Dr Franziska Knolle

University position

Research Associate


Department of Psychiatry

Home page

https://franziskaknolle.com (personal home page)

Research Themes

Cognitive and Behavioural Neuroscience

Systems and Computational Neuroscience


I am interested in applying the framework of predictive processing to understanding psychiatric disorders, especially psychosis. I wish to explore how and if potentially dysfunctional predictive processing across various higher and lower cognitive domains might lead to psychotic symptoms, such as delusions or hallucinations. I am particularly interested in the interaction between subcortical and cortical regions. In my research, I am using fMRI and MEG/EEG as well as behavioural paradigms to explore these topics.

Research Focus


Predictive processing


Prediction error



Clinical conditions

Obsessive compulsive disorder




Behavioural analysis

Computational modelling

Electroencephalography (EEG)

Magnetic resonance imaging (MRI)



Paul Fletcher

Graham Murray

United Kingdom

Rick Adams


Sonja Kotz

Christian Sorg

Associated News Items



AJ Sorby-Adams, WT Schneider, RP Goncalves, F Knolle, AJ Morton (2021), “Measuring executive function in sheep (Ovis aries) using visual stimuli in a semi-automated operant system” Journal of Neuroscience Methods 351, 109009

in press

Knolle F, Ronan L, Murray GK (in press), “The impact of the COVID-19 pandemic on mental health in the general population: a comparison between Germany and the UK” BMC Psychology


Haarsma J, Knolle F, Griffin J, Taverne H, Mada M, Goodyer I, Neuroscience in Psychiatry Network, Fletcher, PC, Murray GK (2020), “Influence of prior beliefs on perception in early psychosis: effects of illness stage and hierarchical level of belief” Journal of Abnormal Psychology 129 (6), 581

Knolle F., Garofalo, S., Viviani R., Justicia, A., Ermakova, A.O., Blank H., Williams, G.B., Arrondo, G., Ramachandra, P., ,Tudor-Sfetea, C., Bunzeck, N., Duezel, E., Robbins,T.W., Barker, R.A., and Murray, G.K. (2020), “Altered subcortical emotional salience processing differentiates Parkinson’s patients with and without psychotic symptoms” NeuroImage: Clinical 102277

M Montagnese, F Knolle, J Haarsma, J Griffin, A Richards, P Vertes, B Kiddle, PC Fletcher, PB Jones, M Owen, P Fonagy, ET Bullmore, R Dolan, NSPN Consortium, M Moutoussis, I Goodyer, GK Murray (2020), “Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population” Schizophrenia Research

Mihai A, Brandl F, Knolle F, Cabello J, Leucht C, Scherr M, Mustafa M, Koutsouleris N,Leucht S, Ziegler S, Sorg C (2020), “Cortico-thalamic dysconnectivity links with aberrant striatal dopamine in schizophrenia. A simultaneous 18F-DOPA-PET/resting-state fMRI study” Brain

Mihatsch L, von der Linde M, Knolle F, Luchting B, Dimitriadis K, Heyn J (2020), “Commitment of medical students during the COVID-19-pandemic in Germany” medRxiv


Ermakova AO, Gileadi N, Knolle F, Justicia Diaz A, Anderson R, Fletcher PC, Moutoussis M, Murray GK (2019), “Cost evaluation during decision making in patients at early stages of psychosis” Computational Psychiatry 3, 18-39

Knolle F, Schwartze M, Schröger E, Kotz SA (2019), “Auditory predictions and prediction errors in response to self-initiated vowels” Frontiers in Auditory Neuroscience 13, 1146

Knolle, F., Goncalves, R.P., Davies, E.L., Duff, A.R., Morton, J.A. (2019), “Response-inhibition during problem solving in sheep” International Journal of Comparative Psychology 3

Murray*, G.K., Knolle*, F., Ersche, K.D., Craig, K.J., Abbott, S., Shabbir, S.S., Suckling, J., Sahakian, B.J., Bullmore, E.T., Robbins, T.W. (2019), “Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder” Psychopharmacology 236: 2325.


Ermakova*, A.O., Knolle*, F., Justicia, A., Bullmore, E.T., Jones, P.J., Robbins, T.W., Fletcher, P.C., & Murray, G.K. (2018), “Abnormal reward prediction error signalling in antipsychotic naïve individuals with first episode psychosis or clinical risk for psychosis.” Neuropsychopharmacology 43, 1691–1699

Knolle* F, Ermakova* AO, Justicia A., Fletcher PC, Bunseck N, Düzel E & Murray GK. (2018), “Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study” Translational Psychiatry 8:196


Knolle F, McBride SD, Stewart JE, Goncalves R Morton, AJ (2017), “A stop-signal task for sheep: Introduction and validation of a direct measure for the stop-signal reaction time” Animal Cognition 20(4):615-626

Knolle F, Vallotton C, Ayoub C (2017), “Deficit or difference? Effects of early maltreatment on children’s language skills and use of grammatical negations.” Journal of Child and Family Studies 1-12

Knolle, F., Goncalves, R. & Morton, J. (2017), “Sheep recognise familiar and unfamiliar human faces from two-dimensional images.” Royal Society Open Science 4: 171228


Knolle F, Schröger E, Kotz SA (2013), “Cerebellar contribution to the prediction of self-initiated sounds.” Cortex 49(9), 2449-2461

Knolle F, Schröger E, Kotz SA (2013), “Prediction errors in self- and externally-generated deviants.” Biological Psychology 92(2), 410-416


Knolle F (2012), “Knowing what's next: The role of the cerebellum in generating predictions. ” PhD Thesis, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig ISBN: 978-3-941504-26-4

Knolle F, Schröger E, Baess P, Kotz SA (2012), “The cerebellum generates motor-to-auditory predictions: ERP lesion evidence” Journal of Cognitive Neuroscience 24(3), 698-706