Mr Daniel Lam

Daniel Lam

University position

PhD student
Supervised by Dr Lora Heisler

Departments

Department of Pharmacology

Institutes

Institute of Metabolic Science

Home page

http://www.phar.cam.ac.uk/

Research Themes

Cellular and Molecular Neuroscience

Cognitive and Behavioural Neuroscience

The Cambridge Neuroscience Community

Interests

I am engaged in the study of the neurobiology of energy balance. In my research, I attempt to delineate the central mechanisms involved in regulating appetite, ingestive behaviour, energy expenditure, and metabolism.

Localization of the serotonin 2C receptor (green) on melancortin neurons (red), providing a neuroanatomical substrate for regulation of the melancortin system by serotonin
Localization of the serotonin 2C receptor (green) on melancortin neurons (red), providing a neuroanatomical substrate for regulation of the melancortin system by serotonin
Click image to view full-size

Research Focus

Keywords

obesity

type 2 diabetes

energy balance

glucose homeostasis

food intake

Clinical conditions

Diabetes

Digestion and nutrition disorders

Eating disorders

Genetic disorders

Hormonal disorders

Obesity

Equipment

Behavioural analysis

Cell culture

Fluorescence microscopy

Immunohistochemistry

In situ hybridization

Microscopy

Collaborators

Cambridge

Mark Evans

United Kingdom

Peter Clifton Web: http://www.lifesci.susx.ac.uk/home/Pe...

International

Andrew Butler Web: http://www.pbrc.edu/Post_Do...

Key publications

Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK (2008), “Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.” Endocrinology 149(3):1323-8 Details

Lam DD, Heisler LK (2007), “Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes.” Expert Rev Mol Med 9(5):1-24 Details

Publications

2009

Lam DD, Zhou L, Vegge A, Xiu PY, Christensen BT, Osundiji MA, Yueh CY, Evans ML, Heisler LK (2009), “Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia.” Behav Brain Res 196(1):139-43 Details

2008

Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, Kousoulas KG, Rogers PM, Kesterson RA, Thearle M, Ferrante AW Jr, Mynatt RL, Burris TP, Dong JZ, Halem HA, Culler MD, Heisler LK, Stephens JM, Butler AA (2008), “Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.” Cell Metab 8(6):468-81 Details

2007

Lam DD, Farooqi IS, Heisler LK (2007), “Melanocortin receptors as targets in the treatment of obesity.” Curr Top Med Chem 7(11):1085-1097 Details

Zhou L, Sutton GM, Rochford JJ, Semple RK, Lam DD, Oksanen LJ, Thornton-Jones ZD, Clifton PG, Yueh CY, Evans ML, McCrimmon RJ, Elmquist JK, Butler AA, Heisler LK (2007), “Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways.” Cell Metab 6(5):398-405 Details