Dr Emmanuel A Stamatakis

Emmanuel  A Stamatakis

University position

Stephen Erskine Fellow, Queens' College

Dr Emmanuel A Stamatakis is pleased to consider applications from prospective PhD students.

Departments

Department of Medicine

Institutes

Behavioural and Clinical Neurosciences Institute and Division of Anaesthesia

Home page

https://sites.google.com/site/cc... (personal home page)

Research Themes

Cognitive and Behavioural Neuroscience

Systems and Computational Neuroscience

Interests

My research aims to decode complex relationships between remote and/or proximal brain regions, which form networks at rest or during goal directed behaviour. This includes work on network adaptive behaviour (reorganisation/plasticity) triggered by abrupt (e.g. trauma, stroke) or gradual structural changes (e.g. neuropsychiatric/neurodegenerative diseases, ageing), or pharmacological agents. Although I primarily work with task related networks, I am also interested in the significance of resting networks and their relationship with task networks. In this context, my research questions are: Can resting network connectivity in individuals/groups provide insights to their ability to complete certain tasks? What happens to resting network connectivity during goal directed behaviour? How does structural integrity relate to network connectivity and behaviour? How do pharmacological agents modulate network organisation at rest or during tasks?

Motor system connectivity in healthy controls and brain injured patients. Green lines - positive interactions. Red lines - negative interactions. Solid lines - significant cluster level with  p < 0.05 corrected for multiple comparisons. Dotted lines - significant at voxel level with p < 0.001 uncorrected.  Neurology. 2010 Jul 13;75(2):168-76.
Motor system connectivity in healthy controls and brain injured patients. Green lines - positive interactions. Red lines - negative interactions. Solid lines - significant cluster level with p < 0.05 corrected for multiple comparisons. Dotted lines - significant at voxel level with p < 0.001 uncorrected. Neurology. 2010 Jul 13;75(2):168-76.
Click image to view full-size

Research Focus

Keywords

fMRI

Functional/structural connectivity

Pharmacological fMRI

Resting state fMRI

Clinical conditions

Stroke

Traumatic brain injury

Equipment

Behavioural analysis

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

Cambridge

Tristan Bekinschtein

Srivas Chenu

Simon Godsill

David Menon

Brechtje Post

Barbara Sahakian

Lorraine K Tyler

International

Antonio Verdejo-García Web: http://directorio.ugr.es/static/...

W Alan C Mutch Web: http://umanitoba.ca/faculti...

Kirsten Taylor Web: http://www.memoryclinic.ch/

Eleni Vassilaki Web: http://www.edc.uoc.gr/ptde/in...

Associated News Items


    Key publications

    Chennu S, Stamatakis EA, Menon DK (2016), “The see-saw brain: recovering consciousness after brain injury” Lancet Neurol S1474-4422(16)30027-8.

    Moreno-López L, Sahakian BJ, Manktelow A, Menon DK, Stamatakis EA (in press), “Depression following traumatic brain injury: A functional connectivity perspective ” Brain Injury

    Vatansever D, Manktelow AE, Sahakian BJ, Menon DK, Stamatakis EA (in press), “Angular Default Mode Network Connectivity Across Working Memory Load” Human Brain Mapping

    Vatansever D, Manktelow AE, Sahakian BJ, Menon DK, Stamatakis EA (2016), “Cognitive Flexibility: A Default Network and Basal Ganglia Connectivity Perspective” Brain Connectivity 6(3): 201-207

    Vatansever D Menon DK, Manktelow AE, Sahakian BJ, Stamatakis EA (2015), “Default mode dynamics for global functional integration” Journal of Neuroscience 35(46):15254-62

    Meunier D, Stamatakis EA, Tyler LK (2014), “Age-related functional reorganization, structural changes, and preserved cognition.” Neurobiol Aging 35(1):42-54 Details

    Rolheiser T, Stamatakis EA, Tyler LK (2011), “Dynamic processing in the human language system: synergy between the arcuate fascicle and extreme capsule.” J Neurosci 31(47):16949-57 Details

    Kasahara M, Menon DK, Salmond CH, Outtrim JG, Taylor Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2010), “Altered functional connectivity in the motor network after traumatic brain injury.” Neurology 75(2):168-76 Details

