Professor Franklin Aigbirhio

Franklin  Aigbirhio

University position


Professor Franklin Aigbirhio is pleased to consider applications from prospective PhD students.


Department of Clinical Neurosciences


Wolfson Brain Imaging Centre

Home page

Research Theme

Clinical and Veterinary Neuroscience


Research in the development and application of molecular imaging probes, in particular for the in vivo imaging technique of positron emission tomography. Objectives are to design, develop and apply imaging probes that are specific and selective to biological markers and are sensitivity to biochemical changes associated with disease mechanisms. In addition we research novel radiosynthetic methods with an objective of 1) developing rapid and efficient methods for the regular preparation of radiopharmaceuticals and 2) facilitating the discovery of new chemical entities for imaging.

Research Focus




molecular imaging


brain imaging

Clinical conditions


Alzheimer's disease

Attention deficit hyperactivity disorder


Cerebrovascular disorders



Obsessive compulsive disorder

Progressive supranuclear palsy


Traumatic brain injury


Cyclotron radionuclide generation


Gas chromatography

In vitro radiopharmacology

LC-Mass Spectroscopy

Organic synthesis

Positron Emission Tomography (PET)



Jean-Claude Baron

Jonathan Coles

Jeff Dalley

Anthony Davenport

Tim Fryer

David Menon

John O'Brien

John Pickard

Trevor Robbins

James Rowe

United Kingdom

Matthias Koepp Web:


Vic Pike Web:

Associated News Items



    Alawneh JA, Moustafa RR, Marrapu ST, Jensen-Kondering U, Morris RS, Jones PS, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2014), “Diffusion and perfusion correlates of the (18)F-MISO PET lesion in acute stroke: pilot study.” Eur J Nucl Med Mol Imaging 41(4):736-44 Details

    Baron JC, Farid K, Dolan E, Turc G, Marrapu ST, O'Brien E, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Hong YT (2014), “Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage.” J Cereb Blood Flow Metab Details

    Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC (2014), “Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.” J Neurosci 34(22):7663-76 Details

    Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK (2014), “Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.” JAMA Neurol 71(1):23-31 Details


    Caprioli D, Fryer TD, Sawiak SJ, Aigbirhio FI, Dalley JW (2013), “Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls.” Curr Opin Neurobiol 23(4):597-606 Details

    Caprioli D, Hong YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Adrian Carpenter T, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer TD, Dalley JW (2013), “Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome.” Neuropsychopharmacology 38(8):1460-71 Details

    Carrera E, Jones PS, Morris RS, Alawneh J, Hong YT, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2013), “Is neural activation within the rescued penumbra impeded by selective neuronal loss?” Brain 136(Pt 6):1816-29 Details

    del Campo N, Fryer TD, Hong YT, Smith R, Brichard L, Acosta-Cabronero J, Chamberlain SR, Tait R, Izquierdo D, Regenthal R, Dowson J, Suckling J, Baron JC, Aigbirhio FI, Robbins TW, Sahakian BJ, Müller U (2013), “A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.” Brain 136(Pt 11):3252-70 Details

    Ejaz S, Williamson DJ, Ahmed T, Sitnikov S, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Baron JC (2013), “Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.” Neurobiol Dis 51:120-32 Details

    Li L, Brichard L, Larsen L, Menon DK, Smith RA, Murphy MP, Aigbirhio FI (2013), “Radiosynthesis of 11-[(18) F]fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer.” J Labelled Comp Radiopharm 56(14):717-21 Details

    Porteous CM, Menon DK, Aigbirhio FI, Smith RA, Murphy MP (2013), “P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain.” Biochim Biophys Acta 1830(6):3458-65 Details

    Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI (2013), “Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging.” J Nucl Med 54(2):299-305 Details

    Williamson DJ, Ejaz S, Sitnikov S, Fryer TD, Sawiak SJ, Burke P, Baron JC, Aigbirhio FI (2013), “A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke.” Nucl Med Biol 40(3):338-44 Details


    Burton TJ, Mackenzie IS, Balan K, Koo B, Bird N, Soloviev DV, Azizan EA, Aigbirhio F, Gurnell M, Brown MJ (2012), “Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas.” J Clin Endocrinol Metab 97(1):100-9 Details

