invest Ophthalmol Vis Sci 43(12):3735-43 Details

Vecino E (2002), “[Therapeutic strategies for retinal degenerations].” Arch Soc Esp Oftalmol 77(12):649-51 Details