Dr Guy Williams
University position
Senior Research Associate
Dr Guy Williams is pleased to consider applications from prospective PhD students.
Departments
Department of Clinical Neurosciences
Institutes
Home page
Research Theme
Interests
Our group’s research interests lie broadly in nuclear magnetic resonance (NMR). This phenomenon allows data to be collected noninvasively on both the structure and function of the human brain. We research novel acquisition methods to provide contrasts relevant for neuroscience. As a group embedded in the WBIC, the common theme is to translate basic physics research into relevant tools for a range of neuroscience investigations.
For example, we are developing and optimising pulse sequences for inferring the diffusion characteristics in the brain. These provide a useful tool for assessing tissue following head trauma and for dementia projects. We also have interests in novel fMRI acquisitions that we are using in experiments for the investigation of the minimally conscious state.
Of equal importance is the subsequent processing and analysis of the acquired datasets. We have various interests ranging from distortion correction to optimal processing strategies for structural data.
Click image to view full-size
Research Focus
KeywordsMRI |
Clinical conditionsDementia Traumatic brain injury |
Equipment
Computational modelling
Magnetic resonance imaging (MRI)
Collaborators
Cambridge |
Key publications
Hosey TP, Harding SG, Carpenter TA, Ansorge RE, Williams GB (2008), “Application of a probabilistic double-fibre structure model to diffusion-weighted MR images of the human brain.” Magn Reson Imaging 26(2):236-45 Details
Newcombe VF, Williams GB, Nortje J, Bradley PG, Harding SG, Smielewski P, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2007), “Analysis of acute traumatic axonal injury using diffusion tensor imaging.” Br J Neurosurg 21(4):340-8 Details
Williams GB, Nestor PJ, Hodges JR (2005), “Neural correlates of semantic and behavioural deficits in frontotemporal dementia” NeuroImage 24:1042-1051 Details
Publications
2012
Ersche KD, Jones PS, Williams GB, Turton AJ, Robbins TW, Bullmore ET (2012), “Abnormal brain structure implicated in stimulant drug addiction.” Science 335(6068):601-4 Details
2011
Acosta-Cabronero J, Patterson K, Fryer TD, Hodges JR, Pengas G, Williams GB, Nestor PJ (2011), “Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story.” Brain 134(Pt 7):2025-35 Details
Ash T, Suckling J, Walter M, Ooi C, Tempelmann C, Carpenter A, Williams G (2011), “Detection of physiological noise in resting state fMRI using machine learning.” Hum Brain Mapp Details
Correia MM, Newcombe VF, Williams GB (2011), “Contrast-to-noise ratios for indices of anisotropy obtained from diffusion MRI: A study with standard clinical b-values at 3T.” Neuroimage Details
Diaz-de-Grenu LZ, Acosta-Cabronero J, Pereira JM, Pengas G, Williams GB, Nestor PJ (2011), “MRI detection of tissue pathology beyond atrophy in Alzheimer's disease: Introducing T2-VBM.” Neuroimage Details
Dickson JD, Ash TW, Williams GB, Sukstanskii AL, Ansorge RE, Yablonskiy DA (2011), “Quantitative phenomenological model of the BOLD contrast mechanism.” J Magn Reson Details
Malone IB, Ansorge RE, Williams GB, Nestor PJ, Carpenter TA, Fryer TD (2011), “Attenuation Correction Methods Suitable for Brain Imaging with a PET/MRI Scanner: A Comparison of Tissue Atlas and Template Attenuation Map Approaches.” J Nucl Med 52(7):1142-9 Details
Newcombe V, Chatfield D, Outtrim J, Vowler S, Manktelow A, Cross J, Scoffings D, Coleman M, Hutchinson P, Coles J, Carpenter TA, Pickard J, Williams G, Menon D (2011), “Mapping traumatic axonal injury using diffusion tensor imaging: correlations with functional outcome.” PLoS One 6(5):e19214 Details
Newcombe VF, Outtrim JG, Chatfield DA, Manktelow A, Hutchinson PJ, Coles JP, Williams GB, Sahakian BJ, Menon DK (2011), “Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury.” Brain 134(Pt 3):759-68 Details
