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Kristian Franze

University Position
Professor

Interests

We are taking an interdisciplinary approach to investigate how cellular forces, local cell and tissue stiffness and cellular mechanosensitivity contribute to CNS development and disease. Methods we are exploiting include atomic force microscopy, traction force microscopy, custom-built simple and complex compliant cell culture substrates, optogenetics and cell biological techniques.

Key Publications

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons.

DOI: http://doi.org/10.1016/j.cell.2018.11.030
Journal: Cell
E-pub date: 10 Jan 2019
Authors: J-M Cioni, JQ Lin, AV Holtermann, M Koppers, MAH Jakobs, A Azizi, B Turner-Bridger, T Shigeoka, K Franze, WA Harris, CE Holt

Publications

Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation

DOI: http://doi.org/10.1101/2022.10.04.510780
Journal:
E-pub date: 1 Aug 2022
Authors: F van Tartwijk, LCS Wunderlich, I Mela, S Makarchuk, MAH Jakobs, S Qamar, K Franze, GK Schierle, P St George-Hyslop, JQ Lin, C Holt, C Kaminski