    Stamatakis EA, Adapa RM, Absalom AR, Menon DK (2010), “Changes in resting neural connectivity during propofol sedation.” PLoS One 5(12):e14224 Details

    Tyler LK, Wright P, Randall B, Marslen-Wilson WD, Stamatakis EA (2010), “Reorganization of syntactic processing following left-hemisphere brain damage: does right-hemisphere activity preserve function?” Brain 133(11):3396-408 Details

    Stamatakis EA, Marslen-Wilson WD, Tyler LK, Fletcher PC (2005), “Cingulate control of fronto-temporal integration reflects linguistic demands: a three-way interaction in functional connectivity.” Neuroimage 28(1):115-21 Details

    Tyler LK, Marslen-Wilson WD, Stamatakis EA (2005), “Differentiating lexical form, meaning, and structure in the neural language system.” Proc Natl Acad Sci U S A 102(23):8375-80 Details

    Publications

    in press

    Agarwal S, Stamatakis EA, Geva S, Warburton EA (in press), “Dominant hemisphere functional networks compensate for structural connectivity loss to preserve phonological word retrieval with aging” Brain and Behavior

    Ahmad MF, Murphy J, Vatansever D, Stamatakis EA and Godsill S (in press), “Bayesian Inference of Task-Based Functional Brain Connectivity Using Markov Chain Monte Carlo Methods” IEEE Journal of Selected Topics in Signal Processing

    Moreno-Lopez L, Contreras-Rodriguez O, Soriano-Mas C, Stamatakis EA, Verdejo-Garcia A (in press), “Disrupted functional connectivity in adolescent obesity” NeuroImage: Clinical

    2015

    Barttfeld P, Bekinschtein TA, Salles A, Stamatakis EA, Adapa, R, Menon DK, Sigman M (2015), “Factoring the brain signatures of anesthesia concentration and level of arousal across individuals” NeuroImage:Clinical 9:385-91

    Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A; CENTER-TBI Participants and Investigators (2015), “Colaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study” Neurosurgery 76:67-80

    Vatansever D, Menon DK, Manktelow AE, Sahakian BJ, Stamatakis EA (2015), “Default mode network connectivity during task execution” Neuroimage 122:96-104

    2014

    Adapa RM, Davis MH, Stamatakis EA, Absalom AR, Menon DK (2014), “Neural correlates of successful semantic processing during propofol sedation” Hum Brain Mapp 35(7):2935-49

    Goon SS, Stamatakis EA, Adapa RM, Kasahara M, Bishop S, Wood DF, Wheeler DW, Menon DK, Gupta AK (2014), “Clinical decision-making augmented by simulation training: neural correlates demonstrated by functional imaging: a pilot study.” Br J Anaesth 112(1):124-32 Details

    Zhuang J, Tyler LK, Randall B, Stamatakis EA, Marslen-Wilson WD (2014), “Optimally efficient neural systems for processing spoken language.” Cereb Cortex 24(4):908-18 Details

    2013

    Griffiths JD, Marslen-Wilson WD, Stamatakis EA, Tyler LK (2013), “Functional organization of the neural language system: dorsal and ventral pathways are critical for syntax.” Cereb Cortex 23(1):139-47 Details

    Moreno-López L, Fernández-Serrano MJ, Stamatakis EA, Gómez-Río M, Rodríguez-Fernández A, Pérez-García M, Verdejo-García A (2013), “[Differential association between the regional metabolism of the prefrontal cortex and limbic structures, and the time of abstinence in substance dependent individuals].” Adicciones 25(4):348-55 Details

    2012

    Moreno-López L, Catena A, Fernández-Serrano MJ, Delgado-Rico E, Stamatakis EA, Pérez-García M, Verdejo-García A (2012), “Trait impulsivity and prefrontal gray matter reductions in cocaine dependent individuals.” Drug Alcohol Depend 125(3):208-14 Details

    Moreno-López L, Stamatakis EA, Fernández-Serrano MJ, Gómez-Río M, Rodríguez-Fernández A, Pérez-García M, Verdejo-García A (2012), “Neural correlates of hot and cold executive functions in polysubstance addiction: association between neuropsychological performance and resting brain metabolism as measured by positron emission tomography.” Psychiatry Res 203(2-3):214-21 Details

