Dr Dawn Eagle

Dawn Eagle

University position

Senior Research Associate

Dr Dawn Eagle is pleased to consider applications from prospective PhD students.

Departments

Department of Psychology

Institutes

Behavioural and Clinical Neuroscience Institute

Email

d.eagle@psychol.cam.ac.uk

Home page

http://www.psychol.cam.ac.uk/

Research Theme

Cognitive and Behavioural Neuroscience

Interests

How does the brain control impulsive and compulsive actions and stop inappropriate or unwanted behaviour? This question is relevant to many illnesses where brain function is altered (e.g,. ADHD, Parkinson's disease, OCD, schizophrenia, compulsive gambling, eating disorders and drug addiction), each of which has symptoms of excessive or unwanted impulsive/compulsive behaviour.

Models of rodent behaviour allow us to study the anatomy and pharmacology of inhibitory failure in great detail. We develop behavioural tests that can be used in rats and mice to analyse drug actions on behaviour and often these behavioural methods can translate directly to assess patients in the clinic. This may improve how new treatment strategies for these debilitating disorders are developed.

Research Focus

Keywords

impulsivity

compulsivity

animal models

stop-signal task

dopamine

Clinical conditions

Addiction

Anxiety disorders

Attention deficit hyperactivity disorder

Eating disorders

Huntington's disease

Obsessive compulsive disorder

Parkinson's disease

Schizophrenia

Equipment

Behavioural analysis

Collaborators

Cambridge

Johan Alsio

Jeff Dalley

Adam Mar

Amy Milton

Sharon Morein

Trevor Robbins

Gonzalo Urcelay

International

Christelle Baunez Web: http://sites.univ-provence.fr/lnc/ind...

Associated News Items


Publications

2014

Camilla d'Angelo LS, Eagle DM, Grant JE, Fineberg NA, Robbins TW, Chamberlain SR (2014), “Animal models of obsessive-compulsive spectrum disorders.” CNS Spectr 19(1):28-49 Details

Eagle DM, Noschang C, d'Angelo LS, Noble CA, Day JO, Dongelmans ML, Theobald DE, Mar AC, Urcelay GP, Morein-Zamir S, Robbins TW (2014), “The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: A novel possible model of OCD.” Behav Brain Res 264:207-29 Details

2011

Bari A, Mar AC, Theobald DE, Elands SA, Oganya KC, Eagle DM, Robbins TW (2011), “Prefrontal and monoaminergic contributions to stop-signal task performance in rats.” J Neurosci 31(25):9254-63 Details

Eagle DM, Wong JC, Allan ME, Mar AC, Theobald DE, Robbins TW (2011), “Contrasting Roles for Dopamine D1 and D2 Receptor Subtypes in the Dorsomedial Striatum but Not the Nucleus Accumbens Core during Behavioral Inhibition in the Stop-Signal Task in Rats.” J Neurosci 31(20):7349-56 Details

Mar AC, Walker AL, Theobald DE, Eagle DM, Robbins TW (2011), “Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat.” J Neurosci 31(17):6398-404 Details

2010

Eagle DM, Baunez C (2010), “Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition.” Neurosci Biobehav Rev 34(1):50-72 Details

2009

Bari A, Eagle DM, Mar AC, Robinson ES, Robbins TW (2009), “Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats.” Psychopharmacology (Berl) 205(2):273-83 Details

Eagle DM, Lehmann O, Theobald DE, Pena Y, Zakaria R, Ghosh R, Dalley JW, Robbins TW (2009), “Serotonin depletion impairs waiting but not stop-signal reaction time in rats: implications for theories of the role of 5-HT in behavioral inhibition.” Neuropsychopharmacology 34(5):1311-21 Details

Robinson ES, Eagle DM, Economidou D, Theobald DE, Mar AC, Murphy ER, Robbins TW, Dalley JW (2009), “Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'.” Behav Brain Res 196(2):310-6 Details

2008

Eagle DM, Bari A, Robbins TW (2008), “The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks.” Psychopharmacology (Berl) 199(3):439-56 Details

Eagle DM, Baunez C, Hutcheson DM, Lehmann O, Shah AP, Robbins TW (2008), “Stop-signal reaction-time task performance: role of prefrontal cortex and subthalamic nucleus.” Cereb Cortex 18(1):178-88 Details

Robinson ES, Eagle DM, Mar AC, Bari A, Banerjee G, Jiang X, Dalley JW, Robbins TW (2008), “Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat.” Neuropsychopharmacology 33(5):1028-37 Details

2007

Aron AR, Durston S, Eagle DM, Logan GD, Stinear CM, Stuphorn V (2007), “Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognition.” J Neurosci 27(44):11860-4 Details

Eagle DM, Tufft MR, Goodchild HL, Robbins TW (2007), “Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol.” Psychopharmacology (Berl) 192(2):193-206 Details

2006

Winstanley CA, Eagle DM, Robbins TW (2006), “Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies.” Clin Psychol Rev 26(4):379-95 Details

2003

Eagle DM, Robbins TW (2003), “Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and d-amphetamine.” Behav Neurosci 117(6):1302-17 Details

Eagle DM, Robbins TW (2003), “Lesions of the medial prefrontal cortex or nucleus accumbens core do not impair inhibitory control in rats performing a stop-signal reaction time task.” Behav Brain Res 146(1-2):131-44 Details

2002

Dalley JW, Theobald DE, Eagle DM, Passetti F, Robbins TW (2002), “Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex.” Neuropsychopharmacology 26(6):716-28 Details

2001

Baunez C, Humby T, Eagle DM, Ryan LJ, Dunnett SB, Robbins TW (2001), “Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection.” Eur J Neurosci 13(8):1609-16 Details

2000

Watts C, Brasted PJ, Eagle DM, Dunnett SB, Robbins TW (2000), “Embryonic donor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease.” Experimental Neurology 163:85-97

1999

Eagle DM, Humby T, Dunnett SB, Robbins TW (1999), “Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats.” Behav Neurosci 113(4):718-31 Details

Eagle DM, Humby T, Howman M, Reid-Henry A, Dunnett SB, Robbins TW (1999), “Differential effects of ventral and regional dorsal striatal lesions on sucrose drinking and positive and negative contrst in rats.” Psychobiology 27(2):267-276