Dr Dervila Glynn

Dervila Glynn

University position

Cambridge Neuroscience Coordinator

Departments

Department of Pharmacology

Email

dg248@cam.ac.uk

Research Theme

Cognitive and Behavioural Neuroscience

Interests

Following on from a degree in Biotechnology, I completed a PhD in Pharmacology (Downing College) and worked for 11 years in the field of Huntington’s disease (HD). My research focused on understanding the mechanisms underlying neurodegeneration and abnormal behaviour in HD. I am also interested in the role that changes in synaptic modulators play in neurological illness. I left the bench in December 2011 and joined Cambridge Neuroscience. Cambridge Neuroscience is one of twelve strategic initiatives within the University of Cambridge and it connects >800 researchers across the University, who are involved with research into the nervous system. My position as Cambridge Neuroscience strategic manager involves working with academics from across the University to support the interdisciplinary scientific community in neuroscience. This involves workshops, seminars, facilitating introductions and external interactions, an interactive website, communications and public engagement.

Research Focus

Keywords

complexin

mice

behaviour

Huntington's disease

Clinical conditions

Alzheimer's disease

Depressive disorders

Huntington's disease

Schizoprenia

Equipment

Behavioural analysis

Pharmacological treatment

Collaborators

No collaborators listed

Associated News Items


Key publications

Glynn D, Morton AJ (2011), “Synaptic Dysfunction in Huntington’s disease” Folding for the synapse 233-255

Glynn D, Gibson HE, Harte MK, Reim K, Jones S, Reynolds GP, Morton AJ (2010), “Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse.” Hum Mol Genet Details

Glynn D, Reim K, Brose N, Morton AJ (2007), “Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); support for role for complexin II in behavioural pathology in a mouse model of HD.” Brain Res Bull 72(2-3):108-20 Details

Glynn D, Sizemore RJ, Morton AJ (2007), “Early motor development is abnormal in complexin 1 knockout mice.” Neurobiol Dis 25(3):483-95 Details

Glynn D, Drew CJ, Reim K, Brose N, Morton AJ (2005), “Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits” Human Molecular Genetics 14(16):2369-85 Details

Publications

2011

Wood NI, Glynn D, Morton AJ (2011), “"Brain training" improves cognitive performance and survival in a transgenic mouse model of Huntington's disease.” Neurobiol Dis 42(3):427-37 PDF Details

2009

Morton AJ, Glynn D, Leavens W, Zheng Z, Faull RL, Skepper JN, Wight JM (2009), “Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice.” Neurobiol Dis 33(3):331-41 Details

2003

Glynn D, Bortnick RA, Morton AJ (2003), “Complexin II is essential for normal neurological function in mice.” Hum Mol Genet 12(19):2431-48 Details