Dr Fiona Matthews

Collaborators

Key publications

Brayne C, Stephan BC, Matthews FE (2011), “A European perspective on population studies of dementia.” Alzheimers Dement 7(1):3-9 Details

EClipSE Collaborative Members, Brayne C, Ince PG, Keage HA, McKeith IG, Matthews FE, Polvikoski T, Sulkava R (2010), “Education, the brain and dementia: neuroprotection or compensation?” Brain 133(Pt 8):2210-6 Details

van den Hout A, Matthews FE (2010), “Estimating stroke-free and total life expectancy in the presence of non-ignorable missing values.” J R Stat Soc Ser A Stat Soc 173(2):331-349 Details

Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB, Ince P (2009), “Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study.” PLoS Med 6(11):e1000180 Details

Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2009), “Age, neuropathology, and dementia.” N Engl J Med 360(22):2302-9 Details

Xie J, Brayne C, Matthews FE, Medical Research Council Cognitive Function and Ageing Study collaborators (2008), “Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up.” BMJ 336(7638):258-62 Details

Brayne C, Gao L, Dewey M, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2006), “Dementia before death in ageing societies - the promise of prevention and the reality” PLoS Med 3(10):e397

Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2005), “Incidence of dementia in England and Wales” PLoS Medicine 2(8):e193

Neuropathology Group. Medical Research Council Cognitive Function and Aging Study (2001), “Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” Lancet 357(9251):169-75 Details

Publications

2011

Fox C, Richardson K, Maidment ID, Savva GM, Matthews FE, Smithard D, Coulton S, Katona C, Boustani MA, Brayne C (2011), “Anticholinergic Medication Use and Cognitive Impairment in the Older Population: The Medical Research Council Cognitive Function and Ageing Study.” J Am Geriatr Soc Details

Marioni RE, Matthews FE, Brayne C, MRC Cognitive Function and Ageing Study (2011), “The association between late-life cognitive test scores and retrospective informant interview data.” Int Psychogeriatr 23(2):274-9 Details

Matthews FE, Stephan BC, Khaw KT, Hayat S, Luben R, Bhaniani A, Moore S, Brayne C (2011), “Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version.” J Clin Epidemiol Details

Muniz-Terrera G, Matthews FE, Stephan B, Brayne C, CC75C Collaboration Group (2011), “Are terminal decline and its potential indicators detectable in population studies of the oldest old?” Int J Geriatr Psychiatry 26(6):584-92 Details

Nicoll JA, Savva GM, Stewart J, Matthews FE, Brayne C, Ince P, Medical Research Council Cognitive Function and Ageing Study (2011), “Association between APOE genotype, neuropathology and dementia in the older population of England and Wales.” Neuropathol Appl Neurobiol 37(3):285-94 Details

Piccinin AM, Muniz G, Matthews FE, Johansson B (2011), “Terminal Decline From Within- and Between-Person Perspectives, Accounting for Incident Dementia.” J Gerontol B Psychol Sci Soc Sci Details

Roelfsema MT, Hoekstra RA, Allison C, Wheelwright S, Brayne C, Matthews FE, Baron-Cohen S (2011), “Are Autism Spectrum Conditions More Prevalent in an Information-Technology Region? A School-Based Study of Three Regions in the Netherlands.” J Autism Dev Disord Details

Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2011), “Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.” Neurobiol Aging Details

Stephan BC, Brayne C, Savva GM, Matthews FE, The Medical Research Council Cognitive Function and Ageing Study (2011), “Occurrence of medical co-morbidity in mild cognitive impairment: implications for generalisation of MCI research.” Age Ageing 40(4):501-507 Details

Tsopelas C, Stewart R, Savva GM, Brayne C, Ince P, Thomas A, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (2011), “Neuropathological correlates of late-life depression in older people.” Br J Psychiatry 198(2):109-14 Details

van den Hout A, Muniz-Terrera G, Matthews FE (2011), “Smooth random change point models.” Stat Med 30(6):599-610 Details

Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG (2011), “Epidemiological Neuropathology: The MRC Cognitive Function and Aging Study Experience.” J Alzheimers Dis Details

Wills AK, Lawlor DA, Matthews FE, Aihie Sayer A, Bakra E, Ben-Shlomo Y, Benzeval M, Brunner E, Cooper R, Kivimaki M, Kuh D, Muniz-Terrera G, Hardy R (2011), “Life Course Trajectories of Systolic Blood Pressure Using Longitudinal Data from Eight UK Cohorts.” PLoS Med 8(6):e1000440 Details

