Dr Guy Brown

Collaborators

Key publications

Borutaite V, Brown GC (2007), “Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state.” J Biol Chem 282(43):31124-30 Details

Jekabsone A, Neher JJ, Borutaite V, Brown GC (2007), “Nitric oxide from neuronal nitric oxide synthase sensitises neurons to hypoxia-induced death via competitive inhibition of cytochrome oxidase.” J Neurochem 103(1):346-56 Details

Jekabsone A, Mander PK, Tickler A, Sharpe M, Brown GC (2006), “Fibrillar beta-amyloid peptide Ab1-40 activates microglial proliferation via stimulating TNF-b release and H2O2 derived from NADPH oxidase: a cell culture study” J Neuroinflam 3:24 Details

Publications

2012

Fricker M, Neher JJ, Zhao JW, Théry C, Tolkovsky AM, Brown GC (2012), “MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation.” J Neurosci 32(8):2657-66 Details

2011

Brown GC, Borutaite V (2011), “There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells.” Mitochondrion Details

Neher JJ, Neniskyte U, Zhao JW, Bal-Price A, Tolkovsky AM, Brown GC (2011), “Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death.” J Immunol 186(8):4973-83 Details

Neniskyte U, Neher JJ, Brown GC (2011), “Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia.” J Biol Chem 286(46):39904-13 Details

2010

Brown GC (2010), “The principle of sufficiency and the evolution of control: using control analysis to understand the design principles of biological systems.” Biochem Soc Trans 38(5):1210-4 Details

Brown GC (2010), “Nitric oxide and neuronal death.” Nitric Oxide 23(3):153-65 Details

Brown GC, Neher JJ (2010), “Inflammatory neurodegeneration and mechanisms of microglial killing of neurons.” Mol Neurobiol 41(2-3):242-7 Details

2009

Brown RD, Burke GA, Brown GC (2009), “Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine.” Free Radic Biol Med 46(8):1211-20 Details

Thompson AJ, Mander PK, Brown GC (2009), “The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide.” Br J Pharmacol 158(5):1338-43 Details

2008

Brown GC, Borutaite V (2008), “Regulation of apoptosis by the redox state of cytochrome c.” Biochim Biophys Acta 1777(7-8):877-81 Details

2007

Brown GC (2007), “Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase.” Biochem Soc Trans 35(Pt 5):1119-21 Details

Neher JJ, Brown GC (2007), “Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system.” Biochem Soc Trans 35(Pt 5):1166-7 Details

2006

Bal-Price A, Gartlon J, Brown GC (2006), “Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion.” Nitric Oxide 14(3):238-46 Details

Borutaite V, Brown GC (2006), “S-nitrosothiol inhibition of mitochondrial complex I causes a reversible increase in mitochondrial hydrogen peroxide production.” Biochim Biophys Acta 1757(5-6):562-6 Details

Mander PK, Jekabsone A, Brown GC (2006), “Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase.” J Immunol 176(2):1046-52 Details

2005

Mander P, Borutaite V, Moncada S, Brown GC (2005), “Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death.” J Neurosci Res 79(1-2):208-15 Details

Mander P, Brown GC (2005), “Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration.” J Neuroinflammation 2:20 Details

2004

Brown GC, Borutaite V (2004), “Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols.” Biochim Biophys Acta 1658(1-2):44-9 Details

Mander P, Brown GC (2004), “Nitric oxide, hypoxia and brain inflammation.” Biochem Soc Trans 32(Pt 6):1068-9 Details

Yung HW, Bal-Price AK, Brown GC, Tolkovsky AM (2004), “Nitric oxide-induced cell death of cerebrocortical murine astrocytes is mediated through p53- and Bax-dependent pathways.” J Neurochem 89(4):812-21 Details

2003

Brown GC, Bal-Price A (2003), “Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria.” Mol Neurobiol 27(3):325-55 Details

2002

Bal-Price A, Matthias A, Brown GC (2002), “Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production.” J Neurochem 80(1):73-80 Details

Bal-Price A, Moneer Z, Brown GC (2002), “Nitric oxide induces rapid, calcium-dependent release of vesicular glutamate and ATP from cultured rat astrocytes.” Glia 40(3):312-23 Details

Golde S, Chandran S, Brown GC, Compston A (2002), “Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression.” J Neurochem 82(2):269-82 Details

2001

Bal-Price A, Brown GC (2001), “Inflammatory neurodegeneration mediated by nitric oxide from activated glia, inhibiting neuronal respiration, causing glutamate release and excitoxicity” J Neuroscience 21:6480-6491

Bal-Price A, Brown GC (2001), “Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity.” J Neurosci 21(17):6480-91 Details