Professor Dino Giussani
Professor Dino Giussani is pleased to consider applications from prospective PhD students.
We have intertwined our interests in oxygen and the development of the central nervous and cardiovascular systems to propose that oxidative stress underlies the common molecular pathway via which prenatal hypoxia contributes to a developmental origin of both neurodegenerative and cardiovascular disease in adulthood, thereby explaining the high co-incidence of cardiovascular disease in patients with diseases involving memory impairment.
The hypothesis will be tested in adult rat offpring of hypoxic or normoxic pregnancy with and without maternal antenatal antioxidant treatment using an integrative approach to analyse interactions within molecular and cellular networks that control whole animal cardiovascular physiology and behaviour.
In vivo physiology
No collaborators listed
Associated News Items
Kane AD, Hansell JA, Herrera EA, Allison BJ, Niu Y, Brain KL, Kaandorp JJ, Derks JB, Giussani DA (2014), “Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy.” J Physiol 592(Pt 3):475-89 Details
Salinas CE, Blanco CE, Villena M, Giussani DA (2014), “High-Altitude Hypoxia and Echocardiographic Indices of Pulmonary Hypertension in Male and Female Chickens at Adulthood.” Circ J Details
Shaw CJ, ter Haar GR, Rivens IH, Giussani DA, Lees CC (2014), “Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery.” J R Soc Interface 11(95):20140029 Details
Kane AD, Camm EJ, Richter HG, Lusby C, Tijsseling D, Kaandorp JJ, Derks JB, Ozanne SE, Giussani DA (2013), “Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat.” Physiol Rep 1(6):e00156 Details
Kane AD, Herrera EA, Camm EJ, Giussani DA (2013), “Vitamin C prevents intrauterine programming of in vivo cardiovascular dysfunction in the rat.” Circ J 77(10):2604-11 Details
Niu Y, Herrera EA, Evans RD, Giussani DA (2013), “Antioxidant treatment improves neonatal survival and prevents impaired cardiac function at adulthood following neonatal glucocorticoid therapy.” J Physiol 591(Pt 20):5083-93 Details
Soria R, Julian CG, Vargas E, Moore LG, Giussani DA (2013), “Graduated effects of high-altitude hypoxia and highland ancestry on birth size.” Pediatr Res 74(6):633-8 Details
Talmor A, Daemen A, Murdoch E, Missfelder-Lobos H, Timmerman D, Bourne T, Giussani DA, Lees C (2013), “Defining the relationship between fetal Doppler indices, abdominal circumference and growth rate in severe fetal growth restriction using functional linear discriminant analysis.” J R Soc Interface 10(88):20130376 Details
Tarry-Adkins JL, Blackmore HL, Martin-Gronert MS, Fernandez-Twinn DS, McConnell JM, Hargreaves IP, Giussani DA, Ozanne SE (2013), “Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth.” Mol Metab 2(4):480-90 Details
Tijsseling D, Camm EJ, Richter HG, Herrera EA, Kane AD, Niu Y, Cross CM, de Vries WB, Derks JB, Giussani DA (2013), “Statins prevent adverse effects of postnatal glucocorticoid therapy on the developing brain in rats.” Pediatr Res 74(6):639-45 Details