Dr Kristian Franze
Dr Kristian Franze is pleased to consider applications from prospective PhD students.
http://www.pdn.cam.ac.uk/staff/f... (personal home page)
I am mainly interested in the mechanics and optics of cells of the nervous system.
Using atomic force and confocal microscopy as well as a dual-beam IR-laser trap called 'optical stretcher' passive and active mechanical properties of nervous tissue and cells are determined and the interactions between individual neurons and glial cells and cell culture substrates of different compliance are investigated. Optical properties particularly of retinal cells and tissue are illuminated using self-built setups.
Foreign body reactions
Injured peripheral nerves
Spinal cord injury
Traumatic brain injury
Atomic force microscopy
Compliant cell culture substrates
Open laser systems
Traction force microscopy
Luciano da F. Costa
Franze K, Gerdelmann J, Weick M, Betz T, Pawlizak S, Lakadamyali M, Bayer J, Rillich K, Gögler M, Lu YB, Reichenbach A, Janmey P, Käs J (2009), “Neurite branch retraction is caused by a threshold-dependent mechanical impact.” Biophys J 97(7):1883-90 Details
Franze K, Grosche J, Skatchkov SN, Schinkinger S, Foja C, Schild D, Uckermann O, Travis K, Reichenbach A, Guck J (2007), “Muller cells are living optical fibers in the vertebrate retina.” Proc Natl Acad Sci U S A 104(20):8287-92 Details
Lu YB, Franze K, Seifert G, Steinhäuser C, Kirchhoff F, Wolburg H, Guck J, Janmey P, Wei EQ, Käs J, Reichenbach A (2006), “Viscoelastic properties of individual glial cells and neurons in the CNS.” Proc Natl Acad Sci U S A 103(47):17759-64 Details