2010

Hogervorst E, Matthews FE, Brayne C (2010), “Are optimal levels of testosterone associated with better cognitive function in healthy older women and men?” Biochim Biophys Acta 1800(10):1145-52 Details

Keage HA, Matthews FE, Yip A, Gao L, McCracken C, McKeith IG, Rubinsztein DC, Brayne C, MRC Cognitive Function and Ageing Study (2010), “APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA Study.” Age Ageing 39(1):104-11 Details

Llewellyn DJ, Lang IA, Matthews FE, Plassman BL, Rogers MA, Morgenstern LB, Fisher GG, Kabeto MU, Langa KM (2010), “Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.” Alzheimers Res Ther 2(3):19 Details

Matthews FE, Muniz-Terrera G, McKeith I, Brayne C, MRC CFAS (2010), “Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance.” Int J Geriatr Psychiatry 25(7):719-24 Details

Muniz-Terrera G, Matthews FE, Stephan B, Brayne C, the CC75C Collaboration Group (2010), “Are terminal decline and its potential indicators detectable in population studies of the oldest old?” Int J Geriatr Psychiatry

Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C, Ince PG (2010), “Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain.” Neurosci Lett 486(3):246-51 Details

Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C (2010), “Dementia risk prediction in the population: are screening models accurate?” Nat Rev Neurol 6(6):318-26 Details

Stephan BC, Savva GM, Brayne C, Bond J, McKeith IG, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2010), “Optimizing mild cognitive impairment for discriminating dementia risk in the general older population.” Am J Geriatr Psychiatry 18(8):662-73 Details

van den Hout A, Muniz-Terrera G, Matthews FE (2010), “Smooth random change point models.” Stat Med Details

van der Linde R, Stephan BC, Matthews FE, Brayne C, Savva GM, Medical Research Council Cognitive Function and Ageing Study (2010), “Behavioural and psychological symptoms in the older population without dementia--relationship with socio-demographics, health and cognition.” BMC Geriatr 10:87 Details

2009

Baron-Cohen S, Scott FJ, Allison C, Williams J, Bolton P, Matthews FE, Brayne C (2009), “Prevalence of autism-spectrum conditions: UK school-based population study.” Br J Psychiatry 194(6):500-9 Details

Brayne C, Richardson K, Matthews FE, Fleming J, Hunter S, Xuereb JH, Paykel E, Mukaetova-Ladinska EB, Huppert FA, O'Sullivan A, Dening T, Cambridge City Over-75s Cohort Cc75c Study Neuropathology Collaboration (2009), “Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study.” J Alzheimers Dis 18(3):645-58 Details

Byford M, Brayne C, McKeith I, Chatfield M, Ince P, Matthews F, MRC CFAS Neuropathology group (2009), “Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study.” BMC Geriatr 9:22 Details

EClipSE Collaborative Members (2009), “Cohort profile: Epidemiological Clinicopathological studies in Europe (EClipSE).” J Alzheimers Dis 18(3):659-63 Details

Lace G, Savva GM, Forster G, de Silva R, Brayne C, Matthews FE, Barclay JJ, Dakin L, Ince PG, Wharton SB, MRC-CFAS (2009), “Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.” Brain 132(Pt 5):1324-34 Details

Llewellyn DJ, Lang IA, Langa KM, Naughton F, Matthews FE (2009), “Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement.” BMJ 338:b462 Details

Llewellyn DJ, Matthews FE (2009), “Increasing levels of semantic verbal fluency in elderly English adults.” Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16(4):433-45 Details

Matthews FE, Jagger C, Miller LL, Brayne C, MRC CFAS (2009), “Education differences in life expectancy with cognitive impairment.” J Gerontol A Biol Sci Med Sci 64(1):125-31 Details

Savva GM, Zaccai J, Matthews FE, Davidson JE, McKeith I, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2009), “Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population.” Br J Psychiatry 194(3):212-9 Details

Seidel D, Crilly N, Matthews FE, Jagger C, Brayne C, Clarkson PJ, Medical Research Council Cognitive Function and Ageing Study (2009), “Patterns of functional loss among older people: a prospective analysis.” Hum Factors 51(5):669-80 Details

