Dr Fiona Matthews

Fiona Matthews

University position

Senior Statistician (Programme Leader)

Dr Fiona Matthews is pleased to consider applications from prospective PhD students.

Institutes

Medical Research Council Biostatistics Unit and Medical Research Council Cognitive Function and Ageing Study

Home page

http://www.mrc-bsu.cam.ac.uk/BSUsite... (personal home page)

Research Theme

Cognitive and Behavioural Neuroscience

Interests

Drawing on the data resource of the MRC Cognitive Function and Ageing study, but additionally using other population based studies; my programme provides methodologically sound estimates of health and ill health for populations. The methodological problems of missing data, misclassification of diseases and the impact of study design are common themes. Specific aims are to develop methods for estimating longitudinal healthy active life expectancy, generic models for measuring individuals’ trajectories of change (including cognitive trajectories) and incidence of disease estimates (such as dementia incidence) in the presence of informative missing data and complex study designs.

The methods developed are implemented in parallel with papers that focus on the clinical importance of the measure and hence we produce population based methodologically sound estimates that will have direct policy impact.

Research Focus

Keywords

biostatistics

missing data

ageing

trajectories

epidemiology

Clinical conditions

Alzheimer's disease

Autism

Cognitive impairment

Dementia

Equipment

Bayesian modelling

Biostatistical analysis

Collaborators

Cambridge

Carol Brayne

United Kingdom

John Bond Web: http://www.ncl.ac.uk/ihs/peo...

Paul Ince Web: http://www.shef.ac.uk/medicin...

Carol Jagger Web: http://www2.le.ac.uk/departm...

Ian McKeith Web: http://www.ncl.ac.uk/iah/sta...

International

Scott Hofer Web: http://web.uvic.ca/psyc/pe...

Associated News Items


    Key publications

    Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, Brayne C, Medical Research Council Cognitive Function and Ageing Collaboration (2013), “A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II.” Lancet 382(9902):1405-12 Details

    Marioni RE, Valenzuela MJ, van den Hout A, Brayne C, Matthews FE, MRC Cognitive Function and Ageing Study (2012), “Active cognitive lifestyle is associated with positive cognitive health transitions and compression of morbidity from age sixty-five.” PLoS One 7(12):e50940 Details

    Brayne C, Stephan BC, Matthews FE (2011), “A European perspective on population studies of dementia.” Alzheimers Dement 7(1):3-9 Details

    van den Hout A, Muniz-Terrera G, Matthews FE (2011), “Smooth random change point models.” Stat Med 30(6):599-610 Details

    EClipSE Collaborative Members, Brayne C, Ince PG, Keage HA, McKeith IG, Matthews FE, Polvikoski T, Sulkava R (2010), “Education, the brain and dementia: neuroprotection or compensation?” Brain 133(Pt 8):2210-6 Details

    van den Hout A, Matthews FE (2010), “Estimating stroke-free and total life expectancy in the presence of non-ignorable missing values.” J R Stat Soc Ser A Stat Soc 173(2):331-349 Details

    Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB, Ince P (2009), “Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study.” PLoS Med 6(11):e1000180 Details

    Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2009), “Age, neuropathology, and dementia.” N Engl J Med 360(22):2302-9 Details

    Xie J, Brayne C, Matthews FE, Medical Research Council Cognitive Function and Ageing Study collaborators (2008), “Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up.” BMJ 336(7638):258-62 Details

    Brayne C, Gao L, Dewey M, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2006), “Dementia before death in ageing societies - the promise of prevention and the reality” PLoS Med 3(10):e397

    Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2005), “Incidence of dementia in England and Wales” PLoS Medicine 2(8):e193

    Neuropathology Group. Medical Research Council Cognitive Function and Aging Study (2001), “Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” Lancet 357(9251):169-75 Details

    Publications

    2014

    Terrera GM, Minett T, Brayne C, Matthews FE (2014), “Education associated with a delayed onset of terminal decline.” Age Ageing 43(1):26-31 Details

