Dr David Belin

David Belin

University position

Lecturer

Dr David Belin is pleased to consider applications from prospective PhD students.

Departments

Department of Psychology

Institutes

Behavioural and Clinical Neuroscience Institute

Email

bdb26@cam.ac.uk

Research Themes

Cognitive and Behavioural Neuroscience

Cellular and Molecular Neuroscience

Interests

Our research is interested in the neural, cellular and molecular substrates of inter-individual vulnerability to develop impulsive/compulsive disorders such as drug addiction, Obsessive / Compulsive Disorder, Tourette’s syndrome, pathological gambling or dopamine dysregulation syndrome in Parkinson Disease.

Our working hypothesis is that impulses, originating from the amygdalo-insular networks can drive the behavior through explicit knowledge involving prefrontal and orbitofrontal loops or implicit mechanisms that instead depend upon the functional relationships of these structures with several domains of the striatum.

We suggest that inter-individual vulnerability to develop impulsive/compulsive neuropsychiatric disorders stem from aberrant plasticity processes within the corticostriatal networks governing the translation of impulses into actions that ultimately result in a so-called abnormal incentive habit process.

Research Focus

Keywords

compulsivity

impulsivity

addiction

models

corticostriatal circuitry

Clinical conditions

Addiction

Obsessive compulsive disorder

Parkinson's disease

Tourette's syndrome

Equipment

Behavioural analysis

Electrophysiology

in situ hybridization

neuropharmacology

western blot

Collaborators

Cambridge

Jeffrey Dalley

Barry Everitt

International

Antonello Bonci

Sebastien Carnicella

Jean-Luc Houeto

Eric Nestler

Associated News Items


Publications

2015

Belin-Rauscent A, Fouyssac M, Bonci A, Belin D (2015), “How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction.” Biol Psychiatry Details

Brunault P, Salamé E, Jaafari N, Courtois R, Réveillère C, Silvain C, Benyamina A, Blecha L, Belin D, Ballon N (2015), “Why do liver transplant patients so often become obese? The addiction transfer hypothesis.” Med Hypotheses 85(1):68-75 Details

Giuliano C, Goodlett CR, Economidou D, García-Pardo MP, Belin D, Robbins TW, Bullmore ET, Everitt BJ (2015), “The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking.” Neuropsychopharmacology Details

Moreira FA, Jupp B, Belin D, Dalley JW (2015), “Endocannabinoids and striatal function: implications for addiction-related behaviours.” Behav Pharmacol 26(1-2):59-72 Details

Vanhille N, Belin-Rauscent A, Mar AC, Ducret E, Belin D (2015), “High locomotor reactivity to novelty is associated with an increased propensity to choose saccharin over cocaine: new insights into the vulnerability to addiction.” Neuropsychopharmacology 40(3):577-89 Details

2014

Ansquer S, Belin-Rauscent A, Dugast E, Duran T, Benatru I, Mar AC, Houeto JL, Belin D (2014), “Atomoxetine decreases vulnerability to develop compulsivity in high impulsive rats.” Biol Psychiatry 75(10):825-32 Details

Murray JE, Dilleen R, Pelloux Y, Economidou D, Dalley JW, Belin D, Everitt BJ (2014), “Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking.” Biol Psychiatry 76(1):15-22 Details

2013

Belin D, Belin-Rauscent A, Murray JE, Everitt BJ (2013), “Addiction: failure of control over maladaptive incentive habits.” Curr Opin Neurobiol 23(4):564-72 Details

Besson M, Pelloux Y, Dilleen R, Theobald DE, Lyon A, Belin-Rauscent A, Robbins TW, Dalley JW, Everitt BJ, Belin D (2013), “Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats.” Neuropsychopharmacology 38(10):1963-73 Details

2012

Belin D, Deroche-Gamonet V (2012), “Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model.” Cold Spring Harb Perspect Med 2(11) Details

Belin-Rauscent A, Everitt BJ, Belin D (2012), “Intrastriatal shifts mediate the transition from drug-seeking actions to habits.” Biol Psychiatry 72(5):343-5 Details