Seidel D, Jagger C, Brayne C, Matthews FE, Cfas M (2009), “Recovery in instrumental activities of daily living (IADLs): findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” Age Ageing 38(6):663-8 Details

Stephan BC, Matthews FE, Khaw KT, Dufouil C, Brayne C (2009), “Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND).” Alzheimers Res Ther 1(1):4 Details

van den Hout A, Matthews FE (2009), “Estimating dementia-free life expectancy for Parkinson's patients using Bayesian inference and microsimulation.” Biostatistics 10(4):729-43 Details

van den Hout A, Matthews FE (2009), “A piecewise-constant Markov model and the effects of study design on the estimation of life expectancies in health and ill health.” Stat Methods Med Res 18(2):145-62 Details

Wright CF, Hall A, Matthews FE, Brayne C (2009), “Biomarkers, dementia, and public health.” Ann N Y Acad Sci 1180:11-9 Details

2008

Basta NE, Matthews FE, Chatfield MD, Brayne C, MRC-CFAS (2008), “Community-level socio-economic status and cognitive and functional impairment in the older population.” Eur J Public Health 18(1):48-54 Details

Buter TC, van den Hout A, Matthews FE, Larsen JP, Brayne C, Aarsland D (2008), “Dementia and survival in Parkinson disease: a 12-year population study.” Neurology 70(13):1017-22 Details

Fleming J, Matthews FE, Brayne C, Cambridge City over-75s Cohort (CC75C) study collaboration (2008), “Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study.” BMC Geriatr 8:6 Details

Gao L, Matthews FE, Sargeant LA, Brayne C, MRC CFAS (2008), “An investigation of the population impact of variation in HbA1c levels in older people in England and Wales: from a population based multi-centre longitudinal study.” BMC Public Health 8:54 Details

Hogervorst E, Huppert F, Matthews FE, Brayne C (2008), “Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study.” Psychoneuroendocrinology 33(7):1013-22 Details

Kvaal K, McDougall FA, Brayne C, Matthews FE, Dewey ME, MRC CFAS (2008), “Co-occurrence of anxiety and depressive disorders in a community sample of older people: results from the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study).” Int J Geriatr Psychiatry 23(3):229-37 Details

Matthews FE, Stephan BC, McKeith IG, Bond J, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2008), “Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?” J Am Geriatr Soc 56(8):1424-33 Details

Pérès K, Jagger C, Matthews FE, MRC CFAS (2008), “Impact of late-life self-reported emotional problems on Disability-Free Life Expectancy: results from the MRC Cognitive Function and Ageing Study.” Int J Geriatr Psychiatry 23(6):643-9 Details

Stephan BC, Brayne C, McKeith IG, Bond J, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (2008), “Mild cognitive impairment in the older population: Who is missed and does it matter?” Int J Geriatr Psychiatry 23(8):863-71 Details

van den Hout A, Matthews FE (2008), “Multi-state analysis of cognitive ability data: a piecewise-constant model and a Weibull model.” Stat Med 27(26):5440-55 Details

Williams JG, Allison C, Scott FJ, Bolton PF, Baron-Cohen S, Matthews FE, Brayne C (2008), “The Childhood Autism Spectrum Test (CAST): sex differences.” J Autism Dev Disord 38(9):1731-9 Details

Xie J, Matthews FE, Jagger C, Bond J, Brayne C (2008), “The oldest old in England and Wales: a descriptive analysis based on the MRC Cognitive Function and Ageing Study.” Age Ageing 37(4):396-402 Details

2007

Chatfield M, Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2007), “Using the Mini-Mental State Examination for tracking cognition in the older population based on longitudinal data.” J Am Geriatr Soc 55(7):1066-71 Details

Jagger C, Matthews RJ, Matthews FE, Spiers NA, Nickson J, Paykel ES, Huppert FA, Brayne C, Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) (2007), “Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS).” BMC Public Health 7:156 Details

Matthews FE, McKeith I, Bond J, Brayne C, MRC CFAS (2007), “Reaching the population with dementia drugs: what are the challenges?” Int J Geriatr Psychiatry 22(7):627-31 Details

Matthews FE, Stephan BC, Bond J, McKeith I, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2007), “Operationalization of mild cognitive impairment: a graphical approach.” PLoS Med 4(10):1615-9 Details

McDougall FA, Kvaal K, Matthews FE, Paykel E, Jones PB, Dewey ME, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2007), “Prevalence of depression in older people in England and Wales: the MRC CFA Study.” Psychol Med 37(12):1787-95 Details

