Dr Daniel Tozer

University position

Senior Research Associate

Dr Daniel Tozer is pleased to consider applications from prospective PhD students.


Department of Clinical Neurosciences

Research Themes

Clinical and Veterinary Neuroscience

Systems and Computational Neuroscience


I use MRI and associated image processing techniques to investigate stroke and small vessel disease. I am interested in the application of quantitative MR techniques to neurological conditions and developing image processing tools to meet this aim.

Research Focus



Image processing

quantitative MRI


Clinical conditions

Small Vessel Disease



Magnetic resonance imaging (MRI)


No collaborators listed

Associated News Items



    Eshaghi A, Bodini B, Ridgway GR, García-Lorenzo D, Tozer DJ, Sahraian MA, Thompson AJ, Ciccarelli O (2014), “Temporal and spatial evolution of grey matter atrophy in primary progressive multiple sclerosis.” Neuroimage 86:257-64 Details

    Paling D, Thade Petersen E, Tozer DJ, Altmann DR, Wheeler-Kingshott CA, Kapoor R, Miller DH, Golay X (2014), “Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability.” J Cereb Blood Flow Metab 34(1):34-42 Details


    Button T, Altmann D, Tozer D, Dalton C, Hunter K, Compston A, Coles A, Miller D (2013), “Magnetization transfer imaging in multiple sclerosis treated with alemtuzumab.” Mult Scler 19(2):241-4 Details

    Paling D, Solanky BS, Riemer F, Tozer DJ, Wheeler-Kingshott CA, Kapoor R, Golay X, Miller DH (2013), “Sodium accumulation is associated with disability and a progressive course in multiple sclerosis.” Brain 136(Pt 7):2305-17 Details

    Yiannakas MC, Tozer DJ, Schmierer K, Chard DT, Anderson VM, Altmann DR, Miller DH, Wheeler-Kingshott CA (2013), “ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI.” Mult Scler 19(6):732-41 Details


    Fox RJ, Miller DH, Phillips JT, Hutchinson M, Havrdova E, Kita M, Yang M, Raghupathi K, Novas M, Sweetser MT, Viglietta V, Dawson KT, CONFIRM Study Investigators (2012), “Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis.” N Engl J Med 367(12):1087-97 Details

    Hayton T, Furby J, Smith KJ, Altmann DR, Brenner R, Chataway J, Hunter K, Tozer DJ, Miller DH, Kapoor R (2012), “Longitudinal changes in magnetisation transfer ratio in secondary progressive multiple sclerosis: data from a randomised placebo controlled trial of lamotrigine.” J Neurol 259(3):505-14 Details

    Hayton T, Furby J, Smith KJ, Altmann DR, Brenner R, Chataway J, Hunter K, Tozer DJ, Miller DH, Kapoor R (2012), “Clinical and imaging correlates of the multiple sclerosis impact scale in secondary progressive multiple sclerosis.” J Neurol 259(2):237-45 Details

    Paling D, Tozer D, Wheeler-Kingshott C, Kapoor R, Miller DH, Golay X (2012), “Reduced R2' in multiple sclerosis normal appearing white matter and lesions may reflect decreased myelin and iron content.” J Neurol Neurosurg Psychiatry 83(8):785-92 Details

    Tozer DJ, Chard DT, Bodini B, Ciccarelli O, Miller DH, Thompson AJ, Wheeler-Kingshott CA (2012), “Linking white matter tracts to associated cortical grey matter: a tract extension methodology.” Neuroimage 59(4):3094-102 Details


    Connick P, Kolappan M, Patani R, Scott MA, Crawley C, He XL, Richardson K, Barber K, Webber DJ, Wheeler-Kingshott CA, Tozer DJ, Samson RS, Thomas DL, Du MQ, Luan SL, Michell AW, Altmann DR, Thompson AJ, Miller DH, Compston A, Chandran S (2011), “The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments.” Trials 12:62 Details

    Petzold A, Tozer DJ, Schmierer K (2011), “Axonal damage in the making: neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter.” Exp Neurol 232(2):234-9 Details

    Price SJ, Tozer DJ, Gillard JH (2011), “Methodology of diffusion-weighted, diffusion tensor and magnetisation transfer imaging.” Br J Radiol 84 Spec No 2:S121-6 Details

    Tozer DJ, Rees JH, Benton CE, Waldman AD, Jäger HR, Tofts PS (2011), “Quantitative magnetisation transfer imaging in glioma: preliminary results.” NMR Biomed 24(5):492-8 Details


    Caseiras GB, Chheang S, Babb J, Rees JH, Pecerrelli N, Tozer DJ, Benton C, Zagzag D, Johnson G, Waldman AD, Jäger HR, Law M (2010), “Relative cerebral blood volume measurements of low-grade gliomas predict patient outcome in a multi-institution setting.” Eur J Radiol 73(2):215-20 Details