    2013

    Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath P, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE, Brayne C, Simpson JE, the MRC Cognitive Function and Ageing Neuropathology Study Group (2013), “Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.” Neuropathol Appl Neurobiol Details

    Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB, Ince PG, on behalf of the MRC Cognitive Function and Ageing Neuropathology Study (2013), “Brain haemosiderin in older people: pathological evidence for an ischaemic origin of MRI microbleeds.” Neuropathol Appl Neurobiol Details

    Kapetanakis V, Matthews FE, van den Hout A (2013), “A semi-Markov model for stroke with piecewise-constant hazards in the presence of left, right and interval censoring.” Stat Med 32(4):697-713 Details

    Köhler S, Allardyce J, Verhey FR, McKeith IG, Matthews F, Brayne C, Savva GM, Medical Research Council Cognitive Function and Ageing Study (2013), “Cognitive decline and dementia risk in older adults with psychotic symptoms: a prospective cohort study.” Am J Geriatr Psychiatry 21(2):119-28 Details

    Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Hollingworth P, Ramirez A, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Naranjo MC, B (2013), “Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.” Nat Genet 45(12):1452-8 Details

    Leng Y, Wainwright NW, Hayat S, Stephan BC, Matthews FE, Luben R, Surtees PG, Khaw KT, Brayne C (2013), “The association between social stress and global cognitive function in a population-based study: the European Prospective Investigation into Cancer (EPIC)-Norfolk study.” Psychol Med 43(3):655-66 Details

    Lima TA, Adler AL, Minett T, Matthews FE, Brayne C, Marioni RE, on behalf of the Medical Research Council Cognitive Function and Ageing Study (2013), “C-reactive protein, APOE genotype and longitudinal cognitive change in an older population.” Age Ageing Details

    Muniz-Terrera G, van den Hout A, Piccinin AM, Matthews FE, Hofer SM (2013), “Investigating terminal decline: results from a UK population-based study of aging.” Psychol Aging 28(2):377-85 Details

    Norton S, Matthews FE, Brayne C (2013), “A commentary on studies presenting projections of the future prevalence of dementia.” BMC Public Health 13:1 Details

    Restaino M, Matthews FE, Minett T, Albanese E, Brayne C, Stephan BC (2013), “Predicting risk of 2-year incident dementia using the CAMCOG total and subscale scores.” Age Ageing 42(5):649-53 Details

    Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carrière I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LC, Wong CH, Fung AW, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M, Dodge H, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabárbara J (2013), “COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.” BMC Neurol 13(1):165 Details

    Sun X, Allison C, Auyeung B, Matthews FE, Baron-Cohen S, Brayne C (2013), “Service provision for autism in mainland China: Preliminary mapping of service pathways.” Soc Sci Med 98:87-94 Details

    Sun X, Allison C, Auyeung B, Matthews FE, Baron-Cohen S, Brayne C (2013), “The Mandarin Chinese version of the childhood autism spectrum test (CAST): test-retest reliability.” Res Dev Disabil 34(10):3267-75 Details

    Sun X, Allison C, Auyeung B, Matthews FE, Murray S, Baron-Cohen S, Brayne C (2013), “Service provision for autism in mainland China: a service providers' perspective.” Res Dev Disabil 34(1):440-51 Details

    Sun X, Allison C, Matthews FE, Sharp SJ, Auyeung B, Baron-Cohen S, Brayne C (2013), “Prevalence of autism in mainland China, Hong Kong and Taiwan: a systematic review and meta-analysis.” Mol Autism 4(1):7 Details

    van den Hout A, Muniz-Terrera G, Matthews FE (2013), “Change point models for cognitive tests using semi-parametric maximum likelihood.” Comput Stat Data Anal 57(1):684-698 Details

    van der Linde RM, Stephan BC, Matthews FE, Brayne C, Savva GM, Medical Research Council Cognitive Function and Ageing Study (2013), “The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population.” Int J Geriatr Psychiatry 28(7):700-9 Details

