Dr Jane M Anderson

Jane Anderson

University position

PhD student
Supervised by Siddharthan Chandran

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Home page

http://http//www.br...

Research Themes

Clinical and Veterinary Neuroscience

Cellular and Molecular Neuroscience

The Cambridge Neuroscience Community

Interests

Axonal loss is the principal pathological correlate of progressive irreversible disability in multiple sclerosis. The underlying pathophysiology of axonal loss however remains to be defined. Against this backdrop, my research focuses on exploring aspects of the interactions between glia and axons. Specifically, I am interested in the axonal cytoskeleton and its potential contribution to the neuro-degenerative sequelae.

Galactocerebroside-positive oligodendrocyte, in vitro
Galactocerebroside-positive oligodendrocyte, in vitro
Click image to view full-size

Research Focus

Keywords

tau/cytoskeleton

oligodendrocyte

axonopathy

multiple scelrosis

neurodegeneration

Clinical conditions

Alzheimer's disease

Multiple sclerosis

Equipment

Cell culture

Fluorescence microscopy

Immunohistochemistry

Western blotting

Collaborators

Cambridge

Maria Grazia Spillantini

United Kingdom

David Baker Web: http://http//www.ic...

Key publications

Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2010), “Abnormal tau phosphorylation in primary progressive multiple sclerosis.” Acta Neuropathol 119(5):591-600 Details

Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2009), “Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis.” Acta Neuropathol 117(5):583-9 Details

Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S (2008), “Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.” Brain 131(Pt 7):1736-48 Details

Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJ, Baker D, Chandran S (2008), “An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.” J Neuroimmunol 201-202:200-11 Details

Publications

2008

Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S (2008), “A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin.” Stem Cells 26(1):163-72 Details

2006

Gaughwin PM, Caldwell MA, Anderson JM, Schwiening CJ, Fawcett JW, Compston DA, Chandran S (2006), “Astrocytes promote neurogenesis from oligodendrocyte precursor cells.” Eur J Neurosci 23(4):945-56 Details