Dr Grant Hill-Cawthorne

Grant Hill-Cawthorne

University position

Clinical Research Associate

Departments

Department of Clinical Neurosciences

Institutes

Neurology Unit

Email

gah31@cam.ac.uk

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

Alemtuzumab is a monoclonal antibody against CD52 on many haematopoietic cells. It is licensed for B cell lymphoma and is currently in phase III trials for relapsing-remitting MS. Alemtuzumab causes a profound neutropenia following treatment with a gradual recovery of lymphocyte subsets. We are looking back over previous patients treated with alemtuzumab for multiple sclerosis to examine their lymphocyte recovery and how this is related to autoimmunity and age.

Research Focus

Keywords

Neurology

Immunology

Virology

Clinical conditions

Autoimmune diseases

Encephalitis

I have a particular interest in virology and immunology of the central nervous system.

Meningitis

Multiple sclerosis

Prion diseases

Equipment

ELISA, RT-PCR, next generation sequencing, bioinformatics

Collaborators

Cambridge

Alasdair Coles

Alastair Compston

Joanne Jones

United Kingdom

Geoff Hales

Hermann Waldmann

International

Ziad Memish

Arnab Pain

Associated News Items


    Key publications

    Jones JL, Thompson SA, Loh P, Davies JL, Tuohy OC, Curry AJ, Azzopardi L, Hill-Cawthorne G, Fahey MT, Compston A, Coles AJ (2013), “Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation.” Proc Natl Acad Sci U S A 110(50):20200-5 Details

    National Clinical Guideline Centre, Royal College of Physicians (2013), “Hepatitis B (chronic): diagnosis and management of chronic hepatitis B in children, young people and adults.” National Institute for Health and Care Excellence, London

    Sarri G, Westby M, Bermingham S, Hill-Cawthorne G, Thomas H, Guideline Development Group (2013), “Diagnosis and management of chronic hepatitis B in children, young people, and adults: summary of NICE guidance.” BMJ 346:f3893 Details

    Somerfield J, Hill-Cawthorne GA, Lin A, Zandi MS, McCarthy C, Jones JL, Willcox M, Shaw D, Thompson SA, Compston AS, Hale G, Waldmann H, Coles AJ (2010), “A novel strategy to reduce the immunogenicity of biological therapies.” J Immunol 185(1):763-8 Details

    Publications

    2015

    Ali A, Hasan Z, McNerney R, Mallard K, Hill-Cawthorne G, Coll F, Nair M, Pain A, Clark TG, Hasan R (2015), “Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.” PLoS One 10(2):e0117771 Details

    Coll F, McNerney R, Preston MD, Guerra-Assunção JA, Warry A, Hill-Cawthorne G, Mallard K, Nair M, Miranda A, Alves A, Perdigão J, Viveiros M, Portugal I, Hasan Z, Hasan R, Glynn JR, Martin N, Pain A, Clark TG (2015), “Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences.” Genome Med 7(1):51 Details

    Gurjav U, Jelfs P, Hill-Cawthorne GA, Marais BJ, Sintchenko V (2015), “Genotype heterogeneity of Mycobacterium tuberculosis within geospatial hotspots suggests foci of imported infection in Sydney, Australia.” Infect Genet Evol Details

    McCallum N, Gray TJ, Wang Q, Ng J, Hicks L, Nguyen T, Yuen M, Hill-Cawthorne GA, Sintchenko V (2015), “Genomic epidemiology of Clostridium botulinum isolates from temporally related cases of infant botulism in New South Wales, Australia.” J Clin Microbiol Details

    2014

    Abd El Ghany M, Chander J, Mutreja A, Rashid M, Hill-Cawthorne GA, Ali S, Naeem R, Thomson NR, Dougan G, Pain A (2014), “The Population Structure of Vibrio cholerae from the Chandigarh Region of Northern India.” PLoS Negl Trop Dis 8(7):e2981 Details

    Azeem M, Tashani M, Barasheed O, Heron L, Hill-Cawthorne GA, Haworth E, Dwyer DE, Rashid H, Booy R (2014), “Knowledge, Attitude and Practice (KAP) Survey Concerning Antimicrobial Use Among Australian Hajj Pilgrims.” Infect Disord Drug Targets Details

    Banerjee A, Mor SM, Kok J, Sorrell TC, Hill-Cawthorne GA (2014), “Vulnerability, hysteria and fear - conquering Ebola virus.” Med J Aust 201(6):320-1 Details