    Wu YT, Lee HY, Norton S, Chen C, Chen H, He C, Fleming J, Matthews FE, Brayne C (2013), “Prevalence studies of dementia in mainland china, Hong Kong and taiwan: a systematic review and meta-analysis.” PLoS One 8(6):e66252 Details

    2012

    Davis DH, Muniz Terrera G, Keage H, Rahkonen T, Oinas M, Matthews FE, Cunningham C, Polvikoski T, Sulkava R, MacLullich AM, Brayne C (2012), “Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study.” Brain 135(Pt 9):2809-16 Details

    Keage HA, Banks S, Yang KL, Morgan K, Brayne C, Matthews FE (2012), “What sleep characteristics predict cognitive decline in the elderly?” Sleep Med 13(7):886-92 Details

    Keage HA, Ince PG, Matthews FE, Wharton SB, McKeith IG, Brayne C, MRC CFAS and CC75C (2012), “Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort.” J Alzheimers Dis 28(2):485-93 Details

    Lace G, Ince PG, Brayne C, Savva GM, Matthews FE, de Silva R, Simpson JE, Wharton SB (2012), “Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort.” Dement Geriatr Cogn Disord 34(1):15-24 Details

    Marioni RE, van den Hout A, Valenzuela MJ, Brayne C, Matthews FE, MRC Cognitive Function and Ageing Study (2012), “Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline.” J Alzheimers Dis 28(1):223-30 Details

    Matthews F, Marioni R, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2012), “Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: a population-based prospective cohort study.” BMC Geriatr 12:45 Details

    Richardson K, Hunter S, Dening T, Xuereb JH, Matthews FE, Brayne C, Fleming J, Cambridge City over-75s Cohort (CC75C) Study Neuropathology Collaboration (2012), “Neuropathological correlates of falling in the CC75C population-based sample of the older old.” Curr Alzheimer Res 9(6):697-708 Details

    Richardson K, Stephan BC, Ince PG, Brayne C, Matthews FE, Esiri MM (2012), “The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” Curr Alzheimer Res 9(6):687-96 Details

    Stephan BC, Hunter S, Harris D, Llewellyn DJ, Siervo M, Matthews FE, Brayne C (2012), “The neuropathological profile of mild cognitive impairment (MCI): a systematic review.” Mol Psychiatry 17(11):1056-76 Details

    Stephan BC, Matthews FE, Hunter S, Savva GM, Bond J, McKeith IG, Ince P, Brayne C, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2012), “Neuropathological profile of mild cognitive impairment from a population perspective.” Alzheimer Dis Assoc Disord 26(3):205-12 Details

    Stephan BC, Matthews FE, Ma B, Muniz G, Hunter S, Davis D, McKeith IG, Foster G, Ince PG, Brayne C (2012), “Alzheimer and vascular neuropathological changes associated with different cognitive States in a non-demented sample.” J Alzheimers Dis 29(2):309-18 Details

    Valenzuela MJ, Matthews FE, Brayne C, Ince P, Halliday G, Kril JJ, Dalton MA, Richardson K, Forster G, Sachdev PS, Medical Research Council Cognitive Function and Ageing Study (2012), “Multiple biological pathways link cognitive lifestyle to protection from dementia.” Biol Psychiatry 71(9):783-91 Details

    Wills AK, Lawlor DA, Muniz-Terrera G, Matthews F, Cooper R, Ghosh AK, Kuh D, Hardy R, FALCon Study Team (2012), “Population heterogeneity in trajectories of midlife blood pressure.” Epidemiology 23(2):203-11 Details

    2011

    Aarsland D, Muniz G, Matthews F (2011), “Nonlinear decline of mini-mental state examination in Parkinson's disease.” Mov Disord 26(2):334-7 Details

    Cooper R, Kuh D, Cooper C, Gale CR, Lawlor DA, Matthews F, Hardy R, FALCon and HALCyon Study Teams (2011), “Objective measures of physical capability and subsequent health: a systematic review.” Age Ageing 40(1):14-23 Details

