Interests

With our collaborators, we are focused on micro-fabrication and application of microchannel neural-electrode neuroprostheses. The clinical focus is repair of damaged peripheral nerves, integration of recording and stimulating electrodes into the nervous system for fine-tuned control of prosthetic limbs, and a closed loop recording-stimulating neuroprosthetics for artificial bladder control.

Microchannel neuroprosthetic implant. A) Implant within spinal canal containing microdissected dorsal roots. B) Increased magnification of microchannels with gold electrodes for recording. Scale=200um C: Bladder cystometry and electroneurogram of the 3 corresponding microchannel-rootlet interface during bladder filling. D: Discrete action potential spikes recorded
Microchannel neuroprosthetic implant. A) Implant within spinal canal containing microdissected dorsal roots. B) Increased magnification of microchannels with gold electrodes for recording. Scale=200um C: Bladder cystometry and electroneurogram of the 3 corresponding microchannel-rootlet interface during bladder filling. D: Discrete action potential spikes recorded
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Research Focus

Keywords

Neuroprosthetics

Spinal Cord Injury

Dorsal roots

Bladder

Engineering

Clinical conditions

Spinal cord injury

Stroke

Traumatic brain injury

Equipment

Behavioural analysis

Electrophysiological recording techniques

Fluorescence microscopy

Immunohistochemistry

Microscopy

Neurosurgical methods

Collaborators

United Kingdom

Nick Donaldson Web: http://www.ucl.ac.uk/medphys...

Nicolas Granger Web: http://www.bris.ac.uk/vetscie...

Steve McMahon Web: http://www.kcl.ac.uk/bioheal...

John Taylor Web: http://www.bath.ac.uk/elec-en...

International

Nicholas Jeffery Web: http://vetmed.iastate.edu/users/n...

Stephanie Lacour Web: http://people.epfl.ch/stephan...

Peter Shortland Web: http://www.uws.edu.au/staff_p...

Publications

2014

Chew DJ, Carlstedt T, Shortland PJ (2014), “The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats.” J Pain Details

2013

Chew DJ, Murrell K, Carlstedt T, Shortland PJ (2013), “Segmental spinal root avulsion in the adult rat: a model to study avulsion injury pain.” J Neurotrauma 30(3):160-72 Details

Chew DJ, Zhu L, Delivopoulos E, Minev IR, Musick KM, Mosse CA, Craggs M, Donaldson N, Lacour SP, McMahon SB, Fawcett JW (2013), “A microchannel neuroprosthesis for bladder control after spinal cord injury in rat.” Sci Transl Med 5(210):210ra155 Details

Granger N, Chew D, Fairhurst P, Fawcett JW, Lacour SP, Craggs M, Mosse CA, Donaldson N, Jeffery ND (2013), “Use of an implanted sacral nerve stimulator to restore urine voiding in chronically paraplegic dogs.” J Vet Intern Med 27(1):99-105 Details

Gumy LF, Chew DJ, Tortosa E, Katrukha EA, Kapitein LC, Tolkovsky AM, Hoogenraad CC, Fawcett JW (2013), “The Kinesin-2 Family Member KIF3C Regulates Microtubule Dynamics and Is Required for Axon Growth and Regeneration.” J Neurosci 33(28):11329-11345 Details

2012

Chew DJ, Fawcett JW, Andrews MR (2012), “The challenges of long-distance axon regeneration in the injured CNS.” Prog Brain Res 201:253-94 Details

Delivopoulos E, Chew DJ, Minev IR, Fawcett JW, Lacour SP (2012), “Concurrent recordings of bladder afferents from multiple nerves using a microfabricated PDMS microchannel electrode array.” Lab Chip 12(14):2540-51 Details

Minev IR, Chew DJ, Delivopoulos E, Fawcett JW, Lacour SP (2012), “High sensitivity recording of afferent nerve activity using ultra-compliant microchannel electrodes: an acute in vivo validation.” J Neural Eng 9(2):026005 Details

2011

Chew DJ, Carlstedt T, Shortland PJ (2011), “A comparative histological analysis of two models of nerve root avulsion injury in the adult rat.” Neuropathol Appl Neurobiol 37(6):613-32 Details

2008

Chew DJ, Leinster VH, Sakthithasan M, Robson LG, Carlstedt T, Shortland PJ (2008), “Cell death after dorsal root injury.” Neurosci Lett 433(3):231-4 Details