Mr Danyal Akarca BMedSc
My master's degree research work focuses on understanding language impairments, specifically in patients with a specific genetic mutation. Patients with ZDHHC9 mutations (an X-linked gene) consistently provide a complex clinical phenotype associated with poor oromotor control, expressive language difficulties and rolandic epilepsy.
My work consists of discerning both the transient brain dynamics, utilising a hidden Markov model, and the sensor-level mismatch negativities of these patients - all acquired MEG, in a roving oddball paradigm. In conjunction with resting state findings and an integration with current clinical data, we hope to enable a comprehensive foundational description as to the neurophysiological signature for language impairment in these patients.