    Fox C, Richardson K, Maidment ID, Savva GM, Matthews FE, Smithard D, Coulton S, Katona C, Boustani MA, Brayne C (2011), “Anticholinergic Medication Use and Cognitive Impairment in the Older Population: The Medical Research Council Cognitive Function and Ageing Study.” J Am Geriatr Soc Details

    Marioni RE, Chatfield M, Brayne C, Matthews FE, Medical Research Council Cognitive Function and Ageing Study Group (2011), “The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: a population-based prospective cohort study.” BMC Med Res Methodol 11:127 Details

    Marioni RE, Matthews FE, Brayne C, MRC Cognitive Function and Ageing Study (2011), “The association between late-life cognitive test scores and retrospective informant interview data.” Int Psychogeriatr 23(2):274-9 Details

    Matthews FE, Stephan BC, Khaw KT, Hayat S, Luben R, Bhaniani A, Moore S, Brayne C (2011), “Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version.” J Clin Epidemiol Details

    Muniz-Terrera G, Matthews FE, Stephan B, Brayne C, CC75C Collaboration Group (2011), “Are terminal decline and its potential indicators detectable in population studies of the oldest old?” Int J Geriatr Psychiatry 26(6):584-92 Details

    Nicoll JA, Savva GM, Stewart J, Matthews FE, Brayne C, Ince P, Medical Research Council Cognitive Function and Ageing Study (2011), “Association between APOE genotype, neuropathology and dementia in the older population of England and Wales.” Neuropathol Appl Neurobiol 37(3):285-94 Details

    Piccinin AM, Muniz G, Matthews FE, Johansson B (2011), “Terminal Decline From Within- and Between-Person Perspectives, Accounting for Incident Dementia.” J Gerontol B Psychol Sci Soc Sci Details

    Richardson K, Ananou A, Lafortune L, Brayne C, Matthews FE (2011), “Variation over time in the association between polypharmacy and mortality in the older population.” Drugs Aging 28(7):547-60 Details

    Roelfsema MT, Hoekstra RA, Allison C, Wheelwright S, Brayne C, Matthews FE, Baron-Cohen S (2011), “Are Autism Spectrum Conditions More Prevalent in an Information-Technology Region? A School-Based Study of Three Regions in the Netherlands.” J Autism Dev Disord Details

    Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2011), “Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.” Neurobiol Aging Details

    Stephan BC, Brayne C, Savva GM, Matthews FE, The Medical Research Council Cognitive Function and Ageing Study (2011), “Occurrence of medical co-morbidity in mild cognitive impairment: implications for generalisation of MCI research.” Age Ageing 40(4):501-507 Details

    Terrera GM, Piccinin AM, Johansson B, Matthews F, Hofer SM (2011), “Joint Modeling of Longitudinal Change and Survival: An Investigation of the Association Between Change in Memory Scores and Death.” GeroPsych (Bern) 24(4):177-185 Details

    Tsopelas C, Stewart R, Savva GM, Brayne C, Ince P, Thomas A, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (2011), “Neuropathological correlates of late-life depression in older people.” Br J Psychiatry 198(2):109-14 Details

    Valenzuela M, Brayne C, Sachdev P, Wilcock G, Matthews F, Medical Research Council Cognitive Function and Ageing Study (2011), “Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort.” Am J Epidemiol 173(9):1004-12 Details

    Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ, Ince PG (2011), “Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort.” Neurosci Lett 505(1):25-30 Details

    Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG (2011), “Epidemiological Neuropathology: The MRC Cognitive Function and Aging Study Experience.” J Alzheimers Dis Details

    Wills AK, Lawlor DA, Matthews FE, Aihie Sayer A, Bakra E, Ben-Shlomo Y, Benzeval M, Brunner E, Cooper R, Kivimaki M, Kuh D, Muniz-Terrera G, Hardy R (2011), “Life Course Trajectories of Systolic Blood Pressure Using Longitudinal Data from Eight UK Cohorts.” PLoS Med 8(6):e1000440 Details

