Guido Buonincontri

University position

Research Associate

Departments

Department of Medicine

Institutes

Wolfson Brain Imaging Centre

Email

gb396@cam.ac.uk

Research Theme

Clinical and Veterinary Neuroscience

Interests

I am mainly interested in hardware and software development for PET and MRI. My research aims to implement and extend the latest MR imaging techniques for assessing cardiovascular and cerebrovascular function in animal models of heart failure, stroke and neurodegenerative disease. Improved technology allows more sensitive measurement of dysfunction for better assessment of drugs and interventional treatment.

FDG PET and late gadolinium MRI of a mouse heart.
FDG PET and late gadolinium MRI of a mouse heart.
Click image to view full-size

Research Focus

Keywords

PET

MRI

Clinical conditions

Huntington's disease

Myocardial infarction

Stroke

Equipment

Magnetic resonance imaging (MRI)

Positron Emission Tomography (PET)

Collaborators

Cambridge

Thomas Krieg

Jenny Morton

Stephen Sawiak

Associated News Items


    Key publications

    Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Functional assessment of the mouse heart by MRI with a 1-min acquisition.” NMR Biomed Details

    G Buonincontri, C Methner, T Krieg, RC Hawkes, T A Carpenter, S J Sawiak (2014), “PET/MRI assessment of the infarcted mouse heart” Nucl Instr and Meth in Physics Research Section A 734:152-155

    Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2013), “A fast protocol for infarct quantification in mice.” J Magn Reson Imaging Details

    Publications

    2014

    Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Trajectory correction for free-breathing radial cine MRI.” Magn Reson Imaging 32(7):961-4 Details

    Buonincontri G, Wood NI, Puttick SG, Ward AO, Carpenter TA, Sawiak SJ, Morton AJ (2014), “Right ventricular dysfunction in the R6/2 transgenic mouse model of Huntington's disease is unmasked by dobutamine.” J Huntingtons Dis 3(1):25-32 Details

    Chouchani ET, Methner C, Buonincontri G, Hu CH, Logan A, Sawiak SJ, Murphy MP, Krieg T (2014), “Complex I deficiency due to selective loss of ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.” PLoS One 9(4):e94157 Details

    Methner C, Chouchani ET, Buonincontri G, Pell VR, Sawiak SJ, Murphy MP, Krieg T (2014), “Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.” Eur J Heart Fail 16(7):712-7 Details

    2013

    Buonincontri G, Methner C, Carpenter TA, Hawkes RC, Sawiak SJ, Krieg T (2013), “MRI and PET in mouse models of myocardial infarction.” J Vis Exp (82):e50806 Details

    Buonincontri G, Sawiak SJ, Methner C, Krieg T, Hawkes RC, Carpenter TA (2013), “PET/MRI in the infarcted mouse heart with the Cambridge split magnet.” Nucl Instrum Methods Phys Res A 702 Details

    Methner C, Buonincontri G, Hu CH, Vujic A, Kretschmer A, Sawiak S, Carpenter A, Stasch JP, Krieg T (2013), “Riociguat reduces infarct size and post-infarct heart failure in mouse hearts: insights from MRI/PET imaging.” PLoS One 8(12):e83910 Details

    2012

    Wood NI, Sawiak SJ, Buonincontri G, Niu Y, Kane AD, Carpenter TA, Giussani DA, Morton AJ (2012), “Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease.” J Huntingtons Dis 1(1) Details