Dr Faye Begeti

Interests

Problems in cognition are a part of Huntington’s disease (HD) and have a significant impact on quality of life. My main research interest is to investigate the cognitive aspects of HD with the aim of translating animal research into the clinic in order to facilitate the development of future therapies.

Emerging evidence from HD animal models has suggested that the hippocampus, a key structure in learning and memory which if damaged can lead to amnesia, is affected in HD. I am currently using analogous tests to those which have been used in mice to test premanifest and manifest HD gene carriers as well as controls.

Concurrently, I am doing comparable experiments on mice focusing on the neuronal growth in the hippocampus, which is one of only two areas in the brain capable of neurogenesis, a process which plays a key role in learning and memory. This neuronal production is decreased in HD mice and I am investigating the cause and testing potential treatments to remedy this.

Neurogenesis in the dentate gyrus showing proliferating cells (green), immature neurons (red) and mature granule cells (blue)
Neurogenesis in the dentate gyrus showing proliferating cells (green), immature neurons (red) and mature granule cells (blue)
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Research Focus

Keywords

Huntington's

neurodegeneration

cognition

neurogenesis

hippocampus

Clinical conditions

Huntington's disease

Equipment

Behavioural analysis

Confocal microscopy

Cross-sectional and cohort studies

Immunohistochemistry

Microscopy

Neuropsychological testing

Collaborators

No collaborators listed

Associated News Items


    Publications

    2015

    Mason SL, Zhang J, Begeti F, Guzman NV, Lazar AS, Rowe JB, Barker RA, Hampshire A (2015), “The role of the amygdala during emotional processing in Huntington's disease: from pre-manifest to late stage disease.” Neuropsychologia 70:80-9 Details

    2014

    Choi ML, Begeti F, Oh JH, Lee SY, O'Keeffe GC, Clelland CD, Tyers P, Cho ZH, Kim YB, Barker RA (2014), “Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease.” Neurobiol Dis 66:19-27 Details

    2013

    Begeti F, Tan AY, Cummins GA, Collins LM, Guzman NV, Mason SL, Barker RA (2013), “The Addenbrooke's Cognitive Examination-Revised accurately detects cognitive decline in Huntington's disease.” J Neurol 260(11):2777-85 Details

    2012

    Milton AL, Schramm MJ, Wawrzynski JR, Gore F, Oikonomou-Mpegeti F, Wang NQ, Samuel D, Economidou D, Everitt BJ (2012), “Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli.” Psychopharmacology (Berl) 219(3):751-61 Details