Dilleen R, Pelloux Y, Mar AC, Molander A, Robbins TW, Everitt BJ, Dalley JW, Belin D (2012), “High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats.” Psychopharmacology (Berl) 222(1):89-97 Details

Jaafari N, Rachid F, Rotge JY, Polosan M, El-Hage W, Belin D, Vibert N, Pelissolo A (2012), “Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder: a review.” World J Biol Psychiatry 13(3):164-77 Details

Murray JE, Belin D, Everitt BJ (2012), “Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking.” Neuropsychopharmacology 37(11):2456-66 Details

Murray JE, Everitt BJ, Belin D (2012), “N-Acetylcysteine reduces early- and late-stage cocaine seeking without affecting cocaine taking in rats.” Addict Biol 17(2):437-40 Details

2011

Badiani A, Belin D, Epstein D, Calu D, Shaham Y (2011), “Opiate versus psychostimulant addiction: the differences do matter.” Nat Rev Neurosci 12(11):685-700 Details

Belin D, Berson N, Balado E, Piazza PV, Deroche-Gamonet V (2011), “High-novelty-preference rats are predisposed to compulsive cocaine self-administration.” Neuropsychopharmacology 36(3):569-79 Details

Molander AC, Mar A, Norbury A, Steventon S, Moreno M, Caprioli D, Theobald DE, Belin D, Everitt BJ, Robbins TW, Dalley JW (2011), “High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress.” Psychopharmacology (Berl) 215(4):721-31 Details

2010

Besson M, Belin D, McNamara R, Theobald DE, Castel A, Beckett VL, Crittenden BM, Newman AH, Everitt BJ, Robbins TW, Dalley JW (2010), “Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens.” Neuropsychopharmacology 35(2):560-9 Details

McNamara R, Dalley JW, Robbins TW, Everitt BJ, Belin D (2010), “Trait-like impulsivity does not predict escalation of heroin self-administration in the rat.” Psychopharmacology (Berl) 212(4):453-64 Details

Théberge FR, Milton AL, Belin D, Lee JL, Everitt BJ (2010), “The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation.” Learn Mem 17(9):444-53 Details

2009

Belin D, Balado E, Piazza PV, Deroche-Gamonet V (2009), “Pattern of intake and drug craving predict the development of cocaine addiction-like behavior in rats.” Biol Psychiatry 65(10):863-8 Details

Belin D, Jonkman S, Dickinson A, Robbins TW, Everitt BJ (2009), “Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction.” Behav Brain Res 199(1):89-102 Details

2008

Belin D, Everitt BJ (2008), “Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum.” Neuron 57(3):432-41 Details

Belin D, Mar AC, Dalley JW, Robbins TW, Everitt BJ (2008), “High impulsivity predicts the switch to compulsive cocaine-taking.” Science 320(5881):1352-5 Details

Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW (2008), “Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction.” Philos Trans R Soc Lond B Biol Sci 363(1507):3125-35 Details

2007

Belin D, Deroche-Gamonet V, Jaber M (2007), “Cocaine-induced sensitization is associated with altered dynamics of transcriptional responses of the dopamine transporter, tyrosine hydroxylase, and dopamine D2 receptors in C57Bl/6J mice.” Psychopharmacology (Berl) 193(4):567-78 Details

2006

Belin D, Rauscent A (2006), “DeltaFosB: a molecular gate to motivational processes within the nucleus accumbens?” J Neurosci 26(46):11809-10 Details

2004

Deroche-Gamonet V, Belin D, Piazza PV (2004), “Evidence for addiction-like behavior in the rat.” Science 305(5686):1014-7 Details

2003

Bezard E, Dovero S, Belin D, Duconger S, Jackson-Lewis V, Przedborski S, Piazza PV, Gross CE, Jaber M (2003), “Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: involvement of dopamine transporter and trophic factors.” J Neurosci 23(35):10999-1007 Details