McDougall FA, Matthews FE, Kvaal K, Dewey ME, Brayne C (2007), “Prevalence and symptomatology of depression in older people living in institutions in England and Wales.” Age Ageing 36(5):562-8 Details

Stephan BC, Matthews FE, McKeith IG, Bond J, Brayne C, Medical Research Council Cognitive Function and Aging Study (2007), “Early cognitive change in the general population: how do different definitions work?” J Am Geriatr Soc 55(10):1534-40 Details

2006

Brayne C, Gao L, Dewey M, Matthews FE, Medical Research Council Cognitive Function and Ageing Study Investigators (2006), “Dementia before death in ageing societies--the promise of prevention and the reality.” PLoS Med 3(10):e397 Details

Brayne C, McCracken C, Matthews FE, Medical Research Council Coginitive Function and Ageing Study (CFAS) (2006), “Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS).” Int J Epidemiol 35(5):1140-5 Details

Foltynie T, Matthews FE, Ishihara L, Brayne C, MRC CFAS (2006), “The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort.” BMC Neurol 6:29 Details

Matthews FE, Chatfield M, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2006), “An investigation of whether factors associated with short-term attrition change or persist over ten years: data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” BMC Public Health 6:185 Details

Matthews FE, McKeith I, Bond J, Brayne C, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2006), “Reaching the population with dementia drugs: what are the challenges?” Int J Geriatr Psychiatry

Matthews FE, Miller LL, Brayne C, Jagger C, Medical Research Council Cognitive Function and Aging Study (MRC CFAS) (2006), “Regional differences in multidimensional aspects of health: findings from the MRC cognitive function and ageing study.” BMC Public Health 6:90 Details

Yip AG, Brayne C, Matthews FE, MRC Cognitive Function and Ageing Study (2006), “Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study.” Age Ageing 35(2):154-60 Details

2005

Barnes L, Matthews FE, Barber B, Davies L, Lloyd D, Brayne C, Parry B (2005), “Brain donation for research: consent and re-consent post Alder Hey.” Bull Med Ethics (211):17-21 Details

Chatfield MD, Brayne CE, Matthews FE (2005), “A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies.” J Clin Epidemiol 58(1):13-9 Details

Huppert FA, Cabelli ST, Matthews FE, MRC Cognitive Function and Ageing Study (2005), “Brief cognitive assessment in a UK population sample -- distributional properties and the relationship between the MMSE and an extended mental state examination.” BMC Geriatr 5:7 Details

Spiers NA, Matthews RJ, Jagger C, Matthews FE, Boult C, Robinson TG, Brayne C (2005), “Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: findings from the Medical Research Council Cognitive Function and Ageing Study.” J Gerontol A Biol Sci Med Sci 60(2):248-54 Details

Syed A, Chatfield M, Matthews F, Harrison P, Brayne C, Esiri MM (2005), “Depression in the elderly: pathological study of raphe and locus ceruleus.” Neuropathol Appl Neurobiol 31(4):405-13 Details

2004

Fernando MS, Ince PG, MRC Cognitive Function and Ageing Neuropathology Study Group (2004), “Vascular pathologies and cognition in a population-based cohort of elderly people.” J Neurol Sci 226(1-2):13-7 Details

Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG, Neuropathology Group of MRC CFAS (2004), “Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain.” Neuropathol Appl Neurobiol 30(4):385-95 Details

Matthews FE, Chatfield M, Freeman C, McCracken C, Brayne C, MRC CFAS (2004), “Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation.” BMC Public Health 4:12 Details

2003

Williams JG, Huppert FA, Matthews FE, Nickson J, MRC Cognitive Function and Ageing Study (MRC CFAS) (2003), “Performance and normative values of a concise neuropsychological test (CAMCOG) in an elderly population sample.” Int J Geriatr Psychiatry 18(7):631-44 Details

2002

Jagger C, Matthews F (2002), “Gender differences in life expectancy free of impairment at older ages.” J Women Aging 14(1-2):85-97 Details

Matthews FE, Dening T, UK Medical Research Council Cognitive Function and Ageing Study (2002), “Prevalence of dementia in institutional care.” Lancet 360(9328):225-6 Details

2001

Brayne C, Matthews FE, McGee MA, Jagger C (2001), “Health and ill-health in the older population in England and Wales. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” Age Ageing 30(1):53-62 Details