Dr Eneida Mioshi

Eneida Mioshi

University position

Clinical Research Associate

Dr Eneida Mioshi is pleased to consider applications from prospective PhD students.

Departments

Department of Psychiatry

Email

em341@medschl.cam.ac.uk

Research Theme

Cognitive and Behavioural Neuroscience

Interests

My research focuses on the impact of dementias and other progressive neurodegenerative diseases on everyday functioning (e.g., Activities of daily living), and family carers.

To this end, my research involves development of better assessments of disability, investigation of the underlying behavioural and cognitive symptoms behind functional disability, and developing non-pharmacological interventions that compensate for these deficits.

I am very interested in developing more sensitive and specific assessments of disability in dementia and neurodegeneration. In particular, these assessments should tap into cognitive and behavioural symptoms, as well as external factors around the patient. I am committed to creating a novel scientific framework of disability that will support the development of novel interventions. In time, these interventions would be rigorously tested and rolled out to the health services.

Research Focus

Keywords

dementia

functional disability

neuropsychiatric symptoms

assessment

intervention

Clinical conditions

Alzheimer's disease

Frontotemporal dementia

Motor Neuron Disease

Movement disorders

Equipment

Behavioural analysis

Grounded theory

Rasch analysis

Collaborators

Cambridge

Christi Deaton

Michael Hornberger

John O'Brien

James Rowe

United Kingdom

Samrah Ahmed

Chris Kipps

Jonathan Rohrer

International

Suvarna Alladi

Nathalie Bier

Carolina Bottari

Paulo Caramelli

Lindy Clemson

Laura Gitlin

John Hodges

Sharpley Hsieh

Matthew Kiernan

Patricia Lillo

Sofia Pavarini

Olivier Piguet

Monica Yassuda

Associated News Items


    Key publications

    Mioshi E, Caga J, Lillo P, Hsieh S, Ramsey E, Devenney E, Hornberger M, Hodges JR, Kiernan MC (2014), “Neuropsychiatric changes precede classic motor symptoms in ALS and do not affect survival.” Neurology 82(2):149-55 Details

    Mioshi E, Foxe D, Leslie F, Savage S, Hsieh S, Miller L, Hodges JR, Piguet O (2013), “The impact of dementia severity on caregiver burden in frontotemporal dementia and Alzheimer disease.” Alzheimer Dis Assoc Disord 27(1):68-73 Details

    Mioshi E, Lillo P, Yew B, Hsieh S, Savage S, Hodges JR, Kiernan MC, Hornberger M (2013), “Cortical atrophy in ALS is critically associated with neuropsychiatric and cognitive changes.” Neurology 80(12):1117-23 Details

    Mioshi E, McKinnon C, Savage S, O'Connor CM, Hodges JR (2013), “Improving burden and coping skills in frontotemporal dementia caregivers: a pilot study.” Alzheimer Dis Assoc Disord 27(1):84-6 Details

    Mioshi E, Hsieh S, Savage S, Hornberger M, Hodges JR (2010), “Clinical staging and disease progression in frontotemporal dementia.” Neurology 74(20):1591-7 Details

    Mioshi E, Kipps CM, Dawson K, Mitchell J, Graham A, Hodges JR (2007), “Activities of daily living in frontotemporal dementia and Alzheimer disease.” Neurology 68(24):2077-84 Details

    Publications

    2015

    Ahmed RM, Kaizik C, Irish M, Mioshi E, Dermody N, Kiernan MC, Piguet O, Hodges JR (2015), “Characterizing Sexual Behavior in Frontotemporal Dementia.” J Alzheimers Dis Details

    Hsieh S, McGrory S, Leslie F, Dawson K, Ahmed S, Butler CR, Rowe JB, Mioshi E, Hodges JR (2015), “The Mini-Addenbrooke's Cognitive Examination: a new assessment tool for dementia.” Dement Geriatr Cogn Disord 39(1-2):1-11 Details

    Leslie FV, Hsieh S, Caga J, Savage SA, Mioshi E, Hornberger M, Kiernan MC, Hodges JR, Burrell JR (2015), “Semantic deficits in amyotrophic lateral sclerosis.” Amyotroph Lateral Scler Frontotemporal Degener 16(1-2):46-53 Details

    Mioshi E, Roberts R, Hornberger M (2015), “Neuropsychiatric symptoms and survival in amyotrophic lateral sclerosis: a missing link?” Neurodegener Dis Manag 5(2):89-91 Details

    Simon NG, Lee M, Bae JS, Mioshi E, Lin CS, Pfluger CM, Henderson RD, Vucic S, Swash M, Burke D, Kiernan MC (2015), “Dissociated lower limb muscle involvement in amyotrophic lateral sclerosis.” J Neurol Details

    2014

    Ahmed RM, Mioshi E, Caga J, Shibata M, Zoing M, Bartley L, Piguet O, Hodges JR, Kiernan MC (2014), “Body mass index delineates ALS from FTD: implications for metabolic health.” J Neurol 261(9):1774-80 Details