    Papadopoulos K, Tozer DJ, Fisniku L, Altmann DR, Davies G, Rashid W, Thompson AJ, Miller DH, Chard DT (2010), “TI-relaxation time changes over five years in relapsing-remitting multiple sclerosis.” Mult Scler 16(4):427-33 Details

    Schmierer K, Thavarajah JR, An SF, Brandner S, Miller DH, Tozer DJ (2010), “Effects of formalin fixation on magnetic resonance indices in multiple sclerosis cortical gray matter.” J Magn Reson Imaging 32(5):1054-60 Details

    Yiannakas MC, Wheeler-Kingshott CA, Berry AM, Chappell K, Henderson A, Kolappan M, Miller DH, Tozer DJ (2010), “A method for measuring the cross sectional area of the anterior portion of the optic nerve in vivo using a fast 3D MRI sequence.” J Magn Reson Imaging 31(6):1486-91 Details


    Brasil Caseiras G, Ciccarelli O, Altmann DR, Benton CE, Tozer DJ, Tofts PS, Yousry TA, Rees J, Waldman AD, Jäger HR (2009), “Low-grade gliomas: six-month tumor growth predicts patient outcome better than admission tumor volume, relative cerebral blood volume, and apparent diffusion coefficient.” Radiology 253(2):505-12 Details

    Fisniku LK, Altmann DR, Cercignani M, Tozer DJ, Chard DT, Jackson JS, Miszkiel KA, Schmierer K, Thompson AJ, Miller DH (2009), “Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosis.” Mult Scler 15(6):668-77 Details

    Hayton T, Furby J, Smith KJ, Altmann DR, Brenner R, Chataway J, Hughes RA, Hunter K, Tozer DJ, Miller DH, Kapoor R (2009), “Grey matter magnetization transfer ratio independently correlates with neurological deficit in secondary progressive multiple sclerosis.” J Neurol 256(3):427-35 Details

    Rees J, Watt H, Jäger HR, Benton C, Tozer D, Tofts P, Waldman A (2009), “Volumes and growth rates of untreated adult low-grade gliomas indicate risk of early malignant transformation.” Eur J Radiol 72(1):54-64 Details

    Tozer DJ, Marongiu G, Swanton JK, Thompson AJ, Miller DH (2009), “Texture analysis of magnetization transfer maps from patients with clinically isolated syndrome and multiple sclerosis.” J Magn Reson Imaging 30(3):506-13 Details


    Danchaivijitr N, Waldman AD, Tozer DJ, Benton CE, Brasil Caseiras G, Tofts PS, Rees JH, Jäger HR (2008), “Low-grade gliomas: do changes in rCBV measurements at longitudinal perfusion-weighted MR imaging predict malignant transformation?” Radiology 247(1):170-8 Details

    Rashid W, Hadjiprocopis A, Davies G, Griffin C, Chard D, Tiberio M, Altmann D, Wheeler-Kingshott C, Tozer D, Thompson A, Miller DH (2008), “Longitudinal evaluation of clinically early relapsing-remitting multiple sclerosis with diffusion tensor imaging.” J Neurol 255(3):390-7 Details

    Schmierer K, Wheeler-Kingshott CA, Tozer DJ, Boulby PA, Parkes HG, Yousry TA, Scaravilli F, Barker GJ, Tofts PS, Miller DH (2008), “Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation.” Magn Reson Med 59(2):268-77 Details

    Tofts PS, Jackson JS, Tozer DJ, Cercignani M, Keir G, MacManus DG, Ridgway GR, Ridha BH, Schmierer K, Siddique D, Thornton JS, Wroe SJ, Fox NC (2008), “Imaging cadavers: cold FLAIR and noninvasive brain thermometry using CSF diffusion.” Magn Reson Med 59(1):190-5 Details


    Manfredonia F, Ciccarelli O, Khaleeli Z, Tozer DJ, Sastre-Garriga J, Miller DH, Thompson AJ (2007), “Normal-appearing brain t1 relaxation time predicts disability in early primary progressive multiple sclerosis.” Arch Neurol 64(3):411-5 Details

    Ridha BH, Symms MR, Tozer DJ, Stockton KC, Frost C, Siddique MM, Lewis EB, MacManus DG, Boulby PA, Barker GJ, Rossor MN, Fox NC, Tofts PS (2007), “Magnetization transfer ratio in Alzheimer disease: comparison with volumetric measurements.” AJNR Am J Neuroradiol 28(5):965-70 Details

    Ridha BH, Tozer DJ, Symms MR, Stockton KC, Lewis EB, Siddique MM, MacManus DG, Rossor MN, Fox NC, Tofts PS (2007), “Quantitative magnetization transfer imaging in Alzheimer disease.” Radiology 244(3):832-7 Details