    Fleming IN, Whelan M, Baxendale R, Gilbert FJ, Matthews PP, Aigbirhio FI (2012), “Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers.” Nucl Med Commun 33(9):899-906 Details

    Hughes JL, Jones PS, Beech JS, Wang D, Menon DK, Aigbirhio FI, Fryer TD, Baron JC (2012), “A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation.” Neuroimage 59(3):2007-16 Details

    Riss PJ, Ferrari V, Brichard L, Burke P, Smith R, Aigbirhio FI (2012), “Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures.” Org Biomol Chem 10(34):6980-6 Details

    Riss PJ, Hooker JM, Shea C, Xu Y, Carter P, Warner D, Ferrari V, Kim SW, Aigbirhio FI, Fowler JS, Roesch F (2012), “Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter.” Bioorg Med Chem Lett 22(1):679-82 Details

    Riss PJ, Lu S, Telu S, Aigbirhio FI, Pike VW (2012), “Cu(I)-catalyzed (11)C carboxylation of boronic acid esters: a rapid and convenient entry to (11)C-labeled carboxylic acids, esters, and amides.” Angew Chem Int Ed Engl 51(11):2698-702 Details

    Virdee K, Cumming P, Caprioli D, Jupp B, Rominger A, Aigbirhio FI, Fryer TD, Riss PJ, Dalley JW (2012), “Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders.” Neurosci Biobehav Rev 36(4):1188-216 Details


    Buell AK, Esbjörner EK, Riss PJ, White DA, Aigbirhio FI, Toth G, Welland ME, Dobson CM, Knowles TP (2011), “Probing small molecule binding to amyloid fibrils.” Phys Chem Chem Phys 13(45):20044-52 Details

    Carrera E, Jones PS, Alawneh JA, Klærke Mikkelsen I, Cho TH, Siemonsen S, Guadagno JV, Mouridsen K, Ribe L, Hjort N, Fryer TD, Carpenter TA, Aigbirhio FI, Fiehler J, Nighoghossian N, Warburton EA, Ostergaard L, Baron JC (2011), “Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?” Stroke 42(6):1602-7 Details

    Carrera E, Jones PS, Iglesias S, Guadagno JV, Warburton EA, Fryer TD, Aigbirhio FI, Baron JC (2011), “The vascular mean transit time: a surrogate for the penumbra flow threshold?” J Cereb Blood Flow Metab 31(4):1027-35 Details

    del Campo N, Tait RJ, Acosta-Cabronero J, Hong YT, Izquierdo-Garcia D, Smith R, Aigbirhio FI, Sahakian BJ, Müller U, Robbins TW, Fryer TD (2011), “Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.” Neuroimage 55(1):101-12 Details

    Geeraerts T, Coles JP, Aigbirhio FI, Pickard JD, Menon DK, Fryer TD, Hong YT (2011), “Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.” Ann Nucl Med 25(6):396-405 Details

    Landt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.” Arch Neurol 68(7):890-6 Details

    Moustafa RR, Momjian-Mayor I, Jones PS, Morbelli S, Day DJ, Aigbirhio FI, Fryer TD, Warburton EA, Baron JC (2011), “Microembolism versus hemodynamic impairment in rosary-like deep watershed infarcts: a combined positron emission tomography and transcranial Doppler study.” Stroke 42(11):3138-43 Details

    Riss PJ, Aigbirhio FI (2011), “A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups.” Chem Commun (Camb) 47(43):11873-5 Details

    Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011), “Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.” J Cereb Blood Flow Metab 31(12):2334-42 Details

    Takasawa M, Beech JS, Fryer TD, Jones PS, Ahmed T, Smith R, Aigbirhio FI, Baron JC (2011), “Single-subject statistical mapping of acute brain hypoxia in the rat following middle cerebral artery occlusion: a microPET study.” Exp Neurol 229(2):251-8 Details


    Atack JR, Wong DF, Fryer TD, Ryan C, Sanabria S, Zhou Y, Dannals RF, Eng WS, Gibson RE, Burns HD, Vega JM, Vessy L, Scott-Stevens P, Beech JS, Baron JC, Sohal B, Schrag ML, Aigbirhio FI, McKernan RM, Hargreaves RJ (2010), “Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.” J Pharmacol Exp Ther 332(1):17-25 Details