    2010

    Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, Frayling TM, Murray A, Melzer D (2010), “Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.” Neurobiol Aging 31(9):1563-8 Details

    Hogervorst E, Matthews FE, Brayne C (2010), “Are optimal levels of testosterone associated with better cognitive function in healthy older women and men?” Biochim Biophys Acta 1800(10):1145-52 Details

    Keage HA, Matthews FE, Yip A, Gao L, McCracken C, McKeith IG, Rubinsztein DC, Brayne C, MRC Cognitive Function and Ageing Study (2010), “APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA Study.” Age Ageing 39(1):104-11 Details

    Llewellyn DJ, Lang IA, Matthews FE, Plassman BL, Rogers MA, Morgenstern LB, Fisher GG, Kabeto MU, Langa KM (2010), “Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.” Alzheimers Res Ther 2(3):19 Details

    Matthews FE, Muniz-Terrera G, McKeith I, Brayne C, MRC CFAS (2010), “Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance.” Int J Geriatr Psychiatry 25(7):719-24 Details

    Muniz-Terrera G, Matthews FE, Stephan B, Brayne C, the CC75C Collaboration Group (2010), “Are terminal decline and its potential indicators detectable in population studies of the oldest old?” Int J Geriatr Psychiatry

    Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE, Savva GM, Brayne C, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2010), “Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.” Neuropathol Appl Neurobiol 36(1):25-40 Details

    Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C, Ince PG (2010), “Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain.” Neurosci Lett 486(3):246-51 Details

    Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C (2010), “Dementia risk prediction in the population: are screening models accurate?” Nat Rev Neurol 6(6):318-26 Details

    Stephan BC, Savva GM, Brayne C, Bond J, McKeith IG, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2010), “Optimizing mild cognitive impairment for discriminating dementia risk in the general older population.” Am J Geriatr Psychiatry 18(8):662-73 Details

    Terrera GM, Brayne C, Matthews F, CC75C Study Collaboration Group (2010), “One size fits all? Why we need more sophisticated analytical methods in the explanation of trajectories of cognition in older age and their potential risk factors.” Int Psychogeriatr 22(2):291-9 Details

    van den Hout A, Muniz-Terrera G, Matthews FE (2010), “Smooth random change point models.” Stat Med

    van der Linde R, Stephan BC, Matthews FE, Brayne C, Savva GM, Medical Research Council Cognitive Function and Ageing Study (2010), “Behavioural and psychological symptoms in the older population without dementia--relationship with socio-demographics, health and cognition.” BMC Geriatr 10:87 Details

    2009

    Baron-Cohen S, Scott FJ, Allison C, Williams J, Bolton P, Matthews FE, Brayne C (2009), “Prevalence of autism-spectrum conditions: UK school-based population study.” Br J Psychiatry 194(6):500-9 Details

    Brayne C, Richardson K, Matthews FE, Fleming J, Hunter S, Xuereb JH, Paykel E, Mukaetova-Ladinska EB, Huppert FA, O'Sullivan A, Dening T, Cambridge City Over-75s Cohort Cc75c Study Neuropathology Collaboration (2009), “Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study.” J Alzheimers Dis 18(3):645-58 Details

    Byford M, Brayne C, McKeith I, Chatfield M, Ince P, Matthews F, MRC CFAS Neuropathology group (2009), “Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study.” BMC Geriatr 9:22 Details

    EClipSE Collaborative Members (2009), “Cohort profile: Epidemiological Clinicopathological studies in Europe (EClipSE).” J Alzheimers Dis 18(3):659-63 Details

    Lace G, Savva GM, Forster G, de Silva R, Brayne C, Matthews FE, Barclay JJ, Dakin L, Ince PG, Wharton SB, MRC-CFAS (2009), “Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.” Brain 132(Pt 5):1324-34 Details

