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    Elijah Mak

    University Position
    PhD student

    Interests

    I am a Gates Cambridge scholar working on my PhD at the Department of Psychiatry. Broadly, my research interest relates to the use of multi-modal neuroimaging techniques to characterise structural and functional deficits in dementia and related conditions across different scales (i.e. from hippocampal subfields to connectomic changes). This multi-modal approach could facilitate our ongoing efforts to understand the differential contributions of various pathological processes in dementia, and aid in the validation of different imaging techniques to track disease progression. I aim to expand my work with a more integrationist perspective, using graph theoretical approaches to investigate large-scale network perturbations in neurodegenerative conditions such as Alzheimer's disease and Lewy body diseases.

    Key Publications

    Inflammation and cerebral small vessel disease: A systematic review.

    DOI: http://doi.org/10.1016/j.arr.2019.100916
    Journal: Ageing Res Rev
    E-pub date: 31 Aug 2019
    Authors: A Low, E Mak, JB Rowe, HS Markus, JT O'Brien

    Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

    DOI: http://doi.org/10.1093/brain/awy265
    Journal: Brain
    E-pub date: 1 Dec 2018
    Authors: A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, P Vázquez Rodríguez, WR Bevan-Jones, SAE Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    Publications

    Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

    DOI: http://doi.org/10.1093/brain/awad078
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: M Malpetti, TE Cope, D Street, PS Jones, FH Hezemans, E Mak, KA Tsvetanov, T Rittman, WR Bevan-Jones, K Patterson, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    The ‘Resilient Brain’: challenging key characteristics associated with the concept of resilience.

    DOI: http://doi.org/10.1017/S0033291722003907
    Journal: Psychol Med
    E-pub date: 25 Jan 2023
    Authors: G Savulich, E Ferry-Bolder, TV Lim, E Mak, KD Ersche

    Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study

    DOI: http://doi.org/10.1093/brain/awab282
    Journal: Brain
    E-pub date: 29 Mar 2022
    Authors: N Holland, M Malpetti, T Rittman, E Mak, L Passamonti, S Kaalund, F Hezemans, P Jones, G Savulich, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Altered structural connectivity networks in dementia with lewy bodies.

    DOI: http://doi.org/10.1007/s11682-020-00444-x
    Journal: Brain Imaging Behav
    E-pub date: 1 Oct 2021
    Authors: N Nicastro, E Mak, A Surendranathan, T Rittman, JB Rowe, JT O'Brien

    [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.

    DOI: http://doi.org/10.1093/braincomms/fcab177
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, A Kouli, N Holland, N Nicastro, G Savulich, A Surendranathan, M Malpetti, R Manavaki, YT Hong, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien, CH Williams-Gray

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    DOI: http://doi.org/10.1093/braincomms/fcaa198
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.

    DOI: http://doi.org/10.1016/j.neuroimage.2021.117749
    Journal: Neuroimage
    E-pub date: 1 Apr 2021
    Authors: E Mak, M-E Dounavi, A Low, SF Carter, E McKiernan, GB Williams, PS Jones, I Carriere, GT Muniz, K Ritchie, C Ritchie, L Su, JT O'Brien

    Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.10.029
    Journal: Neurobiol Aging
    E-pub date: 1 Feb 2021
    Authors: A Low, L Su, JD Stefaniak, E Mak, M-E Dounavi, G Muniz-Terrera, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    Gray matter changes related to microglial activation in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.06.010
    Journal: Neurobiol Aging
    E-pub date: 1 Oct 2020
    Authors: N Nicastro, M Malpetti, E Mak, GB Williams, WR Bevan-Jones, SF Carter, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

    DOI: http://doi.org/10.1136/jnnp-2020-323894
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 11 Sep 2020
    Authors: A Low, E Mak, M Malpetti, L Passamonti, N Nicastro, JD Stefaniak, G Savulich, L Chouliaras, L Su, JB Rowe, HS Markus, JT O'Brien

    Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage.

    DOI: http://doi.org/10.3389/fnins.2020.00238
    Journal: Front Neurosci
    E-pub date: 1 Aug 2020
    Authors: A Low, E Mak, JD Stefaniak, M Malpetti, N Nicastro, G Savulich, L Chouliaras, HS Markus, JB Rowe, JT O'Brien

    Cortical Complexity Analyses and Their Cognitive Correlate in Alzheimer’s Disease and Frontotemporal Dementia.

    DOI: http://doi.org/10.3233/JAD-200246
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, M Malpetti, TE Cope, WR Bevan-Jones, E Mak, L Passamonti, JB Rowe, JT O'Brien

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

    DOI: http://doi.org/10.1016/j.dadm.2019.08.001
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

    DOI: http://doi.org/10.1101/19011189
    Journal:
    E-pub date: 8 Nov 2019
    Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.dadm.2018.08.005
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2018
    Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1212/WNL.0000000000005610
    Journal: Neurology
    E-pub date: 29 May 2018
    Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Structural Covariance Networks in Children with Autism or ADHD.

    DOI: http://doi.org/10.1093/cercor/bhx135
    Journal: Cereb Cortex
    E-pub date: 1 Aug 2017
    Authors: RAI Bethlehem, R Romero-Garcia, E Mak, ET Bullmore, S Baron-Cohen

    18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/aww340
    Journal: Brain
    E-pub date: 1 Mar 2017
    Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Structural covariance networks in children with autism or ADHD

    DOI: http://doi.org/10.1101/110643
    Journal:
    E-pub date: 21 Feb 2017
    Authors: RAI Bethlehem, R Romero-Garcia, E Mak, ET Bullmore, S Baron-Cohen