    Ambikairajah A, Devenney E, Flanagan E, Yew B, Mioshi E, Kiernan MC, Hodges JR, Hornberger M (2014), “A visual MRI atrophy rating scale for the amyotrophic lateral sclerosis-frontotemporal dementia continuum.” Amyotroph Lateral Scler Frontotemporal Degener Details

    Bae JS, Menon P, Mioshi E, Kiernan MC, Vucic S (2014), “Cortical hyperexcitability and the split-hand plus phenomenon: Pathophysiological insights in ALS.” Amyotroph Lateral Scler Frontotemporal Degener Details

    Caga J, Ramsey E, Hogden A, Mioshi E, Kiernan MC (2014), “A longer diagnostic interval is a risk for depression in amyotrophic lateral sclerosis.” Palliat Support Care :1-6 Details

    Devenney E, Hornberger M, Irish M, Mioshi E, Burrell J, Tan R, Kiernan MC, Hodges JR (2014), “Frontotemporal Dementia Associated With the C9ORF72 Mutation: A Unique Clinical Profile.” JAMA Neurol Details

    Hornberger M, Yew B, Gilardoni S, Mioshi E, Gleichgerrcht E, Manes F, Hodges JR (2014), “Ventromedial-frontopolar prefrontal cortex atrophy correlates with insight loss in frontotemporal dementia and Alzheimer's disease.” Hum Brain Mapp 35(2):616-26 Details

    Mioshi E, Hsieh S, Caga J, Ramsey E, Chen K, Lillo P, Simon N, Vucic S, Hornberger M, Hodges JR, Kiernan MC (2014), “A novel tool to detect behavioural symptoms in ALS.” Amyotroph Lateral Scler Frontotemporal Degener 15(3-4):298-304 Details

    O'Connor CM, Clemson L, Brodaty H, Jeon YH, Mioshi E, Gitlin LN (2014), “Use of the Tailored Activities Program to reduce neuropsychiatric behaviors in dementia: an Australian protocol for a randomized trial to evaluate its effectiveness.” Int Psychogeriatr :1-13 Details

    2013

    Bae JS, Menon P, Mioshi E, Kiernan MC, Vucic S (2013), “Cortical excitability differences between flexor pollicis longus and APB.” Neurosci Lett 541:150-4 Details

    Cushing N, Jang J, O'Connor CM, Burrell JR, Clemson L, Hodges JR, Mioshi E (2013), “Disability in atypical parkinsonian syndromes is more dependent on memory dysfunction than motor symptoms.” Parkinsonism Relat Disord 19(4):436-40 Details

    Hsieh S, Lillo P, Kiernan MC, Hodges JR, Mioshi E (2013), “When more is needed: the utility of the frontotemporal dementia scale in ALS.” Amyotroph Lateral Scler Frontotemporal Degener 14(3):169-71 Details

    Hsieh S, Schubert S, Hoon C, Mioshi E, Hodges JR (2013), “Validation of the Addenbrooke's Cognitive Examination III in frontotemporal dementia and Alzheimer's disease.” Dement Geriatr Cogn Disord 36(3-4):242-50 Details

    Leyton CE, Hsieh S, Mioshi E, Hodges JR (2013), “Cognitive decline in logopenic aphasia: more than losing words.” Neurology 80(10):897-903 Details

    Lima-Silva TB, Bahia VS, Carvalho VA, Guimaraes HC, Caramelli P, Balthazar M, Damasceno B, Bottino CMC, Brucki SMD, Mioshi E, Nitrini R, Yassuda MS (2013), “Translation, applicability and cross-cultural adaptation of the Brazilian version of the Frontotemporal Dementia Rating Scale (FTDFRS)” Dementia & Neuropsychologia 7(4):387-396.

    McKinnon C, O'Connor CM, Savage S, Hodges JR, Mioshi E (2013), “Qualitative results of a structured group program for carers of people with frontotemporal dementia.” Int J Geriatr Psychiatry 28(2):217-8 Details

    Mekala S, Alladi S, Chandrasekar K, Fathima S, O’Connor CM, McKinnon M, Hornberger M, Piguet O, Hodges JR, Mioshi E (2013), “Cultural differences affect factors behind carer burden in FTD: a comparison study between India and Australia” Dementia & Neuropsychologia 7(1):104-109

    Menon P, Bae JS, Mioshi E, Kiernan MC, Vucic S (2013), “Split-hand plus sign in ALS: differential involvement of the flexor pollicis longus and intrinsic hand muscles.” Amyotroph Lateral Scler Frontotemporal Degener 14(4):315-8 Details

    Miller LA, Mioshi E, Savage S, Lah S, Hodges JR, Piguet O (2013), “Identifying cognitive and demographic variables that contribute to carer burden in dementia.” Dement Geriatr Cogn Disord 36(1-2):43-9 Details

    Mioshi E, Hodges JR, Hornberger M (2013), “Neural correlates of activities of daily living in frontotemporal dementia.” J Geriatr Psychiatry Neurol 26(1):51-7 Details

    O’Connor CM, Da Silva TBL, Piguet O, Hodges JR, Clemson L, Mioshi E (2013), “Enhancement of carer skills and patient function in the non-pharmacological managmenet of FTD: a call for randomised controlled studies” Dementia & Neuropsychologia 7(2):143-150

