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    Keywords

  • Addiction
  • Compulsion
  • Dopamine
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  • Obsessive compulsive disorder
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    Professor David Belin PhD

    (he/him/his)
    University Position
    Professor
    Professor David Belin is pleased to consider applications from prospective PhD students.

    Interests

    Our research is interested in the neural, cellular and molecular substrates of inter-individual vulnerability to develop impulsive/compulsive disorders such as drug addiction, Obsessive / Compulsive Disorder, Tourette's syndrome, pathological gambling or dopamine dysregulation syndrome in Parkinson Disease. Our working hypothesis is that impulses, originating from the amygdalo-insular networks can drive the behavior through explicit knowledge involving prefrontal and orbitofrontal loops or implicit mechanisms that instead depend upon the functional relationships of these structures with several domains of the striatum. We suggest that inter-individual vulnerability to develop impulsive/compulsive neuropsychiatric disorders stem from aberrant plasticity processes within the corticostriatal networks governing the translation of impulses into actions that ultimately result in a so-called abnormal incentive habit process.

    Key Publications

    Publications

    Evidence for a Long-Lasting Compulsive Alcohol Seeking Phenotype in Rats.

    DOI: http://doi.org/10.1038/npp.2017.105
    Journal: Neuropsychopharmacology
    E-pub date: 1 Mar 2018
    Authors: C Giuliano, Y Peña-Oliver, CR Goodlett, RN Cardinal, TW Robbins, ET Bullmore, D Belin, BJ Everitt