My principle research area is investigation of the relationship between Tau and Aß (the two proteins that form pathological aggregates in the brains of Alzheimer's patients) and their influence on axonal transport in Alzheimer's Disease. Axonal transport is the movement of organelles (such as mitochondria) or proteins (such as the laboile axon survival factor nmnat2) from the cell body to the distal neurite (or vice versa). Neurons are the most polarised of all cells, axons being in excess of 100 x longer than their cell body, and so are especially reliant on an efficient delivery system. We hypothesise, that mutliple disruptions of axon transport in Alzheimer's disease, coinciding with a decline in axon transport with age, may underly the extensive neurodegeneration seen in this disorder. By understanding how such effects are brought about, we hope to identify novel therapeutic targets.
Live imaging of axonal transport
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