Dr David Parker
Dr David Parker is pleased to consider applications from prospective PhD students.
We examine cellular and synaptic properties in neuronal networks using the lamprey spinal cord locomotor network as a model system. While this network is claimed, and often cited, as being characterised, there are actually significant gaps in our understanding of the network, and in the claimed experimental data (see Parker 2006, 2010).
We combine various approaches to examine:
How short-term activity-dependent synaptic plasticity influences network outputs.
Network cellular and synaptic variability .
Interactions between activity-dependent and modulatory plasticity (“metaplasticity” and “metamodulation”).
A major focus is on recovery after spinal cord lesions. Lower vertebrates recover function after complete spinal lesions. While this is thought to reflect regeneration across lesion sites, there are also changes in networks above and below lesion sites, in sensory feedback, and in neuromodulator-evoked plasticity. We are investigating how these effects influence recovery.
Electrophysiological recording techniques
No collaborators listed
Associated News Items
Parker D (2010), “Neuronal network analyses: premises, promises and uncertainties.” Philos Trans R Soc Lond B Biol Sci 365(1551):2315-28 Details
Cooke RM, Parker D (2009), “Locomotor recovery after spinal cord lesions in the lamprey is associated with functional and ultrastructural changes below lesion sites.” J Neurotrauma 26: 597-612
Parker D (2006), “Complexities and uncertainties of neuronal network function” Philosophical Transactions of the Royal Society B: Biological Sciences 361:81-99
Parker D (2003), “Activity-Dependent Feedforward Inhibition Modulates Synaptic Transmission in a Spinal Locomotor Network” J Neurosci 23:11085-11093
McClelland TJ, Parker D (2017), “Inverse modulation of motor neuron cellular and synaptic properties can maintain the same motor output” Neuroscience Volume 360, 30 September 2017, Pages 28-38
Jia Y, Parker D (2016), “Short-Term Synaptic Plasticity at Interneuronal Synapses Could Sculpt Rhythmic Motor Patterns” Frontiers in Neural Circuits 10:4. doi: 10.3389/fncir.2016.00004
Becker MI, Parker D (2015), “Changes in functional properties and 5-HT modulation above and below a spinal transection in lamprey” Frontiers in Neural Circuits 8:148
Parker D (2015), “Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapse” Neural Plasticity Volume 2015 (2015), Article ID 512156, 14 pages http://dx.doi.org/10.1155/2015/512156
Srivastava V, Sampath S, Parker DJ (2014), “Overcoming Catastrophic Interference in Connectionist Networks Using Gram-Schmidt Orthogonalization.” PLoS ONE 9(9):e105619
Parker D, Srivastava V (2013), “Dynamic systems approaches and levels of analysis in the nervous system” Frontiers in Physiology 4, 15
Svensson E, Kim O, Parker D (2013), “Altered GABA and somatostatin modulation of proprioceptive feedback after spinal cord injury in lamprey. ” Neuroscience 235: 109-118
Cooke RM, Luco S, Parker D (2012), “Manipulations of spinal cord excitability evoke developmentally-dependent compensatory changes in the lamprey spinal cord.” J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198(1):25-41 Details
Hoffman N, Parker D (2011), “Interactive and individual effects of sensory potentiation and region-specific changes in excitability after spinal cord injury.” Neuroscience 199:563-76 Details
N Hoffman, D Parker (2010), “Lesioning alters functional properties in isolated spinal cord hemisegmental networks” Neuroscience 168: 732-743
Cooke RM, Parker D (2009), “Locomotor recovery after spinal cord lesions in the lamprey is associated with functional and ultrastructural changes below lesion sites.” J Neurotrauma 26(4):597-612 Details
Baudoux S, Parker D (2008), “Baudoux S, Parker D (2008) Glial toxin-mediated disruption of spinal cord locomotor network function and its modulation by 5-HT. ” Neuroscience 153:1332–1343.
Bevan S, Vakharia V, Parker D (2008), “Changes in gene expression and integrin-mediated structural changes are associated with long-term plasticity of a spinal cord locomotor network. ” Neuroscience 152:160-168
Srivastava V, Parker D, Edwards S (2008), “The nervous system might ‘orthogonalize’ to discriminate. ” J Theor Biol 253:514-517
Parker D (2007), “The role of activity-dependent synaptic plasticity and variability in the patterning of oscillatory network activity.” Neuronal Network Research Horizons. Nova Science Publications. Editor: Martin L Weiss, pp 1-60
Parker D, Bevan S (2007), “Modulation of cellular and synaptic variability in the lamprey spinal cord.” J Neurophysiol 97(1):44-56 Details
Parker D, Gilbey T (2007), “Developmental differences in neuromodulation and synaptic properties in the lamprey spinal cord.” Neuroscience 145(1):142-52 Details
Parker D (2006), “Complexities and uncertainties of neuronal network function.” Philos Trans R Soc Lond B Biol Sci 361(1465):81-99 Details
Parker D (2006), “Neuroscience and society.” International Journal of the Interdisciplinary Social Sciences 1
Parker D (2005), “Pharmacological approaches to functional recovery after spinal injury.” Curr Drug Targets CNS Neurol Disord 4(2):195-210 Details
Bevan S, Parker D (2004), “Metaplastic facilitation and ultrastructural changes in synaptic properties are associated with long-term modulation of the lamprey locomotor network.” J Neurosci 24(42):9458-68 Details
Parker D (2003), “Variable properties in a single class of excitatory spinal synapse.” J Neurosci 23(8):3154-63 Details
Parker D (2003), “Activity-dependent feedforward inhibition modulates synaptic transmission in a spinal locomotor network.” J Neurosci 23(35):11085-93 Details