Ronan L, Pienaar R, Williams G, Bullmore E, Crow TJ, Roberts N, Jones PB, Suckling J, Fletcher PC (2011), “Intrinsic curvature: a marker of millimeter-scale tangential cortico-cortical connectivity?” Int J Neural Syst 21(5):351-66 Details
Stamatakis EA, Shafto MA, Williams G, Tam P, Tyler LK (2011), “White matter changes and word finding failures with increasing age.” PLoS One 6(1):e14496 Details
2010
Acosta-Cabronero J, Williams GB, Pengas G, Nestor PJ (2010), “Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease.” Brain 133(Pt 2):529-39 Details
Clatworthy PL, Williams GB, Acosta-Cabronero J, Jones SP, Harding SG, Johansen-Berg H, Baron JC (2010), “Probabilistic tractography of the optic radiations--an automated method and anatomical validation.” Neuroimage 49(3):2001-12 Details
Dickson JD, Ash TW, Williams GB, Harding SG, Carpenter TA, Menon DK, Ansorge RE (2010), “Quantitative BOLD: the effect of diffusion.” J Magn Reson Imaging 32(4):953-61 Details
Mion M, Patterson K, Acosta-Cabronero J, Pengas G, Izquierdo-Garcia D, Hong YT, Fryer TD, Williams GB, Hodges JR, Nestor PJ (2010), “What the left and right anterior fusiform gyri tell us about semantic memory.” Brain 133(11):3256-68 Details
Newcombe VF, Williams GB, Scoffings D, Cross J, Carpenter TA, Pickard JD, Menon DK (2010), “Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications.” J Neurol Neurosurg Psychiatry 81(5):552-61 Details
Pereira JM, Xiong L, Acosta-Cabronero J, Pengas G, Williams GB, Nestor PJ (2010), “Registration accuracy for VBM studies varies according to region and degenerative disease grouping.” Neuroimage 49(3):2205-15 Details
Tasker RC, Westland AG, White DK, Williams GB (2010), “Corpus callosum and inferior forebrain white matter microstructure are related to functional outcome from raised intracranial pressure in child traumatic brain injury.” Dev Neurosci 32(5-6):374-84 Details
2009
Correia MM, Carpenter TA, Williams GB (2009), “Looking for the optimal DTI acquisition scheme given a maximum scan time: are more b-values a waste of time?” Magn Reson Imaging 27(2):163-75 Details
Davies RR, Scahill VL, Graham A, Williams GB, Graham KS, Hodges JR (2009), “Development of an MRI rating scale for multiple brain regions: comparison with volumetrics and with voxel-based morphometry.” Neuroradiology 51(8):491-503 Details
Pengas G, Pereira JM, Williams GB, Nestor PJ (2009), “Comparative reliability of total intracranial volume estimation methods and the influence of atrophy in a longitudinal semantic dementia cohort.” J Neuroimaging 19(1):37-46 Details
Pereira JM, Williams GB, Acosta-Cabronero J, Pengas G, Spillantini MG, Xuereb JH, Hodges JR, Nestor PJ (2009), “Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration.” Neurology 72(19):1653-60 Details
Slawik H, Salmond CH, Taylor-Tavares JV, Williams GB, Sahakian BJ, Tasker RC (2009), “Frontal cerebral vulnerability and executive deficits from raised intracranial pressure in child traumatic brain injury.” J Neurotrauma 26(11):1891-903 Details
2008
Abate MG, Trivedi M, Fryer TD, Smielewski P, Chatfield DA, Williams GB, Aigbirhio F, Carpenter TA, Pickard JD, Menon DK, Coles JP (2008), “Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity.” Neurocrit Care 9(3):319-25 Details
Acosta-Cabronero J, Williams GB, Pereira JM, Pengas G, Nestor PJ (2008), “The impact of skull-stripping and radio-frequency bias correction on grey-matter segmentation for voxel-based morphometry.” Neuroimage 39(4):1654-65 Details
Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, Sahakian BJ, Robbins TW, Bullmore ET (2008), “White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives.” Am J Psychiatry 165(10):1308-15 Details
Newcombe VF, Williams GB, Nortje J, Bradley PG, Chatfield DA, Outtrim JG, Harding SG, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2008), “Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma.” Acta Neurochir Suppl 102:247-51 Details
Pereira JM, Nestor PJ, Williams GB (2008), “Impact of inconsistent resolution on VBM studies.” Neuroimage 40(4):1711-7 Details