    Tu S, Mioshi E, Savage S, Hodges JR, Hornberger M (2013), “Dissociation of explicit and implicit long-term memory consolidation in semantic dementia: a case study.” Neurocase 19(4):401-7 Details

    2012

    Go C, Mioshi M, Yew B, Hodges JR, Hornberger M (2012), “Neural correlates of apathy in behavioural variant frontotemporal dementia and Alzheimer’s disease” Dementia & Neuropsychologia 6(1):12-17

    Hsieh S, Hodges JR, Leyton CE, Mioshi E (2012), “Longitudinal changes in primary progressive aphasias: differences in cognitive and dementia staging measures.” Dement Geriatr Cogn Disord 34(2):135-41 Details

    Jang J, Cushing N, Clemson L, Hodges JR, Mioshi E (2012), “Activities of daily living in progressive non-fluent aphasia, logopenic progressive aphasia and Alzheimer's disease.” Dement Geriatr Cogn Disord 33(5):354-60 Details

    Lillo P, Mioshi E, Burrell JR, Kiernan MC, Hodges JR, Hornberger M (2012), “Grey and white matter changes across the amyotrophic lateral sclerosis-frontotemporal dementia continuum.” PLoS One 7(8):e43993 Details

    Lillo P, Mioshi E, Hodges JR (2012), “Caregiver burden in amyotrophic lateral sclerosis is more dependent on patients' behavioral changes than physical disability: a comparative study.” BMC Neurol 12:156 Details

    Lillo P, Savage S, Mioshi E, Kiernan MC, Hodges JR (2012), “Amyotrophic lateral sclerosis and frontotemporal dementia: A behavioural and cognitive continuum.” Amyotroph Lateral Scler 13(1):102-9 Details

    Mioshi E, Lillo P, Kiernan M, Hodges J (2012), “Activities of daily living in motor neuron disease: role of behavioural and motor changes.” J Clin Neurosci 19(4):552-6 Details

    2011

    Lillo P, Mioshi E, Zoing MC, Kiernan MC, Hodges JR (2011), “How common are behavioural changes in amyotrophic lateral sclerosis?” Amyotroph Lateral Scler 12(1):45-51 Details

    Pigliautile M, Ricci M, Mioshi E, Ercolani S, Mangialasche F, Monastero R, Croce MF, Federici S, Mecocci P (2011), “Validation study of the Italian Addenbrooke's Cognitive Examination Revised in a young-old and old-old population.” Dement Geriatr Cogn Disord 32(5):301-7 Details

    Piguet O, Hornberger M, Mioshi E, Hodges JR (2011), “Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management.” Lancet Neurol 10(2):162-72 Details

    2010

    Hornberger M, Savage S, Hsieh S, Mioshi E, Piguet O, Hodges JR (2010), “Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease.” Dement Geriatr Cogn Disord 30(6):547-52 Details

    Leyton CE, Hornberger M, Mioshi E, Hodges JR (2010), “Application of Addenbrooke's cognitive examination to diagnosis and monitoring of progressive primary aphasia.” Dement Geriatr Cogn Disord 29(6):504-9 Details

    2009

    Kipps CM, Mioshi E, Hodges JR (2009), “Emotion, social functioning and activities of daily living in frontotemporal dementia.” Neurocase 15(3):182-9 Details

    Mioshi E, Bristow M, Cook R, Hodges JR (2009), “Factors underlying caregiver stress in frontotemporal dementia and Alzheimer's disease.” Dement Geriatr Cogn Disord 27(1):76-81 Details

    Mioshi E, Hodges JR (2009), “Rate of change of functional abilities in frontotemporal dementia.” Dement Geriatr Cogn Disord 28(5):419-26 Details

    Mioshi E, Kipps CM, Hodges JR (2009), “Activities of daily living in behavioral variant frontotemporal dementia: differences in caregiver and performance-based assessments.” Alzheimer Dis Assoc Disord 23(1):70-6 Details

    2008

    Davies RR, Dawson K, Mioshi E, Erzinçlioğlu S, Hodges JR (2008), “Differentiation of semantic dementia and Alzheimer's disease using the Addenbrooke's Cognitive Examination (ACE).” Int J Geriatr Psychiatry 23(4):370-5 Details

    Wear HJ, Wedderburn CJ, Mioshi E, Williams-Gray CH, Mason SL, Barker RA, Hodges JR (2008), “The Cambridge Behavioural Inventory Revised” Dementia & Neuropsychologia 2(2):102-107

    2007

    Alexopoulos P, Mioshi E, Greim B, Kurz A (2007), “Brief assessment of cognitive mental status in German: the Addenbrooke’s Cognitive Examination (ACE) and the Addenbrooke’s Cognitive Examination Revised (ACE-R)” European Journal of Geriatrics 9(4), 175-180

    Bak TH, Mioshi E (2007), “A cognitive bedside assessment beyond the MMSE: the Addenbrooke's Cognitive Examination.” Pract Neurol 7(4):245-9 Details

    2006

    Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR (2006), “The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening.” Int J Geriatr Psychiatry 21(11):1078-85 Details