    Llewellyn DJ, Lang IA, Langa KM, Naughton F, Matthews FE (2009), “Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement.” BMJ 338:b462 Details

    Llewellyn DJ, Matthews FE (2009), “Increasing levels of semantic verbal fluency in elderly English adults.” Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16(4):433-45 Details

    Matthews FE, Jagger C, Miller LL, Brayne C, MRC CFAS (2009), “Education differences in life expectancy with cognitive impairment.” J Gerontol A Biol Sci Med Sci 64(1):125-31 Details

    Muniz-Terrera G, Matthews F, Dening T, Huppert FA, Brayne C, CC75C Group (2009), “Education and trajectories of cognitive decline over 9 years in very old people: methods and risk analysis.” Age Ageing 38(3):277-82 Details

    Ngondi J, Reacher M, Matthews F, Brayne C, Emerson P (2009), “Trachoma survey methods: a literature review.” Bull World Health Organ 87(2):143-51 Details

    Ngondi J, Reacher MH, Matthews FE, Brayne C, Gatpan G, Becknell S, Kur L, King J, Callahan K, Emerson PM (2009), “Risk factors for trachomatous trichiasis in children: cross-sectional household surveys in Southern Sudan.” Trans R Soc Trop Med Hyg 103(3):305-14 Details

    Ngondi JM, Matthews FE, Reacher MH, King J, Brayne C, Gouda H, Emerson PM (2009), “What will happen if we do nothing to control trachoma: health expectancies for blinding trachoma in southern Sudan.” PLoS Negl Trop Dis 3(3):e396 Details

    Rochester MA, Pashayan N, Matthews F, Doble A, McLoughlin J (2009), “Development and validation of risk score for predicting positive repeat prostate biopsy in patients with a previous negative biopsy in a UK population.” BMC Urol 9:7 Details

    Savva GM, Zaccai J, Matthews FE, Davidson JE, McKeith I, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2009), “Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population.” Br J Psychiatry 194(3):212-9 Details

    Seidel D, Crilly N, Matthews FE, Jagger C, Brayne C, Clarkson PJ, Medical Research Council Cognitive Function and Ageing Study (2009), “Patterns of functional loss among older people: a prospective analysis.” Hum Factors 51(5):669-80 Details

    Seidel D, Jagger C, Brayne C, Matthews FE, Cfas M (2009), “Recovery in instrumental activities of daily living (IADLs): findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” Age Ageing 38(6):663-8 Details

    Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Ince PG, Medical Research Council Cognitive Function and Ageing Study Neuropathology Group (2009), “Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.” Stroke 40(2):369-75 Details

    Stephan BC, Matthews FE, Khaw KT, Dufouil C, Brayne C (2009), “Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND).” Alzheimers Res Ther 1(1):4 Details

    van den Hout A, Matthews FE (2009), “Estimating dementia-free life expectancy for Parkinson's patients using Bayesian inference and microsimulation.” Biostatistics 10(4):729-43 Details

    van den Hout A, Matthews FE (2009), “A piecewise-constant Markov model and the effects of study design on the estimation of life expectancies in health and ill health.” Stat Methods Med Res 18(2):145-62 Details

    Wharton SB, O'Callaghan JP, Savva GM, Nicoll JA, Matthews F, Simpson JE, Forster G, Shaw PJ, Brayne C, Ince PG, MRC Cognitive Function and Ageing Neuropathology Study Group (2009), “Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia.” Dement Geriatr Cogn Disord 27(5):465-73 Details

    Wright CF, Hall A, Matthews FE, Brayne C (2009), “Biomarkers, dementia, and public health.” Ann N Y Acad Sci 1180:11-9 Details

    2008

    Basta NE, Matthews FE, Chatfield MD, Brayne C, MRC-CFAS (2008), “Community-level socio-economic status and cognitive and functional impairment in the older population.” Eur J Public Health 18(1):48-54 Details

