Mr Danyal Akarca BMedSc

Interests

My master's degree research work focuses on understanding language impairments, specifically in patients with a specific genetic mutation. Patients with ZDHHC9 mutations (an X-linked gene) consistently provide a complex clinical phenotype associated with poor oromotor control, expressive language difficulties and rolandic epilepsy.

My work consists of discerning both the transient brain dynamics, utilising a hidden Markov model, and the sensor-level mismatch negativities of these patients - all acquired MEG, in a roving oddball paradigm. In conjunction with resting state findings and an integration with current clinical data, we hope to enable a comprehensive foundational description as to the neurophysiological signature for language impairment in these patients.

Research Focus

Keywords

HMM

MMN

MEG

Language

Clinical conditions

Language disorders

Learning disabilities

Equipment

Computational modelling

Magnetoencephalography

Collaborators

Cambridge

Duncan Astle

Kate Baker

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