Dr Danuta Lisiecka

Interests

I am interested in how MRI techniques can help us understand susceptibility to psychiatric disorders and mechanisms of action of psychiatric treatments.

My current research focuses on:

A) neural mechanism of action of Minocycline on negative symptoms of psychosis in BeneMin study (www.benemin.org.uk). BeneMin is a multicentre CTIMP with 6 MRI sites and 15 NHS Trusts and Health Boards involved. I am an MRI coordinator of the study.

B) white matter microstructure of Autism endophenotype in Structural and functional MRI of autism and broader phenotype study (http://www.autismresearchcentre.com/project_29_sandfmri).

C) association between magnetic transfer and diffusion tensor measurements in white matter in NSPN study (http://www.nspn.org.uk/).

D) pH of the brain in the Acid Test study.

My interests also involve the role of emotional regulation in the susceptibility and resilience to major depressive disorder.

Increased activation in inhibitory areas of first degree relatives of patients with MDD during inhibition of negative stimuli
Increased activation during inhibition of negative stimuli in first degree relatives of patients with major depressive disorder
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Research Focus

Keywords

MRI

psychiatric disorders

endophenotype

neuropsychopharmacology

emotional regulation

Clinical conditions

Autism

Depressive disorders

Schizophrenia

Stroke

Equipment

Magnetic resonance imaging (MRI)

Neuropsychological testing

Collaborators

Cambridge

Sanja Abbott

Michael Spencer

John Suckling

Roger Tait

United Kingdom

Paola Dazzan Web: http://www.iop.kcl.ac.uk/staff/p...

Bill Deakin Web: http://www.bbmh.manchester.ac.uk/staff/B...

Eileen Joyce Web: https://iris.ucl.ac.uk/iris/br...

Stephen Lawrie Web: http://www.ccbs.ed.ac.uk/members...

Shane McKie Web: http://www.bbmh.manchester.ac.uk/staff/7...

International

Erik O'Hanlon Web: http://www.rcsi.ie/index.j...

Associated News Items


    Key publications

    Lisiecka DM, Holt R, Tait R, Ford M, Lai MC, Chura LR, Baron-Cohen S, Spencer MD, Suckling J (2015), “Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence.” Transl Psychiatry 5:e529 Details

    Lisiecka DM, O'Hanlon E, Fagan AJ, Carballedo A, Morris D, Suckling J, Frodl T (2015), “BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls” J Affect Disorders 184: 239-244

    Lisiecka DM, Suckling J, Barnes TR, Chaudhry IB, Dazzan P, Husain N, Jones PB, Joyce EM, Lawrie SM, Upthegrove R, Deakin B (2015), “The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care - extent and mechanism (BeneMin): study protocol for a randomised controlled trial.” Trials 16(1):580

    Lisiecka DM, Carballedo A, Fagan AJ, Ferguson Y, Meaney J, Frodl T (2013), “Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression.” J Psychiatry Neurosci 38(2):117-28 Details

    Lisiecka DM, Carballedo A, Fagan AJ, Connolly G, Meaney J, Frodl T (2012), “Altered inhibition of negative emotions in subjects at family risk of major depressive disorder.” J Psychiatr Res 46(2):181-8 Details

    Lisiecka D, Meisenzahl E, Scheuerecker J, Schoepf V, Whitty P, Chaney A, Moeller HJ, Wiesmann M, Frodl T (2011), “Neural correlates of treatment outcome in major depression.” Int J Neuropsychopharmacol 14(4):521-34 Details

    Publications

    2012

    Amico F, Carballedo A, Lisiecka D, Fagan AJ, Boyle G, Frodl T (2012), “Functional anomalies in healthy individuals with a first degree family history of major depressive disorder.” Biol Mood Anxiety Disord 2(1):1 Details

    Bermingham R, Carballedo A, Lisiecka D, Fagan A, Morris D, Fahey C, Donohoe G, Meaney J, Gill M, Frodl T (2012), “Effect of genetic variant in BICC1 on functional and structural brain changes in depression.” Neuropsychopharmacology 37(13):2855-62 Details

    Carballedo A, Lisiecka D, Fagan A, Saleh K, Ferguson Y, Connolly G, Meaney J, Frodl T (2012), “Early life adversity is associated with brain changes in subjects at family risk for depression.” World J Biol Psychiatry 13(8):569-78 Details

    Chan JS, Maguinness C, Lisiecka D, Setti A, Newell FN (2012), “Evidence for crossmodal interactions across depth on target localisation performance in a spatial array.” Perception 41(7):757-73 Details

    Frodl T, Carballedo A, Fagan AJ, Lisiecka D, Ferguson Y, Meaney JF (2012), “Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression.” J Psychiatry Neurosci 37(1):37-45 Details

    Saleh K, Carballedo A, Lisiecka D, Fagan AJ, Connolly G, Boyle G, Frodl T (2012), “Impact of family history and depression on amygdala volume.” Psychiatry Res 203(1):24-30 Details

    2010

    Frodl T, Bokde AL, Scheuerecker J, Lisiecka D, Schoepf V, Hampel H, Möller HJ, Brückmann H, Wiesmann M, Meisenzahl E (2010), “Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression.” Biol Psychiatry 67(2):161-7 Details