Dr Colin Watts
Clinician Scientist & Hon Consultant Neurosurgeon
Dr Colin Watts is pleased to consider applications from prospective PhD students.
Lab-based research is focused on the genomics of glioblastoma (GBM) and in the role of glial progenitors in their evolution and development. We are also interested in developing patient-specific models of GBM to evaluate intra-tumour variability in genomic and clonal architecture. We have established protocols to generate tumour cell lines from individual patients with high efficiency and used them to evaluate tumour growth, treatment response and the emergence of disease resistance using in-vitro and in-vivo models.
In the operating room we have developed FGMS (Fluorescence-Guided Multiple Sampling) as a unique means of interrogating GBM in real time during surgery. We have coupled this with integrated genomic analysis to establish high-resolution molecular genetic characterisation of GBM, enable phylogenetic reconstruction and define clonal organisation of tumours at the level of the individual patient. see also http://www.cancer.cam.ac.uk/directory/profile.php?cw209
Traumatic brain injury
Cell transplantation & experimental neurosurgery
Magnetic resonance imaging (MRI)
Anthony Chalmers Web: http://www.gla.ac.uk/researc...
Mel Greaves Web: http://Mel.Greaves@icr.ac.uk
Karen Kirkby Web: http://www.ati.surrey.ac.uk/profile...
Christina Curtis Web: http://cancersysbio.usc.edu/index.html
Jackie Trotter Web: http://www.ftn.uni-mainz.de/wp-cont...
Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S (2007), “Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells” Brain 130(5):1263-75 Details
Ozen I, Galichet C, Watts C, Parras C, Guillemot F, Raineteau O (2007), “Proliferating neuronal progenitors in the postnatal hippocampus transiently express the proneural gene Ngn2” Eur J Neurosci 25(9):2591-2603 Details
Watts C, McConkey H, Anderson L, Caldwell M (2005), “Anatomical perspectives on adult stem cells” J Anat 207:197-208 Details