Stevick JW, Harding SG, Paquet U, Ansorge RE, Carpenter TA, Williams GB (2008), “Gaussian process modeling for image distortion correction in echo planar imaging.” Magn Reson Med 59(3):598-606 Details
Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, Gillard JH, Williams GB, Aigbirhio FI, Warburton EA, Østergaard L, Baron JC (2008), “How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET.” Stroke 39(3):870-7 Details
Taylor Tavares JV, Clark L, Furey ML, Williams GB, Sahakian BJ, Drevets WC (2008), “Neural basis of abnormal response to negative feedback in unmedicated mood disorders.” Neuroimage 42(3):1118-26 Details
2007
Coles JP, Fryer TD, Coleman MR, Smielewski P, Gupta AK, Minhas PS, Aigbirhio F, Chatfield DA, Williams GB, Boniface S, Carpenter TA, Clark JC, Pickard JD, Menon DK (2007), “Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.” Crit Care Med 35(2):568-78 Details
2006
Lucas AJ, Hawkes RC, Ansorge RE, Williams GB, Nutt RE, Clark JC, Fryer TD, Carpenter TA (2006), “Development of a combined microPET-MR system.” Technol Cancer Res Treat 5(4):337-41 Details
Perry RJ, Graham A, Williams G, Rosen H, Erzinçlioglu S, Weiner M, Miller B, Hodges J (2006), “Patterns of frontal lobe atrophy in frontotemporal dementia: a volumetric MRI study.” Dement Geriatr Cogn Disord 22(4):278-87 Details
Salmond CH, Menon DK, Chatfield DA, Williams GB, Pena A, Sahakian BJ, Pickard JD (2006), “Diffusion tensor imaging in chronic head injury survivors: correlations with learning and memory indices.” Neuroimage 29(1):117-24 Details
2005
Cunningham AS, Salvador R, Coles JP, Chatfield DA, Bradley PG, Johnston AJ, Steiner LA, Fryer TD, Aigbirhio FI, Smielewski P, Williams GB, Carpenter TA, Gillard JH, Pickard JD, Menon DK (2005), “Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury.” Brain 128(Pt 8):1931-42 Details
Hosey T, Williams G, Ansorge R (2005), “Inference of multiple fiber orientations in high angular resolution diffusion imaging.” Magn Reson Med 54(6):1480-9 Details
Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK (2005), “Imaging of cerebral blood flow and metabolism in brain injury in the ICU.” Acta Neurochir Suppl 95:459-64 Details
2004
Coles JP, Fryer TD, Smielewski P, Chatfield DA, Steiner LA, Johnston AJ, Downey SP, Williams GB, Aigbirhio F, Hutchinson PJ, Rice K, Carpenter TA, Clark JC, Pickard JD, Menon DK (2004), “Incidence and mechanisms of cerebral ischemia in early clinical head injury.” J Cereb Blood Flow Metab 24(2):202-11 Details
Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smieleweski P, Chatfield DA, Aigbirhio F, Williams GB, Boniface S, Rice K, Clark JC, Pickard JD, Menon DK (2004), “Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?” Brain 127(Pt 11):2479-90 Details
Davies RR, Graham KS, Xuereb JH, Williams GB, Hodges JR (2004), “The human perirhinal cortex and semantic memory.” Eur J Neurosci 20(9):2441-6 Details
Ho AK, Nestor PJ, Williams GB, Bradshaw JL, Sahakian BJ, Robbins TW, Barker RA (2004), “Pseudo-neglect in Huntington's disease correlates with decreased angular gyrus density.” Neuroreport 15(6):1061-4 Details
Thompson SA, Graham KS, Williams G, Patterson K, Kapur N, Hodges JR (2004), “Dissociating person-specific from general semantic knowledge: roles of the left and right temporal lobes.” Neuropsychologia 42(3):359-70 Details
2003
Nestor PJ, Graham NL, Fryer TD, Williams GB, Patterson K, Hodges JR (2003), “Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula.” Brain 126(Pt 11):2406-18 Details
2001
Galton CJ, Patterson K, Graham K, Lambon-Ralph MA, Williams G, Antoun N, Sahakian BJ, Hodges JR (2001), “Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia.” Neurology 57(2):216-25 Details
1999
Williams GB, Fisher BJ, Huang CL, Carpenter TA, Hall LD (1999), “Design of biplanar gradient coils for magnetic resonance imaging of the human torso and limbs.” Magn Reson Imaging 17(5):739-54 Details
Research and Collaboration
News, events and seminars
Information for...
