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Department
  • Pharmacology
  • Research Theme Beyond the Neuron
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    Dr David Bulmer

    University Position
    Assistant Professor

    Interests

    Abdominal pain is a leading cause of morbidity in gastrointestinal disease. Despite this we still know little of how pain is triggered in ?functional? gastrointestinal disorders such as irritable bowel syndrome (IBS) and gastrointestinal diseases such as inflammatory bowel disease (IBD). Work from my lab uses normal and diseased human tissue to determine the mediators responsible for the activation of pain sensing nerves (nociceptors) in IBS and iBD patients, and the mechanism by which they activate nociceptors. Recent studies have identified a critical role for the voltage gated sodium channel subtype NaV1.9 in the activation of visceral nociceptors in IBD, and a key role for proteases in visceral nociception.

    Key Publications

    Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain.

    DOI: http://doi.org/10.1097/j.pain.0000000000001890
    Journal: Pain
    E-pub date: 1 Sep 2020
    Authors: S Chakrabarti, Z Hore, LA Pattison, S Lalnunhlimi, CN Bhebhe, G Callejo, DC Bulmer, LS Taams, F Denk, ESJ Smith

    Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain

    DOI: http://doi.org/10.1101/791251
    Journal:
    E-pub date: 1 Aug 2019
    Authors: S Chakrabarti, Z Hore, L Pattison, S Lalnunhlimi, C Bhebhe, G Callejo, D Bulmer, L Taams, F Denk, ESJ Smith

    Single-cell RNAseq reveals seven classes of colonic sensory neuron.

    DOI: http://doi.org/10.1136/gutjnl-2017-315631
    Journal: Gut
    E-pub date: 1 Apr 2019
    Authors: JRF Hockley, TS Taylor, G Callejo, AL Wilbrey, A Gutteridge, K Bach, WJ Winchester, DC Bulmer, G McMurray, ESJ Smith

    Publications

    Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity.

    DOI: http://doi.org/10.1152/ajpgi.00280.2022
    Journal: Am J Physiol Gastrointest Liver Physiol
    E-pub date: 1 Apr 2023
    Authors: KH Barker, JP Higham, LA Pattison, IP Chessell, F Welsh, ESJ Smith, DC Bulmer

    Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity.

    DOI: http://doi.org/10.1113/JP283170
    Journal: J Physiol
    E-pub date: 31 Aug 2022
    Authors: KH Barker, JP Higham, LA Pattison, TS Taylor, IP Chessell, F Welsh, ESJ Smith, DC Bulmer

    Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves.

    DOI: http://doi.org/10.1177/1744806920903150
    Journal: Mol Pain
    E-pub date: 1 Aug 2020
    Authors: JR Hockley, KH Barker, TS Taylor, G Callejo, ZM Husson, DC Bulmer, ESJ Smith

    Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli.

    DOI: http://doi.org/10.14814/phy2.14326
    Journal: Physiol Rep
    E-pub date: 1 Jan 2020
    Authors: TS Taylor, P Konda, SS John, DC Bulmer, JRF Hockley, ESJ Smith

    Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.

    DOI: http://doi.org/10.1038/s41467-019-09045-9
    Journal: Nat Commun
    E-pub date: 4 Mar 2019
    Authors: VB Lu, J Rievaj, EA O'Flaherty, CA Smith, R Pais, LA Pattison, G Tolhurst, AB Leiter, DC Bulmer, FM Gribble, F Reimann

    5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.

    DOI: http://doi.org/10.1126/scisignal.aal2171
    Journal: Sci Signal
    E-pub date: 18 Dec 2018
    Authors: T Bautzova, JRF Hockley, T Perez-Berezo, J Pujo, MM Tranter, C Desormeaux, MR Barbaro, L Basso, P Le Faouder, C Rolland, P Malapert, A Moqrich, H Eutamene, A Denadai-Souza, N Vergnolle, ESJ Smith, DI Hughes, G Barbara, G Dietrich, DC Bulmer, N Cenac

    Human visceral nociception: findings from translational studies in human tissue.

    DOI: http://doi.org/10.1152/ajpgi.00398.2017
    Journal: Am J Physiol Gastrointest Liver Physiol
    E-pub date: 1 Oct 2018
    Authors: JRF Hockley, ESJ Smith, DC Bulmer

    Peripheral KV7 channels regulate visceral sensory function in mouse and human colon.

    DOI: http://doi.org/10.1177/1744806917709371
    Journal: Mol Pain
    E-pub date: 1 Aug 2017
    Authors: M Peiris, JR Hockley, DE Reed, ESJ Smith, DC Bulmer, LA Blackshaw