    Buter TC, van den Hout A, Matthews FE, Larsen JP, Brayne C, Aarsland D (2008), “Dementia and survival in Parkinson disease: a 12-year population study.” Neurology 70(13):1017-22 Details

    Fleming J, Matthews FE, Brayne C, Cambridge City over-75s Cohort (CC75C) study collaboration (2008), “Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study.” BMC Geriatr 8:6 Details

    Gao L, Matthews FE, Sargeant LA, Brayne C, MRC CFAS (2008), “An investigation of the population impact of variation in HbA1c levels in older people in England and Wales: from a population based multi-centre longitudinal study.” BMC Public Health 8:54 Details

    Hogervorst E, Huppert F, Matthews FE, Brayne C (2008), “Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study.” Psychoneuroendocrinology 33(7):1013-22 Details

    Kvaal K, McDougall FA, Brayne C, Matthews FE, Dewey ME, MRC CFAS (2008), “Co-occurrence of anxiety and depressive disorders in a community sample of older people: results from the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study).” Int J Geriatr Psychiatry 23(3):229-37 Details

    Matthews FE, Stephan BC, McKeith IG, Bond J, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2008), “Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?” J Am Geriatr Soc 56(8):1424-33 Details

    Pérès K, Jagger C, Matthews FE, MRC CFAS (2008), “Impact of late-life self-reported emotional problems on Disability-Free Life Expectancy: results from the MRC Cognitive Function and Ageing Study.” Int J Geriatr Psychiatry 23(6):643-9 Details

    Stephan BC, Brayne C, McKeith IG, Bond J, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (2008), “Mild cognitive impairment in the older population: Who is missed and does it matter?” Int J Geriatr Psychiatry 23(8):863-71 Details

    van den Hout A, Matthews FE (2008), “Multi-state analysis of cognitive ability data: a piecewise-constant model and a Weibull model.” Stat Med 27(26):5440-55 Details

    Williams JG, Allison C, Scott FJ, Bolton PF, Baron-Cohen S, Matthews FE, Brayne C (2008), “The Childhood Autism Spectrum Test (CAST): sex differences.” J Autism Dev Disord 38(9):1731-9 Details

    Xie J, Matthews FE, Jagger C, Bond J, Brayne C (2008), “The oldest old in England and Wales: a descriptive analysis based on the MRC Cognitive Function and Ageing Study.” Age Ageing 37(4):396-402 Details

    2007

    Chatfield M, Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2007), “Using the Mini-Mental State Examination for tracking cognition in the older population based on longitudinal data.” J Am Geriatr Soc 55(7):1066-71 Details

    Jagger C, Matthews RJ, Matthews FE, Spiers NA, Nickson J, Paykel ES, Huppert FA, Brayne C, Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) (2007), “Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS).” BMC Public Health 7:156 Details

    Matthews FE, McKeith I, Bond J, Brayne C, MRC CFAS (2007), “Reaching the population with dementia drugs: what are the challenges?” Int J Geriatr Psychiatry 22(7):627-31 Details

    Matthews FE, Stephan BC, Bond J, McKeith I, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2007), “Operationalization of mild cognitive impairment: a graphical approach.” PLoS Med 4(10):1615-9 Details

    McDougall FA, Kvaal K, Matthews FE, Paykel E, Jones PB, Dewey ME, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2007), “Prevalence of depression in older people in England and Wales: the MRC CFA Study.” Psychol Med 37(12):1787-95 Details

    McDougall FA, Matthews FE, Kvaal K, Dewey ME, Brayne C (2007), “Prevalence and symptomatology of depression in older people living in institutions in England and Wales.” Age Ageing 36(5):562-8 Details

    Stephan BC, Matthews FE, McKeith IG, Bond J, Brayne C, Medical Research Council Cognitive Function and Aging Study (2007), “Early cognitive change in the general population: how do different definitions work?” J Am Geriatr Soc 55(10):1534-40 Details

    2006

    Brayne C, Gao L, Dewey M, Matthews FE, Medical Research Council Cognitive Function and Ageing Study Investigators (2006), “Dementia before death in ageing societies--the promise of prevention and the reality.” PLoS Med 3(10):e397 Details

