Dr Kristian Franze
Dr Kristian Franze is pleased to consider applications from prospective PhD students.
http://www.pdn.cam.ac.uk/staff/f... (personal home page)
We are taking an interdisciplinary approach to investigate how cellular forces, local cell and tissue compliance and cellular mechanosensitivity contribute to CNS development and disease. Methods we are exploiting include atomic force microscopy, traction force microscopy, custom-built simple and complex compliant cell culture substrates, optical microscopy including confocal laser scanning microscopy and cell biological techniques. We have shown, for example, that nervous tissue is mechanically inhomogeneous. Furthermore, we found that neurons constantly exert forces on their environment and that both neurons and glial cells respond to mechanical stimuli. Understanding how and when CNS cells actively exert forces and respond to their mechanical environment will shed new light on CNS development, and it could eventually lead to novel biomedical approaches to treat or circumvent pathologies that involve mechanical signalling, such as spinal cord injuries.
Atomic force microscopy
Compliant cell culture substrates
Open laser systems
Traction force microscopy
Associated News Items
Koser DE, Moeendarbary E, Hanne J, Kuerten S, Franze K (2015), “CNS cell distribution and axon orientation determine local spinal cord mechanical properties.” Biophys J 108(9):2137-47 Details
Moshayedi P, Ng G, Kwok JC, Yeo GS, Bryant CE, Fawcett JW, Franze K, Guck J (2014), “The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system.” Biomaterials 35(13):3919-25 Details
Pagliara S, Franze K, McClain CR, Wylde GW, Fisher CL, Franklin RJ, Kabla AJ, Keyser UF, Chalut KJ (2014), “Auxetic nuclei in embryonic stem cells exiting pluripotency.” Nat Mater 13(6):638-44 Details
Franze K (2013), “The mechanical control of nervous system development.” Development 140(15):3069-77 Details
Hardie RC, Franze K (2012), “Photomechanical responses in Drosophila photoreceptors.” Science 338(6104):260-3 Details
Betz T, Koch D, Lu YB, Franze K, Käs JA (2011), “Growth cones as soft and weak force generators.” Proc Natl Acad Sci U S A 108(33):13420-5 Details