    Coll F, Preston M, Guerra-Assunção JA, Hill-Cawthorn G, Harris D, Perdigão J, Viveiros M, Portugal I, Drobniewski F, Gagneux S, Glynn JR, Pain A, Parkhill J, McNerney R, Martin N, Clark TG (2014), “PolyTB: A genomic variation map for Mycobacterium tuberculosis.” Tuberculosis (Edinb) Details

    Hill-Cawthorne GA, Hudson LO, El Ghany MF, Piepenburg O, Nair M, Dodgson A, Forrest MS, Clark TG, Pain A (2014), “Recombinations in Staphylococcal Cassette Chromosome mec Elements Compromise the Molecular Detection of Methicillin Resistance in Staphylococcus aureus.” PLoS One 9(6):e101419 Details

    Outhred AC, Jelfs P, Suliman B, Hill-Cawthorne GA, Crawford AB, Marais BJ, Sintchenko V (2014), “Added value of whole-genome sequencing for management of highly drug-resistant TB.” J Antimicrob Chemother Details

    Perdigão J, Silva H, Machado D, Macedo R, Maltez F, Silva C, Jordao L, Couto I, Mallard K, Coll F, Hill-Cawthorne GA, McNerney R, Pain A, Clark TG, Viveiros M, Portugal I (2014), “Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.” BMC Genomics 15(1):991 Details

    Tuohy O, Costelloe L, Hill-Cawthorne G, Bjornson I, Harding K, Robertson N, May K, Button T, Azzopardi L, Kousin-Ezewu O, Jones J, Compston DA, Coles A (2014), “Alemtuzumab treatment of multiple sclerosis: long-term safety and efficacy.” J Neurol Neurosurg Psychiatry Details

    2013

    Campion S, Hill-Cawthorne GA, Pain A (2013), “Malaria” Clinical Genomics: Practical Applications in Adult Patient Care

    Sarri G, Ritchie G, Hill-Cawthorne G (2013), “ Identification, testing, and support are key in chronic hepatitis B” Clinical Guidelines in Practice 16(11)

    Sarri G, Westby M, Kelsey A, Ritchie G, Hill-Cawthorne G, Thomas H (2013), “Chronic hepatitis B in children, young people and adults: summary of the new NICE guideline.” Viral Hepatitis in Practice

    2012

    Hill-Cawthorne GA, Button T, Tuohy O, Jones JL, May K, Somerfield J, Green A, Giovannoni G, Compston DA, Fahey MT, Coles AJ (2012), “Long term lymphocyte reconstitution after alemtuzumab treatment of multiple sclerosis.” J Neurol Neurosurg Psychiatry 83(3):298-304 Details

    Reid AJ, Vermont SJ, Cotton JA, Harris D, Hill-Cawthorne GA, Könen-Waisman S, Latham SM, Mourier T, Norton R, Quail MA, Sanders M, Shanmugam D, Sohal A, Wasmuth JD, Brunk B, Grigg ME, Howard JC, Parkinson J, Roos DS, Trees AJ, Berriman M, Pain A, Wastling JM (2012), “Comparative Genomics of the Apicomplexan Parasites Toxoplasma gondii and Neospora caninum: Coccidia Differing in Host Range and Transmission Strategy.” PLoS Pathog 8(3):e1002567 Details

    2010

    Deveson P, Goodyear H, Savage W, Bolsin S, Polnay L, Cass H, 228 other doctors (2010), “Support for child-protection whistleblower Kim Holt.” Lancet 375(9723):1343 Details

    Hill-Cawthorne GA, Schelenz S, Lawes M, Dervisevic S (2010), “Oseltamivir-resistant pandemic (H1N1) 2009 in patient with impaired immune system.” Emerg Infect Dis 16(7):1185-6 Details

    2009

    Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C, Banerjee-Basu S, Baron-Cohen S (2009), “Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.” Autism Res 2(3):157-177 Details

    2008

    Benson J, Wishart GC, Hill-Cawthorne G, Forouhi P, Pinder S, Provenzano E (2008), “The role of sentinel node biopsy in patients with a pre-operative diagnosis of ductal carcinoma in situ” EJC SUPPLEMENTS 6(7): 131

    Liau SS, Hill-Cawthorne G, Wishart GC, Wells FC (2008), “Use of an improvised sternal retractor for mediastinal parathyroidectomy through a cervical incision.” Ann R Coll Surg Engl 90(5):430-1 Details

    2007

    Benson JR, Wishart GC, Forouhi P, Hill-Cawthorne G, Pinder SE (2007), “The role of sentinel node biopsy in patients with a pre-operative diagnosis of ductal carcinoma in situ” EJC SUPPLEMENTS 5(3): 22