    Brayne C, McCracken C, Matthews FE, Medical Research Council Coginitive Function and Ageing Study (CFAS) (2006), “Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS).” Int J Epidemiol 35(5):1140-5 Details

    Foltynie T, Matthews FE, Ishihara L, Brayne C, MRC CFAS (2006), “The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort.” BMC Neurol 6:29 Details

    Matthews FE, Chatfield M, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2006), “An investigation of whether factors associated with short-term attrition change or persist over ten years: data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” BMC Public Health 6:185 Details

    Matthews FE, McKeith I, Bond J, Brayne C, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2006), “Reaching the population with dementia drugs: what are the challenges?” Int J Geriatr Psychiatry

    Matthews FE, Miller LL, Brayne C, Jagger C, Medical Research Council Cognitive Function and Aging Study (MRC CFAS) (2006), “Regional differences in multidimensional aspects of health: findings from the MRC cognitive function and ageing study.” BMC Public Health 6:90 Details

    Yip AG, Brayne C, Matthews FE, MRC Cognitive Function and Ageing Study (2006), “Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study.” Age Ageing 35(2):154-60 Details

    2005

    Barnes L, Matthews FE, Barber B, Davies L, Lloyd D, Brayne C, Parry B (2005), “Brain donation for research: consent and re-consent post Alder Hey.” Bull Med Ethics (211):17-21 Details

    Chatfield MD, Brayne CE, Matthews FE (2005), “A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies.” J Clin Epidemiol 58(1):13-9 Details

    Huppert FA, Cabelli ST, Matthews FE, MRC Cognitive Function and Ageing Study (2005), “Brief cognitive assessment in a UK population sample -- distributional properties and the relationship between the MMSE and an extended mental state examination.” BMC Geriatr 5:7 Details

    Matthews F, Brayne C, Medical Research Council Cognitive Function and Ageing Study Investigators (2005), “The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study.” PLoS Med 2(8):e193 Details

    Spiers NA, Matthews RJ, Jagger C, Matthews FE, Boult C, Robinson TG, Brayne C (2005), “Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: findings from the Medical Research Council Cognitive Function and Ageing Study.” J Gerontol A Biol Sci Med Sci 60(2):248-54 Details

    Syed A, Chatfield M, Matthews F, Harrison P, Brayne C, Esiri MM (2005), “Depression in the elderly: pathological study of raphe and locus ceruleus.” Neuropathol Appl Neurobiol 31(4):405-13 Details

    2004

    Fernando MS, Ince PG, MRC Cognitive Function and Ageing Neuropathology Study Group (2004), “Vascular pathologies and cognition in a population-based cohort of elderly people.” J Neurol Sci 226(1-2):13-7 Details

    Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG, Neuropathology Group of MRC CFAS (2004), “Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain.” Neuropathol Appl Neurobiol 30(4):385-95 Details

    Matthews FE, Chatfield M, Freeman C, McCracken C, Brayne C, MRC CFAS (2004), “Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation.” BMC Public Health 4:12 Details

    2003

    Williams JG, Huppert FA, Matthews FE, Nickson J, MRC Cognitive Function and Ageing Study (MRC CFAS) (2003), “Performance and normative values of a concise neuropsychological test (CAMCOG) in an elderly population sample.” Int J Geriatr Psychiatry 18(7):631-44 Details

    2002

    Jagger C, Matthews F (2002), “Gender differences in life expectancy free of impairment at older ages.” J Women Aging 14(1-2):85-97 Details

    Matthews FE, Dening T, UK Medical Research Council Cognitive Function and Ageing Study (2002), “Prevalence of dementia in institutional care.” Lancet 360(9328):225-6 Details

    2001

    Brayne C, Matthews FE, McGee MA, Jagger C (2001), “Health and ill-health in the older population in England and Wales. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” Age Ageing 30(1):53-62 Details