    Schmierer K, Tozer DJ, Scaravilli F, Altmann DR, Barker GJ, Tofts PS, Miller DH (2007), “Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain.” J Magn Reson Imaging 26(1):41-51 Details

    Soon D, Tozer D, Altmann D, Tofts P, Miller D (2007), “Quantification of subtle blood-brain barrier disruption in non-enhancing lesions in multiple sclerosis: a study of disease and lesion subtypes.” Mult Scler 13(7):884-94 Details

    Tofts PS, Benton CE, Weil RS, Tozer DJ, Altmann DR, Jäger HR, Waldman AD, Rees JH (2007), “Quantitative analysis of whole-tumor Gd enhancement histograms predicts malignant transformation in low-grade gliomas.” J Magn Reson Imaging 25(1):208-14 Details

    Tozer DJ, Jäger HR, Danchaivijitr N, Benton CE, Tofts PS, Rees JH, Waldman AD (2007), “Apparent diffusion coefficient histograms may predict low-grade glioma subtype.” NMR Biomed 20(1):49-57 Details


    Manton DJ, Chaturvedi A, Hubbard A, Lind MJ, Lowry M, Maraveyas A, Pickles MD, Tozer DJ, Turnbull LW (2006), “Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy.” Br J Cancer 94(3):427-35 Details

    Samson RS, Wheeler-Kingshott CA, Symms MR, Tozer DJ, Tofts PS (2006), “A simple correction for B1 field errors in magnetization transfer ratio measurements.” Magn Reson Imaging 24(3):255-63 Details

    Tofts PS, Steens SC, Cercignani M, Admiraal-Behloul F, Hofman PA, van Osch MJ, Teeuwisse WM, Tozer DJ, van Waesberghe JH, Yeung R, Barker GJ, van Buchem MA (2006), “Sources of variation in multi-centre brain MTR histogram studies: body-coil transmission eliminates inter-centre differences.” MAGMA 19(4):209-22 Details

    Tozer DJ, Davies GR, Altmann DR, Miller DH, Tofts PS (2006), “Principal component and linear discriminant analysis of T1 histograms of white and grey matter in multiple sclerosis.” Magn Reson Imaging 24(6):793-800 Details


    Cercignani M, Symms MR, Schmierer K, Boulby PA, Tozer DJ, Ron M, Tofts PS, Barker GJ (2005), “Three-dimensional quantitative magnetisation transfer imaging of the human brain.” Neuroimage 27(2):436-41 Details

    Fernando KT, Tozer DJ, Miszkiel KA, Gordon RM, Swanton JK, Dalton CM, Barker GJ, Plant GT, Thompson AJ, Miller DH (2005), “Magnetization transfer histograms in clinically isolated syndromes suggestive of multiple sclerosis.” Brain 128(Pt 12):2911-25 Details

    Tozer DJ, Davies GR, Altmann DR, Miller DH, Tofts PS (2005), “Correlation of apparent myelin measures obtained in multiple sclerosis patients and controls from magnetization transfer and multicompartmental T2 analysis.” Magn Reson Med 53(6):1415-22 Details


    Davies GR, Tozer DJ, Cercignani M, Ramani A, Dalton CM, Thompson AJ, Barker GJ, Tofts PS, Miller DH (2004), “Estimation of the macromolecular proton fraction and bound pool T2 in multiple sclerosis.” Mult Scler 10(6):607-13 Details


    Davies GR, Ramani A, Dalton CM, Tozer DJ, Wheeler-Kingshott CA, Barker GJ, Thompson AJ, Miller DH, Tofts PS (2003), “Preliminary magnetic resonance study of the macromolecular proton fraction in white matter: a potential marker of myelin?” Mult Scler 9(3):246-9 Details

    Tozer D, Ramani A, Barker GJ, Davies GR, Miller DH, Tofts PS (2003), “Quantitative magnetization transfer mapping of bound protons in multiple sclerosis.” Magn Reson Med 50(1):83-91 Details

    Tozer DJ, Tofts PS (2003), “Removing spikes caused by quantization noise from high-resolution histograms.” Magn Reson Med 50(3):649-53 Details


    Gibbs P, Tozer DJ, Liney GP, Turnbull LW (2001), “Comparison of quantitative T2 mapping and diffusion-weighted imaging in the normal and pathologic prostate.” Magn Reson Med 46(6):1054-8 Details


    Liney GP, Tozer DJ, van Hulten HB, Beerens EG, Gibbs P, Turnbull LW (2000), “Bilateral open breast coil and compatible intervention device.” J Magn Reson Imaging 12(6):984-90 Details


    Liney GP, Tozer DJ, Turnbull LW (1999), “A simple and realistic tissue-equivalent breast phantom for MRI.” J Magn Reson Imaging 10(6):968-71 Details