Dr Darren Logan

Darren Logan

University position

Principal Investigator

Dr Darren Logan is pleased to consider applications from prospective PhD students.

Institutes

Monell Chemical Senses Center and Wellcome Trust Sanger Institute

Email

dl5@sanger.ac.uk

Home page

http://www.sanger.ac.uk/science... (personal home page)

Research Themes

Cellular and Molecular Neuroscience

Cognitive and Behavioural Neuroscience

Interests

Our research interest is in understanding the molecular and genetic basis of olfaction, and how that influences behaviour. Our wider aim is to characterise the neural circuits that instruct stereotyped hard-wired behaviours, and investigate how these integrate with learned responses to sensory stimuli.

We currently focus on olfactory and pheromone signaling in mice as our preferred model system. We combine genetic, cellular, computational, and behavioural approaches to identify and experimentally manipulate the genes that mediate chemosensation and influence a range of social behaviours including aggression, fear, mating, suckling, feeding, social recognition and parenting.

Coronal section of a mouse vomeronasal organ showing the sensory epithelia (blue) that detect pheromones
Section through a mouse vomeronasal organ showing the layers of sensory neurons (blue) that detect innate cues, such as pheromones.
View image full-size (1600x1200 pixels)

Research Focus

Keywords

olfaction

pheromones

behaviour

instinct

sensory

Clinical conditions

Anosmia

Behavioural disorders

Cognitive impairment

Eating disorders

Genetic disorders

Learning disabilities

Equipment

Behavioural analysis

Calcium imaging

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

RNA-seq

Whole genome sequencing

Collaborators

Cambridge

Tony Coll

John Marioni

Michele Vendruscolo

Giles Yeo

United Kingdom

John Mulley Web: http://www.bangor.ac.uk/biology...

International

Pablo Chamero Web: http://physiology.uni-saarland.de/Pablo_C...

Signrun Korsching Web: http://www.genetik.uni-koeln.de/groups/...

Joel Mainland Web: http://www.monell.org/faculty...

Peter Mombaerts Web: http://www.mpg.de/342867/...

Fabio Papes Web: http://www.thesgc.org/profile...

Lisa Stowers Web: http://www.scripps.edu/cb/stow...

Associated News Items


    Key publications

    Dey S, Chamero P, Pru JK, Chien MS, Ibarra-Soria X, Spencer KR, Logan DW, Matsunami H, Peluso JJ, Stowers L (2015), “Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior.” Cell 161(6):1334-44 Details

    Saraiva LR, Ibarra-Soria X, Khan M, Omura M, Scialdone A, Mombaerts P, Marioni JC, Logan DW. (2015), “Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq.” Sci Rep. 5:18178 PDF

    Ibarra-Soria X, Levitin MO, Saraiva LR, Logan DW (2014), “The olfactory transcriptomes of mice.” PLoS Genet 10(9):e1004593 Details

    Kaur AW, Ackels T, Kuo TH, Cichy A, Dey S, Hays C, Kateri M, Logan DW, Marton TF, Spehr M, Stowers L (2014), “Murine pheromone proteins constitute a context-dependent combinatorial code governing multiple social behaviors.” Cell 157(3):676-88 Details

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013), “Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes.” Cell 154(2):452-64 PDF Details

    Logan DW, Brunet LJ, Webb WR, Cutforth T, Ngai J, Stowers L (2012), “Learned recognition of maternal signature odors mediates the first suckling episode in mice.” Curr Biol 22(21):1998-2007 Details

    Wynn EH, Sánchez-Andrade G, Carss KJ, Logan DW (2012), “Genomic variation in the vomeronasal receptor gene repertoires of inbred mice.” BMC Genomics 13(1):415 PDF Details

    Papes F, Logan DW, Stowers L (2010), “The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs.” Cell 141(4):692-703 Details

    Publications

    2015

    Oboti L, Ibarra-Soria X, Pérez-Gómez A, Schmid A, Pyrski M, Paschek N, Kircher S, Logan DW, Leinders-Zufall T, Zufall F, Chamero P. (2015), “Pregnancy and estrogen enhance neural progenitor-cell proliferation in the vomeronasal sensory epithelium.” BMC Biol. 13:104 PDF

    Saraiva LR, Ahuja G, Ivandic I, Syed AS, Marioni JC, Korsching SI, Logan DW (2015), “Molecular and neuronal homology between the olfactory systems of zebrafish and mouse.” Sci Rep 5:11487 Details

    2014

    GCAN (2014), “Using ancestry-informative markers to identify fine structure across 15 populations of European origin.” Eur J Hum Genet Details

