Elijah Mak

Elijah Mak

University position

PhD student


Department of Psychiatry



Research Theme

Cognitive and Behavioural Neuroscience


I am a Gates Cambridge scholar working on my PhD at the Department of Psychiatry. Broadly, my research interest relates to the use of multi-modal neuroimaging techniques to characterise structural and functional deficits in dementia and related conditions across different scales (i.e. from hippocampal subfields to connectomic changes). This multi-modal approach could facilitate our ongoing efforts to understand the differential contributions of various pathological processes in dementia, and aid in the validation of different imaging techniques to track disease progression. I aim to expand my work with a more integrationist perspective, using graph theoretical approaches to investigate large-scale network perturbations in neurodegenerative conditions such as Alzheimer's disease and Lewy body diseases.

Constructing the human connectome from anatomically-constrained tractography of 10 million streamlines
Constructing the human connectome from anatomically-constrained tractography of 10 million streamlines
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Research Focus





graph theory

PET imaging

Clinical conditions

Alzheimer's disease


Parkinson's disease


Behavioural analysis

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)



Richard Bethlehem

Associated News Items

Key publications

Mak E, Colloby S, Thomas A, O'Brien JT (2016), “The segregated connectome of late life depression: a combined cortical thickness and structural covariance analysis” Neurobiol Aging

Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker R, Burn DJ, O'Brien JT (2015), “Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study.” Brain Details

Mak E, Su L, Williams GB, Watson R, Firbank MJ, Blamire AM, O’Brien JT (2015), “Progressive cortical thinning and subcortical atrophy in dementia with Lewy bodies and Alzheimer’s disease” Neurobiol Aging



Mak E, Dwyer MG, Ramasamy D, Tan L, Zivadinov R, Kandiah N (2015), “White matter hyperintensities and mild cognitive impairment in Parkinson’s disease” J Neuroimaging

Mak E, Chin R, Ng LT, Yeo D, Hameed S. (2015), “Clinical associations of anosognosia in mild cognitive impairment and Alzheimer’s disease” Int J Geriatr Psychiatry

Mak E, Li S, Guy BW, O'Brien JT (2015), “Neuroimaging correlates of cognitive impairment and dementia in Parkinson's disease” Park Rel Dis

Mak E, Su L, Williams GB, Watson R, Firbank M, Blamire AM, O'Brien JT (2015), “Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies.” Neuroimage Clin 7:456-462 Details

Stinton C, McKeith I, Taylor JP, Lafortune L, Mioshi E, Mak E, Cambridge V, Mason J, Thomas A, O'Brien JT (2015), “Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis.” Am J Psychiatry :appiajp201514121582 Details


Kandiah N, Goh O, Mak E, Marmin M, Ng A (2014), “Carotid stenosis: a risk factor for cerebral white-matter disease.” J Stroke Cerebrovasc Dis 23(1):136-9 Details

Kandiah N, Zainal NH, Narasimhalu K, Chander RJ, Ng A, Mak E, Au WL, Sitoh YY, Nadkarni N, Tan LC (2014), “Hippocampal volume and white matter disease in the prediction of dementia in Parkinson's disease.” Parkinsonism Relat Disord Details

Mak E, Michael D, Niels B, Zivadinov R, Kandiah N. (2014), “Subcortical atrophy is associated with cognitive impairment in mild Parkinson’s disease: a combined investigation of volumetric changes, cortical thickness and vertex-based shape analysis” Amer J Neurol

Mak E, Su L, Williams GB, O'Brien JT (2014), “Neuroimaging characteristics of dementia with Lewy bodies.” Alzheimers Res Ther 6(2):18 Details


Kandiah N, Mak E, Ng A, Huang S, Au WL, Sitoh YY, Tan LC (2013), “Cerebral white matter hyperintensity in Parkinson's disease: a major risk factor for mild cognitive impairment.” Parkinsonism Relat Disord 19(7):680-3 Details

Mak E, Zhou J, Tan LC, Au WL, Sitoh YY, Kandiah N (2013), “Cognitive deficits in mild Parkinson's disease are associated with distinct areas of grey matter atrophy.” J Neurol Neurosurg Psychiatry Details