Dr Jane M Anderson
Supervised by Siddharthan Chandran
Axonal loss is the principal pathological correlate of progressive irreversible disability in multiple sclerosis. The underlying pathophysiology of axonal loss however remains to be defined. Against this backdrop, my research focuses on exploring aspects of the interactions between glia and axons. Specifically, I am interested in the axonal cytoskeleton and its potential contribution to the neuro-degenerative sequelae.
David Baker Web: http://http//www.ic...
Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2010), “Abnormal tau phosphorylation in primary progressive multiple sclerosis.” Acta Neuropathol 119(5):591-600 Details
Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2009), “Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis.” Acta Neuropathol 117(5):583-9 Details
Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S (2008), “Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.” Brain 131(Pt 7):1736-48 Details
Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJ, Baker D, Chandran S (2008), “An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.” J Neuroimmunol 201-202:200-11 Details
Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S (2008), “A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin.” Stem Cells 26(1):163-72 Details
Gaughwin PM, Caldwell MA, Anderson JM, Schwiening CJ, Fawcett JW, Compston DA, Chandran S (2006), “Astrocytes promote neurogenesis from oligodendrocyte precursor cells.” Eur J Neurosci 23(4):945-56 Details