    Moreno-López L, Stamatakis EA, Fernández-Serrano MJ, Gómez-Río M, Rodríguez-Fernández A, Pérez-García M, Verdejo-García A (2012), “Neural correlates of the severity of cocaine, heroin, alcohol, MDMA and cannabis use in polysubstance abusers: a resting-PET brain metabolism study.” PLoS One 7(6):e39830 Details

    Shafto M, Randall B, Stamatakis EA, Wright P, Tyler LK (2012), “Age-related neural reorganization during spoken word recognition: the interaction of form and meaning.” J Cogn Neurosci 24(6):1434-46 Details

    Wright P, Stamatakis EA, Tyler LK (2012), “Differentiating hemispheric contributions to syntax and semantics in patients with left-hemisphere lesions.” J Neurosci 32(24):8149-57 Details

    2011

    Kasahara M, Menon DK, Salmond CH, Outtrim JG, Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2011), “Traumatic brain injury alters the functional brain network mediating working memory.” Brain Inj 25(12):1170-87 Details

    Papoutsi M, Stamatakis EA, Griffiths J, Marslen-Wilson WD, Tyler LK (2011), “Is left fronto-temporal connectivity essential for syntax? Effective connectivity, tractography and performance in left-hemisphere damaged patients.” Neuroimage 58(2):656-64 Details

    Stamatakis EA, Shafto MA, Williams G, Tam P, Tyler LK (2011), “White matter changes and word finding failures with increasing age.” PLoS One 6(1):e14496 Details

    Tyler LK, Marslen-Wilson WD, Randall B, Wright P, Devereux BJ, Zhuang J, Papoutsi M, Stamatakis EA (2011), “Left inferior frontal cortex and syntax: function, structure and behaviour in patients with left hemisphere damage.” Brain 134(Pt 2):415-31 Details

    Zhuang J, Randall B, Stamatakis EA, Marslen-Wilson WD, Tyler LK (2011), “The Interaction of Lexical Semantics and Cohort Competition in Spoken Word Recognition: An fMRI Study.” J Cogn Neurosci Details

    2010

    Green S, Ralph MA, Moll J, Stamatakis EA, Grafman J, Zahn R (2010), “Selective functional integration between anterior temporal and distinct fronto-mesolimbic regions during guilt and indignation.” Neuroimage 52(4):1720-6 Details

    Shafto MA, Stamatakis EA, Tam PP, Tyler LK (2010), “Word retrieval failures in old age: the relationship between structure and function.” J Cogn Neurosci 22(7):1530-40 Details

    Tyler LK, Shafto MA, Randall B, Wright P, Marslen-Wilson WD, Stamatakis EA (2010), “Preserving syntactic processing across the adult life span: the modulation of the frontotemporal language system in the context of age-related atrophy.” Cereb Cortex 20(2):352-64 Details

    2009

    Acres K, Taylor KI, Moss HE, Stamatakis EA, Tyler LK (2009), “Complementary hemispheric asymmetries in object naming and recognition: a voxel-based correlational study.” Neuropsychologia 47(8-9):1836-43 Details

    Raposo A, Moss HE, Stamatakis EA, Tyler LK (2009), “Modulation of motor and premotor cortices by actions, action words and action sentences.” Neuropsychologia 47(2):388-96 Details

    Taylor KI, Stamatakis EA, Tyler LK (2009), “Crossmodal integration of object features: voxel-based correlations in brain-damaged patients.” Brain 132(Pt 3):671-83 Details

    2008

    Bright P, Moss HE, Stamatakis EA, Tyler LK (2008), “Longitudinal studies of semantic dementia: the relationship between structural and functional changes over time.” Neuropsychologia 46(8):2177-88 Details

    Tyler LK, Randall B, Stamatakis EA (2008), “Cortical differentiation for nouns and verbs depends on grammatical markers.” J Cogn Neurosci 20(8):1381-9 Details

    2007

    Bozic M, Marslen-Wilson WD, Stamatakis EA, Davis MH, Tyler LK (2007), “Differentiating morphology, form, and meaning: neural correlates of morphological complexity.” J Cogn Neurosci 19(9):1464-75 Details

    Bright P, Moss HE, Longe O, Stamatakis EA, Tyler LK (2007), “Conceptual structure modulates anteromedial temporal involvement in processing verbally presented object properties.” Cereb Cortex 17(5):1066-73 Details