    Davies JR, Izquierdo-Garcia D, Rudd JH, Figg N, Richards HK, Bird JL, Aigbirhio FI, Davenport AP, Weissberg PL, Fryer TD, Warburton EA (2010), “FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.” Int J Cardiovasc Imaging 26(1):41-8 Details

    Pascu SI, Waghorn PA, Kennedy BW, Arrowsmith RL, Bayly SR, Dilworth JR, Christlieb M, Tyrrell RM, Zhong J, Kowalczyk RM, Collison D, Aley PK, Churchill GC, Aigbirhio FI (2010), “Fluorescent copper(II) bis(thiosemicarbazonates): synthesis, structures, electron paramagnetic resonance, radiolabeling, in vitro cytotoxicity and confocal fluorescence microscopy studies.” Chem Asian J 5(3):506-19 Details

    Porteous CM, Logan A, Evans C, Ledgerwood EC, Menon DK, Aigbirhio F, Smith RA, Murphy MP (2010), “Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes.” Biochim Biophys Acta 1800(9):1009-17 Details


    Clatworthy PL, Lewis SJ, Brichard L, Hong YT, Izquierdo D, Clark L, Cools R, Aigbirhio FI, Baron JC, Fryer TD, Robbins TW (2009), “Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.” J Neurosci 29(15):4690-6 Details

    Dalley JW, Fryer TD, Aigbirhio FI, Brichard L, Richards HK, Hong YT, Baron JC, Everitt BJ, Robbins TW (2009), “Modelling human drug abuse and addiction with dedicated small animal positron emission tomography.” Neuropharmacology 56 Suppl 1:9-17 Details

    Donswijk ML, Jones PS, Guadagno JV, Carpenter TA, Moustafa RR, Fryer TD, Aigbirhio FI, Warburton EA, Baron JC (2009), “T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke.” Cerebrovasc Dis 28(3):306-13 Details

    Price SJ, Fryer TD, Cleij MC, Dean AF, Joseph J, Salvador R, Wang DD, Hutchinson PJ, Clark JC, Burnet NG, Pickard JD, Aigbirhio FI, Gillard JH (2009), “Imaging regional variation of cellular proliferation in gliomas using 3'-deoxy-3'-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study.” Clin Radiol 64(1):52-63 Details


    Abate MG, Trivedi M, Fryer TD, Smielewski P, Chatfield DA, Williams GB, Aigbirhio F, Carpenter TA, Pickard JD, Menon DK, Coles JP (2008), “Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity.” Neurocrit Care 9(3):319-25 Details

    Bayly SR, King RC, Honess DJ, Barnard PJ, Betts HM, Holland JP, Hueting R, Bonnitcha PD, Dilworth JR, Aigbirhio FI, Christlieb M (2008), “In vitro and in vivo evaluations of a hydrophilic 64Cu-bis(thiosemicarbazonato)-glucose conjugate for hypoxia imaging.” J Nucl Med 49(11):1862-8 Details

    Guadagno JV, Jones PS, Aigbirhio FI, Wang D, Fryer TD, Day DJ, Antoun N, Nimmo-Smith I, Warburton EA, Baron JC (2008), “Selective neuronal loss in rescued penumbra relates to initial hypoperfusion.” Brain 131(Pt 10):2666-78 Details

    Leyton J, Smith G, Lees M, Perumal M, Nguyen QD, Aigbirhio FI, Golovko O, He Q, Workman P, Aboagye EO (2008), “Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901.” Mol Cancer Ther 7(9):3112-21 Details

    Nortje J, Coles JP, Timofeev I, Fryer TD, Aigbirhio FI, Smielewski P, Outtrim JG, Chatfield DA, Pickard JD, Hutchinson PJ, Gupta AK, Menon DK (2008), “Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.” Crit Care Med 36(1):273-81 Details

    Pascu SI, Waghorn PA, Conry TD, Lin B, Betts HM, Dilworth JR, Sim RB, Churchill GC, Aigbirhio FI, Warren JE (2008), “Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.” Dalton Trans (16):2107-10 Details

    Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, Gillard JH, Williams GB, Aigbirhio FI, Warburton EA, Østergaard L, Baron JC (2008), “How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET.” Stroke 39(3):870-7 Details


    Atack JR, Scott-Stevens P, Beech JS, Fryer TD, Hughes JL, Cleij MC, Baron JC, Clark JC, Hargreaves RJ, Aigbirhio FI (2007), “Comparison of lorazepam [7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] occupancy of rat brain gamma-aminobutyric acid(A) receptors measured using in vivo [3H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) binding and [11C]flumazenil micro-positron emission tomography.” J Pharmacol Exp Ther 320(3):1030-7 Details

    Cleij MC, Clark JC, Baron J-C, Aigbirhio FI (2007), “Rapid Preparation Of [11C]Flumazenil: Captive Solvent Synthesis Combined With Purification by Analytical Sized Columns” J Labelled Compd Radiopharm (50):19-24

    Coles JP, Fryer TD, Coleman MR, Smielewski P, Gupta AK, Minhas PS, Aigbirhio F, Chatfield DA, Williams GB, Boniface S, Carpenter TA, Clark JC, Pickard JD, Menon DK (2007), “Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.” Crit Care Med 35(2):568-78 Details

    Dalley JW, Fryer TD, Brichard L, Robinson ES, Theobald DE, Lääne K, Peña Y, Murphy ER, Shah Y, Probst K, Abakumova I, Aigbirhio FI, Richards HK, Hong Y, Baron JC, Everitt BJ, Robbins TW (2007), “Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.” Science 315(5816):1267-70 Details

    Holland JP, Aigbirhio FI, Betts HM, Bonnitcha PD, Burke P, Christlieb M, Churchill GC, Cowley AR, Dilworth JR, Donnelly PS, Green JC, Peach JM, Vasudevan SR, Warren JE (2007), “Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: synthetic platforms toward site-specific radiopharmaceuticals.” Inorg Chem 46(2):465-85 Details

    Pascu SI, Waghorn PA, Conry TD, Betts HM, Dilworth JR, Churchill GC, Pokrovska T, Christlieb M, Aigbirhio FI, Warren JE (2007), “Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging.” Dalton Trans (43):4988-97 Details

    Takasawa M, Beech JS, Fryer TD, Hong YT, Hughes JL, Igase K, Jones PS, Smith R, Aigbirhio FI, Menon DK, Clark JC, Baron JC (2007), “Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study.” J Cereb Blood Flow Metab 27(4):679-89 Details


    Guadagno JV, Jones PS, Fryer TD, Barret O, Aigbirhio FI, Carpenter TA, Price CJ, Gillard JH, Warburton EA, Baron JC (2006), “Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain.” Stroke 37(7):1741-8 Details

    Guadagno JV, Warburton EA, Jones PS, Day DJ, Aigbirhio FI, Fryer TD, Harding S, Price CJ, Green HA, Barret O, Gillard JH, Baron JC (2006), “How affected is oxygen metabolism in DWI lesions?: A combined acute stroke PET-MR study.” Neurology 67(5):824-9 Details

    Pickard J, Chir M, Coleman M, Aigbirhio F, Carpenter TA, Owen A (2006), “Head injury: from the Glasgow Coma Scale to quo vadis.” Clin Neurosurg 53:53-7 Details

    Price CJ, Wang D, Menon DK, Guadagno JV, Cleij M, Fryer T, Aigbirhio F, Baron JC, Warburton EA (2006), “Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.” Stroke 37(7):1749-53 Details


    Cunningham AS, Salvador R, Coles JP, Chatfield DA, Bradley PG, Johnston AJ, Steiner LA, Fryer TD, Aigbirhio FI, Smielewski P, Williams GB, Carpenter TA, Gillard JH, Pickard JD, Menon DK (2005), “Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury.” Brain 128(Pt 8):1931-42 Details

    Guadagno JV, Warburton EA, Jones PS, Fryer TD, Day DJ, Gillard JH, Carpenter TA, Aigbirhio FI, Price CJ, Baron JC (2005), “The diffusion-weighted lesion in acute stroke: heterogeneous patterns of flow/metabolism uncoupling as assessed by quantitative positron emission tomography.” Cerebrovasc Dis 19(4):239-46 Details

    Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK (2005), “Imaging of cerebral blood flow and metabolism in brain injury in the ICU.” Acta Neurochir Suppl 95:459-64 Details


    Coles JP, Fryer TD, Smielewski P, Chatfield DA, Steiner LA, Johnston AJ, Downey SP, Williams GB, Aigbirhio F, Hutchinson PJ, Rice K, Carpenter TA, Clark JC, Pickard JD, Menon DK (2004), “Incidence and mechanisms of cerebral ischemia in early clinical head injury.” J Cereb Blood Flow Metab 24(2):202-11 Details

    Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smieleweski P, Chatfield DA, Aigbirhio F, Williams GB, Boniface S, Rice K, Clark JC, Pickard JD, Menon DK (2004), “Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?” Brain 127(Pt 11):2479-90 Details

    Guadagno JV, Warburton EA, Aigbirhio FI, Smielewski P, Fryer TD, Harding S, Price CJ, Gillard JH, Carpenter TA, Baron JC (2004), “Does the acute diffusion-weighted imaging lesion represent penumbra as well as core? A combined quantitative PET/MRI voxel-based study.” J Cereb Blood Flow Metab 24(11):1249-54 Details

    Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD (2004), “Diffusion limited oxygen delivery following head injury.” Crit Care Med 32(6):1384-90 Details


    Steiner LA, Coles JP, Czosnyka M, Minhas PS, Fryer TD, Aigbirhio FI, Clark JC, Smielewski P, Chatfield DA, Donovan T, Pickard JD, Menon DK (2003), “Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury.” J Neurol Neurosurg Psychiatry 74(6):765-70 Details

    Steiner LA, Coles JP, Johnston AJ, Chatfield DA, Smielewski P, Fryer TD, Aigbirhio FI, Clark JC, Pickard JD, Menon DK, Czosnyka M (2003), “Assessment of cerebrovascular autoregulation in head-injured patients: a validation study.” Stroke 34(10):2404-9 Details

    Steiner LA, Coles JP, Johnston AJ, Czosnyka M, Fryer TD, Smielewski P, Chatfield DA, Salvador R, Aigbirhio FI, Clark JC, Menon DK, Pickard JD (2003), “Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure.” J Cereb Blood Flow Metab 23(11):1371-7 Details


    Gupta AK, Hutchinson PJ, Fryer T, Al-Rawi PG, Parry DA, Minhas PS, Kett-White R, Kirkpatrick PJ, Mathews JC, Downey S, Aigbirhio F, Clark J, Pickard JD, Menon DK (2002), “Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method.” J Neurosurg 96(2):263-8 Details

    Hutchinson PJ, Gupta AK, Fryer TF, Al-Rawi PG, Chatfield DA, Coles JP, O'Connell MT, Kett-White R, Minhas PS, Aigbirhio FI, Clark JC, Kirkpatrick PJ, Menon DK, Pickard JD (2002), “Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.” J Cereb Blood Flow Metab 22(6):735-45 Details


    Constantinou M, Aigbirhio FI, Smith RG, Ramsden CA, Pike VW (2001), “Xenon difluoride exchanges fluoride under mild conditions: a simple preparation of [(18)F]xenon difluoride for PET and mechanistic studies.” J Am Chem Soc 123(8):1780-1 Details

    Rubinsztein JS, Fletcher PC, Rogers RD, Ho LW, Aigbirhio FI, Paykel ES, Robbins TW, Sahakian BJ (2001), “Decision-making in mania: a PET study.” Brain 124(Pt 12):2550-63 Details


    Johnström P, Aigbirhio FI, Clark JC, Downey SP, Pickard JD, Davenport AP (2000), “Syntheses of the first endothelin-A- and -B-selective radioligands for positron emission tomography.” J Cardiovasc Pharmacol 36(5 Suppl 1):S58-60 Details


    Pike VW, Aigbirhio FI, Freemantle CA, Page BC, Rhodes CG, Waters SL, Jones T, Olsson P, Ventresca GP, Tanner RJ (1995), “Disposition of inhaled 1,1,1,2-tetrafluoroethane (HFA134A) in healthy subjects and in patients with chronic airflow limitation. Measurement by 18F-labeling and whole-body gamma-counting.” Drug Metab Dispos 23(8):832-9 Details