Dr Claire Quilter

Claire Quilter

University position

Research Associate

Dr Claire Quilter is pleased to consider applications from prospective PhD students.

Departments

Department of Pathology

Home page

http://www.path.cam.ac.uk/pages/a...

Research Themes

Clinical and Veterinary Neuroscience

Cellular and Molecular Neuroscience

Interests

DEFRA/ BBSRC funded project to identify the genetic causes of sow aggression towards their offspring. We propose that this is a good animal model for puerperal psychosis.Transcriptional differences in the hypothalamus between aggressive and non-aggressive sows were measured using expression cDNA microarrays. Confirmation of array results was carried out using QRT-PCR. The microarray analysis was complemented with a quantitative trait loci (QTL) approach using microsatellite markers to scan the porcine genome. An affected sib pair analysis was carried out to determine which markers segregated with the affected phenotype. Further genotyping studies were carried out using the Illumina Porcine SNP array. Haplotypes were identified and were found to be syntenic to human puerperal psychosis and bipolar candidate regions. Current analysis includes deep sequencing of haplotype regions and parent of origin studies for epigenetic changes.

Overall summary of gene networks implicated in porcine maternal infanticide from both microarray and QTL studies (green indicates genes implicated from array results and red, pink, white and grey indicates genes from porcine chromosome QTL regions reported in Quilter et al 2007).
Click image to view full-size

Research Focus

Keywords

Microarray

QTL

SNP

maternal aggression

Puerperal psychosis

Clinical conditions

Alzheimer's disease

Anxiety disorders

Attention deficit hyperactivity disorder

Autism

Bipolar disorder

Borderline personality disorder

Cognitive impairment

Dementia

Depressive disorders

Diabetes

Digestion and nutrition disorders

Dyslexia

Genetic disorders

Hormonal disorders

Obsessive compulsive disorder

Panic disorder

Parkinson's disease

Personality disorders

Puerperal psychosis

Schizophrenia

Seasonal affective disorder

Stress

Equipment

microarrays - expression, SNP, methylation

Microsatellite analysis

Quantitative Real Time PCR

Single nucleotide polymorphism analysis (SNP)

Collaborators

Cambridge

Colin Gilbert

Associated News Items


    Key publications

    Quilter CR, Blott SC, Wilson AE, Bagga MR, Sargent CA, Oliver GL, Southwood OI, Gilbert CL, Mileham A and Affara A (2007), “Porcine maternal infanticide as a model for puerperal psychosis. Am J Med Genet B: Neuropsychiatr Genet. May 14” [Epub ahead of print] Details

    Publications

    2012

    Quilter CR, Sargent CA, Bauer J, Bagga MR, Reiter CP, Hutchinson EL, Southwood OI, Evans G, Mileham A, Griffin DK, Affara NA (2012), “An association and haplotype analysis of porcine maternal infanticide: a model for human puerperal psychosis?” Am J Med Genet B Neuropsychiatr Genet 159B(8):908-27 Details

    2010

    Chen C, Sargent C, Quilter C, Yang Z, Ren J, Affara N, Brenig B, Huang L (2010), “Cloning, mapping and molecular characterization of porcine progesterone receptor membrane component 2 (PGRMC2) gene.” Genet Mol Biol 33(3):471-4 Details

    Cliffe KM, Day AE, Bagga M, Siggens K, Quilter CR, Lowden S, Finlayson HA, Palgrave CJ, Li N, Huang L, Blott SC, Sargent CA (2010), “Analysis of the non-recombining Y chromosome defines polymorphisms in domestic pig breeds: ancestral bases identified by comparative sequencing.” Anim Genet 41(6):619-29 Details

    Quilter CR, Karcanias AC, Bagga MR, Duncan S, Murray A, Conway GS, Sargent CA, Affara NA (2010), “Analysis of X chromosome genomic DNA sequence copy number variation associated with premature ovarian failure (POF).” Hum Reprod 25(8):2139-50 Details

    2008

    Quilter CR, Gilbert CL, Oliver GL, Jafer O, Furlong RA, Blott SC, Wilson AE, Sargent CA, Mileham A, Affara NA (2008), “Gene expression profiling in porcine maternal infanticide: a model for puerperal psychosis.” Am J Med Genet B Neuropsychiatr Genet 147B(7):1126-37 Details

    2005

    Quilter C (2005), “Chromosomal abnormalities & male infertility.” Indian J Med Res 122(1):11-2 Details

    2003

    Day AE, Quilter CR, Sargent CA, Mileham AJ (2003), “Chromosomal mapping, sequence and transcription analysis of the porcine fertilin beta gene (ADAM2).” Anim Genet 34(5):375-8 Details

    Quilter CR, Svennevik EC, Serhal P, Ralph D, Bahadur G, Stanhope R, Sütterlin M, Delhanty JD, Taylor KE (2003), “Cytogenetic and Y chromosome microdeletion screening of a random group of infertile males.” Fertil Steril 79(2):301-7 Details

    Quilter CR, Wood D, Southwood OI, Griffin DK (2003), “X/XY/XYY mosaicism as a cause of subfertility in boars: a single case study.” Anim Genet 34(1):51-4 Details

    2002

    Day AE, Quilter CR, Sargent CA, Mileham AJ (2002), “Characterization of the porcine sperm adhesion molecule gene SPAM1- expression analysis, genomic structure, and chromosomal mapping.” Anim Genet 33(3):211-4 Details

    Quilter CR, Blott SC, Mileham AJ, Affara NA, Sargent CA, Griffin DK (2002), “A mapping and evolutionary study of porcine sex chromosome genes.” Mamm Genome 13(10):588-94 Details

    Quilter CR, Nathwani N, Conway GS, Stanhope R, Ralph D, Bahadur G, Serhal P, Taylor K, Delhanty JD (2002), “A comparative study between infertile males and patients with Turner syndrome to determine the influence of sex chromosome mosaicism and the breakpoints of structurally abnormal Y chromosomes on phenotypic sex.” J Med Genet 39(12):e80 Details

    2001

    Quilter CR, Holman S, AL-Hammadi RM, Theodorides D, Hastings RJ, Delhanty JD (2001), “Aneuploidy screening in direct chorionic villus samples by fluorescence in situ hybridisation: the use of commercial probes in a clinical setting.” BJOG 108(2):215-8 Details

    1999

    Cirigliano V, Sherlock J, Conway G, Quilter C, Rodeck C, Adinolfi M (1999), “Rapid detection of chromosomes X and Y aneuploidies by quantitative fluorescent PCR.” Prenat Diagn 19(12):1099-103 Details

    1998

    Davison RM, Quilter CR, Webb J, Murray A, Fisher AM, Valentine A, Serhal P, Conway GS (1998), “A familial case of X chromosome deletion ascertained by cytogenetic screening of women with premature ovarian failure.” Hum Reprod 13(11):3039-41 Details

    Quilter CR, Taylor K, Conway GS, Nathwani N, Delhanty JD (1998), “Cytogenetic and molecular investigations of Y chromosome sequences and their role in Turner syndrome.” Ann Hum Genet 62(Pt 2):99-106 Details