    Hargreaves AD, Swain MT, Hegarty MJ, Logan DW, Mulley JF (2014), “Restriction and recruitment-gene duplication and the origin and evolution of snake venom toxins.” Genome Biol Evol 6(8):2088-95 Details

    Hargreaves AD, Swain MT, Logan DW, Mulley JF (2014), “Testing the Toxicofera: comparative transcriptomics casts doubt on the single, early evolution of the reptile venom system.” Toxicon 92:140-56 Details

    Ibarra-Soria X, Levitin MO, Logan DW (2014), “The genomic basis of vomeronasal-mediated behaviour.” Mamm Genome 25(1-2):75-86 Details

    Logan DW (2014), “Do you smell what I smell? Genetic variation in olfactory perception.” Biochem Soc Trans 42(4):861-5 Details

    Sánchez-Andrade G, Logan DW (2014), “Deconstructing pheromone-mediated behavior one layer at a time.” BMC Biol 12:33 Details

    The Wellcome Trust Case Control Consortium 3 (2014), “A genome-wide association study of anorexia nervosa.” Mol Psychiatry Details

    2013

    Bateman A, Kelso J, Mietchen D, Macintyre G, Di Domenico T, Abeel T, Logan DW, Radivojac P, Rost B (2013), “ISCB computational biology Wikipedia competition.” PLoS Comput Biol 9(9):e1003242 Details

    Huckins LM, Logan DW, Sánchez-Andrade G (2013), “Olfaction and olfactory-mediated behaviour in psychiatric disease models.” Cell Tissue Res Details

    2012

    Glusman G, Cariaso M, Jimenez R, Swan D, Greshake B, Bhak J, Logan DW, Corpas M (2012), “Low budget analysis of Direct-To-Consumer genomic testing familial data” F1000 Research 1:3 PDF

    McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F, Sanger Mouse Genetics Project, Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ (2012), “Disruption of mouse cenpj, a regulator of centriole biogenesis, phenocopies seckel syndrome.” PLoS Genet 8(11):e1003022 PDF Details

    Migdalska AM, van der Weyden L, Ismail O, The Sanger Mouse Genetics Project, Rust AG, Rashid M, White JK, Sánchez-Andrade G, Lupski JR, Logan DW, Arends MJ, Adams DJ (2012), “Generation of the Sotos syndrome deletion in mice.” Mamm Genome Details

    Migdalska AM, van der Weyden L, Ismail O, White JK, Sanger Mouse Genetics Project, Sánchez-Andrade G, Logan DW, Arends MJ, Adams DJ (2012), “Modeling partial monosomy for human chromosome 21q11.2-q21.1 reveals haploinsufficient genes influencing behavior and fat deposition.” PLoS One 7(1):e29681 PDF Details

    2011

    van der Weyden L, White JK, Adams DJ, Logan DW (2011), “The mouse genetics toolkit: revealing function and mechanism.” Genome Biol 12(6):224 Details

    2010

    Logan DW, Sandal M, Gardner PP, Manske M, Bateman A (2010), “Ten simple rules for editing Wikipedia.” PLoS Comput Biol 6(9) PDF Details

    Stowers L, Logan DW (2010), “Olfactory mechanisms of stereotyped behavior: on the scent of specialized circuits.” Curr Opin Neurobiol 20(3):274-80 Details

    Stowers L, Logan DW (2010), “Sexual dimorphism in olfactory signaling.” Curr Opin Neurobiol 20(6):770-5 Details

    2008

    Logan DW, Marton TF, Stowers L (2008), “Species specificity in major urinary proteins by parallel evolution.” PLoS One 3(9):e3280 PDF Details

    2007

    Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR, Saghatelian A, Cravatt BF, Stowers L (2007), “Identification of protein pheromones that promote aggressive behaviour.” Nature 450(7171):899-902 Details

    2006

    Logan DW, Burn SF, Jackson IJ (2006), “Regulation of pigmentation in zebrafish melanophores.” Pigment Cell Res 19(3):206-13 Details

    2004

    Bryson-Richardson RJ, Logan DW, Currie PD, Jackson IJ (2004), “Large-scale analysis of gene structure in rhodopsin-like GPCRs: evidence for widespread loss of an ancient intron.” Gene 338(1):15-23 Details

    2003

    Logan DW, Bryson-Richardson RJ, Pagán KE, Taylor MS, Currie PD, Jackson IJ (2003), “The structure and evolution of the melanocortin and MCH receptors in fish and mammals.” Genomics 81(2):184-91 Details