    Longe O, Randall B, Stamatakis EA, Tyler LK (2007), “Grammatical categories in the brain: the role of morphological structure.” Cereb Cortex 17(8):1812-20 Details

    Noppeney U, Patterson K, Tyler LK, Moss H, Stamatakis EA, Bright P, Mummery C, Price CJ (2007), “Temporal lobe lesions and semantic impairment: a comparison of herpes simplex virus encephalitis and semantic dementia.” Brain 130(Pt 4):1138-47 Details

    Shafto MA, Burke DM, Stamatakis EA, Tam PP, Tyler LK (2007), “On the tip-of-the-tongue: neural correlates of increased word-finding failures in normal aging.” J Cogn Neurosci 19(12):2060-70 Details

    2006

    Raposo A, Moss HE, Stamatakis EA, Tyler LK (2006), “Repetition suppression and semantic enhancement: an investigation of the neural correlates of priming.” Neuropsychologia 44(12):2284-95 Details

    Taylor KI, Moss HE, Stamatakis EA, Tyler LK (2006), “Binding crossmodal object features in perirhinal cortex.” Proc Natl Acad Sci U S A 103(21):8239-44 Details

    2005

    Bright P, Moss HE, Stamatakis EA, Tyler LK (2005), “The anatomy of object processing: the role of anteromedial temporal cortex.” Q J Exp Psychol B 58(3-4):361-77 Details

    Moss HE, Rodd JM, Stamatakis EA, Bright P, Tyler LK (2005), “Anteromedial temporal cortex supports fine-grained differentiation among objects.” Cereb Cortex 15(5):616-27 Details

    Stamatakis EA, Tyler LK (2005), “Identifying lesions on structural brain images--validation of the method and application to neuropsychological patients.” Brain Lang 94(2):167-77 Details

    Tyler LK, Marslen-Wilson W, Stamatakis EA (2005), “Dissociating neuro-cognitive component processes: voxel-based correlational methodology.” Neuropsychologia 43(5):771-8 Details

    Tyler LK, Stamatakis EA, Post B, Randall B, Marslen-Wilson W (2005), “Temporal and frontal systems in speech comprehension: an fMRI study of past tense processing.” Neuropsychologia 43(13):1963-74 Details

    2004

    Tyler LK, Bright P, Fletcher P, Stamatakis EA (2004), “Neural processing of nouns and verbs: the role of inflectional morphology.” Neuropsychologia 42(4):512-23 Details

    Tyler LK, Stamatakis EA, Bright P, Acres K, Abdallah S, Rodd JM, Moss HE (2004), “Processing objects at different levels of specificity.” J Cogn Neurosci 16(3):351-62 Details

    Tyler LK, Stamatakis EA, Jones RW, Bright P, Acres K, Marslen-Wilson WD (2004), “Deficits for semantics and the irregular past tense: a causal relationship?” J Cogn Neurosci 16(7):1159-72 Details

    2003

    Stamatakis EA, Hetherington MM (2003), “Neuroimaging in eating disorders.” Nutr Neurosci 6(6):325-34 Details

    Tyler LK, Stamatakis EA, Dick E, Bright P, Fletcher P, Moss H (2003), “Objects and their actions: evidence for a neurally distributed semantic system.” Neuroimage 18(2):542-57 Details

    2002

    Stamatakis EA, Wilson JT, Hadley DM, Wyper DJ (2002), “SPECT imaging in head injury interpreted with statistical parametric mapping.” J Nucl Med 43(4):476-83 Details

    2001

    Stamatakis EA, Wilson JT, Wyper DJ (2001), “Spatial normalization of lesioned HMPAO-SPECT images.” Neuroimage 14(4):844-52 Details

    2000

    Stamatakis EA, Wilson JT, Wyper DJ (2000), “Analysis of HMPAO SPECT scans in head injury using Statistical Parametric Mapping.” Behav Neurol 12(1-2):29-37 Details

    1999

    Stamatakis EA, Glabus MF, Wyper DJ, Barnes A, Wilson JT (1999), “Validation of statistical parametric mapping (SPM) in assessing cerebral lesions: A simulation study.” Neuroimage 10(4):397-407 Details